Archiv der Pharmazie

Cover image for Vol. 349 Issue 7

Edited By: Holger Stark

Impact Factor: 2.043

ISI Journal Citation Reports © Ranking: 2015: 36/59 (Chemistry Medicinal); 71/163 (Chemistry Multidisciplinary); 151/253 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Mannich


Centennial Anniversary of Mannich’s Report on the Formation of α-Amino-Ketones in the Journal Archiv der Pharmazie

The Mannich reaction is the well-known organic name reaction that consists of an amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary or secondary amine or ammonia. The final product is a β-amino-carbonyl compound also known as a Mannich base. In the standard work “Namen- und Schlagwort-Reaktionen der organischen Chemie” (Laue, T., Plagens, A. 2004, Teubner, Stuttgart)], the paper published by Mannich in 1917(Arch. Pharm. 1917, 255: 261–2762) is given as the primary source, hence the centennial anniversary of this prominent report will be celebrated in the near future with a special issue of the Archiv der Pharmazie.

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For more information on this Special Issue click here.

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