Macromolecular Rapid Communications

Cover image for Vol. 35 Issue 8

October 27, 2010

Polymer Conjugates: Biologically Inspired Coiled Coil Linkers in Polymer-Drug Conjugates

Polymer Conjugates: Biologically Inspired Coiled Coil Linkers in Polymer-Drug Conjugates

Bojana Apostolovic, Samuel P.E. Deacon, Ruth Duncan, and Harm-Anton Klok*

Polymer-drug conjugates are nanomedicines that consist of a water-soluble, biocompatible polymer backbone to which multiple copies of a drug molecule are bound. The linkers connecting the polymer and the drug can respond to external stimuli (pH or the presence of enzymes) and thereby trigger the release process of the drug. Harm-Anton Klok and co-workers introduced a conceptually novel class of polymer-drug conjugates in which the drug molecules are attached to the polymer via a noncovalent, so called coiled coil motif, which is formed by heterodimerization of two complementary peptide strands, one of which is attached to the polymer carrier and the other to the drug. In this study, further insight into the cell uptake and trafficking behavior of these nanomedicines is obtained using cytotoxicity and FACS experiments. The results provide important information for the design of future polymer-drug conjugates.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000434

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