© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Peter Gregory, Deputy Editors: Mary De Vita, Duoduo Liang, Lorna Stimson
Online ISSN: 1521-4095
Associated Title(s): Advanced Biosystems, Advanced Electronic Materials, Advanced Energy Materials, Advanced Engineering Materials, Advanced Functional Materials, Advanced Healthcare Materials, Advanced Materials Interfaces, Advanced Materials Technologies, Advanced Optical Materials, Advanced Science, Advanced Sustainable Systems, Global Challenges, Laser & Photonics Reviews, Particle & Particle Systems Characterization, Small Methods, Small
Drug Delivery: Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA (Adv. Mater. 43/2010)
A new strategy to create biodegradable drug-loaded coatings on microneedle patches, using a process known as layer-by-layer (LbL) self-assembly, is reported on p. 4851 by Paula Hammond and coworkers. Water-soluble polymers are adsorbed with oppositely-charged drugs or drug-carrying polymer particles in alternating layers, creating extremely thin coatings loaded with high levels of entrapped drugs. These biodegradable films can be used to deposit DNA or drug-carrier nanoparticles into the skin, representing model drug cargos that could be used for vaccination or other therapeutic drug delivery.