IUBMB Life

Cover image for Vol. 67 Issue 1

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 2.755

ISI Journal Citation Reports © Ranking: 2013: 115/185 (Cell Biology); 154/291 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

Featured

  • Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

    Oxicams, a class of nonsteroidal anti‐inflammatory drugs and beyond

    The structure of microsomal PGE2 synthase-1 (mPGES-1) and the oxicam template for mPGES-1 inhibition. A: mPGES-1-GSH complex (PDB ID: 4LA0); the GSH molecules are in red sticks. B: The general template of an oxicam exhibiting potent mPGES-1 inhibition. C: Stereo diagram of the active site of mPGES-1 in complex with bis-phenyl-GSH and β-octylglucoside (PDB ID: 4LA1). The protein structure is shown in cartoon. The molecule of GSH is in red sticks (A), and bis-phenyl-GSH is in yellow sticks, and β-octyl glucoside is colored in light pink. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Tumour suppressors and cellular senescence

    Tumour suppressors and cellular senescence

    Mechanistic target of rapamycin (mTOR). mTOR is a key protein which governs a cell's choice between division and arrest . Its activity is governed by growth suppressors and growth promoters, which can either be intracellular or extracellular. Its activity is important in the context of activated p53 in determining the outcome of the p53 response . Cells that sustain mTOR activity undergo a stable senescence growth arrest, whereas cells in which mTOR is inhibited undergo a reversible quiescence arrest . [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Quorum sensing and biofilm formation in mycobacteria: Role of c-di-GMP and methods to study this second messenger

    Quorum sensing and biofilm formation in mycobacteria: Role of c‐di‐GMP and methods to study this second messenger

    Model depicting c-di-GMP based signaling network in the bacteria. Both DGC and cognate PDE can sense intra and extra cellular signals, which confer altered activity to them. c-di-GMP can inhibit its own synthesis by binding to product inhibition sites on many DGCs to set an upper level of cellular c-di-GMP concentrations. c-di-GMP shows structural polymorphism and these different polymorphic forms have been observed in bound form on different binding partners including proteins and RNAs to change the bacterial life style.

  • Interaction between pancreatic cancer cells and tumor-associated macrophages promotes the invasion of pancreatic cancer cells and the differentiation and migration of macrophages

    Interaction between pancreatic cancer cells and tumor‐associated macrophages promotes the invasion of pancreatic cancer cells and the differentiation and migration of macrophages

    Immunohistochemistry analysis of the immunocompetent cells surrounding human PDAC lesions. The PDAC tissue sections were stained with anti-CD19 for the identification of B lymphocytes (A), anti-CD3 for T lymphocytes (B), anti-CD68 for monocytes/macrophages (C), and anti-CD163 for M2 macrophages (D). Data are representative images (magnification, 400×) from 22 PDAC specimens. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Gray level entropy matrix is a superior predictor than multiplex ELISA in the detection of reactive stroma and metastatic potential of high-grade prostatic adenocarcinoma

    Gray level entropy matrix is a superior predictor than multiplex ELISA in the detection of reactive stroma and metastatic potential of high‐grade prostatic adenocarcinoma

    Images processed (32 bit conversion and pseudocolored) for enhanced visualization of the stromal organization in BPH and PA. Note the highly disorganized matrix in higher grades of PA and disruption of the wavy patterns in tissues obtained from treatment-resistant PA. Warmer solid colors reflect disruptive compactness of stroma in PA. Also note the infiltrative matrix in the treatment-resistant variant. Two panels are shown to reveal variance (obtained from independent samples). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Bornyl acetate has an anti-inflammatory effect in human chondrocytes via induction of IL-11

    Bornyl acetate has an anti‐inflammatory effect in human chondrocytes via induction of IL‐11

    IL-11 moderately antagonizes IL-1β-mediated inflammatory effects. (A) Chondrocytes were stimulated with IL-1β (5 ng/mL) in the presence or absence of IL-11 (50 and 100 ng/mL). IL-6 and IL-8 transcripts were quantified by qPCR (ANOVA, *, P < 0.01 vs. nontreated control; #, P < 0.01 vs. IL-1β treatment; n = 4–5). (B) Chondrocytes were stimulated with IL-1β (5 ng/mL) in the presence or absence of IL-11 (50 and 100 ng/mL). IL-6 and IL-8 concentrations in the conditioned media were determined by ELISA (ANOVA, *, P < 0.01 vs. nontreated control; #, P < 0.01 vs. IL-1β treatment; n = 4–5).

  • Oxicams, a class of nonsteroidal anti‐inflammatory drugs and beyond
  • Tumour suppressors and cellular senescence
  • Quorum sensing and biofilm formation in mycobacteria: Role of c‐di‐GMP and methods to study this second messenger
  • Interaction between pancreatic cancer cells and tumor‐associated macrophages promotes the invasion of pancreatic cancer cells and the differentiation and migration of macrophages
  • Gray level entropy matrix is a superior predictor than multiplex ELISA in the detection of reactive stroma and metastatic potential of high‐grade prostatic adenocarcinoma
  • Bornyl acetate has an anti‐inflammatory effect in human chondrocytes via induction of IL‐11

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Molecular basis of disease: understanding causes and targeting therapies
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IUBMB Life moving to online only in 2015

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In 2015, IUBMB Life will move to online only publication, in trend with Wiley's path of digital transformation, as the company invests in the customizable, technology-enabled products and services needed by our customers in the future.

The gradual migration of journals from print to solely online is part of this transition, supporting investment in forward-looking innovation and building online communities for journal readers and our society partners.

IUBMB Joint Virtual Issue on Cancer Therapies

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We’re pleased to present a new Joint Virtual Issue on Cancer Therapies in celebration of the IUBMB 2015 Miami Winter Symposium, featuring articles from Biofactors, Biotechnologyand Applied Biochemistry, and IUBMB Life.

2014 IUBMB Life Young Investigator Award

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On behalf of the IUBMB, IUBMB Life, and Wiley, it is with great pleasure and honor that we announce Liudmila Abrosimova as the recipient of the 2014 IUBMB Life - Wiley Young Investigator Award for her article, Thermo-switchable activity of the restriction endonuclease Ssoll achieved by site-directed enzyme modification.

Ms. Abrosimova is affiliated with the Department of Bioengineering and Bioinformatics, Department of Chemistry, and Belozersky Institute of Physico-Chemical Biology at Lomonosov Moscow State University. She will be honored with the 2014 IUBMB Life - Wiley Young Investigator Award at the 15th IUBMB - 24th FAOBMB - TSBMB Conference this October 21 - 26, in Taipei, Taiwan, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Ms. Abrosimova as the recipient of the annual IUBMB Life – Wiley Young Investigator Award!

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