Magnetic Resonance in Medicine

Cover image for Vol. 71 Issue 4

Edited By: Matt A. Bernstein

Online ISSN: 1522-2594

Associated Title(s): Journal of Magnetic Resonance Imaging

Virtual Issue: MRI Based Cell Tracking

MRI based cell tracking has matured over the past decade and MRM remains the journal of choice for publishing technical advances in this field. In the first of our retrospective table of contents (TOC) series, we are highlighting cell tracking papers published in MRM over the last two years. This retrospective TOC coincides with an "ISMRM Workshop on MRI-Based Cell Tracking" to be held in Miami Beach, Florida from January 29 – February 1, 2012 (

MRI-based cell tracking has impacted basic research in neuroscience, immunology and developmental biology, and has begun to impact important clinical paradigms such as stem cell transplantation, inflammation, cancer and regenerative medicine. Technical innovations in nanoparticle technology, coupled with advances in MRI technology, have yielded enhanced detection capabilities with sensitivity of individual cells in vivo. Novel probes and applications of molecular biology provide the opportunity to monitor cell function and gene expression in vivo. The papers listed below represent work reported on this topic in MRM over the last 2 years.

lacZ as a genetic reporter for real-time MRI
Niclas E. Bengtsson, Gary Brown, Edward W. Scott and Glenn A. Walter
Volume 63, Issue 3

Cell tracking using iron oxide fails to distinguish dead from living transplanted cells in the infarcted heart
E.M. Winter, B. Hogers, L.M. van der Graaf, A.C. Gittenberger-de Groot, R.E. Poelmann and L. van der Weerd
Volume 63, Issue 3

Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles
Dorota A. Kedziorek, Naser Muja, Piotr Walczak, Jesus Ruiz-Cabello, Assaf A. Gilad, Chunfa C. Jie and Jeff W. M. Bulte
Volume 63, Issue 4

SWIFT detection of SPIO-labeled stem cells grafted in the myocardium
Rong Zhou, Djaudat Idiyatullin, Steen Moeller, Curt Corum, Hualei Zhang, Hui Qiao, Jia Zhong and Michael Garwood
Volume 63, Issue 5

Magnetic nanoparticles for imaging dendritic cells
Saho Kobukai, Richard Baheza, Jared G. Cobb, Jack Virostko, Jingping Xie, Amelie Gillman, Dmitry Koktysh, Denny Kerns, Mark Does, John C. Gore and Wellington Pham
Volume 63, Issue 5

Magnetosonoporation: Instant magnetic labeling of stem cells
Bensheng Qiu, Daohai Xie, Piotr Walczak, Xubin Li, Jesus Ruiz-Cabello, Satoshi Minoshima, Jeff W.M. Bulte and Xiaoming Yang
Volume 63, Issue 6

Imaging iron-loaded mouse glioma tumors with bSSFP at 3 T
Lisa M. Bernas, Paula J. Foster and Brian K. Rutt
Volume 64, Issue 1

S-Gal®, A novel 1H MRI reporter for β-galactosidase
Weina Cui, Li Liu, Vikram D. Kodibagkar and Ralph P. Mason
Volume 64, Issue 1

In vivo MR evaluation of the effect of the CCR2 antagonist on macrophage migration
Yedaun Lee, Je-Won Ryu, Hyeujin Chang, Jin Young Sohn, Kyung Won Lee, Chul Woong Woo, Hee Jung Kang, Seong-Yun Jeong, Eun Kyung Choi and Jin Seong Lee
Volume 64, Issue 1

In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI
Deepak K. K. Kadayakkara, Jelena M. Janjic, Lisa K. Pusateri, Won-Bin Young and Eric T. Ahrens
Volume 64, Issue 5

Simplified synthesis and relaxometry of magnetoferritin for magnetic resonance imaging
Veronica Clavijo Jordan, Michael R. Caplan and Kevin M. Bennett
Volume 64, Issue 5

Longitudinal tracking of human dendritic cells in murine models using magnetic resonance imaging
Karen C. Briley-Saebo, Marylene Leboeuf, Stephen Dickson, Venkatesh Mani, Zahi A. Fayad, A. Karolina Palucka, Jacques Banchereau and Miriam Merad
Volume 64, Issue 5

Intracellular and extracellular T1 and T2 relaxivities of magneto-optical nanoparticles at experimental high fields
Gert Klug, Thomas Kampf, Steffen Bloemer, Johannes Bremicker, Christian H. Ziener, Andrea Heymer, Uwe Gbureck, Eberhard Rommel, Ulrich Nöth, Wolfdieter A. Schenk, Peter M. Jakob and Wolfgang R. Bauer
Volume 64, Issue 6

Photochemical activation of endosomal escape of MRI-Gd-agents in tumor cells
Eliana Gianolio, Francesca Arena, Gustav J. Strijkers, Klaas Nicolay, Anders Högset and Silvio Aime
Volume 65, Issue 1

Long-term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells
Stacey Cromer Berman, Chulani Galpoththawela, Assaf A. Gilad, Jeff W. M. Bulte and Piotr Walczak
Volume 65, Issue 2

19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells
T. Kevin Hitchens, Qing Ye, Danielle F. Eytan, Jelena M. Janjic, Eric T. Ahrens and Chien Ho
Volume 65, Issue 4

Release activation of iron oxide nanoparticles: (REACTION) A novel environmentally sensitive MRI paradigm
Dorit Granot and Erik M. Shapiro
Volume 65, Issue 5

Monitoring bone marrow-originated mesenchymal stem cell traffic to myocardial infarction sites using magnetic resonance imaging
Yidong Yang, Autumn Schumacher, Yuhui Yang, Jimei Liu, Xingming Shi, William D. Hill and Tom C.-C. Hu
Volume 65, Issue 5

Quantification of SPIO nanoparticles in vivo using the finite perturber method
Jason Langley, Wei Liu, E. Kay Jordan, J. A. Frank and Qun Zhao
Volume 65, Issue 5

Enhanced magnetic cell labeling efficiency using –NH2 coated MPIOs
Kevin S. Tang and Erik M. Shapiro
Volume 65, Issue 6

Neural precursors exhibit distinctly different patterns of cell migration upon transplantation during either the acute or chronic phase of EAE: A serial MR imaging study
Naser Muja, Mikhal E. Cohen, Jiangyang Zhang, Heechul Kim, Assaf A. Gilad, Piotr Walczak, Tamir Ben-Hur and Jeff W.M. Bulte
Volume 65, Issue 6

Magnetic poly(lactide-co-glycolide) and cellulose particles for MRI-based cell tracking
Michael K. Nkansah, Durga Thakral and Erik M. Shapiro
Volume 65, Issue 6

Assessment of cell infiltration in myocardial infarction: A dose-dependent study using micrometer-sized iron oxide particles
Yidong Yang, Jimei Liu, Yuhui Yang, Sang Hyun Cho and Tom C.-C. Hu
Volume 66, Issue 5

In vivo and ex vivo MR imaging of slowly cycling melanoma cells
S. Magnitsky, A. Roesch, M. Herlyn and J. D. Glickson
Volume 66, Issue 5

In vivo molecular MRI of cell survival and teratoma formation following embryonic stem cell transplantation into the injured murine myocardium
Jaehoon Chung, Kehkooi Kee, Joëlle K. Barral, Rajesh Dash, Hisanori Kosuge, Xi Wang, Irving Weissman, Robert C. Robbins, Dwight Nishimura, Thomas Quertermous, Renee A. Reijo-Pera and Phillip C. Yang
Volume 66, Issue 5