Archiv der Pharmazie

Cover image for Vol. 348 Issue 5

Edited By: Holger Stark

Impact Factor: 1.396

ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/256 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. In Silico Profiling of the Potentiality of Curcumin and Conventional Drugs for CagA Oncoprotein Inactivation

    Akhileshwar K. Srivastava, Mallika Tewari, Hari S. Shukla and Bijoy K. Roy

    Article first published online: 21 MAY 2015 | DOI: 10.1002/ardp.201400438

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    The oncoprotein cytotoxic associated gene A (CagA) is an important target for anti-Helicobacter pylori drugs. By molecular docking to CagA, a comparative analysis was carried out between curcumin and conventional drugs such as clarithromycin, amoxicillin, pantoprazole, and metronidazole. The results show that curcumin may become a promising lead compound against CagA+ H. pylori infection.

  2. Synthesis and Evaluation of New Dithiocarbamic Acid 6,11-Dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl Methyl Esters

    Nur İpek Onder, Zerrin İncesu and Yusuf Özkay

    Article first published online: 21 MAY 2015 | DOI: 10.1002/ardp.201500063

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    A series of dithiocarbamic acid 6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl methyl esters were synthesized for the first time and their cytotoxic and apoptotic activities were evaluated in HeLa cells. Compounds 2c, 2d, and 2f displayed high cytotoxic activity with an IC50 value of 8 or 10 μM at 24 h.

  3. Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole–Thiazolidinone Hybrids

    Ahmed H. Abdelazeem, Samir A. Salama and Ibrahim A. Maghrabi

    Article first published online: 18 MAY 2015 | DOI: 10.1002/ardp.201500104

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    A new series of diphenylthiazole–thiazolidinone hybrids was evaluated in vitro and in vivo as anti-inflammatory/analgesic agents. The inhibition of cyclooxygenase (COX) enzymes is suggested as molecular mechanism for the hybrids to exert their anti-inflammatory action, since the most potent COX inhibitors, 13b, 14, and 15b, also exhibited the highest anti-inflammatory/analgesic activities compared to diclofenac.

  4. The Old Made New: Natural Compounds against Erectile Dysfunction

    Valeria Pavan, Carla Mucignat-Caretta, Marco Redaelli, Giovanni Ribaudo and Giuseppe Zagotto

    Article first published online: 13 MAY 2015 | DOI: 10.1002/ardp.201500075

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    Even if sildenafil is a blockbuster against erectile dysfunction (ED), the interest in herbal remedies traditionally used for the treatment of this condition keeps growing. After a brief description of the etiology of ED, this minireview provides details on the most interesting remedies coming from traditional medicine, with a special focus on polyphenols and, among others, kraussianones.

  5. Synthesis of Novel Triplets with a 1,3,5-Trioxazatriquinane Skeleton and Their Pharmacologies for Opioid Receptors

    Hiroshi Nagase and Noriki Kutsumura

    Article first published online: 12 MAY 2015 | DOI: 10.1002/ardp.201500031

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    Novel triplet drugs with a 1,3,5-trioxazatriquinane skeleton were synthesized and their pharmacologies were investigated. Among the synthesized compounds, (−)-22c with two m-hydroxyphenyl groups selectively bound and exerted full agonist activity toward the κ opioid receptor.

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