Archiv der Pharmazie

Cover image for Vol. 348 Issue 2

Edited By: Holger Stark

Impact Factor: 1.396

ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/256 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. One-Pot Multi-Component Synthesis of 1,4-Dihydropyridines Using Zn2+@KSF and Evaluating Their Antibacterial and Antioxidant Activities

    Nosrat O. Mahmoodi, Sahar Ramzanpour and Fateme Ghanbari Pirbasti

    Article first published online: 24 FEB 2015 | DOI: 10.1002/ardp.201400414

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    1,4-Dihydropyridines were prepared from the reaction of barbituric acid, aldehydes, and thiazole in the presence of Zn2+@KSF. 10-(4-(4-Methoxyphenyl)thiazole-2-yl)-5-(4-nitrophenyl)-9,10-dihydropyrido[2,3-d:5,6-d′]dipyrimidone-2,4,6,8-(1H,3H,5H,7H)-tetraone showed the best antibacterial and 10-(4-(4-methoxyphenyl)thiazole-2-yl)-5-(2,4-dichlorophenyl)-9,10-dihydropyrido[2,3-d:5,6-d′]dipyrimidone-2,4,6,8-(1H,3H,5H,7H)-tetraone the highest antioxidant activity.

  2. Novel Antiviral Compounds against Gastroenteric Viral Infections

    Mosaad S. Mohamed, Rania H. Abd El-Hameed, Amira I. Sayed and Sameh H. Soror

    Article first published online: 18 FEB 2015 | DOI: 10.1002/ardp.201400387

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    New pyrrole, pyrrolo[2,3-d]pyrimidine, and pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives were synthesized and examined for their antiviral activity against coxsackievirus B4, adenovirus type 7, and the rotavirus Wa strain. The non-toxic doses of these compounds on BGM, Hep-2, and MA-104 cells were determined. 4-Chloro-7-(3-chlorophenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine 5b showed potent activity against coxsackievirus.

  3. Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and β-Amyloid Aggregation Inhibitors

    Sakineh Dadashpour, Tuba Tuylu Kucukkilinc, Oya Unsal Tan, Keriman Ozadali, Hamid Irannejad and Saeed Emami

    Article first published online: 18 FEB 2015 | DOI: 10.1002/ardp.201400400

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    A series of cyclooxygenase (COX)-2 inhibitors with ethyl carboxylate side chain were synthesized based on preliminary docking studies. The subsequent in vitro study indicated that ethyl 2-(5-(4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)-1,2,4-triazin-3-ylthio)acetate 6c is the best COX-2 inhibitor (IC50 = 10.1 µM) and inhibits 94% of the β-amyloid fibril formation after 48 h.

  4. Synthesis and Evaluation of New Bis-1,3,4,2-triazaphospholinoalkane Derivatives as In Vitro α-Amylase and Lipase Inhibitors

    Salwa Hamzaoui, Bochra Ben Salah, Khaled Hamden, Awatef Rekik and Mohamed Kossentini

    Article first published online: 13 FEB 2015 | DOI: 10.1002/ardp.201400283

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    A series of new 1,ω-bis-(5-alkyl-2-oxide-3-tosyl-1,3,4,2-triazaphospholino)alkanes were prepared and screened for their inhibitory effect on the key enzymes related to diabetes and obesity, such as α-amylase and lipase. With IC50 values of 16 µg/mL against α-amylase and lipase, 2d can be considered for future application in the development of antidiabetic and hypolipidemic drugs.

  5. Recent Advances in the Chemistry and Biology of Benzothiazoles

    Rupinder K. Gill, Ravindra K. Rawal and Jitender Bariwal

    Article first published online: 12 FEB 2015 | DOI: 10.1002/ardp.201400340

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    Benzothiazole is a privileged heterocyclic scaffold with a wide range of pharmacological activities. This review highlights the development of novel benzothiazoles for various biological activities along with the best synthetic protocols for their synthesis.