Archiv der Pharmazie
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Edited By: Holger Stark
Impact Factor: 1.531
ISI Journal Citation Reports © Ranking: 2014: 41/59 (Chemistry Medicinal); 75/157 (Chemistry Multidisciplinary); 179/254 (Pharmacology & Pharmacy)
Online ISSN: 1521-4184
|Online Only in 2015|
Archiv der Pharmazie is now online only as of January 2015. All content will be at your fingertips right here on Wiley Online Library.
Recently Published Articles
- Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α-Glucosidase and α-Amylase Inhibitors
Tiantian Guo, Shaoping Wu, Sen Guo, Lu Bai, Qingchao Liu and Naisheng Bai
Article first published online: 24 JUL 2015 | DOI: 10.1002/ardp.201500179
A series of naturally occurring oleanane-type triterpenoid saponins and non-natural oleanolic acid saponins were synthesized, and their inhibitory activities against α-glucosidase and α-amylase were evaluated in vitro. With an IC50 value of 87.3 μM, 28-O-monoglucoside 8 exhibited fivefold stronger inhibitory activity against α-glucosidase than the antidiabetic acarbose.
- In Vitro Inhibition of Human Placental Glutathione S-Transferase by 3-Arylcoumarin Derivatives
Mustafa Muhlis Alparslan and Özkan Danış
Article first published online: 22 JUL 2015 | DOI: 10.1002/ardp.201500151
A series of 3-aryl-2H-chromen-2-one derivatives (4a–d, 5a–d, and 6a,b) are assessed for their inhibitory activity on human GSTP1-1. The most active compound (6a, IC50 = 13.5 µM) shows mixed inhibition with respect to glutathion and non-competitive inhibition against 1-chloro-2,4-dinitrobenzene, and may serve as a lead for developing new glutathione S-transferase inhibitors.
- Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors
Saman Arab, Seyed-Esmail Sadat-Ebrahimi, Maryam Mohammadi-Khanaposhtani, Alireza Moradi, Hamid Nadri, Mohammad Mahdavi, Setareh Moghimi, Mehdi Asadi, Loghman Firoozpour, Morteza Pirali-Hamedani, Abbas Shafiee and Alireza Foroumadi
Article first published online: 20 JUL 2015 | DOI: 10.1002/ardp.201500149
A novel series of chroman-4-one derivatives bearing N-benzyl pyridinium derivatives (8a–l) were synthesized and evaluated in vitro for their acetylcholinesterase inhibitory activities. The most promising compound, (E)-1-(2,3-dibromobenzyl)-4-((7-ethoxy-4-oxochroman-3-ylidene)methyl)pyridinium bromide 8l, showed an IC50 value of 0.048 µM.
- Thiomorpholine Derivatives with Hypolipidemic and Antioxidant Activity
Kyriaki-Konstantina Tooulia, Panagiotis Theodosis-Nobelos and Eleni A. Rekka
Article first published online: 20 JUL 2015 | DOI: 10.1002/ardp.201500147
Based on the already known lipid-lowering and antioxidant action of morpholine derivatives, a series of substituted thiomorpholines were designed, further incorporating an antioxidant moiety as the N-substituent. The new derivatives show considerable antioxidant potential with hypolipidemic activity and may also have combined squalene synthase inhibitory activity.
- Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma
Yuran Xie and Olivia M. Merkel
Article first published online: 7 JUL 2015 | DOI: 10.1002/ardp.201500120
RNA interference (RNAi) may be a promising treatment of asthma, but so far difficulties regarding the delivery of small interference RNA (siRNA), the key factor in RNAi, to target cells/tissues have limited its clinical application. This review summarizes the cytokines, chemokines, transcription factors, tyrosine kinases, and costimulatory factors reported as targets of siRNA-mediated treatment in experimental asthma.