Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Peter Gregory, Deputy Editors: Carolina Novo da Silva, Lorna Stimson
Online ISSN: 1521-4095
Associated Title(s): Advanced Energy Materials, Advanced Engineering Materials, Advanced Functional Materials, Advanced Healthcare Materials, Advanced Materials Interfaces, Advanced Optical Materials, Particle & Particle Systems Characterization, Small
Biomolecular Materials: Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo (Adv. Mater. 28/2012)
Peptide amphiphiles, synthesized by conjugating bioactive peptides to hydrophobic dialkyl tails, have been developed as a modular platform for immunotherapy, as discussed by M. Black, A. Trent and co-workers on page 3845. The image (by Peter Allen at UCSB) illustrates how the amphiphiles self-assemble into dynamic micellar structures in which many copies of peptide antigens are presented on the micelle periphery. Unlike peptides alone, the micelles, without any additional adjuvant, promote peptide-specific immune responses in vivo.