Cover image for Vol. 55 Issue 3

Edited By: Sally A. Moody

Online ISSN: 1526-968X

Virtual Issue: Mouse Genetics and Development


Virtual Issue: Mouse Genetics and Development

The mouse has become a powerful genetic model system in which to elucidate the genetic control of normal development, and underlying causes of birth defects and developmental diseases. The research community is continually developing new genetic tools that allow for fine-tuned temporal and spatial control of gene expression and reporter constructs. This compilation of research articles and technology reports illustrates numerous recent advances in mouse developmental genetic tools that will be of great benefit to the research community. The virtual issue articles are freely available online and will be updated periodically. Please contact authors directly for access to the exciting new lines described within this issue.

Updated June 2015

Off-Target Assessment of CRISPR-Cas9 Guiding RNAs in Human iPS and Mouse ES Cells.
Tan, E-Pien; Li, Yilong; Velasco-Herrera, Martin Del Castillo; Yusa, Kosuke; Bradley, Allan. 2015. 53:225-236.

Genome Editing a Mouse Locus Encoding a Variant Histone, H3.3B, to Report on its Expression in Live Animals.
Wen, Duancheng; Noh, Kyung-Min; Goldberg, Aaron D.; Allis, C. David; Rosenwaks, Zev; Rafii, Shahin; Banaszynski, Laura A. 2014. 52:959-966.

Two New Targeted Alleles for the Comprehensive Analysis of Meis1 Functions in the Mouse.
Gonzalez-Lazaro, Monica; Rosello-Diez, Alberto; Delgado, Irene; Carramolino, Laura; Angeles Sanguino, Maria; Giovinazzo, Giovanna; Torres, Miguel. 2014. 52:967-975.

Generation and Characterization of Neurod1-CreER(T2) Mouse Lines for the Study of Embryonic and Adult Neurogenesis.
Aprea, Julieta; Nonaka-Kinoshita, Miki; Calegari, Federico. 2014. 52:870-878.

In Vivo Cell Tracking of Mouse Embryonic Myoblasts and Fast Fibers During Development.
Guerrero, Lucia; Villar, Pedro; Martinez, Lidia; Badia-Careaga, Claudio; Arredondo, Juan J.; Cervera, Margarita. 2014. 52:793-808.

Neural Crest Cell-Specific Inactivation of Nipbl or Mau2 During Mouse Development Results in a Late Onset of Craniofacial Defects.
Smith, Terence Gordon; Laval, Steve; Chen, Fangli; Rock, Matthew James; Strachan, Tom; Peters, Heiko. 2014. 52:687-694.

Genomic DNA Recombination with Cell-Penetrating Peptide-Tagged Cre Protein in Mouse Skeletal and Cardiac Muscle.
Chien, Wei-Ming; Liu, Yonggang; Chin, Michael T. 2014. 52:695-701.

The Cd6 Gene as a Permissive Locus for Targeted Transgenesis in the Mouse.
Ichise, Hirotake; Ichise, Taeko; Sasanuma, Hiroki; Yoshida, Nobuaki. 2014. 52:440-450.

A Knock-in Foxj1(CreERT2:: GFP)Mouse for Recombination in Epithelial Cells with Motile Cilia.
Muthusamy, Nagendran; Vijayakumar, Akshitha; Cheng, Gang, Jr.; Ghashghaei, H. Troy. 2014. 52:350-358.

Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER(T2) Recombinase in Cartilage.
Lo Cascio, Leandro; Liu, Ke; Nakamura, Hiro; Chu, Grace; Lim, Ngee Han; Chanalaris, Anastasios; Saklatvala, Jeremy; Nagase, Hideaki; Bou-Gharios, George. 2014. 52:110-119.

Modeling Human Epilepsy by TALEN Targeting of Mouse Sodium Channel Scn8a.
Jones, Julie M.; Meisler, Miriam H. 2014. 52:141-148.

SIP1 Expression Patterns in Brain Investigated by Generating a SIP1-EGFP Reporter Knock-in Mouse.
Nishizaki, Yuriko; Takagi, Tsuyoshi; Matsui, Fumiko; Higashi, Yujiro. 2014. 52:56-67.

Nkx2.2:Cre Knock-In Mouse Line: A Novel Tool for Pancreas- and CNS-Specific Gene Deletion.
Balderes, Dina A.; Magnuson, Mark A.; Sussel, Lori. 2013. 51:844-851.

The Ptch1(DL) Mouse: A New Model to Study Lambdoid Craniosynostosis and Basal Cell Nevus Syndrome-Associated Skeletal Defects.
Feng, Weiguo; Choi, Irene; Clouthier, David E.; Niswander, Lee; Williams, Trevor. 2013. 51:677-689.

Generation and Characterization of a Tamoxifen-Inducible Eomes(CreER) Mouse Line.
Pimeisl, Inga-Marie; Tanriver, Yakup; Daza, Ray A.; Vauti, Franz; Hevner, Robert F.; Arnold, Hans-Henning; Arnold, Sebastian J. 2013. 51:725-733.

Engineering Subtle Targeted Mutations Into the Mouse Genome.
Menke, Douglas B. 2013. 51:605-618.

Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation.
Burtscher, Ingo; Barkey, Wenke; Lickert, Heiko. 2013. 51:596-604.

A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics.
Hirsch, Marie-Rose; d'Autreaux, Fabien; Dymecki, Susan M.; Brunet, Jean-Francois; Goridis, Christo. 2013. 51:506-514.

Pax1EGFP: New wildtype and mutant EGFP mouse lines for molecular and fate mapping studies.
Sivakamasundari, V.; Kraus, Petra; Jie, Song; Lufkin, Thomas. 2013. 51:420-429.

Visualization of inactive X chromosome in preimplantation embryos utilizing MacroH2AEGFP transgenic mouse.
Soma, Atsumi; Sato, Kenzo; Nakanishi, Tomoko. 2013. 51:259-267.

Transposon mediated BAC transgenesis via pronuclear injection of mouse zygotes.
Rostovskaya, Maria; Naumann, Ronald; Fu, Jun; Obst, Mandy; Mueller, Doris; Stewart, A. Francis; Anastassiadis, Konstantinos. 2013. 51:135-141.

Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse.
Tang, Michelle C. W.; Jacobs, Shelley A.; Wong, Lee H.; Mann, Jeffrey R. 2013. 51:142-146.

Generation of a novel mouse model for the inducible depletion of macrophages in vivo.
Gheryani, Nabeia; Coffelt, Seth B.; Gartland, Alison; Rumney, Robin M. H.; Kiss-Toth, Endre; Lewis, Claire E.; Tozer, Gillian M.; Greaves, David R.; Dear, T. Neil; Miller, Gaynor. 2013. 51:41-49.

Generation of a germ cell-specific mouse transgenic cherry reporter, Sohlh1-mCherryFlag.
Suzuki, Hitomi; Dann, Christina Tenenhaus; Rajkovic, Aleksandar. 2013. 51:50-58.