21_09/2009Self-Assembled Multicomponent Chromophores: Conjugated Oligoelectrolyte/ssDNA Aggregates: Self-Assembled Multicomponent Chromophores for Protein Discrimination (Adv. Mater. 9/2009)

Guillermo Bazan and Huaping Li show on p. 964 that a range of optical reporters can be prepared by electrostatic interactions between a cationic conjugated oligoelectrolyte (COE) and dye-labeled single-stranded DNAs (ssDNA). Proteins perturb the optical properties of these aggregates and generate unique fluorescence resonance energy transfer (FRET) patterns that allow protein discrimination. Two different signatures can be obtained, depending on whether the fluorescence intensity of the COE or the ssDNAbound dye is observed.

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