Archiv der Pharmazie

Cover image for Vol. 347 Issue 11

Edited By: Holger Stark

Impact Factor: 1.396

ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/254 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. A New Series of Antibacterial Nitrosopyrimidines: Synthesis and Structure–Activity Relationship

    Monica Olivella, Antonio Marchal, Manuel Nogueras, Manuel Melguizo, Beatriz Lima, Alejandro Tapia, Gabriela E. Feresin, Oscar Parravicini, Fernando Giannini, Sebastián A. Andujar, Justo Cobo and Ricardo D. Enriz

    Article first published online: 21 NOV 2014 | DOI: 10.1002/ardp.201400271

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    A new series of nitrosopyrimidines possessing strong antibacterial activity were synthesized. A detailed structure–activity relationship study, supported by theoretical calculations, helped to identify the minimal structural requirements for the antibacterial action of the new nitrosopyrimidines.

  2. Monte Carlo Method-Based QSAR Modeling of Penicillins Binding to Human Serum Proteins

    Jovana B. Veselinović, Andrey A. Toropov, Alla P. Toropova, Goran M. Nikolić and Aleksandar M. Veselinović

    Article first published online: 18 NOV 2014 | DOI: 10.1002/ardp.201400259

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    The binding of penicillins to human serum proteins was modeled with optimal descriptors based on SMILES notation. The Monte Carlo method was used as a chemoinformatic tool to build the QSAR model, which was finally applied to demonstrate the possibility of designing new penicillin derivatives with desired binding properties.

  3. Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

    Ankita Rathore, Mujeeb Ur Rahman, Anees Ahamad Siddiqui, Abuzer Ali and Mohammad Shaharyar

    Article first published online: 9 OCT 2014 | DOI: 10.1002/ardp.201400219

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    A new series of benzimidazole molecules bearing oxadiazole were synthesized from 2-(2-((pyrimidin-2-ylthio)methyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide and screened in vitro for their COX-1 and COX-2 inhibitory potency. One of the new compounds may serve as a lead for developing new COX-2 inhibitors.

  4. Novel Capsaicin Analogues as Potential Anticancer Agents: Synthesis, Biological Evaluation, and In Silico Approach

    Mariana C. F. C. B. Damião, Kerly F. M. Pasqualoto, Adilson K. Ferreira, Sarah F. Teixeira, Ricardo A. Azevedo, José A. M. Barbuto, Fanny Palace-Berl, Gilberto C. Franchi-Junior, Alexandre E. Nowill, Maurício T. Tavares and Roberto Parise-Filho

    Article first published online: 3 OCT 2014 | DOI: 10.1002/ardp.201400233

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    Novel benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed and evaluated for their cytotoxic activity against human and murine cancer cell lines. Exploratory data analysis was used to define the topological and electronic molecular properties responsible for the discrimination process regarding the set of investigated compounds.

  5. New CYP17 Hydroxylase Inhibitors: Synthesis, Biological Evaluation, QSAR, and Molecular Docking Study of New Pregnenolone Analogs

    Najim A. Al-Masoudi, Dawood S. Ali, Bahjat Saeed, Rolf W. Hartmann, Matthias Engel, Sajid Rashid and Aamer Saeed

    Article first published online: 24 SEP 2014 | DOI: 10.1002/ardp.201400255

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    New imine, acyl, and tosylate analogs of pregnenolone were synthesized and evaluated for their CYP17 hydroxylase and HIV inhibition activities. The 5-aryl-1,3,4-thiadiazol-2-yl)-imino-pregnenolone derivatives turned out to be more active than the sulfonate and ester analogs. Molecular docking studies demonstrated similar binding patterns of all new pregnenolone derivatives.