Macromolecular Rapid Communications

Cover image for Vol. 37 Issue 18

March 15, 2012

Polymer Conjugates: Molecular Bottlebrushes with Polypeptide Backbone

Polymer Conjugates: Molecular Bottlebrushes with Polypeptide Backbone

Yu Liu, Ping Chen, and Zhibo Li*

Molecular bottlebrushes display unique macromolecular architectures with interesting properties and potential applications. Molecular bottlebrushes with polypeptides are of particular interest because they synthetically mimic natural proteoglycan. It is a challenging task to make well-defined polypeptide bottlebrush with tunable and variable side chain. Zhibo Li and co-workers (Institute of Chemistry, Chinese Academy of Sciences, Beijing) report the design and synthesis of molecular bottlebrush bearing poly-L-lysine as a backbone. A new bromo-functionalized homopolypeptide is synthesized via ring-opening polymerization, which is then used as an efficient macroinitiator for atom transfer radical polymerization of side chains to give well-defined polypeptide bottlebrushes.

Macromol. Rapid Commun., DOI: 10.1002/marc.201100649

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