IUBMB Life

Cover image for Vol. 66 Issue 10

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 2.755

ISI Journal Citation Reports © Ranking: 2013: 115/185 (Cell Biology); 154/291 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

Featured

  • Heterochromatin structure: Lessons from the budding yeast

    Heterochromatin structure: Lessons from the budding yeast

    Model for a higher order heterochromatin superstructure at HMR. In this model, HMR-E and -I silencers interact to form a chromatin loop associated with Sir proteins. There is also an internal loop that contains functional elements such as the promoter of the a1 and a2 genes and the HO cutting site. This loop is buried in the superstructure. (Adapted from ref. 40.).

  • Cells producing their own nemesis: Understanding methylglyoxal metabolism

    Cells producing their own nemesis: Understanding methylglyoxal metabolism

    Overview of the methylglyoxal metabolism. Abbreviations: G-6-P, glucose-6-phosphate; F-6-P, fructose-6-phosphate; F-1,6-P2, fructose-1,6-bisphosphate; Gld-3-P, glyceraldehyde-3-phosphate; DHAP, dihydroxyacetone phosphate; 1,3-BisPG, 1,3-bisphosphoglycerate; Gly-P, glycerolphosphate; GSH, glutathione; MSH, mycothiol; TSH, trypanothione; Gld, glyceraldehydes. The enzymes involved in the reactions: TPI, triosephosphate isomerase; Mgs, methylglyoxal synthase; GlxI, glyoxalase I; GlxII, glyoxalase II; d-Ldh, d-lactate dehydrogenase; l-Ldh, l-lactate dehydrogenase; l-thr dh, l-threonine dehydrogenase; Acac decarb, acetoacetate decarboxylase; MG red, methylglyoxalreductase; l-lac dh, l-lactaldehyde dehydrogenase; Ac mono ox, acetolmonooxygenase; Ald dh, aldehyde dehydrogenase; MG dh, methylglyoxal dehydrogenase; Sorb dh, sorbitol dehydrogenase; Rpi, ribose-5 phosphate isomerase; Rpe, ribulose-5 phosphate epimerase; Trk, transketolase; Aldose red, aldose reductase. Substrates in green are the initiators of methylglyoxal-producing reactions. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • The Na+/H+ exchanger and pH regulation in the heart

    The Na+/H+ exchanger and pH regulation in the heart

    Schematic model of NHE1 structure. NHE1 consists of two main domains: the 12-transmembrane segment domain where ion exchange takes place (TMI-TMXII) and the regulatory cytoplasmic domain. The cytoplasmic region is phosphorylated by various kinases and interacts with a number of proteins that modulate NHE1 activity at the plasma membrane. Regulatory proteins of particular importance in the myocardium are illustrated at approximate locations of action including calcineurin homologous proteins (CHPs), calmodulin (CaM; A: high-affinity binding site; B: intermediate-affinity binding site), carbonic anhydrase II (CAII), extracellular signal regulated protein 1/2 (ERK1/2), ribosomal protein S6 kinase (p90RSK), serum- and glucocorticoid-inducible kinase (Sgk1), and protein kinase B (PKB).

  • Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3-deoxyglucosone

    Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3‐deoxyglucosone

    Far-UV CD profiles of native histone H2A () and 3-DG-glycated H2A histone (). The far-UV CD spectra were recorded between 190 nm and 250 nm. The protein concentration was 0.5 mg/mL and the path length was 1.0 cm.

  • Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium

    Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium

    Model of β1 integrin-mediated regulation of Egfr and Hh expression in IECs. The model shows that β1 integrins enhance downregulation of Egfr signaling through endocytosis. Egfr signaling inhibits Hh expression. Hh signaling is paracrine in the intestine with Shh and Ihh secreted by the IECs that bind to their cognate receptor Patched (Ptc) expressed on intestinal stromal cells. Hh signaling in stromal cells is mediated by Smoothened (Smo) and Gli transcription factors, and, culminates in the induction of bone morphogenetic protein (Bmp)-2/-4 expression. Bmp signaling is paracrine as well because Bmp receptors are expressed by IECs. Bmp signaling through (SMAD) small body size mothers against decapentaplegic 1/5/8 inhibits proliferative signaling, especially the Wnt pathway, and inhibits Shh transcription in IECs.

  • Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis

    Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis

    Expression of Nrdp1 as well as cleaved caspase 3 is increased in TMZ induced apoptosis. The U118 MG and U87 cells were exposed to TMZ at 100 µM for 0 H, 6 H, 12 H, 24 H, and 36 H, then the cells were harvested and performed for the detection of Nrdp1 and cleaved caspase 3. (A) The representative image of western blotting. (B and C) The statistical analysis of the relative level of Nrdp1 and cleaved caspase 3. *P < 0.05; **P < 0.01.

  • 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase

    2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d‐glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine‐induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase

    TSG abolished LPC-induced apoptosis to HUVECs in vitro. Transmission electron microscope micrographs of HUVECs treated with different compounds as indicated for 24 H. DMEM: Abundant mitochondria were seen in the cytoplasm. LPC: The cells exposed with LPC 10.0 µg/mL showed an abundance of cytoplasmic vacuolation and swollen mitochondria. Simvastatin+LPC: Reduced cytoplasmic vacuolation and swollen mitochondria were seen in the cytoplasm. TSG+LPC: With the increase of concentration of TSG, mitochondria condition was improved markedly (original magnification ×30,000). In all treatment groups, swollen mitochondria were detected in comparison to that of DMEM control group. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Heterochromatin structure: Lessons from the budding yeast
  • Cells producing their own nemesis: Understanding methylglyoxal metabolism
  • The Na+/H+ exchanger and pH regulation in the heart
  • Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3‐deoxyglucosone
  • Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium
  • Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis
  • 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d‐glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine‐induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase

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New insights into roles of intermediate filament phosphorylation and progeria pathogenesis
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Understanding circadian gene function: Animal models of tissue-specific circadian disruption
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Virtual Issue: Molecular Basis of Disease

Understanding Causes and Targeting Therapies

Molecular basis of disease: understanding causes and targeting therapies
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IUBMB Life moving to online only in 2015

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2014 IUBMB Life Young Investigator Award

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On behalf of the IUBMB, IUBMB Life, and Wiley, it is with great pleasure and honor that we announce Liudmila Abrosimova as the recipient of the 2014 IUBMB Life - Wiley Young Investigator Award for her article, Thermo-switchable activity of the restriction endonuclease Ssoll achieved by site-directed enzyme modification.

Ms. Abrosimova is affiliated with the Department of Bioengineering and Bioinformatics, Department of Chemistry, and Belozersky Institute of Physico-Chemical Biology at Lomonosov Moscow State University. She will be honored with the 2014 IUBMB Life - Wiley Young Investigator Award at the 15th IUBMB - 24th FAOBMB - TSBMB Conference this October 21 - 26, in Taipei, Taiwan, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Ms. Abrosimova as the recipient of the annual IUBMB Life – Wiley Young Investigator Award!

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