Chemical Engineering & Technology

Cover image for Vol. 38 Issue 7

Impact Factor: 2.442

ISI Journal Citation Reports © Ranking: 2014: 33/134 (Engineering Chemical)

Online ISSN: 1521-4125

Associated Title(s): Chemie Ingenieur Technik, ChemBioEng Reviews, Energy Technology

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June 15, 2015

Editors' Choice: High-Tensile-Strength Paracetamol Tablets

Editors' Choice: High-Tensile-Strength Paracetamol TabletsFast-dissolving products are of high interest in the pharmaceutical industry due to drug delivery issues as well as in the food industry. The freeze-casting process can be applied not only to produce dense materials, but also to create materials with adjustable porous microstructures. The low-temperature process facilitates the formulation of drug carrier systems, and the designable microstructure can promote matrix-solvent interaction, therefore, it improves the drug dissolution, bioavailability, the therapeutic effect of the active ingredients as well as the capability to prolong the life time of a bioproduct. P. T. N. Nguyen and J. Ulrich successfully produced fast dissolving porous dosage forms (tablets), containing paracetamol as the active pharmaceutical ingredient and modified starch as an additive, by the freeze-casting technique. The freeze-casted tablets own equal tensile strength and a threefold faster disintegration time compared to commercial compressed tablets, i.e., < 3 min in comparison to 10 min of commercial tablets.


Phuong Thi Nhat Nguyen and Joachim Ulrich
Production of High-Tensile-Strength Paracetamol Tablets Using the Freeze-Casting Process
Chem. Eng. Technol. 2015, 38 (6), 991-998.
DOI: 10.1002/ceat.201400700


June 15, 2015
Editors' Choice: High-Tensile-Strength Paracetamol Tablets

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