Archiv der Pharmazie
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Edited By: Holger Stark
Impact Factor: 1.396
ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/256 (Pharmacology & Pharmacy)
Online ISSN: 1521-4184
|Online Only in 2015|
Archiv der Pharmazie will be online only as of January 2015. All content will be at your fingertips right here on Wiley Online Library.
Recently Published Articles
- One-Pot Multi-Component Synthesis of 1,4-Dihydropyridines Using Zn2+@KSF and Evaluating Their Antibacterial and Antioxidant Activities
Nosrat O. Mahmoodi, Sahar Ramzanpour and Fateme Ghanbari Pirbasti
Article first published online: 24 FEB 2015 | DOI: 10.1002/ardp.201400414
1,4-Dihydropyridines were prepared from the reaction of barbituric acid, aldehydes, and thiazole in the presence of Zn2+@KSF. 10-(4-(4-Methoxyphenyl)thiazole-2-yl)-5-(4-nitrophenyl)-9,10-dihydropyrido[2,3-d:5,6-d′]dipyrimidone-2,4,6,8-(1H,3H,5H,7H)-tetraone showed the best antibacterial and 10-(4-(4-methoxyphenyl)thiazole-2-yl)-5-(2,4-dichlorophenyl)-9,10-dihydropyrido[2,3-d:5,6-d′]dipyrimidone-2,4,6,8-(1H,3H,5H,7H)-tetraone the highest antioxidant activity.
- Novel Antiviral Compounds against Gastroenteric Viral Infections
Mosaad S. Mohamed, Rania H. Abd El-Hameed, Amira I. Sayed and Sameh H. Soror
Article first published online: 18 FEB 2015 | DOI: 10.1002/ardp.201400387
New pyrrole, pyrrolo[2,3-d]pyrimidine, and pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives were synthesized and examined for their antiviral activity against coxsackievirus B4, adenovirus type 7, and the rotavirus Wa strain. The non-toxic doses of these compounds on BGM, Hep-2, and MA-104 cells were determined. 4-Chloro-7-(3-chlorophenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine 5b showed potent activity against coxsackievirus.
- Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and β-Amyloid Aggregation Inhibitors
Sakineh Dadashpour, Tuba Tuylu Kucukkilinc, Oya Unsal Tan, Keriman Ozadali, Hamid Irannejad and Saeed Emami
Article first published online: 18 FEB 2015 | DOI: 10.1002/ardp.201400400
A series of cyclooxygenase (COX)-2 inhibitors with ethyl carboxylate side chain were synthesized based on preliminary docking studies. The subsequent in vitro study indicated that ethyl 2-(5-(4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)-1,2,4-triazin-3-ylthio)acetate 6c is the best COX-2 inhibitor (IC50 = 10.1 µM) and inhibits 94% of the β-amyloid fibril formation after 48 h.
- Synthesis and Evaluation of New Bis-1,3,4,2-triazaphospholinoalkane Derivatives as In Vitro α-Amylase and Lipase Inhibitors
Salwa Hamzaoui, Bochra Ben Salah, Khaled Hamden, Awatef Rekik and Mohamed Kossentini
Article first published online: 13 FEB 2015 | DOI: 10.1002/ardp.201400283
A series of new 1,ω-bis-(5-alkyl-2-oxide-3-tosyl-1,3,4,2-triazaphospholino)alkanes were prepared and screened for their inhibitory effect on the key enzymes related to diabetes and obesity, such as α-amylase and lipase. With IC50 values of 16 µg/mL against α-amylase and lipase, 2d can be considered for future application in the development of antidiabetic and hypolipidemic drugs.
- Recent Advances in the Chemistry and Biology of Benzothiazoles
Rupinder K. Gill, Ravindra K. Rawal and Jitender Bariwal
Article first published online: 12 FEB 2015 | DOI: 10.1002/ardp.201400340
Benzothiazole is a privileged heterocyclic scaffold with a wide range of pharmacological activities. This review highlights the development of novel benzothiazoles for various biological activities along with the best synthetic protocols for their synthesis.