Macromolecular Rapid Communications

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April 17, 2015

TALENT: Regioselective Metal-Free Click Polymerization of Azides and Alkynes

TALENT: Regioselective Metal-Free Click Polymerization of Azides and Alkynes

Anjun Qin,* Yong Liu, Ben Zhong Tang*

Metal-free click polymerization (MFCP) has been developed to circumvent the problems inherent in the broadly-applied Cu(I)-catalyzed azide-alkyne click polymerization reactions. The regioselective MFCP of azides and alkynes to produce regioregular polytriazoles is summarized, and the properties and applications of the resultant polymers are also discussed.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400571

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

February 03, 2015

TALENT: Bioinspired Polymeric Nanocomposites for Regenerative Medicine

TALENT: Bioinspired Polymeric Nanocomposites for Regenerative Medicine

James K. Carrow and Akhilesh K. Gaharwar*

Designing bioinspired nanomaterials for tissue-engineering applications requires a fundamental understanding of the interactions between polymers, nanostructures, and cells. Biomimetic structures composed of fibrous architectures are discussed, the emerging trends in designing complex nanocomposites with multiple functionalities are assessed and finally, some of the most critical challenges that come with the design and fabrication of bioinspired polymeric nanocomposites are highlighted.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400427

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

January 30, 2015

POLYOLEFINS: The Use of Solid-State NMR to Investigate the Development of Segmental Mobility in Commercial Heterophasic Ethylene Propylene Copolymers (HEPCs)

POLYOLEFINS: The Use of Solid-State NMR to Investigate the Development of Segmental Mobility in Commercial Heterophasic Ethylene Propylene Copolymers (HEPCs)

Linda Botha, Pritish Sinha, H. Duveskog, Albert J. Van Reenen*

Solid state 13C NMR probes the changes in distribution of ethylene in rigid and amorphous domains of impact copolymers. In this publication, the observations from the perspective of the solid-state analyses are outlined and placed in the context of the evolution of microscopic, chemical, microstructural, and mechanical properties.

Macromol. React. Eng. DOI: 10.1002/mren.201400043

Other contributions to the article series on "Polyolefins - Catalyst and Process Innovations" can be found here.

January 30, 2015

TREND: Supramolecular Assembly-Assisted Synthesis of Responsive Polymeric Materials with Controlled Chain Topologies

TREND: Supramolecular Assembly-Assisted Synthesis of Responsive Polymeric Materials with Controlled Chain Topologies

Jinming Hu, Shiyong Liu*

Recent advances concerning the fabrication of stimuli-responsive polymeric materials under the assistance of supramolecular self-assembly are summarized. The templated synthesis of linear (multiblock) copolymers, non-linear shaped copolymers, as well as crosslinked nanostructures on the basis of supramolecular assemblies is discussed.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400578

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

January 21, 2015

TREND: Polymers and Ionic Liquids: A Successful Wedding

TREND: Polymers and Ionic Liquids: A Successful Wedding

Sébastien Livi,* Jannick Duchet-Rumeau, Jean-François Gérard, Thi Nhan Pham

Different pathways for development of nanostructured and advanced materials are summarized, based on the use of ionic liquids (ILs) as multifunctional agents of polymer matrices. The true potential of ILs in the design of new polymeric materials with unprecedented mechanical per­formance, thermal stability, and barrier properties is highlighted.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400425

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

August 26, 2014

POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

Saeid Ahmadjo, Samaneh Dehghani, Gholam Hossein Zohuri, Gholam Reza Nejabat, Hamed Jafarian, Mostafa Ahmadi and Seyed Mohammad Mahdi Mortazavi*

Ziegler-Natta (ZN) and late transition metal (LTM) hybrid catalysts were synthesized and utilized in preparation of polyethylene (PE) reactor alloys. By changing reaction parameters, versatile thermal behavior from LTM-PE to ZN-PE could be obtained. The proposed method seems to be a promising approach for synthesis of tailor-made polyethylene in a single reactor.

Macromol. React. Eng. DOI: 10.1002/mren.201400024

Other contributions to the article series on "Polyolefins - Catalyst and Process Innovations" can be found here.

March 15, 2012

Polymer Conjugates: Molecular Bottlebrushes with Polypeptide Backbone

Polymer Conjugates: Molecular Bottlebrushes with Polypeptide Backbone

Yu Liu, Ping Chen, and Zhibo Li*

Molecular bottlebrushes display unique macromolecular architectures with interesting properties and potential applications. Molecular bottlebrushes with polypeptides are of particular interest because they synthetically mimic natural proteoglycan. It is a challenging task to make well-defined polypeptide bottlebrush with tunable and variable side chain. Zhibo Li and co-workers (Institute of Chemistry, Chinese Academy of Sciences, Beijing) report the design and synthesis of molecular bottlebrush bearing poly-L-lysine as a backbone. A new bromo-functionalized homopolypeptide is synthesized via ring-opening polymerization, which is then used as an efficient macroinitiator for atom transfer radical polymerization of side chains to give well-defined polypeptide bottlebrushes.

Macromol. Rapid Commun., DOI: 10.1002/marc.201100649

March 15, 2012

Polymer Conjugates: A Plethora of Block Copolypeptides

Polymer Conjugates: A Plethora of Block Copolypeptides

Gijs J. M. Habraken, Andreas Heise, and Paul D. Thornton*

While natural polypeptides with a specific sequence of amino acid constituents adopt structural motifs such as α-helices, β-sheets, and random coils through non-covalent interactions, the occurrence of these features in synthetic polymers is rare. However, extended (homo)polypeptides consisting of a limited number of amino acids that lack a specific sequence can be created by N-carboxyanhydride ring-opening polymerization (NCA ROP) as a synthetically straightforward methodology to afford polypeptidic materials that may adopt secondary structures analogous to those of natural proteins. Such structures may offer biocompatibility in addition to stimuli-responsive and self-assembly properties. Paul D. Thornton and co-workers from Dublin City University offer an insight into contemporary synthetic approaches toward NCA ROP before highlighting a number of block copolypeptide architectures.

Macromol. Rapid Commun., DOI: 10.1002/marc.201100730

October 07, 2011

Polymer Conjugates: 3D Arrangement of Short DNA Oligonucleotides at Surfaces

Polymer Conjugates: 3D Arrangement of Short DNA Oligonucleotides at Surfaces

Olivier Y. F. Henry,* Ahmed D. Mehdi, Sinead Kirwan, Josep Luis Acero Sanchez, and Ciara K. O'Sullivan*

The need for new approaches to realize rapid and highly sensitive diagnostic devices and environmental monitoring systems requires ever more effective surface chemistries. The arrangement of short DNA oligonucleotides at surfaces plays a major role in the overall surface binding capacity of the complementary sequence present in a sample. Henry, O'Sullivan and co-workers incorporate short DNA oligonucleotide into acrylamide brushes via surface initiated ATRP in an attempt to increase the DNA surface density by building 3D molecular architectures. The morphology and the performance of the resulting polymer are characterized by surface plasmon resonance and ATR-FTIR spectroscopy, as well as MALDI-TOF analysis, and compared to monolayers of thiolated DNA strands. This new approach offers a promising alternative to SAM-based nucleic acid and aptamer sensors and could enable the realization of more complex soft materials of controlled architecture capable of both recognition and signaling by including additional optically or electrochemically active moieties.

Macromol. Rapid Commun., DOI: 10.1002/marc.201100317

January 25, 2011

Polymer Conjugates: Grafting-from and RAFT Polymerization - A Powerful Combination

Polymer Conjugates: Grafting-from and RAFT Polymerization - A Powerful Combination

Ming Li, Hongmei Li, Priyadarsi De, and Brent S. Sumerlin*

Modification of biomacromolecules with synthetic polymers is an effective means to enhance the solubility, biocompatibility, stability and activity of proteins, nucleic acids, and polysaccharides, potentially enabling a variety of new biotechnology applications. The group of Brent Sumerlin (Dallas, USA) presents the first example of combining the grafting-from and RAFT technique, providing a new method for the preparation of block copolymer polymer-protein conjugates. The resulting conjugates prepared by two consecutive grafting-from reactions via RAFT polymerization exhibit thermoresponsive behavior due to the temperature-sensitivity of the PNIPAM block.
This article is addtionally featured on MaterialsViews.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000619

December 09, 2010

Polymer Conjugates: Amine-Reactive PEGylated Nanoparticles for Potential Bioconjugation

Polymer Conjugates: Amine-Reactive PEGylated Nanoparticles for Potential Bioconjugation

Guillaume Delaittre,* Gemma Justribo-Hernandez, Roeland J. M. Nolte, and Jeroen J. L. M. Cornelissen*

Functionalization of the surface of nanoparticles (NPs) is a highly important field, especially regarding their application as transport agents in drug delivery systems. Amongst others, a suitable way to obtain polymeric NPs is through the self-assembly of amphiphilic block copolymers. If the watersoluble block contains a specific moiety then the NPs will also be functionalized on their surface. Guillaume Delaittre, Jeroen Cornelissen and co-workers have developed a route towards amine-reactive polymeric NPs by using an amphiphilic block copolymer, which contains an N-hydrosuccinimidyl (NHS) ester at its water-soluble end. The reactivity of the NPs was evidenced by reacting them with primary amines, including a fluorescent dye. The activated ester remained stable throughout all synthetic steps and a nearly quantitative coupling efficiency was obtained. This work represents the first example of a PEGylated nanoparticular system with reactivity towards amines.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000365

October 27, 2010

Polymer Conjugates: Biologically Inspired Coiled Coil Linkers in Polymer-Drug Conjugates

Polymer Conjugates: Biologically Inspired Coiled Coil Linkers in Polymer-Drug Conjugates

Bojana Apostolovic, Samuel P.E. Deacon, Ruth Duncan, and Harm-Anton Klok*

Polymer-drug conjugates are nanomedicines that consist of a water-soluble, biocompatible polymer backbone to which multiple copies of a drug molecule are bound. The linkers connecting the polymer and the drug can respond to external stimuli (pH or the presence of enzymes) and thereby trigger the release process of the drug. Harm-Anton Klok and co-workers introduced a conceptually novel class of polymer-drug conjugates in which the drug molecules are attached to the polymer via a noncovalent, so called coiled coil motif, which is formed by heterodimerization of two complementary peptide strands, one of which is attached to the polymer carrier and the other to the drug. In this study, further insight into the cell uptake and trafficking behavior of these nanomedicines is obtained using cytotoxicity and FACS experiments. The results provide important information for the design of future polymer-drug conjugates.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000434

April 17, 2015
TALENT: Regioselective Metal-Free Click Polymerization of Azides and Alkynes

February 03, 2015
TALENT: Bioinspired Polymeric Nanocomposites for Regenerative Medicine

January 30, 2015
POLYOLEFINS: The Use of Solid-State NMR to Investigate the Development of Segmental Mobility in Commercial Heterophasic Ethylene Propylene Copolymers (HEPCs)

January 30, 2015
TREND: Supramolecular Assembly-Assisted Synthesis of Responsive Polymeric Materials with Controlled Chain Topologies

January 21, 2015
TREND: Polymers and Ionic Liquids: A Successful Wedding

August 26, 2014
POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

March 15, 2012
Polymer Conjugates: Molecular Bottlebrushes with Polypeptide Backbone

March 15, 2012
Polymer Conjugates: A Plethora of Block Copolypeptides

October 07, 2011
Polymer Conjugates: 3D Arrangement of Short DNA Oligonucleotides at Surfaces

January 25, 2011
Polymer Conjugates: Grafting-from and RAFT Polymerization - A Powerful Combination

December 09, 2010
Polymer Conjugates: Amine-Reactive PEGylated Nanoparticles for Potential Bioconjugation

October 27, 2010
Polymer Conjugates: Biologically Inspired Coiled Coil Linkers in Polymer-Drug Conjugates

September 29, 2010
Polymer Conjugates: A Playground for Novel Copolymers

August 19, 2010
Polymer Conjugates: How to Purify Proteins Using Polymers

August 18, 2010
Polymer Conjugates: Studying Controlled Release from Liposomes Using Polymer-Enzyme Conjugates

July 08, 2010
Polymer Conjugates: Cell Receptor-Responsiveness and Targeted Delivery of Growth Factors

July 06, 2010
Polymer Conjugates: Bioorganic Nanoobjects of DNA Block Copolymers

June 24, 2010
Polymer Conjugates: Chemistry Meets Biology

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