Archiv der Pharmazie
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Edited By: Holger Stark
Impact Factor: 1.396
ISI Journal Citation Reports © Ranking: 2013: 42/58 (Chemistry Medicinal); 74/148 (Chemistry Multidisciplinary); 180/256 (Pharmacology & Pharmacy)
Online ISSN: 1521-4184
|Online Only in 2015|
Archiv der Pharmazie is now online only as of January 2015. All content will be at your fingertips right here on Wiley Online Library.
Recently Published Articles
- In Silico Profiling of the Potentiality of Curcumin and Conventional Drugs for CagA Oncoprotein Inactivation
Akhileshwar K. Srivastava, Mallika Tewari, Hari S. Shukla and Bijoy K. Roy
Article first published online: 21 MAY 2015 | DOI: 10.1002/ardp.201400438
The oncoprotein cytotoxic associated gene A (CagA) is an important target for anti-Helicobacter pylori drugs. By molecular docking to CagA, a comparative analysis was carried out between curcumin and conventional drugs such as clarithromycin, amoxicillin, pantoprazole, and metronidazole. The results show that curcumin may become a promising lead compound against CagA+ H. pylori infection.
- Synthesis and Evaluation of New Dithiocarbamic Acid 6,11-Dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl Methyl Esters
Nur İpek Onder, Zerrin İncesu and Yusuf Özkay
Article first published online: 21 MAY 2015 | DOI: 10.1002/ardp.201500063
A series of dithiocarbamic acid 6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl methyl esters were synthesized for the first time and their cytotoxic and apoptotic activities were evaluated in HeLa cells. Compounds 2c, 2d, and 2f displayed high cytotoxic activity with an IC50 value of 8 or 10 μM at 24 h.
- Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole–Thiazolidinone Hybrids
Ahmed H. Abdelazeem, Samir A. Salama and Ibrahim A. Maghrabi
Article first published online: 18 MAY 2015 | DOI: 10.1002/ardp.201500104
A new series of diphenylthiazole–thiazolidinone hybrids was evaluated in vitro and in vivo as anti-inflammatory/analgesic agents. The inhibition of cyclooxygenase (COX) enzymes is suggested as molecular mechanism for the hybrids to exert their anti-inflammatory action, since the most potent COX inhibitors, 13b, 14, and 15b, also exhibited the highest anti-inflammatory/analgesic activities compared to diclofenac.
- The Old Made New: Natural Compounds against Erectile Dysfunction
Valeria Pavan, Carla Mucignat-Caretta, Marco Redaelli, Giovanni Ribaudo and Giuseppe Zagotto
Article first published online: 13 MAY 2015 | DOI: 10.1002/ardp.201500075
Even if sildenafil is a blockbuster against erectile dysfunction (ED), the interest in herbal remedies traditionally used for the treatment of this condition keeps growing. After a brief description of the etiology of ED, this minireview provides details on the most interesting remedies coming from traditional medicine, with a special focus on polyphenols and, among others, kraussianones.
- Synthesis of Novel Triplets with a 1,3,5-Trioxazatriquinane Skeleton and Their Pharmacologies for Opioid Receptors
Hiroshi Nagase and Noriki Kutsumura
Article first published online: 12 MAY 2015 | DOI: 10.1002/ardp.201500031
Novel triplet drugs with a 1,3,5-trioxazatriquinane skeleton were synthesized and their pharmacologies were investigated. Among the synthesized compounds, (−)-22c with two m-hydroxyphenyl groups selectively bound and exerted full agonist activity toward the κ opioid receptor.