24_27b/2012Drug Delivery: Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012)

Liposomes with multistage pH-response to a mildly acidic tumor extracellular matrix and acidic intracellular compartments are like rockets for transporting anticancer drugs to mitochondria, as reported by C. Zhang and co-workers. On page 3659, liposomes reverse the charge of the tumor microenvironment, enhancing cellular uptake (white flying rocket), escape from endolysosomes (blue sphere), and delivery to mitochondria in tumor cells (black flying rocket), providing a safe, efficient carrier platform for cascade drug delivery on the basis of a kinetic process.

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