Advanced Materials

Cover image for Vol. 29 Issue 4

21_41/2009Enzyme-Responsive Hydrogels: Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels (Adv. Mater. 41/2009)

On p. 4148, Sarah Heilshorn and Karin Straley demonstrate the design of a family of adaptive protein polymers with highly tunable and predictable degradation rates suitable for complex tissue-engineering applications. The cover image shows fluorescently labeled neurons grow and extend neurites on a protein-engineered biomaterial. Enzymes secreted by the neurons trigger selective degradation of specific regions of the biomaterial, allowing dynamic 3D patterns to emerge over time. Microscope images were acquired by Karin Straley. Digital art by Chelsea Castillo.

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