Chemical Engineering & Technology

Cover image for Vol. 37 Issue 10

Impact Factor: 2.175

ISI Journal Citation Reports © Ranking: 2013: 39/133 (Engineering Chemical)

Online ISSN: 1521-4125

Associated Title(s): Chemie Ingenieur Technik, ChemBioEng Reviews, Energy Technology

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October 08, 2014

Editors' Choice: Microwave Setup Design for Continuous Fine-Chemicals Synthesis

Editors' Choice: Microwave Setup Design for Continuous Fine-Chemicals Synthesis

Beginning its journey in 1986, the field of microwave-assisted organic synthesis has grown multifolds. The core of this surge in popularity lies in the clean and fast supply of heat to reaction media. Microwave heating also permits instantaneous switching on and off of the power and thus heat supply to the reaction system. This possibility makes the operation inherently safe. The current challenge of this heating technology is its application together with continuous-flow systems for the production of high-added-value organic specialties on a kilogram scale. J. C. Schouten tested state-of-the-art multi- and monomode microwave cavities for their suitability in designing a microwave-integrated microflow reactor heat exchanger. Based on this study, a microwave setup consisting of four cavities was designed and constructed. This novel monomode microwave setup not only allowed proper formulation of the complete energy balances, but also reduced the grid to applicator losses by utilizing only one magnetron to supply the four individual cavities. The distribution of maximum microwave power in the four cavities was within the range of 380–540 W for its essential use in unitized scale-up.


Narendra G. Patil, Faysal Benaskar, Evgeny V. Rebrov, Jan Meuldijk, Lumbertus A. Hulshof, Volker Hessel, and Jaap C. Schouten
Microwave Setup Design for Continuous Fine-Chemicals Synthesis
Chem. Eng. Technol. 2014, 37 (10), 1645–1653.
DOI: 10.1002/ceat.201400118


October 08, 2014

Editors' Choice: Liquid-Liquid Chromatography

Editors' Choice: Liquid-Liquid ChromatographyIn support-free liquid-liquid chromatography, also called countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC), the mobile and the stationary phases are two phases of a multicomponent biphasic liquid system. Currently, the selection of biphasic solvent systems is normally done by experimental screening, and it is very often the most time-consuming step in the development of a CCC/CPC separation process. This is the reason why in most cases the screening is limited to a restricted number of standard biphasic multisolvent systems with predefined global compositions, the so-called solvent system families. M. Minceva et al. proposed an approach that includes prediction of the liquid-liquid equilibrium of the screened biphasic solvent system, followed by the prediction of the partition coefficients of target solutes in different preselected global compositions of the screened system. Using predicted partition coefficients, the experimental effort to choose of a suitable solvent system can be drastically reduced, because systems leading to partition coefficients deviating significantly from the desired values can be excluded in advance.


Andreas Frey, Elisabeth Hopmann, and Mirjana Minceva
Selection of Biphasic Liquid Systems in Liquid-Liquid Chromatography Using Predictive Thermodynamic Models
Chem. Eng. Technol. 2014, 37 (10), 1663–1674.
DOI: 10.1002/ceat.201400234


October 08, 2014
Editors' Choice: Microwave Setup Design for Continuous Fine-Chemicals Synthesis

October 08, 2014
Editors' Choice: Liquid-Liquid Chromatography

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