24_26b/2012Covalent Cross-Linking: Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross-Linking and Their Application for Specific Cellular Imaging (Adv. Mater. 26/2012)

Stable and highly fluorescent small semiconducting polymer dots (Pdots) are prepared by D. T. Chiu and co-workers using a covalent cross-linking strategy described on page 3498. In this confocal fluorescence microscopy image, microtubules in HeLa cells are specifically labeled by the cross-linked Pdots, and individual tubular structures can be seen under 488 nm laser illumination. Cross-linked Pdots are shown to have desirable characteristics for improved labeling efficiency and sensitivity in cellular assays.

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