Journal of Bone and Mineral Research

Cover image for Vol. 32 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Juliet E Compston

Impact Factor: 5.622

ISI Journal Citation Reports © Ranking: 2015: 15/133 (Endocrinology & Metabolism)

Online ISSN: 1523-4681


  1. 1 - 66
  1. Original Articles

    1. Bone Microarchitecture Assessed by HR-pQCT as Predictor of Fracture Risk in Postmenopausal Women: The OFELY Study

      Elisabeth Sornay-Rendu, Stephanie Boutroy, François Duboeuf and Roland D Chapurlat

      Version of Record online: 23 MAR 2017 | DOI: 10.1002/jbmr.3105

    2. IGF-1 Receptor Expression on Circulating Osteoblast Progenitor Cells Predicts Tissue-Based Bone Formation Rate and Response to Teriparatide in Premenopausal Women With Idiopathic Osteoporosis

      Adi Cohen, Stavroula Kousteni, Brygida Bisikirska, Jayesh G Shah, J Sanil Manavalan, Robert R Recker, Joan Lappe, David W Dempster, Hua Zhou, Donald J McMahon, Mariana Bucovsky, Mafo Kamanda-Kosseh, Julie Stubby and Elizabeth Shane

      Version of Record online: 23 MAR 2017 | DOI: 10.1002/jbmr.3109

    3. Physical Activity, Sedentary Time, and Bone Strength From Childhood to Early Adulthood: A Mixed Longitudinal HR-pQCT study

      Leigh Gabel, Heather M Macdonald, Lindsay Nettlefold and Heather A McKay

      Version of Record online: 22 MAR 2017 | DOI: 10.1002/jbmr.3115

    4. Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone

      Caressa D Lietman, Joohyun Lim, Ingo Grafe, Yuqing Chen, Hao Ding, Xiaohong Bi, Catherine G Ambrose, Nadja Fratzl-Zelman, Paul Roschger, Klaus Klaushofer, Wolfgang Wagermaier, Ingo Schmidt, Peter Fratzl, Jyoti Rai, MaryAnn Weis, David Eyre, Douglas R Keene, Deborah Krakow and Brendan H Lee

      Version of Record online: 20 MAR 2017 | DOI: 10.1002/jbmr.3108

    5. Fracture risk after bariatric surgery: Roux-en-Y gastric bypass versus adjustable gastric banding

      Elaine W Yu, Moa P Lee, Joan E Landon, Katherine G Lindeman and Seoyoung C Kim

      Version of Record online: 20 MAR 2017 | DOI: 10.1002/jbmr.3101

    6. Proximal Femur Volumetric Bone Mineral Density and Mortality: 13 Years of Follow-Up of the AGES-Reykjavik Study

      Elisa A Marques, Martine Elbejjani, Vilmundur Gudnason, Gunnar Sigurdsson, Thomas Lang, Sigurdur Sigurdsson, Thor Aspelund, Osorio Meirelles, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir and Tamara B Harris

      Version of Record online: 20 MAR 2017 | DOI: 10.1002/jbmr.3104

  2. Short Reports

    1. Clinical Features of 24 Patients With Rebound-Associated Vertebral Fractures After Denosumab Discontinuation: Systematic Review and Additional Cases

      Athanasios D Anastasilakis, Stergios A Polyzos, Polyzois Makras, Berengere Aubry-Rozier, Stella Kaouri and Olivier Lamy

      Version of Record online: 13 MAR 2017 | DOI: 10.1002/jbmr.3110

  3. Original Articles

    1. The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool

      Rialnat A Lawal, Xichao Zhou, Kaylind Batey, Corey M Hoffman, Mary A Georger, Freddy Radtke, Matthew J Hilton, Lianping Xing, Benjamin J Frisch and Laura M Calvi

      Version of Record online: 9 MAR 2017 | DOI: 10.1002/jbmr.3106

    2. Bone Resorption Is Regulated by Circadian Clock in Osteoblasts

      Takeshi Takarada, Cheng Xu, Hiroki Ochi, Ryota Nakazato, Daisuke Yamada, Saki Nakamura, Ayumi Kodama, Shigeki Shimba, Michihiro Mieda, Kazuya Fukasawa, Kakeru Ozaki, Takashi Iezaki, Koichi Fujikawa, Yukio Yoneda, Rika Numano, Akiko Hida, Hajime Tei, Shu Takeda and Eiichi Hinoi

      Version of Record online: 3 MAR 2017 | DOI: 10.1002/jbmr.3053

    3. A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites

      Alessandra Chesi, Jonathan A Mitchell, Heidi J Kalkwarf, Jonathan P Bradfield, Joan M Lappe, Diana L Cousminer, Sani M Roy, Shana E McCormack, Vicente Gilsanz, Sharon E Oberfield, Hakon Hakonarson, John A Shepherd, Andrea Kelly, Babette S Zemel and Struan FA Grant

      Version of Record online: 2 MAR 2017 | DOI: 10.1002/jbmr.3097

    4. Association of Body Size at Birth and Childhood Growth With Hip Fractures in Older Age: An Exploratory Follow-Up of the Helsinki Birth Cohort Study

      Tuija M Mikkola, Mikaela B von Bonsdorff, Clive Osmond, Minna K Salonen, Eero Kajantie and Johan G Eriksson

      Version of Record online: 2 MAR 2017 | DOI: 10.1002/jbmr.3100

    5. Abnormally High and Heterogeneous Bone Matrix Mineralization After Childhood Solid Organ Transplantation: A Complex Pathology of Low Bone Turnover and Local Defects in Mineralization

      Nadja Fratzl-Zelman, Helena Valta, Renata C Pereira, Barbara M Misof, Paul Roschger, Hannu Jalanko, Katherine Wesseling-Perry, Klaus Klaushofer and Outi Mäkitie

      Version of Record online: 1 MAR 2017 | DOI: 10.1002/jbmr.3087

    6. Association of Muscle Weakness With Post-Fracture Mortality in Older Men and Women: A 25-Year Prospective Study

      Hanh M Pham, Sing C Nguyen, Thao P Ho-Le, Jacqueline R Center, John A Eisman and Tuan V Nguyen

      Version of Record online: 1 MAR 2017 | DOI: 10.1002/jbmr.3037

    7. Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice

      Erivan S Ramos-Junior, Gisele A Leite, Cecilia C Carmo-Silva, Thaise M Taira, Karla B Neves, David F Colón, Lea AB da Silva, Sergio L Salvador, Rita C Tostes, Fernando Q Cunha and Sandra Y Fukada

      Version of Record online: 1 MAR 2017 | DOI: 10.1002/jbmr.3072

    8. CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis

      F Andrea Sass, Katharina Schmidt-Bleek, Agnes Ellinghaus, Sebastian Filter, Alexander Rose, Bernd Preininger, Simon Reinke, Sven Geissler, Hans-Dieter Volk, Georg N Duda and Anke Dienelt

      Version of Record online: 1 MAR 2017 | DOI: 10.1002/jbmr.3062

    9. Relationship Between Low Bone Mineral Density and Fractures With Incident Cardiovascular Disease: A Systematic Review and Meta-Analysis

      Nicola Veronese, Brendon Stubbs, Gaetano Crepaldi, Marco Solmi, Cyrus Cooper, Nicolas CW Harvey, Jean-Yves Reginster, Renè Rizzoli, Roberto Civitelli, Patricia Schofield, Stefania Maggi and Sarah E Lamb

      Version of Record online: 1 MAR 2017 | DOI: 10.1002/jbmr.3089

    10. Diaphyseal Femur Fractures in Osteogenesis Imperfecta: Characteristics and Relationship With Bisphosphonate Treatment

      Pamela Trejo, François Fassier, Francis H Glorieux and Frank Rauch

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jbmr.3071

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      Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

      Nicolai Ernlund Lassen, Thomas Levin Andersen, Gro Grunnet Pløen, Kent Søe, Ellen Margrethe Hauge, Søren Harving, Gete Ester Toft Eschen and Jean-Marie Delaisse

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jbmr.3091

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      An HDAC Inhibitor, Entinostat/MS-275, Partially Prevents Delayed Cranial Suture Closure in Heterozygous Runx2 Null Mice

      Han-Sol Bae, Won-Joon Yoon, Young-Dan Cho, Rabia Islam, Hye-Rim Shin, Bong-Soo Kim, Jin-Muk Lim, Min-Seok Seo, Seo-Ae Cho, Kang-Young Choi, Seung-Hak Baek, Hong-Gee Kim, Kyung-Mi Woo, Jeong-Hwa Baek, Yun-Sil Lee and Hyun-Mo Ryoo

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jbmr.3076

    13. Inflammatory Bowel Disease in a Rodent Model Alters Osteocyte Protein Levels Controlling Bone Turnover

      Corinne E Metzger, Anand Narayanan, David C Zawieja and Susan A Bloomfield

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jbmr.3027

  4. Commentaries

    1. You have free access to this content
  5. Original Articles

    1. You have full text access to this OnlineOpen article
      Low Testosterone, but Not Estradiol, Is Associated With Incident Falls in Older Men: The International MrOS Study

      Liesbeth Vandenput, Dan Mellström, Gail A Laughlin, Peggy M Cawthon, Jane A Cauley, Andrew R Hoffman, Magnus K Karlsson, Björn E Rosengren, Östen Ljunggren, Maria Nethander, Anna L Eriksson, Mattias Lorentzon, Jason Leung, Timothy Kwok, Eric S Orwoll and Claes Ohlsson

      Version of Record online: 27 FEB 2017 | DOI: 10.1002/jbmr.3088

    2. The Selective Serotonin Reuptake Inhibitor Fluoxetine Directly Inhibits Osteoblast Differentiation and Mineralization During Fracture Healing in Mice

      Vivian Bradaschia-Correa, Anne M Josephson, Devan Mehta, Matthew Mizrahi, Shane S Neibart, Chao Liu, Oran D Kennedy, Alesha B Castillo, Kenneth A Egol and Philipp Leucht

      Version of Record online: 27 FEB 2017 | DOI: 10.1002/jbmr.3045

    3. Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice

      Stephen H Schlecht, Lauren M Smith, Melissa A Ramcharan, Erin MR Bigelow, Bonnie T Nolan, Noah J Mathis, Amber Cathey, Eugene Manley Jr, Rajasree Menon, Richard C McEachin, Joseph H Nadeau and Karl J Jepsen

      Version of Record online: 27 FEB 2017 | DOI: 10.1002/jbmr.3093

    4. A Large Inversion Involving GNAS Exon A/B and All Exons Encoding Gsα Is Associated With Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B)

      Giedre Grigelioniene, Pasi I Nevalainen, Monica Reyes, Susanne Thiele, Olta Tafaj, Angelo Molinaro, Rieko Takatani, Marja Ala-Houhala, Daniel Nilsson, Jesper Eisfeldt, Anna Lindstrand, Marie-Laure Kottler, Outi Mäkitie and Harald Jüppner

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/jbmr.3083

    5. TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid

      Ee Min Tan, Lei Li, Inthrani Raja Indran, Nicholas Chew and Eu-Leong Yong

      Version of Record online: 23 FEB 2017 | DOI: 10.1002/jbmr.3031

  6. Perspectives

    1. CRISPR/Cas9 Technologies

      Bart O Williams and Matthew L Warman

      Version of Record online: 23 FEB 2017 | DOI: 10.1002/jbmr.3086

  7. Original Articles

    1. You have full text access to this OnlineOpen article
      Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1

      Ji-Hyun Lee, Seon-Ae Jeon, Byung-Gyu Kim, Michiko Takeda, Jae-Jin Cho, Dong-Ik Kim, Hiroshi Kawabe and Je-Yoel Cho

      Version of Record online: 23 FEB 2017 | DOI: 10.1002/jbmr.3073

    2. You have full text access to this OnlineOpen article
    3. You have full text access to this OnlineOpen article
      VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption

      Yuko Nakamichi, Nobuyuki Udagawa, Kanji Horibe, Toshihide Mizoguchi, Yoko Yamamoto, Takashi Nakamura, Akihiro Hosoya, Shigeaki Kato, Tatsuo Suda and Naoyuki Takahashi

      Version of Record online: 22 FEB 2017 | DOI: 10.1002/jbmr.3096

    4. Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss: the Osteoporotic Fractures in Men Study

      Howard A Fink, Tien N Vo, Lisa Langsetmo, Joshua I Barzilay, Jane A Cauley, John T Schousboe, Eric S Orwoll, Muna T Canales, Areef Ishani, Nancy E Lane and Kristine E Ensrud

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/jbmr.3065

    5. Dietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative

      Tonya Orchard, Vedat Yildiz, Susan E Steck, James R Hébert, Yunsheng Ma, Jane A Cauley, Wenjun Li, Yasmin Mossavar-Rahmani, Karen C Johnson, Maryam Sattari, Meryl LeBoff, Jean Wactawski-Wende and Rebecca D Jackson

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/jbmr.3070

  8. Clinical Vignette

    1. Osteosarcoma in a Patient With Pseudohypoparathyroidism Type 1b Due to Paternal Uniparental Disomy of Chromosome 20q

      Hye-Sun Park, Chang Gon Kim, Namki Hong, Seok Joo Lee, Da Hea Seo and Yumie Rhee

      Version of Record online: 17 FEB 2017 | DOI: 10.1002/jbmr.3043

      Thumbnail image of graphical abstract

      Chronically high level of parathyroid hormone (PTH) might be associated with the development of bone tumor. A patient in this report had a pseudohypoparathyroidism type 1b (PHP1b) by paternal uniparental disomy of chromosome 20q who developed a mandibular osteosarcoma. PHP1b is characterized by specific resistances in the proximal renal tubule but sensitive responses in the bone to the persistent PTH elevation. It is possible that persistently elevated PTH could have been pernicious to the bone tumor cells.

  9. Original Articles

    1. Risk of Fracture in Primary Aldosteronism: A Population-Based Cohort Study

      Vin-Cent Wu, Chia-Hui Chang, Cheng-Yi Wang, Yen-Hung Lin, Tze-Wah Kao, Po-Chih Lin, Tzong-Shinn Chu, Yuan-Shian Chang, Likwang Chen, Kwan-Dun Wu and Shih-Chieh Jeff Chueh

      Version of Record online: 14 FEB 2017 | DOI: 10.1002/jbmr.3033

      Thumbnail image of graphical abstract

      Our research provides the first evidence on primary aldosteronism (PA)-related long-term risk in bone fracture from a large population-based cohort and under a study design of case-control match on propensity score. PA is tightly associated with higher risk of bone fracture, even in the case where the competing risk of death was controlled. Particularly, female PA patients treated with MRA were confronted with significantly higher risk in bone fracture than their essential hypertensive controls.

    2. Adaptations in the Microarchitecture and Load Distribution of Maternal Cortical and Trabecular Bone in Response to Multiple Reproductive Cycles in Rats

      Chantal MJ de Bakker, Allison R Altman-Singles, Yihan Li, Wei-Ju Tseng, Connie Li and X Sherry Liu

      Version of Record online: 9 FEB 2017 | DOI: 10.1002/jbmr.3084


    1. Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study

      Adrian Tan, Kirsteen Goodman, Allan Walker, Jemma Hudson, Graeme S MacLennan, Peter L Selby, William D Fraser, Stuart H Ralston and for the PRISM-EZ Trial Group

      Version of Record online: 8 FEB 2017 | DOI: 10.1002/jbmr.3066

  11. Perspectives

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      Understanding Bone Strength Is Not Enough

      Christopher J Hernandez and Marjolein CH van der Meulen

      Version of Record online: 7 FEB 2017 | DOI: 10.1002/jbmr.3078

  12. Original Articles

    1. Responses to Treatment With Teriparatide in Patients With Atypical Femur Fractures Previously Treated With Bisphosphonates

      Nelson B Watts, Deborah Aggers, Edward F McCarthy, Tina Savage, Stephanie Martinez, Rachel Patterson, Erin Carrithers and Paul D Miller

      Version of Record online: 7 FEB 2017 | DOI: 10.1002/jbmr.3081

    2. CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

      Basem M Abdallah, Florence Figeac, Kenneth H Larsen, Nicholas Ditzel, Pankaj Keshari, Adiba Isa, Abbas Jafari, Thomas L Andersen, Jean-Marie Delaisse, Yoshio Goshima, Toshio Ohshima and Moustapha Kassem

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jbmr.3069

    3. Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice

      Wensheng Wang, Hua Wang, Xichao Zhou, Xing Li, Wen Sun, Michael Dellinger, Brendan F Boyce and Lianping Xing

      Version of Record online: 31 JAN 2017 | DOI: 10.1002/jbmr.3077

  13. Perspective

  14. Original Articles

    1. Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts

      Sang Wan Kim, Yanhui Lu, Elizabeth A Williams, Forest Lai, Ji Yeon Lee, Tetsuya Enishi, Deepak H Balani, Michael S Ominsky, Hua Zhu Ke, Henry M Kronenberg and Marc N Wein

      Version of Record online: 30 JAN 2017 | DOI: 10.1002/jbmr.3038

      Thumbnail image of graphical abstract

      Sclerostin antibody rapidly increases osteoblast numbers, but the underlying cellular mechanisms responsible remain unknown. Kim et al. used two lineage tracing models to demonstrate the sclerostin antibody directly converts quiescent bone lining cells into active osteoblasts.

    2. Femoral Neck External Size But Not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause

      Karl J Jepsen, Andrew Kozminski, Erin MR Bigelow, Stephen H Schlecht, Robert W Goulet, Sioban D Harlow, Jane A Cauley and Carrie Karvonen-Gutierrez

      Version of Record online: 30 JAN 2017 | DOI: 10.1002/jbmr.3082

    3. Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice Are Susceptible to Osteoarthritis Associated With Enhanced Inflammation

      Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida and Ryosuke Kuroda

      Version of Record online: 27 JAN 2017 | DOI: 10.1002/jbmr.3080

  15. Short Report

    1. Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

      Karen L de Mesy Bentley, Ryan Trombetta, Kohei Nishitani, Sheila N Bello-Irizarry, Mark Ninomiya, Longze Zhang, Hung Li Chung, James L McGrath, John L Daiss, Hani A Awad, Stephen L Kates and Edward M Schwarz

      Version of Record online: 26 JAN 2017 | DOI: 10.1002/jbmr.3055

  16. Clinical Trial

    1. You have full text access to this OnlineOpen article
      Effect of Teriparatide or Risedronate in Elderly Patients With a Recent Pertrochanteric Hip Fracture: Final Results of a 78-Week Randomized Clinical Trial

      Jorge Malouf-Sierra, Umberto Tarantino, Pedro A García-Hernández, Costantino Corradini, Søren Overgaard, Jan J Stepan, Lars Borris, Eric Lespessailles, Frede Frihagen, Kyriakos Papavasiliou, Helmut Petto, Per Aspenberg, José Ramón Caeiro and Fernando Marin

      Version of Record online: 26 JAN 2017 | DOI: 10.1002/jbmr.3067

  17. Original Articles

    1. Assessment of Sex Differences in Fracture Risk Among Patients With Anorexia Nervosa: A Population-Based Cohort Study Using The Health Improvement Network

      Jason M Nagata, Neville H Golden, Mary B Leonard, Lawrence Copelovitch and Michelle R Denburg

      Version of Record online: 19 JAN 2017 | DOI: 10.1002/jbmr.3068

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      Type 2 Diabetes Mellitus Is Associated With Better Bone Microarchitecture But Lower Bone Material Strength and Poorer Physical Function in Elderly Women: A Population-Based Study

      Anna G Nilsson, Daniel Sundh, Lisa Johansson, Martin Nilsson, Dan Mellström, Robert Rudäng, Michail Zoulakis, Märit Wallander, Anna Darelid and Mattias Lorentzon

      Version of Record online: 18 JAN 2017 | DOI: 10.1002/jbmr.3057

    3. BMI-1 Mediates Estrogen-Deficiency–Induced Bone Loss by Inhibiting Reactive Oxygen Species Accumulation and T Cell Activation

      Jinbo Li, Qian Wang, Renlei Yang, Jiaqi Zhang, Xing Li, Xichao Zhou and Dengshun Miao

      Version of Record online: 18 JAN 2017 | DOI: 10.1002/jbmr.3059

    4. Differences in Trabecular Microstructure Between Black and White Women Assessed by Individual Trabecular Segmentation Analysis of HR-pQCT Images

      Melissa S Putman, Elaine W Yu, David Lin, Karin Darakananda, Joel S Finkelstein and Mary L Bouxsein

      Version of Record online: 18 JAN 2017 | DOI: 10.1002/jbmr.3060

    5. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice

      Frank C Ko, Lamya Karim, Daniel J Brooks, Mary L Bouxsein and Marie B Demay

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/jbmr.3052

    6. A Mendelian randomization study of the effect of type-2 diabetes and glycemic traits on bone mineral density

      Omar S Ahmad, Aaron Leong, Julie Ann Miller, John A Morris, Vincenzo Forgetta, Muhammad Mujammami and J Brent Richards

      Version of Record online: 12 JAN 2017 | DOI: 10.1002/jbmr.3063

  18. Case Reports

    1. Hypercalcemia in Necrobiotic Xanthogranuloma: First Reported Case and Insight Into Treatment

      Jad G Sfeir, Richard J Zogala and Violeta B Popii

      Version of Record online: 27 DEC 2016 | DOI: 10.1002/jbmr.3047

  19. Original Articles

    1. The Circadian Gene Clock Regulates Bone Formation Via PDIA3

      Gongsheng Yuan, Bingxuan Hua, Yang Yang, Lirong Xu, Tingting Cai, Ning Sun, Zuoqin Yan, Chao Lu and Ruizhe Qian

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/jbmr.3046

    2. Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660)

      Michael P Whyte, William H McAlister, Michael D Fallon, Mary Ella Pierpont, Vinieth N Bijanki, Shenghui Duan, Ghada A Otaify, William S Sly and Steven Mumm

      Version of Record online: 14 DEC 2016 | DOI: 10.1002/jbmr.3034

      Thumbnail image of graphical abstract

      In 1985, we briefly characterized “congenital sclerosing osteomalacia with cerebral calcification” (CSOCC) in infant sisters. Later, Raine syndrome (RNS) became known, with FAM20C deactivation discovered in 2007. FAM20C is a kinase for the secreted phosphoproteome, including FGF23 and SIBLINGs that regulate mineralization. We find the sisters carried two unique mutations in FAM20C. Skeletal histopathology indicated severe osteomalacia yet no rickets. Our findings clarify FAM20C's role in osteogenesis and hard tissue mineralization, and show RNS is CSOCC.

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      Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys

      Michael S Ominsky, Steven K Boyd, Aurore Varela, Jacquelin Jolette, Melanie Felx, Nancy Doyle, Nacera Mellal, Susan Y Smith, Kathrin Locher, Sabina Buntich, Ian Pyrah and Rogely W Boyce

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/jbmr.3036

    4. Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue

      Serra Kaya, Jelena Basta-Pljakic, Zeynep Seref-Ferlengez, Robert J Majeska, Luis Cardoso, Timothy G Bromage, Qihong Zhang, Carol R Flach, Richard Mendelsohn, Shoshana Yakar, Susannah P Fritton and Mitchell B Schaffler

      Version of Record online: 12 DEC 2016 | DOI: 10.1002/jbmr.3044

    5. Objectively-Verified Parental Non-Hip Major Osteoporotic Fractures and Offspring Osteoporotic Fracture Risk: A Population-Based Familial Linkage Study

      Shuman Yang, William D Leslie, Randy Walld, Leslie L Roos, Suzanne N Morin, Sumit R Majumdar and Lisa M Lix

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/jbmr.3035

      Thumbnail image of graphical abstract

      The current study tested the effect of parental major osteoporotic fractures (MOF) on offspring MOF risk in 238,054 mothers, fathers 209,423 and 255,512 offspring using population-based administrative data linkage. There was an independent association between parental non-hip MOF and offspring MOF, but this relationship decreased with older parental age at the first fracture. Risks associated with parental hip and non-hip MOF were the same. We also demonstrated dose-response in terms of the number of parents with non-hip MOF, number of parental MOF, and presence of both parental hip and non-hip MOF in combination.

    6. Durability of Response to Zoledronate Treatment and Competing Mortality in Paget's Disease of Bone

      Tim Cundy, Katherine Maslowski, Andrew Grey and Ian R Reid

      Version of Record online: 30 NOV 2016 | DOI: 10.1002/jbmr.3029

      Thumbnail image of graphical abstract

      The potent, long-acting, bisphosphonate zoledronate is now commonly used in the treatment of Paget's disease, but contemporary patients tend to present later in life and to have fewer bones involved than formerly. This work reports that up to 10 years after zoledronate treatment, patients with Paget's disease are nearly four times more likely to die (competing mortality) than suffer biochemical relapse. Most patients with Paget's disease will probably need such treatment only once.

    7. Bone Health in Patients With Hematopoietic Disorders of Bone Marrow Origin: Systematic Review and Meta- Analysis

      Kieran Steer, Mariya Stavnichuk, Martin Morris and Svetlana V Komarova

      Version of Record online: 30 NOV 2016 | DOI: 10.1002/jbmr.3026

    8. Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding

      Åshild Bjørnerem, Ali Ghasem-Zadeh, Xiaofang Wang, Minh Bui, Susan P Walker, Roger Zebaze and Ego Seeman

      Version of Record online: 30 NOV 2016 | DOI: 10.1002/jbmr.3018

    9. Moderate-to-Vigorous Physical Activity But Not Sedentary Time Is Associated With Musculoskeletal Health Outcomes in a Cohort of Australian Middle-Aged Women

      Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones and Tania Winzenberg

      Version of Record online: 25 NOV 2016 | DOI: 10.1002/jbmr.3028

    10. Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis

      David Simon, Arnd Kleyer, Fabian Stemmler, Christoph Simon, Andreas Berlin, Axel J Hueber, Judith Haschka, Nina Renner, Camille Figueiredo, Winfried Neuhuber, Thomas Buder, Matthias Englbrecht, Juergen Rech, Klaus Engelke and Georg Schett

      Version of Record online: 18 NOV 2016 | DOI: 10.1002/jbmr.3025

    11. FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

      Xiaodong Li, Shanaka Stanislaus, Frank Asuncion, Qing-Tian Niu, Narumol Chinookoswong, Kelly Villasenor, Jin Wang, Philip Wong, Rogely Boyce, Denise Dwyer, Chun-Ya Han, Michelle M Chen, Benxian Liu, Marina Stolina, Hua Zhu Ke, Michael S Ominsky, Murielle M Véniant and Jing Xu

      Version of Record online: 9 SEP 2016 | DOI: 10.1002/jbmr.2936

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