Archiv der Pharmazie
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Edited By: Holger Stark
Impact Factor: 1.396
ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/254 (Pharmacology & Pharmacy)
Online ISSN: 1521-4184
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Recently Published Articles
- Mitochondria as a Target in the Therapeutic Properties of Curcumin
Joyce Trujillo, Luis Fernando Granados-Castro, Cecilia Zazueta, Ana Cristina Andérica-Romero, Yolanda Irasema Chirino and José Pedraza-Chaverrí
Article first published online: 22 SEP 2014 | DOI: 10.1002/ardp.201400266
Curcumin is a phenolic compound extracted from Curcuma longa. It is able to induce cytoprotective enzymes, anti-apoptotic signaling, and mitochondrial respiration and to diminish reactive oxygen spices. This review focuses on some of the most recent findings that suggest a close relationship of the antioxidant activity of curcumin with the mitochondrial function.
- Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents
Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai and Ping Gong
Article first published online: 17 SEP 2014 | DOI: 10.1002/ardp.201400230
Novel benzothiazole derivatives bearing the ortho-hydroxy-N-acylhydrazone moiety were synthesized and evaluated for their procaspase-3 kinase activation activities and antiproliferative activities. The most promising compound 18e (procaspase-3 EC50 = 0.31 µM) with IC50 values ranging from 0.24 to 0.92 µM against all tested cell lines was 4.24–12.2 times more active than PAC-1 (procaspase-3 EC50 = 0.41 µM).
- Synthesis and Carbonic Anhydrase Inhibitory Effects of Novel Sulfamides Derived from 1-Aminoindanes and Anilines
Yusuf Akbaba, Enes Bastem, Fevzi Topal, İlhami Gülçin, Ahmet Maraş and Süleyman Göksu
Article first published online: 16 SEP 2014 | DOI: 10.1002/ardp.201400257
Seven novel sulfamides were synthesized and their inhibitory properties against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II) were evaluated. Carbamate 17 showed the most potent inhibitory effect against hCA I (Ki: 153.88 nM), while sulfamide derivative 26 showed the highest inhibitory potential against hCA II (Ki: 117.80 nM).
- Synthesis and Biological Evaluation of tert-Butyl-5-methylpyrimidin-piperazine Derivatives as Anti-Obesity Agents
Jinying Chen, Yuzhi Pu, Heying Pei, Linhong He, Suhong Fu and Lijuan Chen
Article first published online: 15 SEP 2014 | DOI: 10.1002/ardp.201400227
A series of new tert-butyl-5-methylpyrimidin-piperazine derivatives were evaluated for their anti-obesity activities. tert-Butyl-4-(2-(4-(benzyloxy)phenyl)-5-methylpyrimidin-4-yl)piperazine-1-carboxylate 5j showed remarkable therapeutic effects on the diet-induced obesity (DIO) mice and significantly decreased blood glucose levels, suggesting that 5j could be a candidate for obesity treatment.
- Synthesis and Antibacterial Activity of Some Novel 4-Oxopyrido[2,3-a]phenothiazines
Hadeel T. Al-Sinjilawi, Mustafa M. El-Abadelah, Mohammad S. Mubarak, Amal Al-Aboudi, Mohammed M. Abadleh, Adel M. Mahasneh and Asaad K. M. A. Ahmad
Article first published online: 12 SEP 2014 | DOI: 10.1002/ardp.201400196
A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids (6a–d) were prepared. Compound 6a with unsubstituted terminal benzo-ring D was the most active against representative bacterial strains. Compounds 6a–d were also active against methicillin-resistant Staphylococcus aureus (MRSA). Ligand–protein docking modeling predicted that compounds 6a–d are potential inhibitors of topoisomerase IV.