Journal of Bone and Mineral Research

Cover image for Vol. 30 Issue 3

Edited By: Juliet E Compston

Impact Factor: 6.589

ISI Journal Citation Reports © Ranking: 2013: 12/124 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Featured

  • Cortical Bone: A Challenging Geography

    Cortical Bone: A Challenging Geography

    Intracortical and endocortical remodeling erode the cortex. The endocortical surface (white line A of a specimen from a 27-year-old) denotes the true medullary cavity/cortical interface achieved at completion of growth. If the surface of the thinned but still compact-appearing cortex (white line B in a 70-year-old or C in a 90-year-old) is erroneously described as the endocortical surface, several errors occur by incorrectly apportioning in the cortical fragments and porosity that created them to the seemingly expanded medullary canal.

  • SDF-1/CXCR4 Axis in Tie2-Lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture Healing

    SDF‐1/CXCR4 Axis in Tie2‐Lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture Healing

    EPC functions and EPC recruitment to fracture site. (A) In vivo EPC recruitment assay. Representative microscopic photographs of double fluorescence in perifracture sites at day 7. Transplanted DiI-labeled EPCs were identified by red fluorescence in histological sections retrieved from perifracture capillaries. Host mouse capillaries were identified by isolectin B4 (green fluorescence). DAPI (blue) was used for nuclear staining. Arrows indicate recruited DiI-positive transplanted EPCs. Scale bar = 100 µm. (B) Quantitative analysis for the recruited EPCs was performed and expressed as a density of DiI-labeled EPCs (red fluorescence) in tissue sections retrieved from perifracture sites. **p < 0.001. (C, D) Colony-forming assay of EPCs in vitro. (C) Representative images of a small colony and a large colony. Scale bar = 100 µm. (D) Average numbers of large EPC colonies and small EPC colonies per dish were expressed as colony-forming activity. **p < 0.001. (E, F) Proliferation and migration activities of EPCs. (E) The proliferation activity is expressed as optical density (490 nm). (F) The migration activity is expressed as the number of migrated cells to SDF-1. *p < 0.05 and **p < 0.001.

  • Vitamin D Receptor Signaling Enhances Locomotive Ability in Mice

    Vitamin D Receptor Signaling Enhances Locomotive Ability in Mice

    Morphological changes in acetylcholine receptor (AChR) clusters on extensor digitorum longus muscle in VDR KO mice. Extensor digitorum longus muscle from WT or VDR KO mice were fixed with 10% formalin. AChRs were visualized with rhodamine-conjugated α-bungarotoxin and observed under fluorescence microscope with a ×40 objective lens (A). The average area of AChR cluster on extensor digitorum longus muscles from 3 of each WT and VDR KO mice are shown. Statistical analysis was performed for area of individual AChR clusters (B). Data are presented as mean ± SD. *p < 0.05 by unpaired t test. Scale bar = 50 µm.

  • PHEX 3′-UTR c.*231A>G Near The Polyadenylation Signal is a Relatively Common, Mild, American Mutation That Masquerades as Sporadic or X-Linked Recessive Hypophosphatemic Rickets

    PHEX 3′‐UTR c.*231A>G Near The Polyadenylation Signal is a Relatively Common, Mild, American Mutation That Masquerades as Sporadic or X‐Linked Recessive Hypophosphatemic Rickets

    Poly A mutation. Forward DNA sequence from the 3′-UTR of PHEX showing the pA mutation (c.*231A > G) in a carrier mother (heterozygous) and her son the propositus (hemizygous) compared to a normal control. Arrow indicates site of mutation. Horizontal line shows polyadenylation signal (AATAAA).

  • Childhood Cortical Porosity Is Related to Microstructural Properties of the Bone-Muscle Junction

    Childhood Cortical Porosity Is Related to Microstructural Properties of the Bone‐Muscle Junction

    Schematic representation of the three types of osteons in growing cortical bone (periosteal surface facing down). Giant asymmetric drifting osteons predominated before the mid-teens, and smaller symmetrical eccentric and concentric osteons thereafter.

  • The Longitudinal Effects of Physical Activity and Dietary Calcium on Bone Mass Accrual Across Stages of Pubertal Development

    The Longitudinal Effects of Physical Activity and Dietary Calcium on Bone Mass Accrual Across Stages of Pubertal Development

    For NB males, for each TS, expected annualized BMC change (adjusted for the basic model and calcium intake) is shown, along with the ±1 standard error range, predicted for a high-activity child (at Q3, the 75th percentile of PA for the subgroup and TS) and a low-activity child (at Q1, the 25th percentile). The figure also shows activity hours, Q1 and Q3, for each TS. (A) Q1 and Q3 of weight-bearing activity. (B) TBBMC expected annualized accrual. (C) SPBMC expected annualized accrual. (D) HP BMC expected annualized accrual.

  • Cortical Bone: A Challenging Geography
  • SDF‐1/CXCR4 Axis in Tie2‐Lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture Healing
  • Vitamin D Receptor Signaling Enhances Locomotive Ability in Mice
  • PHEX 3′‐UTR c.*231A>G Near The Polyadenylation Signal is a Relatively Common, Mild, American Mutation That Masquerades as Sporadic or X‐Linked Recessive Hypophosphatemic Rickets
  • Childhood Cortical Porosity Is Related to Microstructural Properties of the Bone‐Muscle Junction
  • The Longitudinal Effects of Physical Activity and Dietary Calcium on Bone Mass Accrual Across Stages of Pubertal Development

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eCompendia – special issues of recent JBMR® articles on hot topics

eCompendia bring together recently published JBMR® articles on topical issues. Specific topics are selected for each eCompendium to provide the reader with an easy-to-access update that brings together original research articles in the chosen area.

Examples of topics addressed in recent eCompendia include Kidney Disease and Bone, Sclerostin: Preclinical and Clinical Studies and Genetics of Osteogenesis Imperfecta.

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Announcing

JBMR® Announces Workflow Changes and Author Guidelines Updates

In response to rising concerns over the reproducibility of biomedical research, the author guidelines and submission procedures for the Journal of Bone and Mineral Research’s (JBMR®) have recently been updated. These updates affect the submission workflow of author forms required for peer review and publication, as detailed below:


ARRIVE: Authors submitting preclinical research are now required to complete an adapted ARRIVE (Animals in Research: Reporting In Vivo Experiments) checklist at submission.


CONSORT: Authors of manuscripts reporting results of clinical trials are now required to upload the CONSORT checklist at submission.


Author Agreement: The conflict of interest (COI) and copyright transfer (CTA) portions of the current Author Agreement can now be completed electronically as a web form, eliminating the need for authors to print, scan and upload a PDF form upon submission.


• COI information will be collected during submission via an online questionnaire on ScholarOne.


• The CTA will be completed at manuscript acceptance: If a manuscript is accepted for publication, the corresponding author will receive an e-mail prompt to log in to Author Services. Author Services is a Wiley web application that provides production tracking, as well as other resources for authors. From this site, corresponding authors can complete the CTA on behalf of all authors on the paper.

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