Cover image for Vol. 69 Issue 8

Edited By: Angelo Azzi and William J. Whelan

Impact Factor: 3.141

ISI Journal Citation Reports © Ranking: 2016: 99/189 (Cell Biology); 123/286 (Biochemistry & Molecular Biology)

Online ISSN: 1521-6551

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, BioFactors

IUBMB Virtual Issue: Molecular Basis of Disease

Molecular Basis of Disease: Understanding Causes and Targeting Therapies
The Virtual Issue deals with medical problems of central importance such as neurodegenerative disease, cancer, myocardial infarction, HIV, gouts and some new therapeutic targets of these diseases. The molecular aspects are particularly described, which are the basis of a more rational approach to disease.

•Role of astrocytes in major neurological disorders: The evidence and implications
Scuderi, C., Stecca, C., Iacomino, A., Steardo, L.

•Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy
Miao, P., Sheng, S., Sun, X., Liu, J., Huang, G.

•The multifaceted activities of AMPK in tumor progression - Why the "one size fits all" definition does not fit at all?
Bonini, M.G., Gantner, B.N.

•Advances in pathogenesis and therapy of hemolytic uremic syndrome caused by Shiga toxin-2
Ibarra, C., Amaral, M.M., Palermo, M.S.

•Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
Swellam, M., Gabal, K.M.A., Youssef, S.S.

•HPIP is upregulated in liver cancer and promotes hepatoma cell proliferation via activation of G2/M transition
Xu, X. et al.

•Determination of telaprevir in plasma of HCV-infected patients by HPLC-UV
Tempestilli, M., Milano, E., D'Offizi, G., Montalbano, M., D'Avolio, A., Gasperi, T., Narciso, P., Ascenzi, P., Pucillo, L.P.

•Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma
Wang, A.-X., Qi, X.-Y.

•Cell death in the myocardium: My heart won't go on
Orogo, A.M., Gustafsson, A.B.

•Targeting the therapeutic effects of exercise on redox-sensitive mechanisms in the vascular endothelium during tumor progression
Wolff, G., Toborek, M.

•A small disturbance, but a serious disease: The possible mechanism of D52H-mutant of human PRS1 that causes gout
Chen, P., Li, J., Ma, J., Teng, M., Li, X.

•Effect of lipopolysaccharide on the biological characteristics of human skin fibroblasts and hypertrophic scar tissue formation
Yang, H., Hu, C., Li, F., Liang, L., Liu, L.

•Mitochondrial involvement in neurodegenerative diseases
Zsurka, G., Kunz, W.S.

•Mitochondria as a pharmacological target: Magnum overview
Olszewska, A., Szewczyk, A.

•Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier
András, I.E., Toborek, M.

•Phosphodiesterases in neurodegenerative disorders
Bollen, E., Prickaerts, J.

•The impairment of insulin signaling in Alzheimer's disease
Candeias, E., Duarte, A.I., Carvalho, C., Correia, S.C., Cardoso, S., Santos, R.X., Plácido, A.I., Perry, G., Moreira, P.I.

•Cholesterol and Alzheimer's disease: A still poorly understood correlation
Ricciarelli, R., Canepa, E., Marengo, B., Marinari, U.M., Poli, G., Pronzato, M.A., Domenicotti, C.

•Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer
Zhi, X., Wang, Y., Yu, J., Yu, J., Zhang, L., Yin, L., Zhou, P.

•NOS-2 signaling and cancer therapy
Bian, K., Ghassemi, F., Sotolongo, A., Siu, A., Shauger, L., Kots, A., Murad, F.

•MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells
Wei, Q., Li, Y.-X., Liu, M., Li, X., Tang, H.

•NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo
Duncan, K., Uwimpuhwe, H., Czibere, A., Sarkar, D., Libermann, T.A., Fisher, P.B., Zerbini, L.F.

•Simultaneous determination of lamivudine, lopinavir, ritonavir, and zidovudine concentration in plasma of HIV-infected patients by HPLC-MS/MS
Notari, S., Sergi, M., Montesano, C., Ivanovic, J., Narciso, P., Pucillo, L.P., Ascenzi, P.

•Neuroprotective and neuroregenerative properties of metallothioneins
Santos, C.R.A., Martinho, A., Quintela, T., Gonçalves, I.

•Mechanism of DNA depurination by carcinogens in relation to cancer initiation
Cavalieri, E., Saeed, M., Zahid, M., Cassada, D., Snow, D., Miljkovic, M., Rogan, E.

•Antibacterial components of honey
Kwakman, P.H.S., Zaat, S.A.J.

•Exploring frataxin function
Busi, M.V., Gomez-Casati, D.F.

•Contribution of individual PKC isoforms to breast cancer progression
Urtreger, A.J., Kazanietz, M.G., Bal De Kier Joffé, E.D.

•Acinetobacter infection - An emerging threat to human health
Visca, P., Seifert, H., Towner, K.J.

•Genetic basis of antibiotic resistance in pathogenic Acinetobacter species
Poirel, L., Bonnin, R.A., Nordmann, P

•New insights into therapeutic options for Pompe disease
Richard, E., Douillard-Guilloux, G., Caillaud, C.

•Early endocrine and molecular changes in metabolic syndrome models
Larqué, C., Velasco, M., Navarro-Tableros, V., Duhne, M., Aguirre, J., Gutiérrez-Reyes, G., Moreno, J., Robles-Diaz, G., Hong, E., Hiriart, M.

• The role of iron as a mediator of oxidative stress in Alzheimer disease
Rudy J. Castellani, Paula I. Moreira, George Perry and Xiongwei Zhu

• Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease
George J. Brewer

• Zinc in the central nervous system: From molecules to behavior
Shannon D. Gower-Winter and Cathy W. Levenson

• Serum peptidome patterns for early screening of esophageal squamous cell carcinoma
Nai-Jun Fan, Chun-Fang Gao, Guang Zhao, Xiu-Li Wang and Liang Qiao

• Large-scale production of human mesenchymal stem cells for clinical applications
Sunghoon Jung, Krishna M. Panchalingam, Reynold D. Wuerth, Lawrence Rosenberg and Leo A. Behie