Journal of Bone and Mineral Research

Cover image for Vol. 32 Issue 11

Edited By: Juliet E Compston

Impact Factor: 6.284

ISI Journal Citation Reports © Ranking: 2016: 15/138 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Associated Title(s): JBMR Plus

eCompendia


 


eCompendia bring together recently published JBMR® articles on topical issues. Specific topics are selected for each eCompendium to provide the reader with an easy-to-access update that brings together original research articles in the chosen area.

Examples of topics addressed in recent eCompendia include Kidney Disease and Bone, Sclerostin: Preclinical and Clinical Studies and Genetics of Osteogenesis Imperfecta.

Weight_Loss_and_Bone

Fracture Risk After Bariatric Surgery: Roux-en-Y Gastric Bypass Versus Adjustable Gastric Banding
Elaine W Yu, Moa P Lee, Joan E Landon, Katherine G Lindeman and Seoyoung C Kim

Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status
Anne L Schafer, Connie M Weaver, Dennis M Black, Amber L Wheeler, Hanling Chang, Gina V Szefc, Lygia Stewart, Stanley J Rogers, Jonathan T Carter, Andrew M Posselt, Dolores M Shoback and Deborah E Sellmeyer

Assessment of Sex Differences in Fracture Risk Among Patients With Anorexia Nervosa: A Population-Based Cohort Study Using The Health Improvement Network
Jason M Nagata, Neville H Golden, Mary B Leonard, Lawrence Copelovitch and Michelle R Denburg

Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women
Katherine N Bachmann, Alexander G Bruno, Miriam A Bredella, Melanie Schorr, Elizabeth A Lawson, Corey M Gill, Vibha Singhal, Erinne Meenaghan, Anu V Gerweck, Kamryn T Eddy, Seda Ebrahimi, Stuart L Koman, James M Greenblatt, Robert J Keane, Thomas Weigel, Esther Dechant, Madhusmita Misra, Anne Klibanski, Mary L Bouxsein, and Karen K Miller

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial
Dennis T Villareal, Luigi Fontana, Sai Krupa Das, Leanne Redman, Steven R Smith, Edward Saltzman, Connie Bales, James Rochon, Carl Pieper, Megan Huang, Michael Lewis, Ann V Schwartz and for the CALERIE Study Group

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials
Jessica Zibellini, Radhika V Seimon, Crystal MY Lee, Alice A Gibson, Michelle SH Hsu, Sue A Shapses, Tuan V Nguyen and Amanda Sainsbury

Decline in Bone Mass During Weight Loss: A Cause for Concern?
Anne L Schafer

Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women
Juliet E Compston, Allison Wyman, Gordon FitzGerald, Jonathan D Adachi, Roland D Chapurlat, Cyrus Cooper, Adolfo Díez-Pérez, Stephen H Gehlbach, Susan L Greenspan, Frederick H Hooven, Andrea Z LaCroix, Lyn March, J Coen Netelenbos, Jeri W Nieves, Johannes Pfeilschifter, Maurizio Rossini, Christian Roux, Kenneth G Saag, Ethel S Siris, Stuart Silverman, Nelson B Watts and Frederick A Anderson Jr

Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice
Ann-Kathrin Behrendt, Angela Kuhla, Anja Osterberg, Christian Polley, Philipp Herlyn, Dagmar-Christiane Fischer, Maike Scotland, Andreas Wree, Tina Histing, Michael D Menger, Brigitte Müller-Hilke, Thomas Mittlmeier and Brigitte Vollmar

Osteoporosis: The Treatment Gap

Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study
Jose Leal, Alastair M Gray, Samuel Hawley, Daniel Prieto-Alhambra, Antonella Delmestri, Nigel K Arden, Cyrus Cooper, M Kassim Javaid, Andrew Judge, and the REFReSH Study Group

Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis
Samuel Hawley, Jose Leal, Antonella Delmestri, Daniel Prieto-Alhambra, Nigel K Arden, Cyrus Cooper, M Kassim Javaid, Andrew Judge, for the REFReSH Study Group

A Crisis in the Treatment of Osteoporosis
Sundeep Khosla, Elizabeth Shane

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward
Sundeep Khosla, Jane A Cauley, Juliet Compston, Douglas P Kiel, Clifford Rosen, Kenneth G Saag, Elizabeth Shane

Impact of the U.S. Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates After Hip Fracture
Seoyoung C Kim, Dae Hyun Kim, Helen Mogun, Wesley Eddings, Jennifer M Polinski, Jessica M Franklin, Daniel H Solomon

Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis
Smita Jha, Zhong Wang, Nicholas Laucis, Timothy Bhattacharyya

Overdiagnosis and Overtreatment of Osteoporosis: A Wolf in Sheep's Clothing
Michael R McClung

Osteoporosis Medication use After hip Fracture in U.S. Patients Between 2002 and 2011
Daniel H Solomon, Stephen S Johnston, Natalie N Boytsov, Donna McMorrow, Joseph M Lane, Kelly D Krohn

The Osteoporosis Treatment Gap
John A Kanis, Axel Svedbom, Nicholas Harvey, Eugene V McCloskey

The Potential Economic Benefits of Improved Postfracture Care: A Cost-Effectiveness Analysis of a Fracture Liaison Service in the US Health-Care System
Daniel H Solomon, Amanda R Patrick, John Schousboe, Elena Losina


ASBMR 2016 Annual Meeting Featured Articles

MiR-503 Regulates Osteoclastogenesis via Targeting RANK
Chao Chen, Peng Cheng, Hui Xie, Hou-De Zhou, Xian-Ping Wu, Er-Yuan Liao and Xiang-Hang Luo

Female Mice Lacking Estrogen Receptor-Alpha in Osteoblasts Have Compromised Bone Mass and Strength
Katherine M Melville, Natalie H Kelly, Sohaib A Khan, John C Schimenti, F Patrick Ross, Russell P Main and Marjolein C H van der Meulen

microRNA-103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2
Bin Zuo, JunFeng Zhu, Jiao Li, ChuanDong Wang, XiaoYing Zhao, GuiQuan Cai, Zheng Li, Jianping Peng, Peng Wang, Chao Shen, Yan Huang, Jiake Xu, XiaoLing Zhang, and XiaoDong Chen

Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
Claudine Seeliger, Katrin Karpinski, Alexander T Haug, Helen Vester, Andreas Schmitt, Jan S Bauer and Martijn van Griensven

Denosumab Rapidly Increases Cortical Bone in Key Locations of the Femur: A 3D Bone Mapping Study in Women With Osteoporosis
Kenneth ES Poole, Graham M Treece, Andrew H Gee, Jacques P Brown, Michael R McClung, Andrea Wang and Cesar Libanati

How Tough Is Brittle Bone? Investigating Osteogenesis Imperfecta in Mouse Bone
Alessandra Carriero, Elizabeth A Zimmermann, Adriana Paluszny, Simon Y Tang, Hrishikesh Bale, Bjorn Busse, Tamara Alliston, Galateia Kazakia, Robert O Ritchie and Sandra J Shefelbine

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes
Joshua N Farr, Matthew T Drake, Shreyasee Amin, L Joseph Melton III, Louise K McCready and Sundeep Khosla

Cortical Porosity Identifies Women With Osteopenia at Increased Risk for Forearm Fractures
Yohann Bala, Roger Zebaze, Ali Ghasem-Zadeh, Elizabeth J Atkinson, Sandra Iuliano, James M Peterson, Shreyasee Amin, Åshild Bjørnerem, L Joseph Melton III, Helena Johansson, John A Kanis, Sundeep Khosla and Ego Seeman

The Effects of Calcium Supplementation on Verified Coronary Heart Disease Hospitalization and Death in Postmenopausal Women: A Collaborative Meta-Analysis of Randomized Controlled Trials
Joshua R Lewis, Simone Radavelli-Bagatini, Lars Rejnmark, Jian Sheng Chen, Judy M Simpson, Joan M Lappe, Leif Mosekilde, Ross L Prentice and Richard L Prince


Bone and the Nervous System

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights
Beata Lecka-Czernik and Clifford J Rosen

Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System
Guillaume Vignaux, Jean DLC Ndong, Daniel S Perrien and Florent Elefteriou

Obstructive Sleep Apnea and Metabolic Bone Disease: Insights Into the Relationship Between Bone and Sleep
Christine M Swanson, Steven A Shea, Katie L Stone, Jane A Cauley, Clifford J Rosen, Susan Redline, Gerard Karsenty, and Eric S Orwoll

Major Depressive Disorder and Bone Mass in Adolescents and Young Adults
Chadi A Calarge, Brandon D Butcher, Trudy L Burns, William H Coryell, Janet A Schlechte, and Babette S Zemel

Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits
PA Baldock, S Lin, L Zhang, T Karl, Y Shi, F Driessler, A Zengin, B Hormer, NJ Lee, IPL Wong, EJD Lin, RF Enriquez, B Stehrer, MJ During, E Yulyaningsih, S Zolotukhin, ST Ruohonen, E Savontaus, A Sainsbury, and H Herzog

Bone remodeling is regulated by inner ear vestibular signals
Guillaume Vignaux, Stephane Besnard, Jean Ndong, Bruno Philozene, Pierre Denise, and Florent Elefteriou

Altered Thermogenesis and Impaired Bone Remodeling in Misty Mice
Katherine J Motyl, Kathleen A Bishop, Victoria E DeMambro, Sheila A Bornstein, Phuong Le, Masanobu Kawai, Sutada Lotinun, Mark C Horowitz, Roland Baron, Mary L Bouxsein and Clifford J Rosen

Neuropeptide Y Is a Critical Modulator of Leptin's Regulation of Cortical Bone
Iris PL Wong, Amy D Nguyen, Ee Cheng Khor, Ronaldo F Enriquez, John A Eisman, Amanda Sainsbury, Herbert Herzog and Paul A Baldock

Rare Bone Diseases

Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis
Michael P Whyte, Katherine L Madson, Steven Mumm, William H McAlister, Deborah V Novack, Jo C Blair, Timothy R Helliwell, Marina Stolina, Laurence J Abernethy and Nicholas J Shaw

Sclerostin Deficiency Is Linked to Altered Bone Composition
Norbert Hassler, Andreas Roschger, Sonja Gamsjaeger, Ina Kramer, Sonja Lueger, Antoon van Lierop, Paul Roschger, Klaus Klaushofer, Eleftherios P Paschalis, Michaela Kneissel and Socrates Papapoulos

Osteoporosis Caused by Mutations in PLS3: Clinical and Bone Tissue Characteristics
Somayyeh Fahiminiya, Jacek Majewski, Hadil Al-Jallad, Pierre Moffatt, John Mort, Francis H Glorieux, Paul Roschger, Klaus Klaushofer and Frank Rauch

Clinical and Radiographic Findings in Adults With Persistent Hypophosphatasemia
Fergus Eoin McKiernan, Richard L Berg and Jay Fuehrer

Panostotic Expansile Bone Disease With Massive Jaw Tumor Formation and a Novel Mutation in the Signal Peptide of RANK
Anne L Schafer, Steven Mumm, Ivan El-Sayed, William H McAlister, Andrew E Horvai, Andrea M Tom, Edward C Hsiao, Frederick V Schaefer, Michael T Collins, Mark S Anderson, Michael P Whyte and Dolores M Shoback

Pregnancy-Associated Osteoporosis With a Heterozygous Deactivating LDL Receptor-Related Protein 5 (LRP5) Mutation and a Homozygous Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism
Fiona J Cook, Steven Mumm, Michael P Whyte and Deborah Wenker

Lenz-Majewski Hyperostotic Dwarfism with Hyperphosphoserinuria from a Novel Mutation in PTDSS1 Encoding Phosphatidylserine Synthase 1
Michael P Whyte, Amanda Blythe, William H McAlister, Angela R Nenninger, Vinieth N Bijanki and Steven Mumm

Atypical Femoral Fracture in Osteoporosis Pseudoglioma Syndrome Associated with Two Novel Compound Heterozygous Mutations in LRP5
Nerea Alonso, Dinesh C Soares, Eugene V McCloskey, Gregory D Summers, Stuart H Ralston and Celia L Gregson

Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and FBN1 Genotype
Elsa Haine, Jean-Pierre Salles, Philippe Khau Van Kien, Françoise Conte-Auriol, Isabelle Gennero, Aurélie Plancke, Sophie Julia, Yves Dulac, Maithé Tauber and Thomas Edouard

Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23–related hypophosphatemia, dental anomalies, and ectopic calcification
Silje Hjorth Rafaelsen MD, Helge Ræder, Anne Kristine Fagerheim, Per Knappskog, Thomas O Carpenter, Stefan Johansson and Robert Bjerknes

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65)
Anja L Frederiksen, Martin J Larsen, Klaus Brusgaard, Deborah V Novack, Peter Juel Thiis Knudsen, Henrik Daa Schrøder, Weimin Qiu, Christina Eckhardt, William H McAlister, Moustapha Kassem, Steven Mumm, Morten Frost and Michael P Whyte



Selected Altmetric Articles

In this eCompendium we highlight the most “attention-getting” recent JBMR articles. Following are the articles getting the most print and online buzz including press releases and social media channels like Facebook and Twitter as gathered by Altmetrics.

Bone Strength and Structural Deficits in Children and Adolescents With a Distal Forearm Fracture Resulting From Mild Trauma
Joshua N Farr, Shreyasee Amin, L Joseph Melton III, Salman Kirmani, Louise K McCready, Elizabeth J Atkinson, Ralph Müller and Sundeep Khosla

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
Leonardo Mellibovsky, Daniel Prieto-Alhambra, Fernando Mellibovsky, Roberto Güerri-Fernández, Xavier Nogués, Connor Randall, Paul K Hansma and Adolfo Díez-Perez

Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry
Scott M Smith, Martina A Heer, Linda C Shackelford, Jean D Sibonga, Lori Ploutz-Snyder and Sara R Zwart

Developmental Dysplasia of the Hip: Linkage Mapping and Whole Exome Sequencing Identify a Shared Variant in CX3CR1 in All Affected Members of a Large Multigeneration Family
George J Feldman, Javad Parvizi, Mark Levenstien, Kathryn Scott, Jill A Erickson, Paolo Fortina, Marcella Devoto and Christopher L Peters

Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women
Ailsa A Welch, Eirini Kelaiditi, Amy Jennings, Claire J Steves, Tim D Spector and Alexander MacGregor

Architecture of the osteocyte network correlates with bone material quality
Michael Kerschnitzki, Philip Kollmannsberger, Manfred Burghammer, Georg N Duda, Richard Weinkamer, Wolfgang Wagermaier and Peter Fratzl

Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness
Bruce W Hollis, Donna Johnson, Thomas C Hulsey, Myla Ebeling and Carol L Wagner

Childhood Bone Mineral Content Is Associated With Methylation Status of the RXRA Promoter at Birth
Nicholas C Harvey, Allan Sheppard, Keith M Godfrey, Cameron McLean, Emma Garratt, Georgia Ntani, Lucy Davies, Robert Murray, Hazel M Inskip, Peter D Gluckman, Mark A Hanson, Karen A Lillycrop, and Cyrus Cooper

Reduction in Proximal Femoral Strength in Patients With Acute Spinal Cord Injury
W Brent Edwards, Thomas J Schnitzer and Karen L Troy

Life Expectancy in Patients Treated for Osteoporosis: Observational Cohort Study Using National Danish Prescription Data
Bo Abrahamsen, Clive Osmond and Cyrus Cooper

The Influence of High-Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention
Sarah J Allison, Kenneth E S Poole, Graham M Treece, Andrew H Gee, Carol Tonkin, Winston J Rennie, Jonathan P Folland, Gregory D Summers and Katherine Brooke-Wavell

Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996–2012: An Ecological Analysis
Smita Jha, Zhong Wang, Nicholas Laucis and Timothy Bhattacharyya



Genetics and Osteoporosis

Assessment of gene-by-sex interaction effect on bone mineral density
Ching-Ti Liu, Karol Estrada, Laura M Yerges-Armstrong, Najaf Amin, Evangelos Evangelou, Guo Li, Ryan L Minster, Melanie A Carless, Candace M Kammerer, Ling Oei, Yanhua Zhou, Nerea Alonso, Zoe Dailiana, Joel Eriksson, Natalia García-Giralt, Sylvie Giroux, Lise Bjerre Husted, Rita I Khusainova, Theodora Koromila, Annie WaiChee Kung, Joshua R Lewis, Laura Masi, Simona Mencej-Bedrac, Xavier Nogues, Millan S Patel, Janez Prezelj, J Brent Richards, Pak Chung Sham, Timothy Spector, Liesbeth Vandenput, Su-Mei Xiao, Hou-Feng Zheng, Kun Zhu, Susana Balcells, Maria Luisa Brandi, Morten Frost, David Goltzman, Jesús González-Macías, Magnus Karlsson, Elza K Khusnutdinova, Panagoula Kollia, Bente Lomholt Langdahl, Östen Ljunggren, Mattias Lorentzon, Janja Marc, Dan Mellström, Claes Ohlsson, José M Olmos, Stuart H Ralston, José A Riancho, François Rousseau, Roser Urreizti, Wim Van Hul, María T Zarrabeitia, Martha Castano-Betancourt, Serkalem Demissie, Elin Grundberg, Lizbeth Herrera, Tony Kwan, Carolina Medina-Gómez, Tomi Pastinen, Gunnar Sigurdsson, Gudmar Thorleifsson, Joyce BJ vanMeurs, John Blangero, Albert Hofman, Yongmei Liu, Braxton D Mitchell, Jeffrey R O'Connell, Ben A Oostra, Jerome I Rotter, Kari Stefansson, Elizabeth A Streeten, Unnur Styrkarsdottir, Unnur Thorsteinsdottir, Frances A Tylavsky, Andre Uitterlinden, Jane A Cauley, Tamara B Harris, John PA Ioannidis, Bruce M Psaty, John A Robbins, M Carola Zillikens, Cornelia M vanDuijn, Richard L Prince, David Karasik, Fernando Rivadeneira, Douglas P Kiel, L Adrienne Cupples and Yi-Hsiang Hsu

Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS)
Alireza Moayyeri, Christopher J Hammond, Deborah J Hart and Timothy D Spector

Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density
Tie-Lin Yang, Yan Guo, Jian Li, Lei Zhang, Hui Shen, Siyang M Li, Siyuan K Li, Qing Tian, Yong-Jun Liu, Christopher J Papasian and Hong-Wen Deng J

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
Daniel L Koller, Hou-Feng Zheng, David Karasik, Laura Yerges-Armstrong, Ching-Ti Liu, Fiona McGuigan, John P Kemp, Sylvie Giroux, Dongbing Lai, Howard J Edenberg, Munro Peacock, Stefan A Czerwinski, Audrey C Choh, George McMahon, Beate St Pourcain, Nicholas J Timpson, Debbie A Lawlor, David M Evans, Bradford Towne, John Blangero, Melanie A Carless, Candace Kammerer, David Goltzman, Christopher S Kovacs, Jerilynn C Prior, Tim D Spector, Francois Rousseau, Jon H Tobias, Kristina Akesson, Michael J Econs, Braxton D Mitchell, J Brent Richards, Douglas P Kiel and Tatiana Foroud

Osteoporosis Caused by Mutations in PLS3: Clinical and Bone Tissue Characteristics
Somayyeh Fahiminiya, Jacek Majewski, Hadil Al-Jallad, Pierre Moffatt, John Mort, Francis H Glorieux, Paul Roschger, Klaus Klaushofer and Frank Rauch

A Novel Splice Mutation in PLS3 Causes X-linked Early Onset Low-Turnover Osteoporosis
Christine M Laine, Maija Wessman, Sanna Toiviainen-Salo, Mari A Kaunisto, Mervi K Mäyränpää, Tero Laine, Minna Pekkinen, Heikki Kröger, Ville-Valtteri Välimäki, Matti J Välimäki, Anna-Elina Lehesjoki and Outi Mäkitie

Susceptibility genes for osteoporotic fracture in postmenopausal chinese women
Chun Wang, Zeng Zhang, Hao Zhang, Jin-Wei He, Jie-Mei Gu, Wei-Wei Hu, Yun-Qiu Hu, Miao Li, Yu-Juan Liu, Wen-Zhen Fu, Hua Yue, Yao-Hua Ke and Zhen-Lin Zhang.

Evidence for a genetic link between bone and vascular measures in African ancestry families
Allison L Kuipers, Iva Miljkovic, Candace M Kammerer, Rhobert W Evans, Clareann H Bunker, Alan L Patrick, Victor W Wheeler, Kim Sutton-Tyrrell and Joseph M Zmuda

Analyses of RANK and RANKL in the Post-GWAS Context: Functional Evidence of Vitamin D Stimulation Through a RANKL Distal Region
Guy Yoskovitz, Natalia Garcia-Giralt, Maria Rodriguez-Sanz, Roser Urreizti, Robert Guerri, Sergi Ariño-Ballester, Daniel Prieto-Alhambra, Leonardo Mellibovsky, Daniel Grinberg, Xavier Nogues, Susana Balcells and Adolfo Diez-Perez



Muscle and Bone

Bone and Skeletal Muscle: Neighbors With Close Ties.
Douglas J DiGirolamo,Douglas P Kiel and Karyn A Esser

Forum on bone and skeletal muscle interactions: Summary of the proceedings of an ASBMR workshop
Lynda F Bonewald,Douglas P Kiel,Thomas L Clemens, Karyn Esser, Eric S Orwoll, Regis J O'Keefe and Roger A Fielding

Pamidronate Attenuates Muscle Loss After Pediatric Burn Injury .
Elisabet Børsheim, David N Herndon, Hal K Hawkins, Oscar E Suman, Matthew Cotter, and Gordon L Klein

Muscle Size, Strength, and Physical Performance and Their Associations With Bone Structure in the Hertfordshire Cohort Study
Mark H Edwards, Celia L Gregson, Harnish P Patel, Karen A Jameson, Nicholas C Harvey, Avan Aihie Sayer, Elaine M Dennison and Cyrus Cooper

Dairy Food Intake, Peripheral Bone Structure, and Muscle Mass in Elderly Ambulatory Women
Simone Radavelli-Bagatini, Kun Zhu1, Joshua R Lewis, and Richard L Prince

Impaired Bone Microarchitecture at the Distal Radius in Older Men With Low Muscle Mass and Grip Strength: The STRAMBO Study
Pawel Szulc, Stéphanie Blaizot, Stephanie Boutroy, Nicolas Vilayphiou, Steven Boonen and Roland Chapurlat

Childhood Cortical Porosity Is Related to Microstructural Properties of the Bone-Muscle Junction
Christine M Schnitzler

METTL21C Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-kappa B Signaling Pathway
Jian Huang, Yi-Hsiang Hsu, Chenglin Mo,Eduardo Abreu, Douglas P Kiel, Lynda F Bonewald, Marco Brotto, and David Karasik

Interdependence of Muscle Atrophy and Bone Loss Induced by Mechanical Unloading
Shane A Lloyd, Charles H Lang, Yue Zhang, Emmanuel M Paul, Lacee J Laufenberg, Gregory S Lewis and Henry J Donahue

Delayed Bone Regeneration Is Linked to Chronic Inflammation in Murine Muscular Dystrophy .
Rana Abou-Khalil1, Frank Yang2, Marie Mortreux, Shirley Lieu, Yan-Yiu Yu, Maud Wurmser, Catia Pereira, Frédéric Relaix, Theodore Miclau, Ralph S Marcucio and Céline Colnot

Botulinum Toxin Induces Muscle Paralysis and Inhibits Bone Regeneration in Zebrafish .
Anthony M Recidoro, Amanda C Roof, Michael Schmitt, Leah E Worton, Timothy Petrie, Nicholas Strand, Brandon J Ausk, Sundar Srinivasan, Randall T Moon, Edith M Gardiner, Werner Kaminsky, Steven D Bain, Christopher H Allan, Ted S Gross and Ronald Y Kwon



Kidney Disease and Bone

Rapid cortical bone loss in patients with chronic kidney disease
Thomas L Nickolas, Emily M Stein, Elzbieta Dworakowski, Kyle K Nishiyama, Mafo Komandah-Kosseh, Chiyuan A Zhang, Donald J McMahon, Xiaowei S Liu, Stephanie Boutroy, Serge Cremers and Elizabeth Shane

Renal safety in patients treated with bisphosphonates for osteoporosis:A review
Paul D Miller, Sophie A Jamal, Pieter Evenepoel, Richard Eastell and Steven Boonen

Cardiovascular and renal complications to postsurgical hypoparathyroidism: A Danish nationwide controlled historic follow-up study
Line Underbjerg, Tanja Sikjaer, Leif Mosekilde and Lars Rejnmark

Osteogenesis of Heterotopically Transplanted Mesenchymal Stromal Cells in Rat Models of Chronic Kidney Disease
Rafael Kramann, Uta Kunter, Vincent M Brandenburg, Isabelle Leisten, Josef Ehling, Barbara M Klinkhammer, Ruth Knüchel, Jürgen Floege and Rebekka K Schneider

A single-dose study of denosumab in patients with various degrees of renal impairment
Geoffrey A Block, Henry G Bone, Liang Fang, Edward Lee and Desmond Padhi

Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease
Jason R Stubbs, Nan He, Arun Idiculla, Ryan Gillihan, Shiguang Liu, Valentin David, Yan Hong and L Darryl Quarles

The Impact of Acute Kidney Injury With Temporary Dialysis on the Risk of Fracture
Wei-Jie Wang, Chia-Ter Chao, Yu-Chin Huang, Cheng-Yi Wang, Chia-Hsui Chang, Tao-Min Huang, Chun-Fu Lai, Hui-Yu Huang, Chih-Chung Shiao, Tzong-Shinn Chu, Yung-Ming Chen, Vin-Cent Wu, Wen-Je Ko, Kwan-Dun Wu and the National Taiwan University Study Group on Acute Renal Failure

A Comparison of Calcium to Zoledronic Acid for Improvement of Cortical Bone in an Animal Model of CKD
Sharon M Moe, Neal X Chen, Christopher L Newman, Vincent H Gattone II, Jason M Organ, Xianming Chen and Matthew R Allen

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy
Yves Sabbagh, Fabiana Giorgeti Graciolli, Stephen O'Brien, Wen Tang, Luciene Machado dos Reis, Susan Ryan, Lucy Phillips, Joseph Boulanger, Wenping Song, Christina Bracken, Shiguang Liu, Steven Ledbetter, Paul Dechow, Maria Eugenia F Canziani, Aluizio B Carvalho, Vanda Jorgetti, Rosa MA Moyses and Susan C Schiavi

Role of TGF- beta in a Mouse Model of High Turnover Renal Osteodystrophy
Liu, Shiguang; Song, Wenping; Boulanger, Joseph H.; et al.



Sclerostin: Preclinical and Clinical Implications

Preclinical
Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2
Masakazu Kogawa, Asiri R Wijenayaka, Renee T Ormsby, Gethin P Thomas, Paul H Anderson, Lynda F Bonewald, David M Findlay and Gerald J Atkins

Sclerostin antibody stimulates bone regeneration after experimental periodontitis
Andrei D Taut, Qiming Jin, Jong-Hyuk Chung, Pablo Galindo-Moreno, Erica S Yi, James V Sugai, Hua Z Ke, Min Liu and William V Giannobile

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
Jordan M Spatz, Rachel Ellman, Alison M Cloutier, Leeann Louis, Miranda van Vliet, Larry J Suva, Denise Dwyer, Marina Stolina, Hua Zhu Ke and Mary L Bouxsein

Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels
Sandra Jastrzebski, Judith Kalinowski, Marina Stolina, Faryal Mirza, Elena Torreggiani, Ivo Kalajzic, Hee Yeon Won, Sun-Kyeong Lee and Joseph Lorenzo

Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus
Christine Hamann, Martina Rauner, Yvonne Höhna, Ricardo Bernhardt, Jan Mettelsiefen, Claudia Goettsch, Klaus-Peter Günther, Marina Stolina, Chun-Ya Han, Franklin J Asuncion, Michael S Ominsky and Lorenz C Hofbauer

Clinical
High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study
Mohammed-Salleh M Ardawi, Abdulrahim A Rouzi, Sharifa A Al-Sibiani, Nawal S Al-Senani, Mohammed H Qari and Shaker A Mousa

Sclerostin and bone strength in women in their 10th decade of life
Sara Thorson, Tanushree Prasad, Yahtyng Sheu, Michelle E Danielson, Aarthi Arasu, Steven R Cummings and Jane A Cauley

Correlates of bone microarchitectural parameters and serum sclerostin levels in men: The STRAMBO study
Pawel Szulc, Stéphanie Boutroy, Nicolas Vilayphiou, Michael Schoppet, Martina Rauner, Roland Chapurlat, Christine Hamann and Lorenz C Hofbauer

Lower fracture risk in older men with higher sclerostin concentration: A prospective analysis from the MINOS study
Pawel Szulc, Cindy Bertholon, Olivier Borel, Francois Marchand and Roland Chapurlat

Reversing LRP5-Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
Ming-Kang Chang, Ina Kramer, Hansjoerg Keller, Jonathan H Gooi, Corinne Collett, David Jenkins, Seth A Ettenberg, Feng Cong, Christine Halleux and Michaela Kneissel



Genetics of Osteogenesis Imperfecta

A Novel IFITM5 Mutation in Severe Atypical Osteogenesis Imperfecta Type VI Impairs Osteoblast Production of Pigment Epithelium-Derived Factor
Adi Reich

A non-classical IFITM5 mutation located in the coding region causes severe Osteogenesis imperfecta with prenatal onset
Heike Hoyer-Kuhn

Osteogenesis imperfecta without features of type V caused by a mutation in the IFITM5 gene
Monica Grover

A mouse model for human osteogenesis imperfecta type VI
Thomas Clemens

Phenotypic variability of Osteogenesis Imperfecta type V caused by an IFITM5 mutation
Philippe Campeau

Skeletal Clinical Characteristics of Osteogenesis Imperfecta Caused by Haploinsufficiency Mutations in COL1A1
I mouna ben amor

Sclerostin Antibody Improves Skeletal Parameters in a Brtl/ Mouse Model of Osteogenesis Imperfecta
Ken Kozloff

Lack of expression of SERPINF1, the gene coding for PEDF, causes progressively deforming Osteogenesis Imperfecta with normal type I collagen
Monica Mottes

First Mouse Model for Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome
Frieda Chen

Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta
Christina Jacobsen



Exercise and Bone Health in Children and Young Adults

Bone mineral accrual in 4- to 10-year-old precompetitive, recreational gymnasts: A 4-year longitudinal study
Marta C Erlandson, Saija A Kontulainen, Phil D Chilibeck, Catherine M Arnold and Adam DG Baxter-Jones

Effects of repetitive loading on the growth-induced changes in bone mass and cortical bone geometry: A 12-month study in pre/peri- and postmenarcheal tennis players
Gaele Ducher, Shona L Bass, Leanne Saxon and Robin M Daly

Influence of a 3-year exercise intervention program on fracture risk, bone mass, and bone size in prepubertal children
Bjarne Löfgren, Fredrik Detter, Magnus Dencker, Susanna Stenevi-Lundgren, Jan-Åke Nilsson and Magnus K Karlsson

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children
M Loreto Reyes, Marta Hernández, Luz J Holmgren, Enrique Sanhueza and Raúl G Escobar

Higher premenarcheal bone mass in elite gymnasts is maintained into young adulthood after long-term retirement from sport: A 14-year follow-up Marta C Erlandson, Saija A Kontulainen, Phil D Chilibeck, Cathy M Arnold, Robert A Faulkner and Adam DG Baxter-Jones

Increased physical activity is associated with enhanced development of peak bone mass in men: A five-year longitudinal study
Martin Nilsson, Claes Ohlsson, Anders Odén, Dan Mellström and Mattias Lorentzon

Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: Results from a population-based study of adolescents
Kevin Deere, Adrian Sayers, Jörn Rittweger and Jon H Tobias

Former premenarcheal gymnasts exhibit site-specific skeletal benefits in adulthood after long-term retirement
Marta C Erlandson, Saija A Kontulainen, Phil D Chilibeck, Cathy M Arnold, Robert A Faulkner and Adam DG Baxter-Jones



Obesity, Fat and bone

BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)

Carrie M Nielson, Lynn M Marshall, Annette L Adams, Erin S LeBlanc, Peggy M Cawthon, Kristine Ensrud, Marcia L Stefanick, Elizabeth Barrett-Connor and Eric S Orwoll, for the Osteoporotic Fractures in Men Study (MrOS) Research Group

 

Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women

Miranda EG Armstrong, Elizabeth A Spencer, Benjamin J Cairns, Emily Banks, Kirstin Pirie, Jane Green, F Lucy Wright, Gillian K Reeves and Valerie Beral, for the Million Women Study Collaborators

Adipokines and the risk of fracture in older adults

Kamil E Barbour, Joseph M Zmuda, Robert Boudreau, Elsa S Strotmeyer, Mara J Horwitz, Rhobert W Evans, Alka M Kanaya, Tamara B Harris, Douglas C Bauer and Jane A Cauley 

Leptin's balancing act between bone and fat

Jeffrey M Gimble

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones

Krupa Shah, Reina Armamento-Villareal, Nehu Parimi, Suresh Chode, David R Sinacore, Tiffany N Hilton, Nicola Napoli, Clifford Qualls and Dennis T Villareal

Obesity and fracture in men and women: An epidemiologic perspective

Carrie M Nielson, Priya Srikanth and Eric S Orwoll

The association between fracture and obesity is site-dependent: A population-based study in postmenopausal women

Daniel Prieto-Alhambra, Melissa O Premaor, Francesc Fina Avilés, Eduard Hermosilla, Daniel Martinez-Laguna, Cristina Carbonell-Abella, Xavier Nogués, Juliet E Compston and Adolfo Díez-Pérez

Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: Results from the look AHEAD randomized trial

Ann V Schwartz, Karen C Johnson, Steven E Kahn, John A Shepherd, Michael C Nevitt, Anne L Peters, Michael P Walkup, Amelia Hodges, Carrie C Williams and George A Bray, the Look AHEAD Research Group

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

Reina Armamento-Villareal, Corinn Sadler, Nicola Napoli, Krupa Shah, Suresh Chode, David R Sinacore, Clifford Qualls and Dennis T Villareal

High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden

Helena Johansson, Anders Odén, Ulf H Lerner, Hans Jutberger, Mattias Lorentzon, Elizabeth Barrett-Connor, Magnus K Karlsson, Östen Ljunggren, Ulf Smith, Eugene McCloskey, John A Kanis, Claes Ohlsson and Dan Mellström

Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats

Urszula T Iwaniec, Stéphane Boghossian, Cynthia H Trevisiol, Thomas J Wronski, Russell T Turner and Satya P Kalra

Type 2 diabetes and bone

William D Leslie, Mishaela R Rubin, Ann V Schwartz and John A Kanis



The editorial team at JBMR is pleased to present a new eCompendium on stem cells. eCompendia (formerly known as virtual issues) are online-only collections of previously published materials in which the editor highlights important topics relevant to bone and mineral research. With this issue on stem cells and future volumes, we intend to showcase selected papers of importance and interest to JBMR's readership. Check back later in 2013 for our next installment!

Stem Cells

Clinical characteristics influence in vitro action of 1,25-dihydroxyvitamin D3 in human marrow stromal cells
Shuanhu Zhou, Julie Glowacki, Sung Won Kim, Jochen Hahne, Shuo Geng, Stefan M Mueller, Longxiang Shen, Ilan Bleiberg and Meryl S LeBoff


Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity
Danielle E Green, Benjamin J Adler, Meilin E Chan and Clinton T Rubin


Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation
Sogol Mostoufi-Moab, Jill P Ginsberg, Nancy Bunin, Babette Zemel, Justine Shults and Mary B Leonard


Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: A possible cause for reduced osteogenesis and increased adipogenesis in older individuals
Yan Li, Xu He, Yulin Li, Jiaxue He, Björn Anderstam, Göran Andersson and Urban Lindgren


BMPs


Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling

Bing Yu, Xiaoli Zhao, Chaozhe Yang, Janet Crane, Lingling Xian, William Lu, Mei Wan and Xu Cao


Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells
Enyi Huang, Gaohui Zhu, Wei Jiang, Ke Yang, Yanhong Gao, Qing Luo, Jian-Li Gao, Stephanie H Kim, Xing Liu, Mi Li, Qiong Shi, Ning Hu, Linyuan Wang, Hong Liu, Jing Cui, Wenwen Zhang, Ruidong Li, Xiang Chen, Yu-Han Kong, Jiye Zhang, Jinhua Wang, Jikun Shen, Yang Bi, Joseph Statz, Bai-Cheng He, Jinyong Luo, Huicong Wang, Feng Xiong, Hue H Luu, Rex C Haydon, Li Yang and Tong-Chuan He


Heterotopic ossification


The role of endothelial-mesenchymal transition in heterotopic ossification
Damian Medici and Bjorn R Olsen


Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification
Michael N Wosczyna, Arpita A Biswas, Catherine A Cogswell and David J Goldhamer


Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
Robert J Pignolo, Meiqi Xu, Elizabeth Russell, Alec Richardson, Josef Kaplan, Paul C Billings, Frederick S Kaplan and Eileen M Shore

Endochondral ossification


Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing
Do Y Soung, Laleh Talebian, Christina J Matheny, Rosa Guzzo, Maren E Speck, Jay R Lieberman, Nancy A Speck and Hicham Drissi


The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation
Rachel Grimes, Karl J Jepsen, Jennifer L Fitch, Thomas A Einhorn and Louis C Gerstenfeld

Wnt/Beta-catenin


WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production
Martina Rauner, Nicola Stein, Maria Winzer, Claudia Goettsch, Jochen Zwerina, Georg Schett, Jörg HW Distler, Joachim Albers, Jochen Schulze, Thorsten Schinke, Martin Bornhäuser, Uwe Platzbecker and Lorenz C Hofbauer


Male Osteoporosis

2011

Regulation of circulating sclerostin levels by sex steroids in women and in men
Ulrike IL Mödder, Jackie A Clowes, Kelley Hoey, James M Peterson, Louise McCready, Merry Jo Oursler, B Lawrence Riggs and Sundeep Khosla

Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: A population-based HR-pQCT study
Heather M Macdonald, Kyle K Nishiyama, Jian Kang, David A Hanley and Steven K Boyd

Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: The osteoporotic fractures in men (MrOS) study
Yahtyng Sheu, Joseph M Zmuda, Robert M Boudreau, Moira A Petit, Kristine E Ensrud, Douglas C Bauer, Christopher L Gordon, Eric S Orwoll and Jane A Cauley, for the Osteoporotic Fractures in Men (MrOS) Research Group

Relation of age, gender, and bone mass to circulating sclerostin levels in women and men
Ulrike I Mödder, Kelley A Hoey, Shreyasee Amin, Louise K McCready, Sara J Achenbach, B Lawrence Riggs, L Joseph Melton III and Sundeep Khosla

BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)
Carrie M Nielson, Lynn M Marshall, Annette L Adams, Erin S LeBlanc, Peggy M Cawthon, Kristine Ensrud, Marcia L Stefanick, Elizabeth Barrett-Connor and Eric S Orwoll, for the Osteoporotic Fractures in Men Study (MrOS) Research Group

Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study
Claes Ohlsson, Dan Mellström, Daniel Carlzon, Eric Orwoll, Östen Ljunggren, Magnus K Karlsson and Liesbeth Vandenput

Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: The STRAMBO study
Pawel Szulc, Stéphanie Boutroy, Nicolas Vilayphiou, Ali Chaitou, Pierre D Delmas and Roland Chapurlat

Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis
Janina M Patsch, Thomas Kohler, Andrea Berzlanovich, Christian Muschitz, Christian Bieglmayr, Paul Roschger, Heinrich Resch and Peter Pietschmann

Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS
M Kassim Javaid, Daniel Prieto-Alhambra, Li-Yung Lui, Peggy Cawthon, Nigel K Arden, Thomas Lang, Nancy E Lane, Eric Orwoll, Elizabeth Barrett-Conner, Michael C Nevitt, Cyrus Cooper and Steven R Cummings, for the Osteoporotic Fractures in Men (MrOS) Research Group

2012

Prediction of fracture risk in men: A cohort study
Liisa Byberg, Rolf Gedeborg, Thomas Cars, Johan Sundström, Lars Berglund, Lena Kilander, Håkan Melhus and Karl Michaëlsson

High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Helena Johansson, Anders Odén, Ulf H Lerner, Hans Jutberger, Mattias Lorentzon, Elizabeth Barrett-Connor, Magnus K Karlsson, Östen Ljunggren, Ulf Smith, Eugene McCloskey, John A Kanis, Claes Ohlsson and Dan Mellström

Change in hip bone mineral density and risk of subsequent fractures in older men
Peggy M Cawthon, Susan K Ewing, Dawn C Mackey, Howard A Fink, Steven R Cummings, Kristine E Ensrud, Marcia L Stefanick, Doug C Bauer, Jane A Cauley and Eric S Orwoll, for the Osteoporotic Fractures in Men (MrOS) Research Group

The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: The osteoporotic fractures in men (MrOS) study
Elizabeth Barrett-Connor, Gail A Laughlin, Hong Li, Carrie M Nielson, P Ying Wang, Tien T Dam, Jane A Cauley, Kristine E Ensrud, Marcia L Stefanick, Edith Lau, Andrew R Hoffman and Eric S Orwoll, for the Osteoporotic Fractures in Men (MrOS) Research Group

Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study
Lang Yang, Annabel C Burton, Mike Bradburn, Carrie M Nielson, Eric S Orwoll and Richard Eastell, for the Osteoporotic Fractures in Men (MrOS) Study Group



Atypical Femoral Fractures

 

Trends in Incidence of Subtrochanteric Fragility Fractures and Bisphosphonate Use Among the US Elderly, 1996–2007
Zhong Wang and Timothy Bhattacharyya

Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort
Seo Young Kim, Sebastian Schneeweiss, Jeffrey N Katz, Raisa Levin and Daniel H Solomon

Subtrochanteric/femoral shaft versus hip fractures: Incidences and identification of risk factors
Milka Maravic, Agnès Ostertag and Martine Cohen-Solal

Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures
Eve Donnelly, Dennis S Meredith, Joseph T Nguyen, Brian P Gladnick, Brian J Rebolledo, Andre D Shaffer, Dean G Lorich, Joseph M Lane and Adele L Boskey

Atypical femur fractures: Refining the clinical picture
Bo Abrahamsen

Incidence and demography of femur fractures with and without atypical features
Adrianne C Feldstein, Dennis Black, Nancy Perrin, A Gabriela Rosales, Darin Friess, David Boardman, Richard Dell, Arthur Santora, Julie M Chandler, Mary M Rix and Eric Orwoll

“Atypical femoral fractures” during bisphosphonate exposure in adult hypophosphatasia
Roger AL Sutton, Steven Mumm, Stephen P Coburn, Karen L Ericson and Michael P Whyte

Low-energy fractures of the humeral shaft and bisphosphonate use
Maria P Yavropoulou, Andrea Giusti, Sharita R Ramautar, Sander Dijkstra, Neveen AT Hamdy and Socrates E Papapoulos

Incidence of atypical nontraumatic diaphyseal fractures of the femur
Richard M Dell, Annette L Adams, Denise F Greene, Tadashi T Funahashi, Stuart L Silverman, Eric O Eisemon, Hui Zhou, Raoul J Burchette and Susan M Ott

 



Raisz-Drezner First Paper Award Winners 2008-2014

 

2014

Fracture Risk Predictions Based on Statistical Shape and Density Modeling of the Proximal Femur

Todd Bredbenner, Ph.D

2013

Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development

Takamitsu Maruyama, Ming Jiang, Wei Hsu

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Steven D. Rhodes, Xiaohua Wu, Yongzheng He, Shi Chen, Hao Yang, Karl W. Staser, Jiapeng Wang, Ping Zhang, Chang Jiang, Hiroki Yokota, Ruizhi Dong, Xianghong Peng, Xianlin Yang, Sreemala Murthy, Mohamad Azhar, Khalid S. Mohammad, Mingjiang Xu, Theresa A. Guise, Feng-Chun Yang

2012

Mutations in SERPINF1 cause osteogenesis imperfecta type VI
Erica P Homan, Frank Rauch, Ingo Grafe, Caressa Lietman, Jennifer A Doll, Brian Dawson, Terry Bertin, Dobrawa Napierala, Roy Morello, Richard Gibbs, Lisa White, Rika Miki, Daniel H Cohn, Susan Crawford, Rose Travers, Francis H Glorieux and Brendan Lee

Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
Glenn C Rowe, Vincent Vialou, Kazusa Sato, Hiroaki Saito, Min Yin, Thomas A Green, Sutada Lotinun, Marie Kveiborg, William C Horne, Eric J Nestler and Roland Baron

2011

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment
Hamid Saeed, Basem M Abdallah, Nicholas Ditzel, Philip Catala-Lehnen, Weimin Qiu, Michael Amling and Moustapha Kassem

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
Kylie A Alexander, Ming K Chang, Erin R Maylin, Thomas Kohler, Ralph Müller, Andy C Wu, Nico Van Rooijen, Matthew J Sweet, David A Hume, Liza J Raggatt and Allison R Pettit

2010

Fracture healing is accelerated in the absence of the adaptive immune system
Daniel Toben, Ireen Schroeder, Thaqif El Khassawna, Manav Mehta, Jan-Erik Hoffmann, Jan-Tilmann Frisch, Hanna Schell, Jasmin Lienau, Alessandro Serra, Andreas Radbruch and Georg N Duda

2009

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice
Mei Zhu, Dezhi Tang, Qiuqian Wu, Suyang Hao, Mo Chen, Chao Xie, Randy N Rosier, Regis J O'Keefe, Michael Zuscik and Di Chen

2008

Functional Adaptation to Loading of a Single Bone Is Neuronally Regulated and Involves Multiple Bones
Susannah J Sample, Mary Behan, Lesley Smith, William E Oldenhoff, Mark D Markel, Vicki L Kalscheur, Zhengling Hao, Vjekoslav Miletic and Peter Muir

Bone Morphometry Strongly Predicts Cortical Bone Stiffness and Strength, but Not Toughness, in Inbred Mouse Models of High and Low Bone Mass
Romain Voide, G Harry van Lenthe and Ralph Müller

 



Osteoporosis Treatment


Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis
Michael R McClung, Steven Boonen, Ove Törring, Christian Roux, René Rizzoli, Henry G Bone, Claude-Laurent Benhamou, Willem F Lems, Salvatore Minisola, Johan Halse, Hans C Hoeck, Richard Eastell, Andrea Wang, Suresh Siddhanti and Steven R Cummings

Long-term impact of adherence to oral bisphosphonates on osteoporotic fracture incidence
John S Sampalis, Jonathan D Adachi, Emmanouil Rampakakis, Julie Vaillancourt, Angela Karellis and Christian Kindundu

FRAX underestimates fracture risk in patients with diabetes
Lora M Giangregorio, William D Leslie, Lisa M Lix, Helena Johansson, Anders Oden, Eugene McCloskey and John A Kanis

The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
Dennis M Black, Ian R Reid, Steven Boonen, Christina Bucci-Rechtweg, Jane A Cauley, Felicia Cosman, Steven R Cummings, Trisha F Hue, Kurt Lippuner, Peter Lakatos, Ping Chung Leung, Zulema Man, Ruvie Lou Maria Martinez, Monique Tan, Mary Ellen Ruzycky, Guoqin Su and Richard Eastell

Effects of antiresorptive treatment on nonvertebral fracture outcomes
Dawn C Mackey, Dennis M Black, Douglas C Bauer, Eugene V McCloskey, Richard Eastell, Peter Mesenbrink, John R Thompson and Steven R Cummings

WHO absolute fracture risk models (FRAX): Do clinical risk factors improve fracture prediction in older women without osteoporosis?
Teresa A Hillier, Jane A Cauley, Joanne H Rizzo, Kathryn L Pedula, Kristine E Ensrud, Douglas C Bauer, Li-Yung Lui, Kimberly K Vesco, Dennis M Black, Meghan G Donaldson, Erin S LeBlanc and Steven R Cummings

Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: The manitoba study
Didier Hans, Andrew L Goertzen, Marc-Antoine Krieg and William D Leslie

Prolonged antiresorptive activity of zoledronate: A randomized, controlled trial
Andrew Grey, Mark Bolland, Diana Wattie, Anne Horne, Greg Gamble and Ian R Reid

Bone material properties in actively bone-forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once-yearly Zoledronic acid
Sonja Gamsjaeger, Birgit Buchinger, Elizabeth Zwettler, Robert Recker, Dennis Black, Juerg A Gasser, Erik F Eriksen, Klaus Klaushofer and Eleftherios P Paschalis

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane, David Burr, Peter R Ebeling, Bo Abrahamsen, Robert A Adler, Thomas D Brown, Angela M Cheung, Felicia Cosman, Jeffrey R Curtis, Richard Dell, David Dempster, Thomas A Einhorn, Harry K Genant, Piet Geusens, Klaus Klaushofer, Kenneth Koval, Joseph M Lane, Fergus McKiernan, Ross McKinney, Alvin Ng, Jeri Nieves, Regis O'Keefe, Socrates Papapoulos, Howe Tet Sen, Marjolein CH van der Meulen, Robert S Weinstein and Michael Whyte
 



JBMR Classics


Bone Histomorphometry: Standardization of Nomenclature, Symbols, and Units: Report of the ASBMR Histomorphometry Nomenclature Committee
Parfitt, AM; Drezner, MK; Glorieux, FH; Kanis, JA; Malluche, H; Meunier, PJ; Ott, SM; Recker, RR

Vertebral Fracture Assessment Using a Semiquantitative Technique
Genant, HK; Wu, CY; Vankuijk, C; Nevitt, MC 

Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: Report from the national osteoporosis foundation
Ray, NF; Chan, JK; Thamer, M; Melton, LJ

How Many Women Have Osteoporosis?
Melton, LJ; Chrischilles, EA; Cooper, C; Lane, AW; Riggs, BL

Patients with prior fractures have an increased risk of future fractures: A summary of the literature and statistical synthesis
Klotzbuecher, CM; Ross, PD; Landsman, PB; Abbott, TA; Berger, M

The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
Haussler, MR; Whitfield, GK; Haussler, CA; Hsieh, JC; Thompson, PD; Selznick, SH; Dominguez, CE; Jurutka, PW

Incidence of Clinically Diagnosed Vertebral Fractures - A Population-Based Study in Rochester, Minnesota, 1985-1989
Cooper, C; Atkinson, EJ; Ofallon, WM; Melton, LJ

New Approaches For Interpreting Projected Bone Densitometry Data
Carter, DR; Bouxsein, ML; Marcus, R

Long-Term Fracture Prediction by Bone-Mineral Assessed at Different Skeletal Sites
Melton, LJ; Atkinson, EJ; Ofallon, WM; Wahner, HW; Riggs, BL

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
Luckman, SP; Hughes, DE; Coxon, FP; Russell, RGG; Rogers, MJ



Top 10 Downloads 


Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane, David Burr, Peter R Ebeling, Bo Abrahamsen, Robert A Adler, Thomas D Brown, Angela M Cheung, Felicia Cosman, Jeffrey R Curtis, Richard Dell, David Dempster, Thomas A Einhorn, Harry K Genant, Piet Geusens, Klaus Klaushofer, Kenneth Koval, Joseph M Lane, Fergus McKiernan, Ross McKinney, Alvin Ng, Jeri Nieves, Regis O'Keefe, Socrates Papapoulos, Howe Tet Sen, Marjolein CH van der Meulen, Robert S Weinstein, Michael Whyte

Why the IOM recommendations for vitamin D are deficient
Robert P Heaney, Michael F Holick

Effect of 6-Month Whole Body Vibration Training on Hip Density, Muscle Strength, and Postural Control in Postmenopausal Women: A Randomized Controlled Pilot Study
Sabine MP Verschueren, Machteld Roelants, Christophe Delecluse, Stephan Swinnen, Dirk Vanderschueren, Steven Boonen

The amazing osteocyte
Lynda F Bonewald

The osteoblast: An insulin target cell controlling glucose homeostasis
Thomas L Clemens, Gerard Karsenty

The diagnosis of osteoporosis
Professor John A. Kanis, L. Joseph Melton III, Claus Christiansen, Conrad C. Johnston, Nikolai Khaltaev

Evidence-based policy on dietary calcium and vitamin D
Ian R Reid, Alison Avenell

Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research
Sundeep Khosla (Chair), David Burr, Jane Cauley, David W Dempster, Peter R Ebeling, Dieter Felsenberg, Robert F Gagel, Vincente Gilsanz, Theresa Guise, Sreenivas Koka, Laurie K McCauley, Joan McGowan, Marc D McKee, Suresh Mohla, David G Pendrys, Lawrence G Raisz, Salvatore L Ruggiero, David M Shafer, Lillian Shum, Stuart L Silverman, Catherine H Van Poznak, Nelson Watts, Sook-Bin Woo, Elizabeth Shane

Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005-2025
Russel Burge, Bess Dawson-Hughes, Daniel H Solomon, John B Wong, Alison King PhD, Anna Tosteson

Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian, Aliya Khan, John T Potts Jr, Maria Luisa Brandi, Bart L Clarke, Dolores Shoback, Harald Jüppner, Pierre D'Amour, John Fox, Lars Rejnmark, Leif Mosekilde, Mishaela R Rubin, David Dempster, Rachel Gafni, Michael T Collins, Jim Sliney, James Sanders



Parathyroid Hormone (PTH) Articles


Building bone with a SOST-PTH partnership
Natalie A Sims

Parathyroid hormone regulates fetal-placental mineral homeostasis
Charlene S Simmonds, Gerard Karsenty, Andrew C Karaplis, Christopher S Kovacs

The role of mast cells in parathyroid bone disease
Russell T Turner, Urszula T Iwaniec, Kevin Marley, Jean D Sibonga

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact
Sebastien Elis, Hayden-William Courtland, Yingjie Wu, J Christopher Fritton, Hui Sun, Clifford J Rosen, Shoshana Yakar

Increased osteocyte death and mineralization inside bone after parathyroidectomy in patients with secondary hyperparathyroidism
Aiji Yajima, Masaaki Inaba, Yoshihiro Tominaga, Yoshiki Nishizawa, Kyoji Ikeda, Akemi Ito

Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1–associated primary hyperparathyroidism
Delmar M Lourenço, Flavia L Coutinho, Rodrigo A Toledo, Fabio LM Montenegro, Joya EM Correia-Deur, Sergio PA Toledo

Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms
Robert L Jilka, Charles A O'Brien, Shoshana M Bartell, Robert S Weinstein, Stavros C Manolagas

Tissue-specific regulatory regions of the PTH gene localized by novel chromosome 11 rearrangement breakpoints in a parathyroid adenoma
Sanjay M Mallya, H Irene Wu, Elizabeth A Saria, Kristin R Corrado, Andrew Arnold

Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patients
Kamyar Kalantar-Zadeh, Jessica E Miller, Csaba P Kovesdy, Rajnish Mehrotra, Lilia R Lukowsky, Elani Streja, Joni Ricks, Jennie Jing, Allen R Nissenson, Sander Greenland, Keith C Norris

Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1–34)] in postmenopausal osteoporosis
Felicia Cosman, Erik Fink Eriksen, Chris Recknor, Paul D Miller, Núria Guañabens, Christian Kasperk, Philemon Papanastasiou, Aimee Readie, Hanumantha Rao, Jürg A Gasser, Christina Bucci-Rechtweg, Steven Boonen

Differential effects of teriparatide on regional bone formation using 18 F-fluoride positron emission tomography
Michelle L Frost, Musib Siddique, Glen M Blake, Amelia EB Moore, Paul J Schleyer, Joel T Dunn, Edward J Somer, Paul K Marsden, Richard Eastell, Ignac Fogelman

PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
Yumie Rhee, Matthew R Allen, Keith Condon, Virginia Lezcano, Ana C Ronda, Carlo Galli, Naomi Olivos, Giovanni Passeri, Charles A O'Brien, Nicoletta Bivi, Lilian I Plotkin, Teresita Bellido

The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates
Lei Shu, Ji Ji, Qi Zhu, Guofan Cao, Andrew Karaplis, Martin R Pollak, Edward Brown, David Goltzman, Dengshun Miao

Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow
Christian E Jacome-Galarza, Sun-Kyeong Lee, Joseph A Lorenzo, Hector Leonardo Aguila

FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH
Quan Yuan, Tadatoshi Sato, Michael Densmore, Hiroaki Saito, Christiane Schüler, Reinhold G Erben, Beate Lanske

A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover
Mara J Horwitz, Mary Beth Tedesco, Susan M Sereika, Linda Prebehala, Caren M Gundberg, Bruce W Hollis, Alessandro Bisello, Adolfo Garcia-Ocaña, Raquel M Carneiro, Andrew F Stewart

Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian, Aliya Khan, John T Potts, Maria Luisa Brandi, Bart L Clarke, Dolores Shoback, Harald Jüppner, Pierre D'Amour, John Fox, Lars Rejnmark, Leif Mosekilde, Mishaela R Rubin, David Dempster, Rachel Gafni, Michael T Collins, Jim Sliney, James Sanders

The effect of adding PTH(1–84) to conventional treatment of hypoparathyroidism: A randomized, placebo-controlled study
Tanja Sikjaer, Lars Rejnmark, Lars Rolighed, Lene Heickendorff, Leif Mosekilde,

Parathyroid hormone signaling via Gαs is selectively inhibited by an NH 2 -terminally truncated Gαs: Implications for pseudohypoparathyroidism
Svetlana Puzhko, Cynthia Gates Goodyer, Mohammad Amin Kerachian, Lucie Canaff, Madhusmita Misra, Harald Jüppner, Murat Bastepe, Geoffrey N Hendy

Skeletal anabolism, PTH, and the bone–vascular axis
Dwight A Towler

Intermittent PTH(1–84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites
Rhonda Prisby, Alain Guignandon, Arnaud Vanden-Bossche, Fabrice Mac-Way, Marie-Thérèse Linossier, Mireille Thomas, Norbert Laroche, Luc Malaval, Max Langer, Zoltz-Andrei Peter, Françoise Peyrin, Laurence Vico, Marie-Hélène Lafage-Proust

PTH(1–84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism
Mishaela R Rubin, David W Dempster, James Sliney Jr., Hua Zhou, Thomas L Nickolas, Emily M Stein, Elzbieta Dworakowski, Maryann Dellabadia, Rebecca Ives, Donald J McMahon, Chiyuan Zhang, Shonni J Silverberg, Elizabeth Shane, Serge Cremers, John P Bilezikian

Teriparatide increases bone mineral density in a man with osteoporosis pseudoglioma
Henrique Pierotti Arantes, Elizabete Ribeiro Barros, Ilda Kunii, John P Bilezikian, Marise Lazaretti-Castro

Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting
Verónica Alonso, Clara E Magyar, Bin Wang, Alessandro Bisello, Peter A Friedman

 



Vitamin D Articles 2009 - Present

 

Effects of 25-hydroxyvitamin D3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase
Shuo Geng, Shuanhu Zhou and Julie Glowacki

The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial
Hector F DeLuca, Wendy Bedale, Neil Binkley, J Chris Gallagher, Michael Bolognese, Munro Peacock, John Aloia, Margaret Clagett-Dame and Lori Plum

Why the IOM recommendations for vitamin D are deficient
Robert P Heaney and Michael F Holick

Evidence-based policy on dietary calcium and vitamin D
Ian R Reid and Alison Avenell

The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: A 6-month randomized, controlled trial
Sabine MP Verschueren, An Bogaerts, Christophe Delecluse, Albrecht L Claessens, Patrick Haentjens, Dirk Vanderschueren and Steven Boonen

Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patients
Kamyar Kalantar-Zadeh, Jessica E Miller, Csaba P Kovesdy, Rajnish Mehrotra, Lilia R Lukowsky, Elani Streja, Joni Ricks, Jennie Jing, Allen R Nissenson, Sander Greenland and Keith C Norris

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study
Cédric Annweiler, Anne-Marie Schott, Manuel Montero-Odasso, Gilles Berrut, Bruno Fantino, François R Herrmann and Olivier Beauchet

Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob/ob Mice
Kiyomi Tsuji, Toyonobu Maeda, Tetsuya Kawane, Ayako Matsunuma and Noboru Horiuchi

The calcium-sensing receptor and 25-hydroxyvitamin D–1α-hydroxylase interact to modulate skeletal growth and bone turnover
Christian Richard, Rujuan Huo, Rana Samadfam, Isabel Bolivar, Dengshun Miao, Edward M Brown, Geoffrey N Hendy and David Goltzman

Effect of vitamin D3 and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial—the OSTPRE-FPS
Kari Salovaara, Marjo Tuppurainen, Matti Kärkkäinen, Toni Rikkonen, Lorenzo Sandini, Joonas Sirola, Risto Honkanen, Esko Alhava and Heikki Kröger

A patient with severe hypercalcemia in multiple organ dysfunction syndrome: Role of elevated circulating 1α,25(OH)2vitamin D levels
Junichiro James Kazama, Takashi Yamamoto, Hiroshi Oya, Satoshi Yamamoto, Yoshinobu Sato, Junko Sakurada, Tadayuki Honda, Hiroshi Endoh and Ichiei Narita

Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats
Akishige Hokugo, Russell Christensen, Evelyn M Chung, Eric C Sung, Alan L Felsenfeld, James W Sayre, Neal Garrett, John S Adams and Ichiro Nishimura

A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
Masahiko Sato, Jianliang Lu, Stephen Iturria, Keith R Stayrook, Lorri L Burris, Qing Qiang Zeng, Allen Schmidt, Robert J Barr, Chahrzad Montrose-Rafizadeh, Henry U Bryant and Yanfei L Ma

CDP/cut is an osteoblastic coactivator of the vitamin D receptor (VDR)
Eiji Ochiai, Hirochika Kitagawa, Ichiro Takada, Sally Fujiyama, Shun Sawatsubashi, Mi-sun Kim, Yoshihiro Mezaki, Yu Tsushima, Ken-ichiro Takagi, Yoshiaki Azuma, Ken-ichi Takeyama, Kazuyoshi Yamaoka, Shigeaki Kato and Takashi Kamimura

Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D
Guy B Mulligan and Angelo Licata

Persistent secondary hyperparathyroidism and vertebral fractures in kidney transplantation: Role of calcium-sensing receptor polymorphisms and vitamin D deficiency
Sandro Giannini, Stefania Sella, Fatima Silva Netto, Catia Cattelan, Luca Dalle Carbonare, Roberta Lazzarin, Francesco Marchini, Paolo Rigotti, Claudio Marcocci, Filomena Cetani, Elena Pardi, Angela D'Angelo, Giuseppe Realdi and Luciana Bonfante

Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail
Shaochun Bai, Hongwei Wang, Jikun Shen, Randal Zhou, David A Bushinsky and Murray J Favus

Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men
Jane A Cauley, Neeta Parimi, Kristine E Ensrud, Douglas C Bauer, Peggy M Cawthon, Steven R Cummings, Andrew R Hoffman, James M Shikany, Elizabeth Barrett-Connor and Eric Orwoll

Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion
Francesco Bertoldo, Serena Pancheri, Sonia Zenari, Stefania Boldini, Benedetta Giovanazzi, Mirko Zanatta, Maria Teresa Valenti, Luca Dalle Carbonare and Vincenzo Lo Cascio

Vitamin D receptor (VDR) gene polymorphism is associated with left ventricular (LV) mass and predicts left ventricular hypertrophy (LVH) progression in end-stage renal disease (ESRD) patients
Alessandra Testa, Francesca Mallamaci, Francesco A Benedetto, Anna Pisano, Giovanni Tripepi, Lorenzo Malatino, Ravi Thadhani and Carmine Zoccali

Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients
Matthias Priemel, Christoph von Domarus, Till Orla Klatte, Steffen Kessler, Julia Schlie, Simon Meier, Nils Proksch, Frederic Pastor, Clemens Netter, Thomas Streichert, Klaus Püschel and Michael Amling

Low maternal vitamin D status and fetal bone development: Cohort study
Pamela Mahon, Nicholas Harvey, Sarah Crozier, Hazel Inskip, Sian Robinson, Nigel Arden, Rama Swaminathan, Cyrus Cooper and Keith Godfrey

Vitamin D insufficiency and skeletal development in utero
Martin Hewison and John S Adams

Effects of hPTH(1-34) Infusion on Circulating Serum Phosphate, 1,25-Dihydroxyvitamin D, and FGF23 Levels in Healthy Men
Sherri-Ann M Burnett-Bowie, Maria P Henao, Melissa E Dere, Hang Lee and Benjamin Z Leder

1α,25(OH)2 Vitamin D3 Induction of ATP Secretion in Osteoblasts
Payal Biswas and Laura P Zanello

Dietary Calcium and Serum 25-Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults
Heike A Bischoff-Ferrari, Douglas P Kiel, Bess Dawson-Hughes, John E Orav, Ruifeng Li, Donna Spiegelman, Thomas Dietrich and Walter C Willett

Vitamin D Status, Parathyroid Function, Bone Turnover, and BMD in Postmenopausal Women With Osteoporosis: Global Perspective
Natalia O Kuchuk, Natasja M van Schoor, Saskia M Pluijm, Arkadi Chines and Paul Lips

Compound Heterozygous Mutations in the Vitamin D Receptor in a Patient With Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets With Alopecia
Yulin Zhou, Jining Wang, Peter J Malloy, Zdenek Dolezel and David Feldman

Wintertime Vitamin D Supplementation Inhibits Seasonal Variation of Calcitropic Hormones and Maintains Bone Turnover in Healthy Men
Heli T Viljakainen, Milja Väisänen, Virpi Kemi, Toni Rikkonen, Heikki Kröger, E Kalevi A Laitinen, Hannu Rita and Christel Lamberg-Allardt

Analysis of CYP27B1, Encoding 25-Hydroxyvitamin D-1α-Hydroxylase, as a Candidate Tumor Suppressor Gene in Primary and Severe Secondary/Tertiary Hyperparathyroidism
Kelly Lauter and Andrew Arnold

Vitamin D–Independent Therapeutic Effects of Extracellular Calcium in a Mouse Model of Adult-Onset Secondary Hyperparathyroidism
Karin Weber, Ute Zeitz, Claudia Bergow, Sieglinde Hirmer, Christiane Schüler and Reinhold G Erben



Basic Research Perspectives


Vitamin D and Health: Perspectives From Mice and Man

Roger Bouillon, Heike Bischoff-Ferrari, and Walter Willett

Review of Nonprimate, Large Animal Models for
Osteoporosis Research

Susan Reinwald and David Burr

Where Wnts Went: The Exploding Field of Lrp5 and Lrp6
Signaling in Bone

Bart O Williams and Karl L Insogna

Role of the Osteoblast Lineage in the Bone Marrow
Hematopoietic Niches

Joy Y. Wu, David T. Scadden, and Henry M. Kronenberg

Osteoclasts and Arthritis
Georg Schett and Steven L. Teitelbaum

Regulation of Osteogenesis-Angiogenesis Coupling
by HIFs and VEGF

Ernestina Schipani, Christa Maes, Geert Carmeliet, and Gregg L. Semenza

Spatiotemporal Delivery Strategies for Promoting Musculoskeletal
Tissue Regeneration

Robert E. Guldberg

Myeloma Bone Disease
Ralph D. Sanderson and Joshua Epstein

Future of Osteoporosis Genetics: Enhancing Genome-Wide Association Studies
Charles R. Farber and Aldons J. Lusis

Of mice and (wo)men: Mouse models of breast cancer metastasis to bone
Robert H. Goldstein, Robert A. Weinberg and Michael Rosenblatt

Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches
Joy Y. Wu, David T. Scadden and Henry M. Kronenberg

Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Mary L. Bouxsein, Stephen K. Boyd, Blaine A. Christiansen, Robert E. Guldberg, Karl J. Jepsen, and Ralph Müller

Gr-1 CD11b myeloid-derived suppressor cells: Formidable partners in tumor metastasis
Li Yang, Claire M. Edwards, Gregory R. Mundy

Sclerostin: A gem from the genome leads to bone-building antibodies
Chris Paszty, Charles H. Turner and Martyn K. Robinson

FGF-23: More than a regulator of renal phosphate handling?
Harald Jüppner, Myles Wolf and Isidro B. Salusky

IGF-1 and bone: New discoveries from mouse models
Shoshana Yakar, Hayden-William Courtland and David Clemmons 

Osteosarcoma
Richard Gorlick and Chand Khanna

The amazing osteocyte
Lynda F Bonewald

The osteoblast: An insulin target cell controlling glucose homeostasis
Thomas L Clemens and Gerard Karsenty

FoxO1: A molecule for all seasons
Stavroula Kousteni

Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation
J Wesley Pike

Circulating osteogenic cells: Implications for injury, repair, and regeneration
Robert J Pignolo and Moustapha Kassem



Clinical Perspectives


Considerations for Development of Surrogate Endpoints for
Antifracture Efficacy of New Treatments in Osteoporosis:
A Perspective

Mary L Bouxsein and Pierre D Delmas

Theoretical Implications of the Biomechanical Fracture Threshold
Tony M Keaveny and Mary L Bouxsein

Bridging the Osteoporosis Quality Chasm
Jeffrey R Curtis, Jonathan D Adachi, and Kenneth G Saag

Assessing the Clinical Utility of Serum CTX in Postmenopausal
Osteoporosis and Its Use in Predicting Risk of
Osteonecrosis of the Jaw

Sanford Baim and Paul D Miller

FRAX Facts
Nelson B. Watts, Bruce Ettinger, and Meryl S. LeBoff 

Clinical Value of Monitoring BMD in Patients Treated With
Bisphosphonates for Osteoporosis

Nelson B. Watts, E. Michael Lewiecki, Sydney L. Bonnick, Andrew J. Laster, Neil Binkley, Robert D. Blank,
Piet P. Geusens, Paul D. Miller, Steven M. Petak, Robert R. Recker, Kenneth G. Saag, John Schousboe,
Ethel S. Siris, and John P. Bilezikian

Following BMD in Patients on Bisphosphonates: Another Perspective
Robert A. Adler and Murray J. Favus

Atrial fibrillation and bisphosphonate therapy
Michael Pazianas, Juliet Compston and Christopher L. Huang

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a Task Force of the American Society for Bone and Mineral Research
lElizabeth Shane, David Burr, Peter R. Ebeling, Bo Abrahamsen, Robert A. Adler, Thomas D. Brown, Angela M. Cheung, Felicia Cosman, Jeffrey R. Curtis, Richard Dell, David Dempster, Thomas A. Einhorn, Harry K. Genant, Piet Geusens, Klaus Klaushofer, Kenneth Koval, Joseph M. Lane, Fergus McKiernan, Ross McKinney, Alvin Ng, Jeri Nieves, Regis O'Keefe, Socrates Papapoulos, Howe Tet Sen, Marjolein CH van der Meulen, Robert S. Weinstein and Michael Whyte 

The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?
Sundeep Khosla, L Joseph Melton III and B Lawrence Riggs

Evidence-based policy on dietary calcium and vitamin D
Ian R Reid and Alison Avenell

Why the IOM recommendations for vitamin D are deficient
Robert P Heaney and Michael F Holick

A clinician's guide to X-linked hypophosphatemia
Thomas O Carpenter, Erik A Imel, Ingrid A Holm, Suzanne M Jan de Beur and Karl L Insogna

Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis
Karen E Hansen, H Alexander Wilson, Carol Zapalowski, Howard A Fink, Salvatore Minisola and Robert A Adler

Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian, Aliya Khan, John T Potts Jr, Maria Luisa Brandi, Bart L Clarke, Dolores Shoback, Harald Jüppner, Pierre D'Amour, John Fox, Lars Rejnmark, Leif Mosekilde, Mishaela R Rubin, David Dempster, Rachel Gafni, Michael T Collins, Jim Sliney and James Sanders

Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop
Sundeep Khosla, Teresita M Bellido, Marc K Drezner, Catherine M Gordon, Tamara B Harris, Douglas P Kiel, Barbara E Kream, Meryl S LeBoff, Jane B Lian, Charlotte A Peterson, Clifford J Rosen, John P Williams, Karen K Winer and Sherry S Sherman

Obesity and fracture in men and women: An epidemiologic perspective
Carrie M Nielson, Priya Srikanth and Eric S Orwoll

 

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