Macromolecular Chemistry and Physics
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Recently Published Articles
- Effect of Supercritical Carbon Dioxide on the Loading and Release of Model Drugs from Polyurethane Films: Comparison with Solvent Casting
Jing Zhang, Darren J. Martin, Elena Taran, Kristofer J. Thurecht and Rodney F. Minchin
Article first published online: 2 DEC 2013 | DOI: 10.1002/macp.201300492
Supercritical CO2 can be used to load drug-like molecules into thin polyurethane films for time-dependent drug release. Minimal changes to its mechanical properties occur, but microphase rearrangement of the hard segments to the surface of the film during CO2 annealing may affect the drug release. Drug efflux profiles are dependent on both the chemical structure of the drug and the composition of the polyurethane, which may allow for fine tuning of the drug-release kinetics for in vivo applications.
- Convenient Synthesis of a Polyester-co-Polyether Block for Assembling Biocompatible Hyperbranched Macromolecules
Igor Elkin and Patrice Hildgen
Article first published online: 29 NOV 2013 | DOI: 10.1002/macp.201300578
Synthesis of a novel multifunctional polyester-co-polyether (PEPE) block based on asymmetrically substituted pentaerythritol, succinic acid, and tetraethylene glycol is reported. The proposed reaction conditions allow selective preparation of the product in high overall yield. The block is used in the assembly of PEPE dendrons of second generation by classical step-by-step and alternative “block by block” strategies.
- Collective Dynamics and Transient Behavior of Partially Hydrophobic Hyaluronic Acid Chains
Ivana Finelli, Ester Chiessi, Letizia Oddo, Devis Galesso, Davide Renier and Gaio Paradossi
Article first published online: 29 NOV 2013 | DOI: 10.1002/macp.201300503
Fluorescence recovery after photobleaching shows dramatic differences in the diffusional behavior of hyaluronic acid (HA) and partially hydrophobized hyaluronic acid (HYADD4): in HA, the fluorescence is recovered after about 50 s, whereas in HYADD4 the bleach remains after several minutes. The polymer concentration, Cp = 0.8% (w/v), is the same in both experiments.
- Synthesis of Amphiphilic Polymers Based on Fatty Acids and Glycerol-Derived Monomers – A Study of Their Self-Assembly in Water
Jefferson Rotta, Phuoc Dien Pham, Vincent Lapinte, Rédouane Borsali, Edson Minatti and Jean-Jacques Robin
Article first published online: 26 NOV 2013 | DOI: 10.1002/macp.201300483
Various biobased compounds are polymerized to give amphiphilic polymers according to a simple procedure. Telomerization of glycerin-derived acrylate with mercaptan-modified fatty acids as telogen agents is studied, leading to telomers capable of self-assembling into nanosized spherical particles in aqueous solution.
- Dual-Functional PEI–Poly(γ-Cholesterol-l-Glutamate) Copolymer for Drug/Gene Co-delivery
Jinkun Zhang, Dailong Fang, Qing Ma, Zhiyao He, Ke Ren, Rui Zhou, Shi Zeng, Bo Li, Lili He, Gu He and Xiangrong Song
Article first published online: 24 NOV 2013 | DOI: 10.1002/macp.201300551
A series of novel amphiphilic PEI-poly(γ-cholesterol-L-glutamate) (PEI-PCHLG) copolymers are synthesized and characterized. One of PEI-PCHLG copolymers can self-assemble into micelles. The PCHLG block assembles into micelles with high drug entrapment, and the grafted PEI block can act as a hydrophilic section exposed outside the micelles, which are capable of carrying genes. Thus PEI-PCLG copolymers are potential carriers for drug/gene co-delivery.