25_22/2013Biomedical Applications: Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer-Functionalized Gold Nanostars (Adv. Mater. 22/2013)

Chlorin e6-conjugated gold nanostars (GNSPEG-Ce6) are constructed by X. Chen, G. Lu, and co-workers on page 3055 as a novel theranostic system for imaging, and photodynamic and photothermal therapy. Utilizing the difference in photostability between chlorin e6 and gold nanostars, GNS-PEG-Ce6 can coordinate the early-phase photodynamic effect with the late-phase photothermal effect upon single wavelength continuous wave laser irradiation. With significantly improved anti-cancer efficacy and simplified treatment process, the GNS-PEGCe6 formula shows high potential for translation into clinical practice to treat cancer patients.

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