24_40b/2012Nanosensors: Ordered Arrays of Raman Nanosensors for Ultrasensitive and Location Predictable Biochemical Detection (Adv. Mater. 40/2012)

Surface-enhanced raman scattering (SERS) effect is sensitive enough for single-molecule biochemical detection, but it is extremely difficult to obtain a large number of SERS hotspots for sensitive and reproducible detection. It is even more challenging to assemble the hot-spots at designated positions for location predictable sensing. On page 5457, D. L. Fan and co-workers report an original strategy for the synthesis, manipulation, and assembling of plasmonic nanocapsule SERS sensors for high-sensitivity biochemical detection at predictable locations.

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