Archiv der Pharmazie

Cover image for Vol. 347 Issue 10

Edited By: Holger Stark

Impact Factor: 1.396

ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/254 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

    Ankita Rathore, Mujeeb Ur Rahman, Anees Ahamad Siddiqui, Abuzer Ali and Mohammad Shaharyar

    Article first published online: 9 OCT 2014 | DOI: 10.1002/ardp.201400219

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    A new series of benzimidazole molecules bearing oxadiazole were synthesized from 2-(2-((pyrimidin-2-ylthio)methyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide and screened in vitro for their COX-1 and COX-2 inhibitory potency. One of the new compounds may serve as a lead for developing new COX-2 inhibitors.

  2. Novel Capsaicin Analogues as Potential Anticancer Agents: Synthesis, Biological Evaluation, and In Silico Approach

    Mariana C. F. C. B. Damião, Kerly F. M. Pasqualoto, Adilson K. Ferreira, Sarah F. Teixeira, Ricardo A. Azevedo, José A. M. Barbuto, Fanny Palace-Berl, Gilberto C. Franchi-Junior, Alexandre E. Nowill, Maurício T. Tavares and Roberto Parise-Filho

    Article first published online: 3 OCT 2014 | DOI: 10.1002/ardp.201400233

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    Novel benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed and evaluated for their cytotoxic activity against human and murine cancer cell lines. Exploratory data analysis was used to define the topological and electronic molecular properties responsible for the discrimination process regarding the set of investigated compounds.

  3. New CYP17 Hydroxylase Inhibitors: Synthesis, Biological Evaluation, QSAR, and Molecular Docking Study of New Pregnenolone Analogs

    Najim A. Al-Masoudi, Dawood S. Ali, Bahjat Saeed, Rolf W. Hartmann, Matthias Engel, Sajid Rashid and Aamer Saeed

    Article first published online: 24 SEP 2014 | DOI: 10.1002/ardp.201400255

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    New imine, acyl, and tosylate analogs of pregnenolone were synthesized and evaluated for their CYP17 hydroxylase and HIV inhibition activities. The 5-aryl-1,3,4-thiadiazol-2-yl)-imino-pregnenolone derivatives turned out to be more active than the sulfonate and ester analogs. Molecular docking studies demonstrated similar binding patterns of all new pregnenolone derivatives.

  4. Design, Synthesis, and Biological Evaluation of Hydrazone Incorporated 1,2,4-Triazines as Anticonvulsant Agents

    Mohammed Amir, Israr Ali, Mohd. Zaheen Hassan and Naveen Mulakayala

    Article first published online: 24 SEP 2014 | DOI: 10.1002/ardp.201400045

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    New hydrazone incorporated triazines were designed and evaluated for their anticonvulsant activity. 4-[{2-(5-(3-Chlorobenzyl)-3-phenyl-1,2,4-triazine-6-yl)hydrazono}methyl]-N,N-dimethylaniline 6k (MES ED50 54.31, scPTZ ED50 92.01) and 4-[{2-(5-(4-chlorobenzyl)-3-phenyl-1,2,4-triazine-6-yl)hydrazono}methyl]-N,N-dimethylaniline 6r (MES ED50 46.05, scPTZ ED50 83.90) emerged as the most active anticonvulsant agents with GABAergic effects.

  5. Mitochondria as a Target in the Therapeutic Properties of Curcumin

    Joyce Trujillo, Luis Fernando Granados-Castro, Cecilia Zazueta, Ana Cristina Andérica-Romero, Yolanda Irasema Chirino and José Pedraza-Chaverrí

    Article first published online: 22 SEP 2014 | DOI: 10.1002/ardp.201400266

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    Curcumin is a phenolic compound extracted from Curcuma longa. It is able to induce cytoprotective enzymes, anti-apoptotic signaling, and mitochondrial respiration and to diminish reactive oxygen spices. This review focuses on some of the most recent findings that suggest a close relationship of the antioxidant activity of curcumin with the mitochondrial function.

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