Nano-in-Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery
Rita B. Restani, A. Sofia Silva, Rita F. Pires, Renato Cabral, Ilídio J. Correia, Teresa Casimiro, Vasco D. B. Bonifácio and Ana Aguiar-Ricardo
Version of Record online: 3 AUG 2016 | DOI: 10.1002/ppsc.201600123
Nano-in-micro dry powder formulations with high swelling rate enable efficient drug delivery to the deep lung. Nontoxic (S)-ibuprofen-loaded nanoparticles are incorporated in chitosan microparticles using supercritical-fluid-assisted spray drying. The biocompatible and biodegradable formulations show high cellular uptake and promising physical and chemical properties, suitable for smart delivery through the lungs for both systemic and local delivery.