Archiv der Pharmazie

Cover image for Vol. 347 Issue 9

Edited By: Holger Stark

Impact Factor: 1.396

ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/254 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. Mitochondria as a Target in the Therapeutic Properties of Curcumin

    Joyce Trujillo, Luis Fernando Granados-Castro, Cecilia Zazueta, Ana Cristina Andérica-Romero, Yolanda Irasema Chirino and José Pedraza-Chaverrí

    Article first published online: 22 SEP 2014 | DOI: 10.1002/ardp.201400266

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    Curcumin is a phenolic compound extracted from Curcuma longa. It is able to induce cytoprotective enzymes, anti-apoptotic signaling, and mitochondrial respiration and to diminish reactive oxygen spices. This review focuses on some of the most recent findings that suggest a close relationship of the antioxidant activity of curcumin with the mitochondrial function.

  2. Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents

    Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai and Ping Gong

    Article first published online: 17 SEP 2014 | DOI: 10.1002/ardp.201400230

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    Novel benzothiazole derivatives bearing the ortho-hydroxy-N-acylhydrazone moiety were synthesized and evaluated for their procaspase-3 kinase activation activities and antiproliferative activities. The most promising compound 18e (procaspase-3 EC50 = 0.31 µM) with IC50 values ranging from 0.24 to 0.92 µM against all tested cell lines was 4.24–12.2 times more active than PAC-1 (procaspase-3 EC50 = 0.41 µM).

  3. Synthesis and Carbonic Anhydrase Inhibitory Effects of Novel Sulfamides Derived from 1-Aminoindanes and Anilines

    Yusuf Akbaba, Enes Bastem, Fevzi Topal, İlhami Gülçin, Ahmet Maraş and Süleyman Göksu

    Article first published online: 16 SEP 2014 | DOI: 10.1002/ardp.201400257

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    Seven novel sulfamides were synthesized and their inhibitory properties against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II) were evaluated. Carbamate 17 showed the most potent inhibitory effect against hCA I (Ki: 153.88 nM), while sulfamide derivative 26 showed the highest inhibitory potential against hCA II (Ki: 117.80 nM).

  4. Synthesis and Biological Evaluation of tert-Butyl-5-methylpyrimidin-piperazine Derivatives as Anti-Obesity Agents

    Jinying Chen, Yuzhi Pu, Heying Pei, Linhong He, Suhong Fu and Lijuan Chen

    Article first published online: 15 SEP 2014 | DOI: 10.1002/ardp.201400227

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    A series of new tert-butyl-5-methylpyrimidin-piperazine derivatives were evaluated for their anti-obesity activities. tert-Butyl-4-(2-(4-(benzyloxy)phenyl)-5-methylpyrimidin-4-yl)piperazine-1-carboxylate 5j showed remarkable therapeutic effects on the diet-induced obesity (DIO) mice and significantly decreased blood glucose levels, suggesting that 5j could be a candidate for obesity treatment.

  5. Synthesis and Antibacterial Activity of Some Novel 4-Oxopyrido[2,3-a]phenothiazines

    Hadeel T. Al-Sinjilawi, Mustafa M. El-Abadelah, Mohammad S. Mubarak, Amal Al-Aboudi, Mohammed M. Abadleh, Adel M. Mahasneh and Asaad K. M. A. Ahmad

    Article first published online: 12 SEP 2014 | DOI: 10.1002/ardp.201400196

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    A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids (6ad) were prepared. Compound 6a with unsubstituted terminal benzo-ring D was the most active against representative bacterial strains. Compounds 6ad were also active against methicillin-resistant Staphylococcus aureus (MRSA). Ligand–protein docking modeling predicted that compounds 6ad are potential inhibitors of topoisomerase IV.