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Recently Published Articles
- 5-Nitro-5′hydroxy-indirubin-3′oxime Is a Novel Inducer of Somatic Cell Transdifferentiation
Da-Woon Jung, Young J. Hong, Soo-Yeon Kim, Woong-Hee Kim, Shinae Seo, Jung-Eun Lee, Haihong Shen, Yong-Chul Kim and Darren R. Williams
Article first published online: 2 SEP 2014 | DOI: 10.1002/ardp.201400223
5-Nitro-5′hydroxy-indirubin-3′oxime (5′-HNIO) is shown to induce muscle transdifferentiation into adipogenic and osteogenic cells, without up-regulating potentially oncogenic induced pluripotent stem cell (iPSC) reprogramming factors. Thus, 5′-HNIO is an attractive molecular tool for cell transdifferentiation and cell fate research.
- In Silico Study Combining Docking and QSAR Methods on a Series of Matrix Metalloproteinase 13 Inhibitors
Lili Xi, Shuyan Li, Xiaojun Yao, Yuhui Wei, Jiazhong Li, Huanxiang Liu and Xin'an Wu
Article first published online: 2 SEP 2014 | DOI: 10.1002/ardp.201400200
Combining docking and QSAR methods, the structure–activity relationships of a series of carboxylic acid based matrix metalloproteinase 13 inhibitors were studied, considering selection of the bioactive conformation for each molecule and model internal and external validations. The critical factors influencing the inhibition activity were elucidated, with receptor–ligand complex descriptors having an advantage over directly reflecting receptor–ligand interactions.
- Design, Synthesis, and Local Anti-Inflammatory Activity of 17β-Carboxamide Derivatives of Glucocorticoids
Vladimir Dobričić, Bojan Marković, Nikola Milenković, Vladimir Savić, Vesna Jaćević, Nemanja Rančić, Sote Vladimirov and Olivera Čudina
Article first published online: 27 AUG 2014 | DOI: 10.1002/ardp.201400165
The combination of molecular docking studies and the exponential model for glucocorticoid receptor binding affinity prediction was used for the selection of 17β-carboxamide steroids with potential local anti-inflammatory activity. Local anti-inflammatory activity test and additional in vivo and in silico experiments indicate that these derivatives might be new soft glucocorticoids with significantly better biological profile than dexamethasone.
- Rationally Designed Less Toxic SPD-304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects
Polyxeni Alexiou, Athanasios Papakyriakou, Evangelos Ntougkos, Christos P. Papaneophytou, Fotini Liepouri, Anthi Mettou, Ioannis Katsoulis, Anna Maranti, Katerina Tsiliouka, Alexandros Strongilos, Sotiria Chaitidou, Eleni Douni, George Kontopidis, George Kollias, Elias Couladouros and Elias Eliopoulos
Article first published online: 27 AUG 2014 | DOI: 10.1002/ardp.201400198
A series of SPD-304 analogs was rationally designed aiming to diminish its toxicophore groups while maintaining its tumor necrosis factor alpha (TNF) inhibitory activity. Modification of the N-indole substituent with an aromatic deactivating group, in combination with elimination of the 6′-methyl group of the 4-chromone of SPD-304, resulted in a significantly less toxic and equally potent TNF inhibitor (3c).
- An Elegant Microwave Assisted One-Pot Synthesis of Di(α-aminophosphonate) Pesticides
Gangireddy Chandra Sekhar Reddy, Chinthaparthi Radha Rani, Mudumala Veera Narayana Reddy and Cirandur Suresh Reddy
Article first published online: 21 AUG 2014 | DOI: 10.1002/ardp.201400213
New di(α-aminophosphonate) derivatives with pesticidal activity were prepared by Kabachnik–Fields reaction under solvent- and catalyst-free conditions using microwave irradiation. Among all the compounds, 4f, 4c, and 4h exhibited good activity against Spodoptera litura, with 92.6, 91.3, and 89.3% mortality.