Archiv der Pharmazie

Cover image for Vol. 350 Issue 2

Edited By: Holger Stark

Impact Factor: 2.043

ISI Journal Citation Reports © Ranking: 2015: 36/59 (Chemistry Medicinal); 71/163 (Chemistry Multidisciplinary); 151/255 (Pharmacology & Pharmacy)

Online ISSN: 1521-4184


Highlights

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This issue covers a plurality of topics ranging from cancer, tumors over Parkinson and Alzheimer Desease. These papers are typically attracting large numbers of readers as inferred from numerous hits at the Archiv der Pharmazie website and many downloads.


Table of contents
• Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists
• Ibuprofen and Glutathione Conjugate as a Potential Therapeutic Agent for Treating Alzheimer's Disease
• Synthesis, Encapsulation and Antitumor Activity of New Betulin Derivatives
• Antimicrobial and Antineoplastic Activities of Agelasine Analogs Modified in the Purine 2-Position
• Evaluation of Polyhydroxybenzophenones as a-Glucosidase Inhibitors
• Design, Synthesis and Structure–Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors
• Design, Synthesis and Evaluation of Novel Rhodanine-containing Sorafenib Analogs as Potential Antitumor Agents
• Antioxidant, Cytotoxic Activities, and Structure–Activity Relationship of Gallic Acid-based Indole Derivatives
• Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates
• 4,5-Diaryl-3-aminopyrazole Derivatives as Analogs of Combretastatin A-4: Synthesis and Biological Evaluation

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists
Anna Drabczyńska, Małgorzata Zygmunt, Jacek Sapa, Barbara Filipek, Christa E. Müller and Katarzyna Kieć-Kononowicz
Keywords: Antiparkinsonian activity; Adenosine A2A receptors; Pyrimido[2,1-f]purinedione; Pyrazino[2,1-f]purinedione; Xanthin


Ibuprofen and Glutathione Conjugate as a Potential Therapeutic Agent for Treating Alzheimer's Disease
Francesco Pinnen, Piera Sozio, Ivana Cacciatore, Catia Cornacchia, Adriano Mollica, Antonio Iannitelli, Eleonora D′Aurizio, Amelia Cataldi, Susi Zara, Cinzia Nasuti and Antonio Di Stefan
Keywords: Alzheimer Disease; Codrug; Glutathione; Ibuprofen


Synthesis, Encapsulation and Antitumor Activity of New Betulin Derivatives
René Csuk, Alexander Barthel, Ronny Sczepek, Bianka Siewert and Stefan Schwarz
Keywords: Antitumor activity; Betulin; Betulinic acid; 1,3-Dipolar-cycloaddition; Liposomes; SRB assay


Antimicrobial and Antineoplastic Activities of Agelasine Analogs Modified in the Purine 2-Position
Heidi Roggen, Colin Charnock, Robert Burman, Jenny Felth, Rolf Larsson, Lars Bohlin and Lise-Lotte Gundersen
Keywords: Agelasine; Antibacterial activity; Anticancer acivitity; Antifungal activity; Antiprotozoal activity


Evaluation of Polyhydroxybenzophenones as a-Glucosidase Inhibitors
Xuesen Hu, Yang Xiao, Jianlong Wu and Lin Ma
Keywords: α-Glucosidase; Inhibitor; Polyhydroxybenzophenone


Design, Synthesis and Structure–Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors
Nermin S. Ahmed, Bernard D. Gary, Hethar N. Tinsley, Gary A. Piazza, Stefan Laufer and Ashraf H. Abadi
Keywords: beta-Carbolines; PDE5 inhibitors; SAR; Synthesis; Tadalafil


Design, Synthesis and Evaluation of Novel Rhodanine-containing Sorafenib Analogs as Potential Antitumor Agents
Wei Li, Xin Zhai, Zheng Zhong, Guangyue Li, Yongxiao Pu and Ping Gong
Keywords:Antitumor activity; Design; Rhodanine-containing sorafenib analogs; Structure–activity relationship


Antioxidant, Cytotoxic Activities, and Structure–Activity Relationship of Gallic Acid-based Indole Derivatives
Hamid Khaledi, Abeer A. Alhadi, Wagee A. Yehye, Hapipah Mohd Ali, Mahmood A. Abdulla and Pouya Hassandarvish
Keywords: Antioxidant activity; Cytotoxic activity; Gallic hydrazone; Indole


Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates
Dmytro Havrylyuk, Natalya Kovach, Borys Zimenkovsky, Olexandr Vasylenko and Roman Lesyk
Keywords: Anticancer activity; Isatines; Pyrazolines; 4-Thiazolidinones

4,5-Diaryl-3-aminopyrazole Derivatives as Analogs of Combretastatin A-4: Synthesis and Biological Evaluation
Tao Liu, Rong Cui, Jing Chen, Jun Zhang, Qiaojun He, Bo Yang and Yongzhou Hu
Keywords: Antitumor agents; Combretastatin A-4 analogs; Cytotoxicity; 4,5-Diaryl-3-aminopyrazole derivatives



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