20_03b/2008Inside Front Cover: Enzyme-Based Multi-Component Optical Nanoprobes for Sequence-Specific Detection of DNA Hybridization (Adv. Mater. 3/2008)

A novel multicomponent gold nanoparticle (AuNP)-based nanoprobe can be assembled from a thiolated DNA detection probe, horseradish peroxidase (HRP), and bovine serum albumin (BSA), report Shiping Song, Yun Zhao, Chunhui Fan, and co-workers on p. 497. The DNA detection probe is employed to construct a complex for “sandwich”-based DNA detection, the HRP translates the hybridization event into an enzymatic catalysis-based optical signal, and BSA serves as a non-specific blocker.

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