Chemical Engineering & Technology
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Every month, the Editors select two papers referring to current discussions in the scientific, public and economic communities and in view of the potential for further developments. The papers are freely accessible for one month.
High-Tensile-Strength Paracetamol Tablets
June 15, 2015
Fast-dissolving products are of high interest in the pharmaceutical industry due to drug delivery issues as well as in the food industry. The freeze-casting process can be applied not only to produce dense materials, but also to create materials with adjustable porous microstructures. The low-temperature process facilitates the formulation of drug carrier systems, and the designable microstructure can promote matrix-solvent interaction, therefore, it improves the drug dissolution, bioavailability, the therapeutic effect of the active ingredients as well as the capability to prolong the life time of a bioproduct. P. T. N. Nguyen and J. Ulrich successfully produced fast dissolving porous dosage forms (tablets), containing paracetamol as the active pharmaceutical ingredient and modified starch as an additive, by the freeze-casting technique. The freeze-casted tablets own equal tensile strength and a threefold faster disintegration time compared to commercial compressed tablets, i.e., < 3 min in comparison to 10 min of commercial tablets.
Phuong Thi Nhat Nguyen and Joachim Ulrich
Production of High-Tensile-Strength Paracetamol Tablets Using the Freeze-Casting Process
Chem. Eng. Technol. 2015, 38 (6), 991-998.