Macromolecular Chemistry and Physics
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
November 17, 2010
TALENT: Polymers for Control Freaks
Compared to biological polymers, most synthetic polymers utilized in medicine are often polydisperse in nature, statistically modified, and empirically optimized. Inherent distributions result in disperse structure-property relationships, which renders interpretation of the biological properties for such polymers difficult. Laura Hartmann presents in her Talent Article a novel synthetic strategy towards monodisperse, sequence-defined poly(amidoamine)s. Variations of the chemical structures are used to directly control the ability of such polycations to complex DNA and function as non-viral vectors. Her future work is expected to provide a deeper understanding of the interactions of fully synthetic with biological systems and using these interactions for the design of bioactive polymer-based materials.
This Talent Article is addtionally featured on MaterialsViews.
Macromol. Chem. Phys., DOI: 10.1002/macp.201000479