IUBMB Life

Cover image for Vol. 68 Issue 8

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 2.653

ISI Journal Citation Reports © Ranking: 2015: 108/187 (Cell Biology); 145/289 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

Featured

  • Serum miRNA-499 and miRNA-210: A potential role in early diagnosis of acute coronary syndrome

    Serum miRNA‐499 and miRNA‐210: A potential role in early diagnosis of acute coronary syndrome

    Receiver operating characteristic (ROC) curve of miRNA-499, miRNA-210, and their combinations as a diagnostic marker for unstable angina (UA): (A) miRNA-499; (B) miRNA-210; (C) miRNA-499 + miRNA-210.

  • 4-n-butylresorcinol, a depigmenting agent used in cosmetics, reacts with tyrosinase

    4‐n‐butylresorcinol, a depigmenting agent used in cosmetics, reacts with tyrosinase

    Computational docking results for mushroom tyrosinase (Agaricus bisporus) in the met-form and ligands. A. Lowest energy AutoDock of BR in the tyrosinase active site is shown in orange sticks. The possible interactions of the inhibitor with the copper ions are shown in dotted red lines. The l-tyrosine docking pose is shown as light green sticks. The atom colors are as follows: red = oxygen, blue = nitrogen, yellow = copper, carbon = green and white = hydrogen. B. Surface representation of tyrosinase docked with BR (sticks).

  • Cecropin A-induced apoptosis is regulated by ion balance and glutathione antioxidant system in Candida albicans

    Cecropin A‐induced apoptosis is regulated by ion balance and glutathione antioxidant system in Candida albicans

    Detection of apoptotic features with fluorescence microscopy. C. albicans cells were preincubated with ion channel blockers DIDS, TEA, and RR for 20 min and incubated with cecropin A. Then, the cells were stained with CaspACE FITC-VADFMK, DAPI and TUNEL, respectively. (A) Caspase activation. (B) Nuclear fragmentation. (C) DNA fragmentation.

  • Neuroglobin overexpression induced by the 17β-Estradiol–Estrogen receptor-α Pathway reduces the sensitivity of MCF-7 Breast cancer cell to paclitaxel

    Neuroglobin overexpression induced by the 17β‐Estradiol–Estrogen receptor‐α Pathway reduces the sensitivity of MCF‐7 Breast cancer cell to paclitaxel

    E2 and paclitaxel effect on NGB expression. A: Western blot (left) and densitometric analyses (right) of NGB protein levels in MCF-7 cells treated for 4 h with the vehicle (ethanol/PBS 1/10), E2 (10 nM), and PPT (ERα agonist, 10 nM). Data are the mean ± SD of five different experiments. P < 0.001 was determined with Student's t-test with respect to the vehicle (*). B: NGB mRNA levels in MCF-7 cells treated either with the vehicle (ethanol/PBS 1/10) or E2 (10 nM) or paclitaxel (100 nM). The NGB expression is reported as fold of induction over the vehicle (set to 100). Data represent the mean ± SD of five different experiments. P < 0.001 was determined by Student's t-test with respect to the vehicle (*). C: Western blot (left) and densitometric analyses (right) of NGB protein levels in MCF-7 cells pretreated 24 h with either the vehicle or E2 (10 nM) or paclitaxel (100 nM) or E2 (4 h) and paclitaxel (100 nM). The amount of protein was normalized to tubulin levels. Data are mean ± SD of three different experiments. P < 0.001 was determined with Student's t-test with respect of either the vehicle (*) or paclitaxel-treated (°) samples. D: NGB protein amount (ng/mg protein lysate) in MCF-7 cells treated as reported in panel C. The cell content of NGB protein was quantified by comparing the intensity of the NGB band of Western blot of treated samples with the intensity of the NGB band of 5 ng of the recombinant protein used as the NGB standard. Data are mean ± SD of three independent experiments. P < 0.05 was determined with Student's t-test with respect to the vehicle (*) or paclitaxel-treated (°) samples.

  • Immunohistochemical distinction of metastases of renal cell carcinoma with molecular analysis of overexpression of the chemokines CXCR2 and CXCR3 as independent positive prognostic factors for the tumorigenesis

    Immunohistochemical distinction of metastases of renal cell carcinoma with molecular analysis of overexpression of the chemokines CXCR2 and CXCR3 as independent positive prognostic factors for the tumorigenesis

    Low and high expression of CXCR3 and CXCR2 in RCC patient's tissues.

  • S-nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis

    S‐nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis

    M. smegmatis biofilms formed in TSB media supplemented with 1% procalamine and incubated at 30 °C for 72 h with no disturbance. Wild-type strain compared with SHP1 (mscR−), SHP1C (complemented SHP1), S24 (mshC−), S24C (complemented S24), R119 (egtA−), and R119C (complemented R119).

  • Serum miRNA‐499 and miRNA‐210: A potential role in early diagnosis of acute coronary syndrome
  • 4‐n‐butylresorcinol, a depigmenting agent used in cosmetics, reacts with tyrosinase
  • Cecropin A‐induced apoptosis is regulated by ion balance and glutathione antioxidant system in Candida albicans
  • Neuroglobin overexpression induced by the 17β‐Estradiol–Estrogen receptor‐α Pathway reduces the sensitivity of MCF‐7 Breast cancer cell to paclitaxel
  • Immunohistochemical distinction of metastases of renal cell carcinoma with molecular analysis of overexpression of the chemokines CXCR2 and CXCR3 as independent positive prognostic factors for the tumorigenesis
  • S‐nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis

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New insights into roles of intermediate filament phosphorylation and progeria pathogenesis
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Understanding circadian gene function: Animal models of tissue-specific circadian disruption
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IUBMB Joint Virtual Issue on Cancer Therapies

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We’re pleased to present a new Joint Virtual Issue on Cancer Therapies in celebration of the IUBMB 2015 Miami Winter Symposium, featuring articles from Biofactors, Biotechnologyand Applied Biochemistry, and IUBMB Life.

2015 IUBMB Life Young Investigator Award

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On behalf of the IUBMB, IUBMB Life, and Wiley, it is with great pleasure and honor that we announce Yang Chao as the recipient of the 2015 IUBMB Life - Wiley Young Investigator Award for his article, Aquaporin-4 knockdown ameliorates hypoxic-ischemic cerebral edema in newborn piglets.

Yang Chao, M. D. is an attending physician in Department of Radiology at Dalian Medical University of China, His research interest is in molecular imaging and neuroimaging. The winning article Aquaporin-4 knockdown ameliorates hypoxic-ischemic cerebral edema in newborn piglets is main part of his doctoral thesis under guidance of professor Bian Jie. Yang Chao will be honored with the 2015 IUBMB Life - Wiley Young Investigator Award at the 23rd International Union for Biochemistry and Molecular Biology (IUBMB) Congress and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology in Foz do Iguaçu, Brazil from August 24th to 28th, 2015, and his award-winning article will be FREELY available online through the conference.

Please join us in congratulating Mr. Yang Chao as the recipient of the annual IUBMB Life– Wiley Young Investigator Award!

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