Archiv der Pharmazie
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Edited By: Holger Stark
Impact Factor: 1.531
ISI Journal Citation Reports © Ranking: 2014: 41/59 (Chemistry Medicinal); 75/157 (Chemistry Multidisciplinary); 180/255 (Pharmacology & Pharmacy)
Online ISSN: 1521-4184
|Online Only in 2015|
Archiv der Pharmazie is now online only as of January 2015. All content will be at your fingertips right here on Wiley Online Library.
Recently Published Articles
- Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis
Vishnu N. Badavath, İpek Baysal, Gülberk Uçar, Susanta K. Mondal, Barij N. Sinha and Venkatesan Jayaprakash
Article first published online: 23 NOV 2015 | DOI: 10.1002/ardp.201500317
A series of ferulic acid amides 6a–m were designed and tested for their inhibitory activity on human monoamine oxidase (hMAO) isoforms. All the compounds were found to have inhibitory activity, with a gradual shift from hMAO-B selectivity (6a,b) to non-selectivity (6c–f). Molecular docking simulation showed that compound 6k is a competitive and reversible inhibitor of hMAO-B.
- You have full text access to this OnlineOpen articleDesign, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates
Abdelaaziz Ouahrouch, Moha Taourirte, Dominique Schols, Robert Snoeck, Graciela Andrei, Joachim W. Engels and Hassan B. Lazrek
Article first published online: 17 NOV 2015 | DOI: 10.1002/ardp.201500292
Ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonate analogs were synthesized through the Kabachnik–Fields reaction and copper-catalyzed cycloaddition of the azide–alkyne reaction. All compounds were tested against various strains of DNA and RNA viruses. Compounds 4b and 4c showed modest inhibitory activity against respiratory syncytial virus while compound 4h displayed modest inhibitory activity against Coxsackie virus B4.
- Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells
Sini K. Radhakrishnan, Ronald G. Shimmon, Costa Conn and Anthony T. Baker
Article first published online: 17 NOV 2015 | DOI: 10.1002/ardp.201500298
A series of hydroxy-substituted chalcone oxime derivatives were synthesized and evaluated for their inhibitory activities on tyrosinase and melanogenesis in murine B16F10 melanoma cells. Two of the compounds exhibited much higher tyrosinase inhibitory activities than kojic acid. The active inhibitors were shown to strongly interact with the tyrosinase residues of Agaricus bisporus.
- Mechanochemical Synthesis and Antioxidant Activity of Curcumin-Templated Azoles
Daisy R. Sherin and Kallikat N. Rajasekharan
Article first published online: 10 NOV 2015 | DOI: 10.1002/ardp.201500305
3,5-Bis(4-hydroxy-3-methoxystyryl)pyrazoles 2a–f and 3,5-bis(4-hydroxy-3-methoxystyryl)isoxazole 2g were rapidly prepared mechanochemically from curcumin 1 and hydrazines or hydroxylamine. Several of these compounds exhibit better antioxidant activity than curcumin. For example, the EC50 values based on the percentage of DPPH inhibition by 1, 2a, and 2g are 40, 14, and 8 µmol, respectively.
- 1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities
Alka Madaan, Ritu Verma, Vivek Kumar, Anu T. Singh, Swatantra K. Jain and Manu Jaggi
Article first published online: 9 NOV 2015 | DOI: 10.1002/ardp.201500237
The 1,8-naphthyridine (C8H6N2) scaffold is one of the six isomeric forms of diazanaphthalenes or pyridopyridines. Nalidixic acid (1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid) was the first of the synthetic quinolone antibiotics. This comprehensive review summarizes the diverse biological activities of the 1,8-naphthyridine derivatives reported so far.