Advanced Materials

Cover image for Vol. 26 Issue 48

24_28/2012Biomolecular Materials: Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo (Adv. Mater. 28/2012)

Peptide amphiphiles, synthesized by conjugating bioactive peptides to hydrophobic dialkyl tails, have been developed as a modular platform for immunotherapy, as discussed by M. Black, A. Trent and co-workers on page 3845. The image (by Peter Allen at UCSB) illustrates how the amphiphiles self-assemble into dynamic micellar structures in which many copies of peptide antigens are presented on the micelle periphery. Unlike peptides alone, the micelles, without any additional adjuvant, promote peptide-specific immune responses in vivo.

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