Archiv der Pharmazie

Cover image for Vol. 347 Issue 4

Edited By: Holger Stark

Impact Factor: 1.54

ISI Journal Citation Reports © Ranking: 2012: 40/59 (Chemistry Medicinal); 69/152 (Chemistry Multidisciplinary); 178/261 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184

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Recently Published Articles

  1. Cell-Penetrable Lysine Dendrimers for Anti-Cancer Drug Delivery: Synthesis and Preliminary Biological Evaluation

    Jing Zhao, Rui Zhou, Xiaoyu Fu, Wen Ren, Lifang Ma, Ran Li, Yi Zhao and Li Guo

    Article first published online: 17 APR 2014 | DOI: 10.1002/ardp.201300415

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    Cell-penetrable lysine dendrimers (G1–G3) were evaluated as carriers for the model drug 5-fluorouracil. As expected, these prodrugs showed stable drug release, low cytotoxicity to normal cells, and moderate inhibition of tumor cells. The preliminary biological evaluation results imply that lysine dendrimers are potential drug carriers with effective translocation and reduced cytotoxicity for anti-cancer drug delivery.

  2. Synthesis and Antibacterial and Cytotoxic Activities of New N-3 Substituted Thiazolidine-2,4-dione Derivatives Bearing the Pyrazole Moiety

    Nisheeth C. Desai, Hitesh M. Satodiya, Ghanshyam M. Kotadiya and Hasit V. Vaghani

    Article first published online: 14 APR 2014 | DOI: 10.1002/ardp.201300466

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    Two new series of N-3 substituted thiazolidine-2,4-dione derivatives bearing the pyrazole moiety were assessed in vitro for their efficacy as antibacterial agents. Compounds 7b, 7c, 7i, and 7j were found to be active against Staphylococcus aureus and Streptococcus pyogenes. Compounds 7c and 7j also inhibited the growth of methicillin-resistant S. aureus. The lipophilicity profiles of the compounds were found to be crucial for their antibacterial activities.

  3. Design, Synthesis and Anticancer Activity Evaluation of Some Novel Pyrrolo[1,2-a]azepine Derivatives

    Amany Belal

    Article first published online: 14 APR 2014 | DOI: 10.1002/ardp.201400004

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    New pyrrolo[1,2-a]azepine derivatives 37 were synthesized and their antitumor activities were evaluated against liver, breast, and colon cancer cell lines. Compounds 3 and 7 showed broad-spectrum anticancer activity against all tested cell lines, with IC50 values in the nanomolar range. The ability of the new compounds to interact with cyclin-dependent kinases was also explored.

  4. 1-Amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates as Acyclic Analogs of Nucleotides

    Iwona E. Głowacka, Jan Balzarini and Dorota G. Piotrowska

    Article first published online: 6 APR 2014 | DOI: 10.1002/ardp.201300471

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    Among a new series of 1-amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates, compound (R)-16g (B = 3-acetylindole) was found to be active against vesicular stomatitis virus in HeLa cell cultures. In addition, (S)-16c (B = adenine), (R)-16f (B = N3-Bz-benzuracil), (R)-16g (B = 3-acetylindole), and (R)-16h (B = 5,6-dimethylbenzimidazole) displayed cytotoxicity toward Crandell-Rees feline kidney cells and compounds (R)-16g, (S)-16g, and (S)-16h were slightly cytostatic to different tumor cell lines.

  5. Role of AMP-Activated Protein Kinase in Cancer Therapy

    Gauhar Rehman, Adeeb Shehzad, Abdul Latif Khan and Muhammad Hamayun

    Article first published online: 28 MAR 2014 | DOI: 10.1002/ardp.201300402

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    AMP-activated protein kinase (AMPK) is a cellular energy sensor that regulates several metabolic pathways. AMPK may also act to inhibit tumor formation through the modulation of cell growth, cell proliferation, autophagy, stress responses, and cell polarity. This review focuses on AMPK activation and its possible therapeutic role in the treatment of cancer.