IUBMB Life

Cover image for Vol. 66 Issue 8

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 2.755

ISI Journal Citation Reports © Ranking: 2013: 115/185 (Cell Biology); 154/291 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

Featured

  • NAC transcription factor gene regulatory and protein–protein interaction networks in plant stress responses and senescence

    NAC transcription factor gene regulatory and protein–protein interaction networks in plant stress responses and senescence

    Structure of NAC proteins. (a) X-ray structure of the NAC019 NAC DBD in complex with the ANAC019 binding site 5′-TCAGTCTTGCGTGTTGGAACACGCAACAGGGA-3′ (PDB accession code 3SWP). Specific phosphates of the NACBS protected from cleavage in uranyl photo-footprinting in the presence of ANAC019 are shown by bold lines and the NAC binding core is underlined . (b) Schematic structure of an intrinsically disordered NAC C-terminus. Sub-group specific sequence motifs, representing putative protein interaction determinants, some of which may represent regions with local structure, for example, preformed structural elements or molecular recognition features, are shown. (c) ID and interactions of NAC TFs. ID was predicted using PONDR-FIT with a threshold value of 0.5. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Redox control of enzymatic functions: The electronics of life's circuitry

    Redox control of enzymatic functions: The electronics of life's circuitry

    Schematic representation of step by step electron and proton transfer reactions catalyzed by CcO. This complex (IV in the mitochondrial electron transfer chain) catalyzes the transfer of four electrons and four protons to O2 reducing it completely to H2O. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies

    Cell‐penetrating peptides: A tool for effective delivery in gene‐targeted therapies

    Drug delivery technologies and cellular entry mechanisms proposed. A: Variety of drug delivery systems available to conjugate with diverse payloads to be delivered into cells. Conjugation can be either covalent or non-covalent binding. Combination of two or more drug delivery systems is also possible (i.e., micelles/liposomes/nanoparticles conjugated with CPP to increase cell specificity and entry). B: Delivery routes that the conjugate may take to reach the cell cytoplasm. Entry pathways range from endocytic mechanisms (clathrin-/caveolae-dependent or nondependent and macropinocytosis/micropinocytosis) to nonendocytic routes by various proposed lipid membrane direct translocation models: toroidal pore, barrel stave pore, inverted micelle, or carpet models. Once inside the cell according to the payload delivered it may execute different functions and trigger a diverse range of cellular processes and reach various cellular compartments. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • New insights into roles of intermediate filament phosphorylation and progeria pathogenesis

    New insights into roles of intermediate filament phosphorylation and progeria pathogenesis

    Possible mechanism by which compromised mitotic IF phosphorylation promotes cellular senescence (A) that is manifested as lens cataract (B). Micrographs showing IF-bridge or binucleation were reproduced from ©Yasui, Y., et al., 2001 (originally published in Oncogene, doi: 10.1038/sj.onc.1204407) or ©Yamaguchi, T., et al., 2005 (originally published in J. Cell Biol., doi: 10.1083/jcb.200504091), respectively.

  • Heterologous expression and characterization of human cellular glutathione peroxidase mutants

    Heterologous expression and characterization of human cellular glutathione peroxidase mutants

    PAGE and Western blot analysis of recombinant hGPx1. SDS-PAGE analysis of purified seleno-hGPx1Sec and seleno-hGPx1Ser with (A) and without (B) 6× His tag. (C) Western blot analysis of purified seleno-hGPx1 mutants. (D) SDS-PAGE analysis of fractions from E. coli BL21(DE3)cys cells transformed with pCGPx1(C2/78/115/156/202S). Lane 1, marker; lane 2, soluble fraction of E. coli without isopropyl-β-d-1-thiogalactopyranoside (IPTG) induction; lane 3, soluble fraction of E. coli after IPTG induction; lane 4, the purified seleno-hGPx1Ser; lane 5, the complex with nondenatured and denatured seleno-hGPx1Ser. (E) Nondenaturing PAGE analysis of the purified seleno-hGPx1Ser. Lane 1, denatured seleno-hGPx1Ser; lane 2, nondenatured seleno-hGPx1Ser. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com .]

  • Suppression of MicroRNA-203 improves survival of rat bone marrow mesenchymal stem cells through enhancing PI3K-induced cellular activation

    Suppression of MicroRNA‐203 improves survival of rat bone marrow mesenchymal stem cells through enhancing PI3K‐induced cellular activation

    Identification of the bone marrow-derived cells as BM-MSCs. A: The second passage of rat bone marrow-derived adherent cells (×40). B: The expression of cell surface markers for MSCs identification were measured by incubating the cells with fluorescence-labeled antibodies and detecting by flow cytometry. C: For differentiation detection, cells were maintained in special induction media. The differentiation capability of BM-MSCs into adipogenic or osteogenic cells was evaluated by oil red O or Von Kossa staining, respectively (×100). The uninduced cells were the control . The arrows indicate the red lipid droplets or the black calcium deposition . [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • NAC transcription factor gene regulatory and protein–protein interaction networks in plant stress responses and senescence
  • Redox control of enzymatic functions: The electronics of life's circuitry
  • Cell‐penetrating peptides: A tool for effective delivery in gene‐targeted therapies
  • New insights into roles of intermediate filament phosphorylation and progeria pathogenesis
  • Heterologous expression and characterization of human cellular glutathione peroxidase mutants
  • Suppression of MicroRNA‐203 improves survival of rat bone marrow mesenchymal stem cells through enhancing PI3K‐induced cellular activation

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Volume 66, Issue 4, April 2014

New insights into roles of intermediate filament phosphorylation and progeria pathogenesis
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Volume 66, Issue 3, March 2014

Understanding circadian gene function: Animal models of tissue-specific circadian disruption
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15th IUBMB - 24th FAOBMB - TSBMB International Conference, Taipei, Taiwan

Biochemistry and Molecular Biology in Transition: from Basic to Translational

15th IUBMB - 24th FAOBMB - TSBMB International Conference

2014 IUBMB Life Young Investigator Award

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On behalf of the IUBMB, IUBMB Life, and Wiley, it is with great pleasure and honor that we announce Liudmila Abrosimova as the recipient of the 2014 IUBMB Life - Wiley Young Investigator Award for her article, Thermo-switchable activity of the restriction endonuclease Ssoll achieved by site-directed enzyme modification.

Ms. Abrosimova is affiliated with the Department of Bioengineering and Bioinformatics, Department of Chemistry, and Belozersky Institute of Physico-Chemical Biology at Lomonosov Moscow State University. She will be honored with the 2014 IUBMB Life - Wiley Young Investigator Award at the 15th IUBMB - 24th FAOBMB - TSBMB Conference this October 21 - 26, in Taipei, Taiwan, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Ms. Abrosimova as the recipient of the annual IUBMB Life – Wiley Young Investigator Award!

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