24_21i/2012Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012)

Multifunctional drug-delivery systems have shown promising applications in cancer therapy. J. Ren, X. Qu, and co-workers report a novel, cell-targeting, NIR light responsive drug-delivery system on page 2890, which is based on gold nanorods incorporated within a mesoporous silica framework and surface-functionalized with aptamer DNA. With its high NIR absorbance, good biocompatibility, and selectivity, the as-prepared nanovehicle can be used as chemo-photothermal therapy agent to destroy cancer cells efficiently with high spatial/temperal resolution.

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