IUBMB Life

Cover image for Vol. 66 Issue 8

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 2.755

ISI Journal Citation Reports © Ranking: 2013: 115/185 (Cell Biology); 154/291 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

Featured

  • Selection and evolution of resistance to antimicrobial drugs

    Selection and evolution of resistance to antimicrobial drugs

    Fluoroquinolone resistant E. coli in Europe. Increase in the proportion of fluoroquinolone resistant (R+I) E. coli isolates in Europe from 2002 to 2012. From the website of the European Centre for Disease Prevention and Control (http://www.ecdc.europa.eu/en/healthtopics/antimicrobial_resistance/database/). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Endoplasmic reticulum stress and endothelial dysfunction

    Endoplasmic reticulum stress and endothelial dysfunction

    ER stress triggers a signaling network that coordinates adaptive and/or apoptotic responses. In response to ER stress, BiP dissociates from the ER stress sensors, including PERK, IRE1, and ATF6, resulting in their activation. The intent of the UPR is to restore protein homeostasis. This adaptive mechanism involves suppression of protein translation, elimination of unfolded proteins through the ERAD and autophagy mechanisms, and returning to normal ER function. Excessive and prolonged ER stress is associated with increased inflammation and apoptosis contributing to the development and progression of diseases. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton

    Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton

    Actin-Translation connections found in yeasts. A: eEF1A bound to F-actin and Yih1p bound to G-actin do not participate in translation and in controlling Gcn2p-mediated translational regulation, respectively. B: eEF1A can be released from F-actin by either Bni1p or the α subunit of the guanine nucleotide exchange factor eEF1B, and may then participate in protein synthesis. Studies support the idea that Yih1p released from G-actin sequesters Gcn1p thereby inhibiting Gcn2p function. For more detailed explanation please see text.

  • A review of starch-branching enzymes and their role in amylopectin biosynthesis

    A review of starch‐branching enzymes and their role in amylopectin biosynthesis

    Phylogenetic tree showing the amino acid sequence relationships of plant SBEs. Data are generated using BLAST-EXPLORER. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • The strength of aversive and appetitive associations and maladaptive behaviors

    The strength of aversive and appetitive associations and maladaptive behaviors

    The magnitude (A) and persistence (B) of cocaine-induced place preference (CPP) is dependent on the different schedules of cocaine administration. A: The magnitude of CPP following training by escalating doses of cocaine was significantly higher than that induced by fixed and descending doses of cocaine (#P < 0.05). Note that no differences between the two escalating schedules of cocaine were observed despite the difference in total amount of drug given during the four training days (*P < 0.05 is the differences between all drug groups when compared with saline control group). B: The persistence of CPP in the escalating group (Esc-C) was significantly longer than in the fixed group (Fix-C; *P < 0.05) for at least 7 days post-training. The x-axis represents the number of days that place preference was recorded post-training (data from ref. 76).

  • Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

    Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus

    X-ray structures of PBP2a in (A) the apo-enzyme form (PDB code 1VQQ); (B) complex with ceftaroline bound at the active site and allosteric site (3ZG0); and (C) complex of PBP2a with ceftobiprole acylating the active site (4DKI). The side chains of Y446 and M641, which act as gatekeepers of the active site, are shown as black sticks (1 o'clock). (D) Chemical structures of ceftobiprole and ceftaroline. The R1 and R2 groups are shown in blue and red, respectively.

  • Ubiquitin-activating enzyme is necessary for 17β-estradiol-induced breast cancer cell proliferation and migration

    Ubiquitin‐activating enzyme is necessary for 17β‐estradiol‐induced breast cancer cell proliferation and migration

    The involvement of the ubiquitin-activating enzyme in E2-induced migration of MCF-7 cells. (A) Actin staining and (B) wound healing assays were performed as described in the “Experimental Procedures” section in MCF-7 cells treated with E2 for 5 min (A; left panels), EGF for 5 min (A; right panels), or with E2 for 48 h (B). Where indicated, cells were treated with Pyr-41 (1 µM), the PI3K inhibitor Ly 294002 (Ly, 1 µM), or with the p38/MAPK inhibitor SB 203580 (SB, 1 µM). *Significant differences with respect to the control sample; °significant differences with respect to the E2 sample (P < 0.01). The figure shows representative image areas.

  • Selection and evolution of resistance to antimicrobial drugs
  • Endoplasmic reticulum stress and endothelial dysfunction
  • Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton
  • A review of starch‐branching enzymes and their role in amylopectin biosynthesis
  • The strength of aversive and appetitive associations and maladaptive behaviors
  • Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus
  • Ubiquitin‐activating enzyme is necessary for 17β‐estradiol‐induced breast cancer cell proliferation and migration

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15th IUBMB - 24th FAOBMB - TSBMB International Conference, Taipei, Taiwan

Biochemistry and Molecular Biology in Transition: from Basic to Translational

15th IUBMB - 24th FAOBMB - TSBMB International Conference

2014 IUBMB Life Young Investigator Award

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On behalf of the IUBMB, IUBMB Life, and Wiley, it is with great pleasure and honor that we announce Liudmila Abrosimova as the recipient of the 2014 IUBMB Life - Wiley Young Investigator Award for her article, Thermo-switchable activity of the restriction endonuclease Ssoll achieved by site-directed enzyme modification.

Ms. Abrosimova is affiliated with the Department of Bioengineering and Bioinformatics, Department of Chemistry, and Belozersky Institute of Physico-Chemical Biology at Lomonosov Moscow State University. She will be honored with the 2014 IUBMB Life - Wiley Young Investigator Award at the 15th IUBMB - 24th FAOBMB - TSBMB Conference this October 21 - 26, in Taipei, Taiwan, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Ms. Abrosimova as the recipient of the annual IUBMB Life – Wiley Young Investigator Award!

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