Macromolecular Rapid Communications

Cover image for Vol. 35 Issue 8

December 09, 2010

Polymer Conjugates: Amine-Reactive PEGylated Nanoparticles for Potential Bioconjugation

Polymer Conjugates: Amine-Reactive PEGylated Nanoparticles for Potential Bioconjugation

Guillaume Delaittre,* Gemma Justribo-Hernandez, Roeland J. M. Nolte, and Jeroen J. L. M. Cornelissen*

Functionalization of the surface of nanoparticles (NPs) is a highly important field, especially regarding their application as transport agents in drug delivery systems. Amongst others, a suitable way to obtain polymeric NPs is through the self-assembly of amphiphilic block copolymers. If the watersoluble block contains a specific moiety then the NPs will also be functionalized on their surface. Guillaume Delaittre, Jeroen Cornelissen and co-workers have developed a route towards amine-reactive polymeric NPs by using an amphiphilic block copolymer, which contains an N-hydrosuccinimidyl (NHS) ester at its water-soluble end. The reactivity of the NPs was evidenced by reacting them with primary amines, including a fluorescent dye. The activated ester remained stable throughout all synthetic steps and a nearly quantitative coupling efficiency was obtained. This work represents the first example of a PEGylated nanoparticular system with reactivity towards amines.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000365

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