Advanced Materials

Cover image for Vol. 27 Issue 20

25_26i/2013Cancer Therapy: Diamond-Lipid Hybrids Enhance Chemotherapeutic Tolerance and Mediate Tumor Regression (Adv. Mater. 26/2013)

To facilitate targeted drug delivery using nanodiamond (ND) vehicles, epirubicin-functionalized ND/lipid hybrids are coupled to epidermal growth factor receptor (EGFR) antibodies. The resulting particles mediate tumor regression, and markedly improve drug tolerance in a triplenegative breast cancer model in vivo. Furthermore, comprehensive biocompatibility analysis following intravenous ND administration indicate that the particles are well tolerated by mice. Further information can be found in the article by Dean Ho and co-workers on page 3532.

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