Hepatology

Copyright © 2013 American Association for the Study of Liver Diseases

Cover image for Vol. 57 Issue 5

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Michael H. Nathanson

Impact Factor: 11.665

ISI Journal Citation Reports © Ranking: 2011: 2/74 (Gastroenterology & Hepatology)

Online ISSN: 1527-3350

Associated Title(s): Clinical Liver Disease, Liver Transplantation

  1. Hepatology Elsewhere

    1. Bevacizumab – finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia

      Lawrence H Young, Katharine J Henderson, Robert I White and Guadalupe Garcia-Tsao

      Accepted manuscript online: 17 MAY 2013 08:43AM EST | DOI: 10.1002/hep.26472

  2. Liver Biology and Pathobiology

    1. Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Oppositely regulated by IL-4 and IFN-γ

      Hua Wang, Dechun Feng, Ogyi Park, Shi Yin and Bin Gao

      Accepted manuscript online: 17 MAY 2013 08:42AM EST | DOI: 10.1002/hep.26471

  3. Liver Injury and Regeneration

    1. Adipose tissue-derived stem cells as a regenerative therapy for a murine steatohepatitis-induced cirrhosis model

      Akihiro Seki, Yoshio Sakai, Takuya Komura, Alessandro Nasti, Keiko Yoshida, Mami Higashimoto, Masao Honda, Soichiro Usui, Masayuki Takamura, Toshinari Takamura, Takahiro Ochiya, Kengo Furuichi, Takashi Wada and Shuichi Kaneko

      Accepted manuscript online: 17 MAY 2013 08:40AM EST | DOI: 10.1002/hep.26470

  4. Autoimmune, Cholestatic and Biliary Disease

    1. Therapeutic advantage of anti-vascular adhesion protein-1 over anti-α4 integrin antibody in concanavalin a-induced hepatitis

      Woo-Yong Lee, Marko Salmi, Margaret Kelly, Sirpa Jalkanen and Paul Kubes

      Accepted manuscript online: 17 MAY 2013 08:39AM EST | DOI: 10.1002/hep.26469

    2. Adjuvant gemcitabine therapy improves survival in a locally induced, r0-resectable model of metastatic intrahepatic cholangiocarcinoma

      Engin Gürlevik, Bettina Fleischmann-Mundt, Nina Armbrecht, Thomas Longerich, Norman Woller, Arnold Kloos, Dirk Hoffmann, Axel Schambach, Thomas C. Wirth, Michael P. Manns, Lars Zender, Stefan Kubicka and Florian Kühnel

      Accepted manuscript online: 17 MAY 2013 08:38AM EST | DOI: 10.1002/hep.26468

    3. A randomized trial comparing monthly ibandronate and weekly alendronate for osteoporosis in patients with primary biliary cirrhosis

      Núria Guañabens, Anna Monegal, Dacia Cerdá, África Muxí, Laia Gifre, Pilar Peris and Albert Parés

      Accepted manuscript online: 17 MAY 2013 08:22AM EST | DOI: 10.1002/hep.26466

  5. Steatohepatitis and Metabolic Liver Disease

    1. Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

      Mazen Noureddin, Katherine P Yates, Ivana A Vaughn, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Arthur McCullough, Raphael Merriman, Bilal Hameed, Edward Doo, David E. Kleiner, Cynthia Behling and Rohit Loomba, for the NASH CRN

      Accepted manuscript online: 17 MAY 2013 08:17AM EST | DOI: 10.1002/hep.26465

  6. Liver Injury and Regeneration

    1. The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

      Noémie Péan, Isabelle Doignon, Isabelle Garcin, Aurore Besnard, Boris Julien, Bingkaï Liu, Sophie Branchereau, Anne Spraul, Catherine Guettier, Lydie Humbert, Kristina Schoonjans, Dominique Rainteau and Thierry Tordjmann

      Accepted manuscript online: 17 MAY 2013 08:16AM EST | DOI: 10.1002/hep.26463

  7. Hepatobiliary Malignancies

    1. Effect of type 2 diabetes on risk for hepatocellular carcinoma in chronic hepatitis C

      Yasuji Arase, Mariko Kobayashi and Hiromitsu Kumada

      Accepted manuscript online: 17 MAY 2013 08:15AM EST | DOI: 10.1002/hep.26456

  8. Autoimmune, Cholestatic and Biliary Disease

    1. Primary sclerosing cholangitis, autoimmune hepatitis and overlap in utah children: Epidemiology and natural history

      Mark Deneau, M. Kyle Jensen, John Holmen, Marc S. Williams, Linda S. Book and Stephen L. Guthery

      Accepted manuscript online: 17 MAY 2013 08:14AM EST | DOI: 10.1002/hep.26454

  9. Correspondence

    1. Analyzing risk factors for intrahepatic cholangiocarcinoma

      Tetsuji Fujita

      Accepted manuscript online: 22 APR 2013 03:55PM EST | DOI: 10.1002/hep.26448

  10. Hepatology Elsewhere

    1. Cracking the ENCODE: From transcription to therapeutics

      Gautam Mehta, Rajiv Jalan and Rajeshwar Mookerjee

      Accepted manuscript online: 22 APR 2013 03:55PM EST | DOI: 10.1002/hep.26449

  11. Autoimmune, Cholestatic and Biliary Disease

    1. increased Th17 response to pathogen stimulation in patients with primary sclerosing cholangitis

      Janosch Katt, Dorothee Schwinge, Tanja Schoknecht, Alexander Quaas, Ingo Sobottka, Eike Burandt, Christoph Becker, Markus F. Neurath, Ansgar W. Lohse, Johannes Herkel and Christoph Schramm

      Accepted manuscript online: 8 APR 2013 04:52AM EST | DOI: 10.1002/hep.26447

  12. Liver Injury and Regeneration

    1. IL-25 prevents and cures fulminant hepatitis through a myeloid-derived suppressor cell- dependent mechanism

      Massimiliano Sarra, Maria Laura Cupi, Roberta Bernardini, Giulia Ronchetti, Ivan Monteleone, Marco Ranalli, Eleonora Franzè, Angelamaria Rizzo, Alfredo Colantoni, Flavio Caprioli, Marco Maggioni, Alessandra Gambacurta, Maurizio Mattei, Thomas T. Macdonald, Francesco Pallone and Giovanni Monteleone

      Accepted manuscript online: 8 APR 2013 04:52AM EST | DOI: 10.1002/hep.26446

  13. Viral Hepatitis

    1. α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C

      Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe and Namiki Izumi

      Accepted manuscript online: 8 APR 2013 04:51AM EST | DOI: 10.1002/hep.26442

    2. PNPLA3 I148M affects liver steatosis in patients with chronic hepatitis B

      Mauro Viganò, Luca Valenti, Pietro Lampertico, Floriana Facchetti, Benedetta Maria Motta, Roberta D'Ambrosio, Solange Romagnoli, Paola Dongiovanni, Benedetta Donati, Silvia Fargion and Massimo Colombo

      Accepted manuscript online: 8 APR 2013 04:51AM EST | DOI: 10.1002/hep.26445

  14. Autoimmune, Cholestatic and Biliary Disease

    1. Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: A population based cohort study

      Hanns-Ulrich Marschall, Elisabeth Wikström Shemer, Jonas F. Ludvigsson and Olof Stephansson

      Accepted manuscript online: 8 APR 2013 04:51AM EST | DOI: 10.1002/hep.26444

  15. Correspondence

    1. Reply

      Roongruedee Chaiteerakij, William S. Harmsen, Euijung Ryu, Rosebud O. Roberts, Janet E. Olson, Terry M. Therneau and Lewis R. Roberts

      Accepted manuscript online: 8 APR 2013 04:50AM EST | DOI: 10.1002/hep.26441

  16. Steatohepatitis and Metabolic Liver Disease

    1. Characterization of European-ancestry NAFLD-associated Variants in individuals of African and Hispanic descent

      Nicholette D Palmer, Solomon K Musani, Laura M Yerges-Armstrong, Mary F Feitosa, Lawrence F Bielak, Ruben Hernaez, Bratati Kahali, J Jeffrey Carr, Tamara B Harris, Min A Jhun, Sharon LR Kardia, Carl D Langefeld, Thomas H Mosley Jr, Jill M Norris, Albert V Smith, Herman A Taylor, Lynne E Wagenknecht, Jiankang Liu, Ingrid B Borecki, Patricia A Peyser and Elizabeth K Speliotes

      Accepted manuscript online: 8 APR 2013 04:50AM EST | DOI: 10.1002/hep.26440

  17. Clinical Observations in Hepatology

    1. Now you see it, now you don't

      Eileen Plotkin, David N Assis and James L Boyer

      Accepted manuscript online: 4 APR 2013 05:05AM EST | DOI: 10.1002/hep.26439

  18. Viral Hepatitis

    1. Mericitabine: Small steps toward A better treatment for chronic hepatitis C (CHC) infection: Mericitabine, pegylated interferon and ribavirin in the PROPEL and JUMP trials

      Dawn M. Torres and Stephen A. Harrison

      Accepted manuscript online: 4 APR 2013 05:04AM EST | DOI: 10.1002/hep.26438

    2. The homeostasis model assessment of insulin resistance does not seem to predict response to telaprevir in chronic hepatitis C in the REALIZE trial

      Zobair Younossi, Francesco Negro, Lawrence Serfaty, Stanislas Pol, Moises Diago, Stefan Zeuzem, Pietro Andreone, Eric J Lawitz, Stuart Roberts, Roberto Focaccia, Graham R Foster, Andrzej Horban, Isabelle Lonjon-Domanec, Bruce Coate, Ralph DeMasi, Gaston Picchio and James Witek

      Accepted manuscript online: 4 APR 2013 05:04AM EST | DOI: 10.1002/hep.26437

    3. Response-guided peginterferon therapy in HBeAg-positive chronic hepatitis B using serum hepatitis B surface antigen levels

      Milan J. Sonneveld, Bettina E. Hansen, Teerha Piratvisuth, Ji-Dong Jia, Stefan Zeuzem, Edward Gane, Yun-Fan Liaw, Qing Xie, E. Jenny Heathcote, Henry L-Y Chan and Harry LA Janssen

      Accepted manuscript online: 2 APR 2013 04:32AM EST | DOI: 10.1002/hep.26436

  19. Correspondence

    1. Reply

      Edmondo Falleti, Carlo Fabris and Pierluigi Toniutto

      Accepted manuscript online: 2 APR 2013 04:32AM EST | DOI: 10.1002/hep.26435

    2. Pegylated interferon and ribavirin: A therapeutic option in patients who fail to respond to telaprevir-based triple therapy?

      Chia-Yen Dai, Wan-Long Chuang and Ming-Lung Yu

      Accepted manuscript online: 2 APR 2013 04:32AM EST | DOI: 10.1002/hep.26434

  20. Hepatobiliary Malignancies

    1. Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas

      Nicolas Poté, Theodore Alexandrov, Julie Le Faouder, Samira Laouirem, Thibaut Léger, Mouniya Mebarki, Jacques Belghiti, Jean-Michel Camadro, Pierre Bedossa and Valérie Paradis

      Accepted manuscript online: 2 APR 2013 04:31AM EST | DOI: 10.1002/hep.26433

  21. Correspondence

    1. Vitamin D-binding protein gene polymorphisms may contribute to the racial disparity in genotype 1 chronic hepatitis C treatment outcome

      Steven J. Weintraub, Jaquelyn F. Fleckenstein, Tony N. Marion and Margaret A. Madey

      Accepted manuscript online: 2 APR 2013 04:31AM EST | DOI: 10.1002/hep.26432

  22. Viral Hepatitis

    1. An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

      Alexander W. Tarr, Pierre Lafaye, Luke Meredith, Laurence Damier-Piolle, Richard A. Urbanowicz, Annalisa Meola, Jean-Luc Jestin, Richard J.P. Brown, Jane A. McKeating, Felix A. Rey, Jonathan K. Ball and Thomas Krey

      Accepted manuscript online: 28 MAR 2013 08:05AM EST | DOI: 10.1002/hep.26430

  23. Liver Biology/Pathobiology

    1. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells

      Jean-Philippe Pradere, Johannes Kluwe, Samuele De Minicis, Jing-Jing Jiao, Geum-Youn Gwak, Dianne H. Dapito, Myoung-Kuk Jang, Nina D. Guenther, Ingmar Mederacke, Richard Friedman, Ana-Cristina Dragomir, Costica Aloman and Robert F. Schwabe

      Accepted manuscript online: 28 MAR 2013 08:05AM EST | DOI: 10.1002/hep.26429

  24. Viral Hepatitis

    1. HCV treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals

      Natasha K Martin, Peter Vickerman, Jason Grebely, Margaret Hellard, Sharon J Hutchinson, Viviane D Lima, Graham R Foster, John F Dillon, David J Goldberg, Gregory J Dore and Matthew Hickman

      Accepted manuscript online: 28 MAR 2013 08:03AM EST | DOI: 10.1002/hep.26431

  25. Liver Biology/Pathobiology

    1. Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis

      Tiangang Li, Jessica M. Francl, Shannon Boehme and John Y. L. Chiang

      Accepted manuscript online: 27 MAR 2013 11:11AM EST | DOI: 10.1002/hep.26427

  26. Viral Hepatitis

    1. Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca fascicularis from Mauritius Island

      Tatiana Dupinay, Tarik Gheit, Pierre Roques, Lucyna Cova, Philippe Chevallier-Queyron, Shin-i Tasahsu, Roger Le Grand, François Simon, Geneviève Cordier, Lahcen Wakrim, Soumaya Benjelloun, Christian Trépo and Isabelle Chemin

      Accepted manuscript online: 27 MAR 2013 11:01AM EST | DOI: 10.1002/hep.26428

  27. Liver Biology/Pathobiology

    1. Prospective multi-center clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

      Carlos Benítez, María-Carlota Londoño, Rosa Miquel, Tommaso-Maria Manzia, Juan G. Abraldes, Juan-José Lozano, Marc Martínez-Llordella, Marta López, Roberta Angelico, Felix Bohne, Pilar Sese, Frederic Daoud, Patrick Larcier, Dave L. Roelen, Frans Claas, Gavin Whitehouse, Jan Lerut, Jacques Pirenne, Antoni Rimola, Giuseppe Tisone and Alberto Sánchez-Fueyo

      Accepted manuscript online: 26 MAR 2013 12:21PM EST | DOI: 10.1002/hep.26426

    2. The expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib

      Elisa Herraez, Elisa Lozano, Rocio I.R. Macias, Javier Vaquero, Luis Bujanda, Jesus M. Banales, Jose J.G. Marin and Oscar Briz

      Accepted manuscript online: 26 MAR 2013 12:21PM EST | DOI: 10.1002/hep.26425

  28. Autoimmune, Cholestatic and Biliary Disease

    1. Genotype–phenotype relationships in the low-phospholipid associated cholelithiasis syndrome. A study of 156 consecutive patients

      Raoul Poupon, Olivier Rosmorduc, Pierre Yves Boëlle, Yves Chrétien, Christophe Corpechot, Olivier Chazouillères, Chantal Housset and Véronique Barbu

      Accepted manuscript online: 26 MAR 2013 12:21PM EST | DOI: 10.1002/hep.26424

  29. Hepatology Elsewhere

    1. To binge or not to binge: Binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling

      Carmen Garcia-Ruiz and José C. Fernandez-Checa

      Accepted manuscript online: 26 MAR 2013 12:20PM EST | DOI: 10.1002/hep.26423

  30. Liver Biology and Pathobiology

    1. MiR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells

      Luc Gailhouste, Laura Gomez-Santos, Keitaro Hagiwara, Izuho Hatada, Noriyuki Kitagawa, Kazushi Kawaharada, Muriel Thirion, Nobuyoshi Kosaka, Ryou-u Takahashi, Tatsuhiro Shibata, Atsushi Miyajima and Takahiro Ochiya

      Accepted manuscript online: 26 MAR 2013 12:20PM EST | DOI: 10.1002/hep.26422

  31. Viral Hepatitis

    1. Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin

      Kyoko Mori, Osamu Hiraoka, Masanori Ikeda, Yasuo Ariumi, Akiko Hiramoto, Yusuke Wataya and Nobuyuki Kato

      Accepted manuscript online: 26 MAR 2013 12:20PM EST | DOI: 10.1002/hep.26421

  32. Hepatobiliary Malignancies

    1. Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

      Jiayi Wang, Lifang Ma, Wenhao Weng, Yongxia Qiao, Yue Zhang, Jiangtu He, Hongmei Wang, Weifan Xiao, Lanlan Li, Qinghua Chu, Qiuhui Pan, Yongchun Yu and Fenyong Sun

      Accepted manuscript online: 26 MAR 2013 12:19PM EST | DOI: 10.1002/hep.26420

  33. Liver Biology and Pathobiology

    1. Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury: A critical role for E-selectin

      Adeline Bertola, Ogyi Park and Bin Gao

      Accepted manuscript online: 26 MAR 2013 12:19PM EST | DOI: 10.1002/hep.26419

  34. Autoimmune, Cholestatic and Biliary Disease

    1. Clonality, activated antigen specific CD8+ T cells and development of autoimmune cholangitis in dnTGFβRII mice

      Kazuhito Kawata, Guo-Xiang Yang, Yugo Ando, Hajime Tanaka, Weici Zhang, Yoshimasa Kobayashi, Koichi Tsuneyama, Patrick S.C. Leung, Zhe-Xiong Lian, William M. Ridgway, Aftab A. Ansari, Xiao-Song He and M. Eric Gershwin

      Accepted manuscript online: 26 MAR 2013 12:18PM EST | DOI: 10.1002/hep.26418

  35. Correspondence

    1. Reduction of cirrhosis and hepatocellular carcinoma with antiviral therapy in chronic hepatitis B

      Ching-Lung Lai and Man-Fung Yuen

      Accepted manuscript online: 26 MAR 2013 12:18PM EST | DOI: 10.1002/hep.26417

  36. Liver Failure, Cirrhosis and Portal Hypertension

    1. Smart applications for assessing minimal hepatic encephalopathy: Novelty from the App revolution

      Piero Amodio and Juan Cordoba

      Accepted manuscript online: 26 MAR 2013 12:18PM EST | DOI: 10.1002/hep.26416

  37. Viral Hepatitis

    1. Synergism of tapasin and HLA in resolving HCV infection

      Shirin Ashraf, Katja Nitschke, Usama M Warshow, Collin R Brooks, Arthur Y Kim, Georg M Lauer, Theresa J Hydes, Matthew E Cramp, Graeme Alexander, Ann-Margaret Little, Robert Thimme, Christoph Neumann-Haefelin and Salim I Khakoo

      Accepted manuscript online: 26 MAR 2013 12:18PM EST | DOI: 10.1002/hep.26415

  38. Liver Biology and Pathobiology

    1. Proteome-wide analyses of human hepatocytes during differentiation and de-differentiation

      Cliff Rowe, Dave T. Gerrard, Roz Jenkins, Andrew Berry, Kesta Durkin, Lars Sundstrom, Chris E. Goldring, B. Kevin Park, Neil R. Kitteringham, Karen Piper Hanley and Neil A. Hanley

      Accepted manuscript online: 23 MAR 2013 03:19AM EST | DOI: 10.1002/hep.26414

  39. Viral Hepatitis

    1. SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients

      Jens U. Marquardt, Kerstin Fischer, Katharina Baus, Anubha Kashyap, Shengyun Ma, Markus Krupp, Matthias Linke, Andreas Teufel, Ulrich Zechner, Dennis Strand, Snorri S. Thorgeirsson, Peter R. Galle and Susanne Strand

      Accepted manuscript online: 23 MAR 2013 03:19AM EST | DOI: 10.1002/hep.26413

  40. Liver Injury and Regeneration

    1. The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis

      Laura Elisa Buitrago-Molina, Silke Marhenke, Thomas Longerich, Amar Deep Sharma, Aristeidis E. Boukouris, Robert Geffers, Bruno Guigas, Michael P. Manns and Arndt Vogel

      Accepted manuscript online: 23 MAR 2013 03:19AM EST | DOI: 10.1002/hep.26412

  41. Correspondence

    1. On the role of Notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development

      Matthias Evert, Frank Dombrowski, Fan Biao, Silvia Ribback, Xin Chen and Diego F. Calvisi

      Accepted manuscript online: 23 MAR 2013 03:19AM EST | DOI: 10.1002/hep.26411

    2. “On the role of Notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development”, by Evert et al.

      Petia Jeliazkova, Simone Jörs, Jens T. Siveke and Fabian Geisler

      Accepted manuscript online: 23 MAR 2013 03:19AM EST | DOI: 10.1002/hep.26410

  42. Hepatobiliary Malignancies

    1. Biliary atresia in sea lampreys. What can it tell us about the disorder in human infants?

      Frederick J. Suchy

      Accepted manuscript online: 23 MAR 2013 03:18AM EST | DOI: 10.1002/hep.26409

    2. Inflammation induced hepatocellular carcinoma is dependent on CCR5

      Neta Barashi, Ido D. Weiss, Ori Wald, Hanna Wald, Katia Beider, Michal Abraham, Shiri Klein, Daniel Goldenberg, Jonathan Axelrod, Eli Pikarsky, Rinat Abramovitch, Evelyne Zeira, Eithan Galun and Amnon Peled

      Accepted manuscript online: 21 MAR 2013 07:26PM EST | DOI: 10.1002/hep.26403

  43. Viral Hepatitis

    1. EGFR signaling impairs the antiviral activity of interferon-alpha

      Joachim Lupberger, François H. T. Duong, Isabel Fofana, Laetitia Zona, Fei Xiao, Christine Thumann, Sarah C. Durand, Patrick Pessaux, Mirjam B. Zeisel, Markus H. Heim and Thomas F. Baumert

      Accepted manuscript online: 20 MAR 2013 04:14PM EST | DOI: 10.1002/hep.26404

  44. Steatohepatitis and Metabolic Liver Disease

    1. From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell (DC) populations in the liver

      Frank Tacke and Hiroyuki Yoneyama

      Accepted manuscript online: 20 MAR 2013 04:14PM EST | DOI: 10.1002/hep.26405

  45. Correspondence

    1. Influence of the transjugular intrahepatic portosystemic stent on firstline treatment of hepatocellular carcinoma

      Eva Knüppel, Dominik Bettinger, Wulf Euringer, Robert Thimme, Martin Roessle, Hans Christian Spangenberg and Michael Schultheiß

      Accepted manuscript online: 20 MAR 2013 04:14PM EST | DOI: 10.1002/hep.26406

    2. Genomic profiling of cell lines for personalized targeted therapy for hepatocellular carcinoma

      Manjeet Deshmukh and Yujin Hoshida

      Accepted manuscript online: 20 MAR 2013 04:14PM EST | DOI: 10.1002/hep.26407

    3. Letter to the editor: Genetic basis of gall stone disease

      Saumya Pandey

      Accepted manuscript online: 20 MAR 2013 04:14PM EST | DOI: 10.1002/hep.26408

  46. Hepatobiliary Malignancies

    1. Yttrium 90 radioembolization for the treatment of hepatocellular carcinoma: Biological lessons, current challenges and clinical perspectives

      Riad Salem, Vincenzo Mazzaferro and Bruno Sangro

      Accepted manuscript online: 19 MAR 2013 08:19AM EST | DOI: 10.1002/hep.26382

  47. Liver Biology/Pathobiology

    1. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice

      Chia-Yu Wang and Mitchell D. Knutson

      Accepted manuscript online: 19 MAR 2013 12:43AM EST | DOI: 10.1002/hep.26401

  48. Liver Biology and Pathobiology

    1. Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma

      Kai Wang, Ho Yeong Lim, Stephanie Shi, Jeeyun Lee, Shibing Deng, Tao Xie, Zhou Zhu, Yuli Wang, David Pocalyko, Wei Jennifer Yang, Paul A. Rejto, Mao Mao, Cheol-Keun Park and Jiangchun Xu

      Accepted manuscript online: 18 MAR 2013 04:05AM EST | DOI: 10.1002/hep.26402

  49. Viral Hepatitis

    1. Prevalence and predictors of hepatitis B virus co-infection in a united states cohort of hepatitis C virus-infected patients

      Gia L. Tyson, Jennifer R. Kramer, Zhigang Duan, Jessica A. Davila, Peter A. Richardson and Hashem B. El-Serag

      Accepted manuscript online: 16 MAR 2013 02:17AM EST | DOI: 10.1002/hep.26400

  50. Steatohepatitis and Metabolic Liver Disease

    1. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

      Maite Martínez-Uña, Marta Varela-Rey, Ainara Cano, Larraitz Fernández-Ares, Naiara Beraza, Igor Aurrekoetxea, Ibon Martínez-Arranz, Juan L García-Rodríguez, Xabier Buqué, Daniela Mestre, Zigmund Luka, Conrad Wagner, Cristina Alonso, Richard H Finnell, Shelly C Lu, M Luz Martínez-Chantar, Patricia Aspichueta and José M Mato

      Accepted manuscript online: 16 MAR 2013 02:17AM EST | DOI: 10.1002/hep.26399

  51. Hepatobiliary Malignancies

    1. PROX1 promotes hepatocellular carcinoma metastasis via up-regulating hypoxia-inducible factor 1a expression and protein stability

      Yanfeng Liu, Ju-Bo Zhang, Yi Qin, Wei Wang, Lili Wei, Yigang Teng, Lei Guo, Bo Zhang, Zhenhai Lin, Jing Liu, Zheng-Gang Ren, Qing-Hai Ye and Youhua Xie

      Accepted manuscript online: 16 MAR 2013 02:16AM EST | DOI: 10.1002/hep.26398

  52. Correspondence

    1. The proprotein convertase PC7 sheds the human TfR1 independent of HFE

      Johann Guillemot and Nabil G. Seidah

      Accepted manuscript online: 16 MAR 2013 02:16AM EST | DOI: 10.1002/hep.26397

  53. Hepatobiliary Malignancies

    1. Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion

      Lui Ng, Ronnie Tung-Ping Poon, Simon Yau, Ariel Chow, Colin Lam, Hung-Sing Li, Thomas Chung-Cheung Yau, Wai-Lun Law and Roberta Pang

      Accepted manuscript online: 16 MAR 2013 02:16AM EST | DOI: 10.1002/hep.26396

  54. Liver Injury and Regeneration

    1. Rage is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice

      Tobias Pusterla, Julia Németh, Ilan Stein, Lars Wiechert, David Knigin, Silke Marhenke, Thomas Longerich, Varun Kumar, Bernd Arnold, Arndt Vogel, Angelika Bierhaus, Eli Pikarsky, Jochen Hess and Peter Angel

      Accepted manuscript online: 16 MAR 2013 02:15AM EST | DOI: 10.1002/hep.26395

  55. Hepatobiliary Malignancies

    1. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells

      Ying Wang, Chang Han, Lu Lu, Susan Magliato and Tong Wu

      Accepted manuscript online: 16 MAR 2013 02:15AM EST | DOI: 10.1002/hep.26394

  56. Steatohepatitis and Metabolic Liver Disease

    1. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with NAFLD (The RAED2 randomized trial)

      Elisabetta Bacchi, Carlo Negri, Giovanni Targher, Niccolò Faccioli, Massimo Lanza, Giacomo Zoppini, Elisabetta Zanolin, Federico Schena, Enzo Bonora and Paolo Moghetti

      Accepted manuscript online: 16 MAR 2013 02:15AM EST | DOI: 10.1002/hep.26393

  57. Correspondence

    1. Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis

      Christine Schwienbacher, Alice Serafin, Alessandra Zanon, Peter P. Pramstaller, Irene Pichler and Andrew A. Hicks

      Accepted manuscript online: 16 MAR 2013 02:14AM EST | DOI: 10.1002/hep.26392

  58. Hepatobiliary Malignancies

    1. Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression

      Yu-fei Pan, Ye-xiong Tan, Min Wang, Jian Zhang, Bo Zhang, Chun Yang, Zhi-wen Ding, Li-wei Dong and Hong-yang Wang

      Accepted manuscript online: 16 MAR 2013 02:14AM EST | DOI: 10.1002/hep.26391

  59. Steatohepatitis and Metabolic Liver Disease

    1. Vitamin D and NAFLD: Is it more than just an association?

      Ryan M. Kwok, Dawn M. Torres and Stephen A. Harrison

      Accepted manuscript online: 16 MAR 2013 02:13AM EST | DOI: 10.1002/hep.26390

  60. Viral Hepatitis

    1. The incidence and prevalence of hepatitis C in prisons and other closed settings: Results of a systematic review and meta-analysis

      Sarah Larney, Hannah Kopinski, Curt G. Beckwith, Nickolas D. Zaller, Don Des Jarlais, Holly Hagan, Josiah D. Rich, Brenda J. van den Bergh and Louisa Degenhardt

      Accepted manuscript online: 15 MAR 2013 07:49AM EST | DOI: 10.1002/hep.26387

    2. Prediction models of long-term cirrhosis and HCC risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles

      Mei-Hsuan Lee, Hwai-I Yang, Jessica Liu, Richard Batrla-Utermann, Chin-Lan Jen, Uchenna H. Iloeje, Sheng-Nan Lu, San-Lin You, Li-Yu Wang and Chien-Jen Chen, for the R.E.V.E.A.L.-HBV Study Group

      Accepted manuscript online: 15 MAR 2013 07:49AM EST | DOI: 10.1002/hep.26385

  61. Hepatobiliary Malignancies

    1. Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

      Massimiliano Cadamuro, Giorgia Nardo, Stefano Indraccolo, Luigi Dall'Olmo, Luisa Sambado, Lidia Moserle, Irene Franceschet, Michele Colledan, Marco Massani, Tommaso Stecca, Nicolò Bassi, Stuart Morton, Carlo Spirli, Romina Fiorotto, Luca Fabris and Mario Strazzabosco

      Accepted manuscript online: 15 MAR 2013 07:49AM EST | DOI: 10.1002/hep.26384

  62. Viral Hepatitis

    1. Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing

      Christophe Rodriguez, Stéphane Chevaliez, Paul Bensadoun and Jean-Michel Pawlotsky

      Accepted manuscript online: 15 MAR 2013 07:49AM EST | DOI: 10.1002/hep.26383

    2. Faldaprevir combined with peginterferon Alfa-2a and ribavirin in chronic HCV genotype-1 patients with prior nonresponse: SILEN-C2 trial

      Mark S. Sulkowski, Marc Bourlière, Jean-Pierre Bronowicki, Tarik Asselah, Jean-Michel Pawlotsky, Stephen D. Shafran, Stanislas Pol, Stefan Mauss, Dominique Larrey, Yakov Datsenko, Jerry O. Stern, George Kukolj, Joseph Scherer, Gerhard Nehmiz, Gerhard G. Steinmann and Wulf O. Böcher

      Accepted manuscript online: 15 MAR 2013 07:47AM EST | DOI: 10.1002/hep.26386

    3. Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir

      Fiona McPhee, Dennis Hernandez, Fei Yu, Joseph Ueland, Aaron Monikowski, Arlene Carifa, Paul Falk, Chunfu Wang, Robert Fridell, Timothy Eley, Nannan Zhou and David Gardiner

      Accepted manuscript online: 15 MAR 2013 07:47AM EST | DOI: 10.1002/hep.26388

  63. Steatohepatitis and Metabolic Liver Disease

    1. Furthering the understanding of maternal obesity in NAFLD

      Miriam B. Vos

      Accepted manuscript online: 15 MAR 2013 07:47AM EST | DOI: 10.1002/hep.26389

  64. Hepatobiliary Malignancies

    1. Genome-wide screening revealed that miR-195 targets the TNF-α/NF-κB pathway by downregulating IKKα and TAB3 in hepatocellular carcinoma

      Jie Ding, Shenglin Huang, Ying Wang, Qi Tian, Ruopeng Zha, Haibing Shi, Qifeng Wang, Chao Ge, Taoyang Chen, Yingjun Zhao, Linhui Liang, Jinjun Li and Xianghuo He

      Accepted manuscript online: 11 MAR 2013 09:50AM EST | DOI: 10.1002/hep.26378

  65. Liver Injury and Regeneration

    1. LncRNA-LALR1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-Catenin signaling

      Dan Xu, Fu Yang, Ji-hang Yuan, Ling Zhang, Hai-shan Bi, Chuan-chuan Zhou, Feng Liu, Fang Wang and Shu-han Sun

      Accepted manuscript online: 11 MAR 2013 09:50AM EST | DOI: 10.1002/hep.26361

    2. Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator

      Eun-Sook Park, Yong Kwang Park, ChanYoung Shin, Seung Hwa Park, Sung Hyun Ahn, Doo Hyun Kim, Keo-Heun Lim, So Young Kwon, Kwang Pyo Kim, Sung-Il Yang, Baik L. Seong and Kyun-Hwan Kim

      Accepted manuscript online: 8 MAR 2013 02:26PM EST | DOI: 10.1002/hep.26379

  66. Steatohepatitis and Metabolic Liver Disease

    1. Another armed CD4+ T cell ready to battle hepatocellular carcinoma (HCC)

      Cabrera Roniel and Szabo Gyongyi

      Accepted manuscript online: 8 MAR 2013 11:28AM EST | DOI: 10.1002/hep.26377

  67. Autoimmune, Cholestatic and Biliary Disease

    1. Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells

      Matthias Hardtke-Wolenski, Katja Fischer, Fatih Noyan, Jerome Schlue, Christine S. Falk, Maike Stahlhut, Norman Woller, Florian Kuehnel, Richard Taubert, Michael. P. Manns and Elmar Jaeckel

      Accepted manuscript online: 8 MAR 2013 11:28AM EST | DOI: 10.1002/hep.26380

  68. Liver Failure, Cirrhosis and Portal Hypertension

    1. The nutritional management of hepatic encephalopathy in patients with cirrhosis: Ishen consensus

      Piero Amodio, Chantal Bemeur, Roger Butterworth, Juan Cordoba, Akinobu Kato, Sara Montagnese, Misael Uribe, Hendrik Vilstrup and Marsha Y. Morgan

      Accepted manuscript online: 7 MAR 2013 12:06PM EST | DOI: 10.1002/hep.26370

  69. Hepatobiliary Malignancies

    1. MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

      Hongping Xia, London Lucien P.J. Ooi and Kam M. Hui

      Accepted manuscript online: 7 MAR 2013 12:05PM EST | DOI: 10.1002/hep.26369

  70. Steatohepatitis and Metabolic Liver Disease

    1. Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

      Xin-An Wang, Ran Zhang, Dingsheng Jiang, Wei Deng, Shumin Zhang, Shan Deng, Jinfeng Zhong, Tao Wang, Li-Hua Zhu, Li Yang, Shufen Hong, Sen Guo, Ke Chen, Xiao-Fei Zhang, Zhigang She, Yingjie Chen, Qinglin Yang, Xiao-Dong Zhang and Hongliang Li

      Accepted manuscript online: 7 MAR 2013 12:05PM EST | DOI: 10.1002/hep.26368

  71. Correspondence

    1. Hepatopulmonary syndrome and liver transplantation: Who, when and where?

      Rajasekhar Tanikella and Michael. B. Fallon

      Accepted manuscript online: 7 MAR 2013 12:05PM EST | DOI: 10.1002/hep.26367

  72. Viral Hepatitis

    1. Therapy for LAL deficiency: Replacing a missing link

      Grabowski Gregory

      Accepted manuscript online: 7 MAR 2013 12:05PM EST | DOI: 10.1002/hep.26366

  73. Autoimmune, Cholestatic and Biliary Disease

    1. The impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study

      George Mells, Greta Pells, Julia L Newton, Andrew Bathgate, Andrew Burroughs, Michael Heneghan, James Neuberger, Darren Day, Samantha J Ducker, The UK-PBC Consortiumsup data, Richard Sandford, Graeme Alexander and David EJ Jones

      Accepted manuscript online: 7 MAR 2013 12:04PM EST | DOI: 10.1002/hep.26365

  74. Correspondence

    1. Rifaximin is an efficacious treatment for the parkinsonian phenotype of hepatic encephalopathy

      Beverley Kok, Matthew R Foxton, Christopher Clough and Debbie L Shawcross

      Accepted manuscript online: 7 MAR 2013 12:04PM EST | DOI: 10.1002/hep.26364

    2. Concordance between SVR12and SVR24 in genotype 1 HCV patients receiving interferon-free treatment inthe SOUND-C2 study

      Stefan Zeuzem and Federico J Mensa

      Accepted manuscript online: 7 MAR 2013 12:03PM EST | DOI: 10.1002/hep.26363

  75. Hepatology Elsewhere

    1. Hepatitis C virus 1b viral factors (Core, NS3 and NS5A( and increased risk of hepatocellular carcinoma

      Suresh D. Sharma

      Accepted manuscript online: 7 MAR 2013 12:03PM EST | DOI: 10.1002/hep.26362

  76. Viral Hepatitis

    1. New horizons in Hepatitis C antiviral therapy with direct-acting antivirals

      Alessio Aghemo and Raffaele De Francesco

      Accepted manuscript online: 6 MAR 2013 05:22PM EST | DOI: 10.1002/hep.26371

  77. Liver Injury and Regeneration

    1. An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: Implications for hemostasis and clinical outcome

      Greg C.G. Hugenholtz, Jelle Adelmeijer, Joost C.M. Meijers, Robert J. Porte, R. Todd Stravitz and Ton Lisman

      Accepted manuscript online: 6 MAR 2013 05:22PM EST | DOI: 10.1002/hep.26372

  78. Hepatobiliary Malignancies

    1. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42

      Ruizhi Wang, Na Zhao, Siwen Li, Jian-Hong Fang, Mei-Xian Chen, Jine Yang, Wei-Hua Jia, Yunfei Yuan and Shi-Mei Zhuang

      Accepted manuscript online: 6 MAR 2013 05:22PM EST | DOI: 10.1002/hep.26373

  79. Viral Hepatitis

    1. High incidence of treatment-induced and vaccine-escape hepatitis B virus mutants among HIV-hepatitis B infected patients

      Karine Lacombe, Anders Boyd, Fabien Lavocat, Christian Pichoud, Joel Gozlan, Patrick Miailhes, Caroline Lascoux-Combe, Guy Vernet, Pierre-Marie Girard and Fabien Zoulim

      Accepted manuscript online: 6 MAR 2013 05:22PM EST | DOI: 10.1002/hep.26374

    2. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy

      Wai-Kay Seto, Danny Ka-Ho Wong, James Fung, Fung-Yu Huang, Ching-Lung Lai and Man-Fung Yuen

      Accepted manuscript online: 6 MAR 2013 05:22PM EST | DOI: 10.1002/hep.26376

  80. Correspondence

    1. Correspondence to 11-1370.R2

      Eun Sung Park and Ju-Seog Lee

      Accepted manuscript online: 5 MAR 2013 01:34PM EST | DOI: 10.1002/hep.26347

  81. Viral Hepatitis

    1. Innate immune responses in hepatitis C virus exposed healthcare workers who do not develop acute infection

      Jens Martin Werner, Theo Heller, Ann Marie Gordon, Arlene Sheets, Averell H. Sherker, Ellen Kessler, Kathleen S. Bean, M'Lou Stevens, James Schmitt and Barbara Rehermann

      Accepted manuscript online: 5 MAR 2013 01:34PM EST | DOI: 10.1002/hep.26353

  82. Correspondence

    1. Reduction of cirrhosis and hepatocellular carcinoma with antiviral therapy in chronic hepatitis B

      Yun-Fan Liaw

      Accepted manuscript online: 5 MAR 2013 01:34PM EST | DOI: 10.1002/hep.26358

  83. Liver Failure, Cirrhosis and Portal Hypertension

    1. C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

      Po-sung Chu, Nobuhiro Nakamoto, Hirotoshi Ebinuma, Shingo Usui, Keita Saeki, Atsuhiro Matsumoto, Yohei Mikami, Kazuo Sugiyama, Kengo Tomita, Takanori Kanai, Hidetsugu Saito and Toshifumi Hibi

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26351

  84. Public Policy Corner

    1. Potential consequences of healthcare recommendations: A focus on the USPSTF

      Rohit Satoskar and Nancy Reau

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26349

  85. Correspondence

    1. Connectivity-based risk score for hepatocellular carcinoma prognosis

      Wei Liu and Hua Ye

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26348

  86. Liver Injury and Regeneration

    1. Cellular specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury

      Gary W Nace, Hai Huang, John R Klune, Raymond E Eid, Brian R Rosborough, Sebastian Korff, Shen Li, Richard A Shapiro, Donna B Stolz, Chhinder P Sodhi, David J Hackam, David A Geller, Timothy R Billiar and Allan Tsung

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26346

  87. Liver Biology and Pathobiology

    1. Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma

      Yi-Wei Wang, Kuen-Tyng Lin, Shu-Chuan Chen, De-Leung Gu, Chian-Feng Chen, Pang-Hsien Tu and Yuh-Shan Jou

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26352

  88. Correspondence

    1. Reply to correspondence (HEP-13-0172)

      Zaixing Yang, Yan Liang and Renqian Zhong

      Accepted manuscript online: 4 MAR 2013 12:25PM EST | DOI: 10.1002/hep.26354

  89. Autoimmune, Cholestatic and Biliary Disease

    1. Risk factors associated to hepatocellular carcinoma in primary biliary cirrhosis

      Annarosa Floreani and Fabio Farinati

      Accepted manuscript online: 4 MAR 2013 12:24PM EST | DOI: 10.1002/hep.26355

  90. Comments from the Editors

    1. Connecting the dots from fatty acids to NASH – epigenetics in the spotlight

      Florin M. Selaru and Frank A. Anania

      Accepted manuscript online: 4 MAR 2013 12:24PM EST | DOI: 10.1002/hep.26357

  91. Liver Failure, Cirrhosis and Portal Hypertension

    1. Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure

      Annika Mutanen, Jouko Lohi, Päivi Heikkilä, Antti I Koivusalo, Risto J Rintala and Mikko P Pakarinen

      Accepted manuscript online: 4 MAR 2013 12:24PM EST | DOI: 10.1002/hep.26360

  92. Hepatobiliary Malignancies

    1. Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication

      Shunsuke Muramatsu, Shinji Tanaka, Kaoru Mogushi, Rama Adikrisna, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Takumi Irie, Atsushi Kudo, Noriaki Nakamura, Koh Nakayama, Hiroshi Tanaka, Shoji Yamaoka and Shigeki Arii

      Accepted manuscript online: 27 FEB 2013 03:03PM EST | DOI: 10.1002/hep.26345

  93. Clinical Observations in Hepatology

    1. Cholestasis in a patient with gallstones and a normal gamma-glutamyl transferase

      Sheida Moghadamrad, Matteo Montani, Rosemarie Weimann and Andrea De Gottardi

      Accepted manuscript online: 27 FEB 2013 09:13AM EST | DOI: 10.1002/hep.26344

  94. Viral Hepatitis

    1. Liver stiffness is influenced by a standardized meal in patients with chronic hcv hepatitis at different stages of fibrotic evolution

      Umberto Arena, Monica Lupsor Platon, Cristina Stasi, Stefania Moscarella, Alì Assarat, Giorgio Bedogni, Valeria Piazzolla, Radu Badea, Giacomo Laffi, Fabio Marra, Alessandra Mangia and Massimo Pinzani

      Accepted manuscript online: 27 FEB 2013 09:13AM EST | DOI: 10.1002/hep.26343

  95. Steatohepatitis and Metabolic Liver Disease

    1. Desmosterol in human nonalcoholic steatohepatitis

      Marko Simonen, Ville Männistö, Joel Leppänen, Dorota Kaminska, Vesa Kärjä, Sari Venesmaa, Pirjo Käkelä, Johanna Kuusisto, Helena Gylling, Markku Laakso and Pihlajamäki

      Accepted manuscript online: 27 FEB 2013 09:13AM EST | DOI: 10.1002/hep.26342

  96. Viral Hepatitis

    1. Adiponectin, bile acids and burnt out NASH - new light on an old paradox

      Thierry Claudel and Michael Trauner

      Accepted manuscript online: 27 FEB 2013 09:13AM EST | DOI: 10.1002/hep.26340

    2. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance

      Peixiang Lan, Cai Zhang, Qiuju Han, Jian Zhang and Zhigang Tian

      Accepted manuscript online: 27 FEB 2013 09:13AM EST | DOI: 10.1002/hep.26339

  97. Liver Failure, Cirrhosis and Portal Hypertension

    1. Alcohol dehydrogenase specific T-cell responses are associated with alcohol consumption in patients with alcohol-related cirrhosis

      Fang Lin, Nicholas J. Taylor, Haibin Su, Xiaohong Huang, Munther J Hussain, Robin Daniel Abeles, Laura Blackmore, Yunyun Zhou, Mohammad Mashfick Ikbal, Nigel Heaton, Wayel Jassem, Debbie L. Shawcross, Diego Vergani and Yun Ma

      Accepted manuscript online: 19 FEB 2013 10:26AM EST | DOI: 10.1002/hep.26334

  98. Viral Hepatitis

    1. The sexual transmission rate of HCV among heterosexual couples

      Bart P.X Grady, Maria Prins and Maarten Schim van der Loeff

      Accepted manuscript online: 19 FEB 2013 10:00AM EST | DOI: 10.1002/hep.26331

  99. Correspondence

    1. Elastin-based molecular MRI of liver fibrosis

      Josef Ehling, Matthias Bartneck, Viktor Fech, Britta Butzbach, Richard Cesati, Rene Botnar, Twan Lammers and Frank Tacke

      Accepted manuscript online: 19 FEB 2013 09:52AM EST | DOI: 10.1002/hep.26326

  100. Hepatobiliary Malignancies

    1. Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis

      Tamara Potikha, Evgeniy Stoyanov, Orit Pappo, Antonina Frolov, Lina Mizrahi, Deborah Olam, Temima Shnitzer-Perlman, Ido Weiss, Neta Barashi, Amnon Peled, Gabriele Sass, Gisa Tiegs, Francoise Poirier, Gabriel A. Rabinovich, Eithan Galun and Daniel Goldenberg

      Accepted manuscript online: 19 FEB 2013 09:52AM EST | DOI: 10.1002/hep.26335

  101. Viral Hepatitis

    1. Correspondence Reply to MS 12-2375

      Norah Terrault, Jennifer Dodge and Miriam Alter

      Accepted manuscript online: 19 FEB 2013 09:52AM EST | DOI: 10.1002/hep.26324

  102. Correspondence

    1. Monitoring elastin changes in the progression of liver fibrosis

      Antonella Pellicoro and John P. Iredale

      Accepted manuscript online: 19 FEB 2013 09:51AM EST | DOI: 10.1002/hep.26332

  103. Hepatobiliary Malignancies

    1. Sorafenib perpetuates cellular anti-cancer effector functions by modulating the cross talk between macrophages and natural killer cells

      Martin Franz Sprinzl, Florian Reisinger, Andreas Puschnik, Marc Ringelhan, Kerstin Ackermann, Daniel Hartmann, Matthias Schiemann, Arndt Weinmann, Peter Robert Galle, Marcus Schuchmann, Helmut Friess, Gerd Otto, Mathias Heikenwalder and Ulrike Protzer

      Accepted manuscript online: 19 FEB 2013 09:51AM EST | DOI: 10.1002/hep.26328

  104. Viral Hepatitis

    1. Combination nucleos(t)ide analogue as initial treatmentfor chronic hepatitis B: Have we put this to rest?

      Anna Suk-Fong Lok

      Accepted manuscript online: 19 FEB 2013 09:51AM EST | DOI: 10.1002/hep.26337

  105. Correspondence

    1. Sexual transmission of HCV among monogamous heterosexual couples: Be careful with reassuring counseling messages

      Philippe Halfon

      Accepted manuscript online: 19 FEB 2013 08:18AM EST | DOI: 10.1002/hep.26325

  106. Steatohepatitis and Metabolic Liver Disease

    1. Frequency of the Cholesteryl ester storage disease common LIPA E8SJM mutation (c.894g>a) in various racial and ethnic groups

      Stuart A. Scott, Benny Liu, Irina Nazarenko, Suparna Martis, Julia Kozlitina, Yao Yang, Charina Ramirez, Yumi Kasai, Tommy Hyatt, Inga Peter and Robert J. Desnick

      Accepted manuscript online: 19 FEB 2013 08:17AM EST | DOI: 10.1002/hep.26327

    2. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

      Phillipp Hartmann, Peng Chen, Hui J. Wang, Lirui Wang, Declan F. McCole, Katharina Brandl, Peter Stärkel, Clara Belzer, Claus Hellerbrand, Hidekazu Tsukamoto, Samuel B. Ho and Bernd Schnabl

      Accepted manuscript online: 13 FEB 2013 09:01AM EST | DOI: 10.1002/hep.26321

  107. Autoimmune, Cholestatic and Biliary Disease

    1. Early biochemical response to ursodeoxycholic acid and long-term prognosis of primary biliary cirrhosis: Results of a 14-year cohort study

      Li-Na Zhang, Tian-Yan Shi, Xu-Hua Shi, Li Wang, Yun-Jiao Yang, Bin Liu, Li-Xia Gao, Zong-Wen Shuai, Fang Kong, Hua Chen, Wei Han, Shao-Mei Han, Yun-Yun Fei, Quan-Cai Cui, Qian Wang, Min Shen, Dong Xu, Wen-Jie Zheng, Yong-Zhe Li, Wen Zhang, Xuan Zhang and Feng-Chun Zhang

      Accepted manuscript online: 13 FEB 2013 09:01AM EST | DOI: 10.1002/hep.26322

  108. Viral Hepatitis

    1. Does hepatitis B treatment reduce the incidence of hepatocellular carcinoma?

      Morris Sherman

      Accepted manuscript online: 11 FEB 2013 04:41AM EST | DOI: 10.1002/hep.26317

  109. Liver Injury and Regeneration

    1. You have full text access to this OnlineOpen article
      Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

      Daniel J Antoine, James W Dear, Philip Starkey-Lewis, Vivien Platt, Judy Coyle, Moyra Masson, Ruben H Thanacoody, Alasdair J Gray, David J Webb, Jonathan G Moggs, D. Nicholas Bateman, Christopher E Goldring and B. Kevin Park

      Accepted manuscript online: 6 FEB 2013 07:09PM EST | DOI: 10.1002/hep.26294

    2. Avoiding idiosyncratic DILI: Two is better than one

      Neil Kaplowitz

      Accepted manuscript online: 6 FEB 2013 07:09PM EST | DOI: 10.1002/hep.26295

  110. Viral Hepatitis

    1. Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression

      Shubham Shrivastava, Jessica Petrone, Robert Steele, Georg M. Lauer, Adrian M. Di Bisceglie and Ratna B. Ray

      Accepted manuscript online: 6 FEB 2013 07:09PM EST | DOI: 10.1002/hep.26296

  111. Hepatobiliary Malignancies

    1. A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis

      Han Han, Dan Sun, Wenjuan Li, Hongxing Shen, Yahui Zhu, Chen Li, Yuxing Chen, Longfeng Lu, Wenhua Li, Jinxiang Zhang, Yuan Tian and Youjun Li

      Accepted manuscript online: 6 FEB 2013 07:08PM EST | DOI: 10.1002/hep.26302

  112. Viral Hepatitis

    1. The impact of timing and prioritisation on the cost-effectiveness of birth-cohort testing and treatment for hepatitis C virus in the U.S

      Phil McEwan, Thomas Ward, Yong Yuan, Ray Kim and Gilbert L'Italien

      Accepted manuscript online: 6 FEB 2013 07:08PM EST | DOI: 10.1002/hep.26304

  113. Hepatobiliary Malignancies

    1. MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting IL-6-Stat3 pathway

      Xin Yang, Lei Liang, Xiao-Fei Zhang, Hu-Liang Jia, Yi Qin, Xu-Chao Zhu, Xiao-Mei Gao, Peng Qiao, Yan Zheng, Yuan-Yuan Sheng, Jin-Wang Wei, Hai-Jun Zhou, Ning Ren, Qing-Hai Ye, Qiong-Zhu Dong and Lun-Xiu Qin

      Accepted manuscript online: 6 FEB 2013 07:08PM EST | DOI: 10.1002/hep.26305

  114. Viral Hepatitis

    1. Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis

      Grace Lai-Hung Wong, Henry Lik-Yuen Chan, ChristyWing-Hin Mak, Stanley King-Yeung Lee, Zoe Man-Yi Ip, Andrew Ting-Ho Lam, Henry Wing-Hang Iu, Joyce May-Sum Leung, Jennifer Wing-Yan Lai, Angeline Oi-Shan Lo, Hoi-Yun Chan and Vincent Wai-Sun Wong

      Accepted manuscript online: 6 FEB 2013 12:16PM EST | DOI: 10.1002/hep.26301

  115. Liver Failure, Cirrhosis and Portal Hypertension

    1. The stroop smartphone APP is a short and valid method toscreen for minimal hepatic encephalopathy

      Jasmohan S Bajaj, Leroy R Thacker, Douglas M Heuman, Michael Fuchs, Richard K Sterling, Arun J Sanyal, Puneet Puri, Mohammad S Siddiqui, Richard T Stravitz, Iliana Bouneva, Velimir Luketic, Nicole Noble, Melanie B White, Pamela Monteith, Ariel Unser and James B Wade

      Accepted manuscript online: 6 FEB 2013 12:15PM EST | DOI: 10.1002/hep.26309

  116. Viral Hepatitis

    1. The new front-line in hepatitis B/D research: Identification and blocking of a functional receptor

      Stephen Locarnini and Nadia Warner

      Accepted manuscript online: 6 FEB 2013 12:15PM EST | DOI: 10.1002/hep.26292

  117. Hepatobiliary Malignancies

    1. Interaction of signal transducer and activator of transcription 3 polymorphisms with hbv mutations in hepatocellular carcinoma

      Jiaxin Xie, Yuwei Zhang, Qi Zhang, Yifang Han, Jianhua Yin, Rui Pu, Qiuxia Shen, Wei Lu, Yan Du, Jun Zhao, Xue Han, Hongwei Zhang and Guangwen Cao

      Accepted manuscript online: 5 FEB 2013 11:09AM EST | DOI: 10.1002/hep.26303

    2. Notch2 signaling and undifferentiated liver cancers: Evidence of hepatic stem/progenitor cell origin

      Vincenzo Cardinale, Guido Carpino, Lola M. Reid, Eugenio Gaudio and Domenico Alvaro

      Accepted manuscript online: 29 JAN 2013 04:46AM EST | DOI: 10.1002/hep.26280

  118. Clinical Observations in Hepatology

    1. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or delayed?

      Zi Yin, Chao Liu, Yajin Chen, Yu Bai, hangzhen Shang, Rongyan Yin, Dong Yin and Jie Jie Wang

      Accepted manuscript online: 28 JAN 2013 03:56PM EST | DOI: 10.1002/hep.26283

  119. Correspondence

    1. Functional characteristics of macrophages in patients with acute liver failure

      Richard J. Aspinall

      Accepted manuscript online: 28 JAN 2013 03:56PM EST | DOI: 10.1002/hep.26284

  120. Viral Hepatitis

    1. Hepatitis B testing and access to care among racial and ethnic minorities in selected communities across the United States, 2009-2010

      Dale J. Hu, Jian Xing, Rania A. Tohme, Youlian Liao, Henry Pollack, John W. Ward and Scott D. Holmberg

      Accepted manuscript online: 28 JAN 2013 03:55PM EST | DOI: 10.1002/hep.26286

  121. Correspondence

    1. Response: Prognostic significance of von Willebrand factor in cirrhosis : A possible mechanism

      Monika Ferlitsch, Markus Peck-Radosavljevic and Arnulf Ferlitsch, Vienna Hepatic Hemodynamic Laboratory

      Accepted manuscript online: 28 JAN 2013 03:55PM EST | DOI: 10.1002/hep.26288

    2. Reply

      Charalambos Antoniades

      Accepted manuscript online: 28 JAN 2013 12:57PM EST | DOI: 10.1002/hep.26281

  122. Viral Hepatitis

    1. JUMP-C: A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin for 24 weeks in treatment-naive HCV genotype 1/4 patients

      Paul J. Pockros, Donald Jensen, Naoky Tsai, Ryan Taylor, Alnoor Ramji, Curtis Cooper, Rolland Dickson, Alan Tice, Rohit Kulkarni, John M. Vierling, Marie Lou Munson, Ya-Chi Chen, Isabel Najera and James Thommes, on behalf of the JUMP-C Investigators

      Accepted manuscript online: 28 JAN 2013 12:56PM EST | DOI: 10.1002/hep.26275

    2. Faldaprevir combined with peginterferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype-1 HCV: SILEN-C1 trial

      Mark S. Sulkowski, Tarik Asselah, Jacob Lalezari, Peter Ferenci, Hugo Fainboim, Barbara Leggett, Fernando Bessone, Stefan Mauss, Jeong Heo, Yakov Datsenko, Jerry O. Stern, George Kukolj, Joseph Scherer, Gerhard Nehmiz, Gerhard G. Steinmann and Wulf O. Böcher

      Accepted manuscript online: 28 JAN 2013 12:55PM EST | DOI: 10.1002/hep.26276

  123. Steatohepatitis and Metabolic Liver Disease

    1. Thrsp promotes hepatic lipogenesis, and its expression LXRα through an SREBP1c-dependent mechanism

      Jing Wu, Chunjiong Wang, Shuo Li, Sha Li, Wanyi Wang, Jing Li, Yujing Chi, Hang Yang, Xiaomu Kong, Yunfeng Zhou, Chengyan Dong, Fan Wang, ÅGuoheng Xu, Jichun Yang, Jan-Åke Gustafsson and Youfei Guan

      Accepted manuscript online: 24 JAN 2013 10:02AM EST | DOI: 10.1002/hep.26272

  124. Viral Hepatitis

    1. PROPEL: A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin therapy in treatment-naive HCV Genotype 1/4 patients

      Heiner Wedemeyer, Donald Jensen, Robert Herring Jr., Peter Ferenci, Mang-Ming Ma, Stefan Zeuzem, Maribel Rodriguez-Torres, Natalie Bzowej, Paul Pockros, John Vierling, David Ipe, Marie Lou Munson, Ya-Chi Chen, Isabel Najera and James Thommes, on behalf of the PROPEL Investigators

      Accepted manuscript online: 24 JAN 2013 10:02AM EST | DOI: 10.1002/hep.26274

  125. Correspondence

    1. Prognostic significance of von willebrand factor in cirrhosis : A possible mechanism

      Chundamannil E Eapen, Joshua E Elias, Ian Mackie and Elwyn Elias

      Accepted manuscript online: 24 JAN 2013 10:02AM EST | DOI: 10.1002/hep.26282

    2. Reply to correspondence (HEP-12-2165) to 11-1058.R2

      Chia-Hsuin Chang, Jou-Wei Lin, Mei-Shu Lai and Lee-Ming Chuang

      Accepted manuscript online: 16 JAN 2013 11:28AM EST | DOI: 10.1002/hep.26269

  126. Liver Failure, Cirrhosis and Portal Hypertension

    1. Gene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy

      Boris Görg, Hans Jürgen Bidmon and Dieter Häussinger

      Accepted manuscript online: 16 JAN 2013 10:57AM EST | DOI: 10.1002/hep.26265

  127. Hepatobiliary Malignancies

    1. BTB/POZ domain-containing protein 7: Epithelial-mesenchymal transition promoter and prognostic biomarker of hepatocellular carcinoma

      Yi-Ming Tao, Jin-Lin Huang, Shan Zeng, Sai Zhang, Xue-Gong Fan, Zhi-Ming Wang, Hui-Xiang Yang, Xiao-Hua Yuan, Pu Wang, Fan Wu, Jia Luo, De-Yu Zeng and Hong Shen

      Accepted manuscript online: 16 JAN 2013 10:57AM EST | DOI: 10.1002/hep.26268

  128. Liver Injury/Regeneration

    1. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

      Su Mi Choi, Yonghak Kim, Joong Sup Shim, Joon Tae Park, Rui-Hong Wang, Steven D. Leach, Jun O. Liu, Chu-Xia Deng, Zhaohui Ye and Yoon-Young Jang

      Accepted manuscript online: 16 JAN 2013 10:56AM EST | DOI: 10.1002/hep.26237

  129. Steatohepatitis and Metabolic Liver Disease

    1. Dendritic cells limit fibro-inflammatory injury in NASH

      Justin R. Henning, Christopher S. Graffeo, Adeel Rehman, Nina C. Fallon, Constantinos P. Zambirinis, Atsuo Ochi, Rocky Barilla, Mohsin Jamal, Michael Deutsch, Stephanie Greco, Melvin Ego-Osuala, Usama Bin Saeed, Raghavendra S. Rao, Sana Badar, Juan P. Quesada, Devrim Acehan and George Miller

      Accepted manuscript online: 15 JAN 2013 03:09PM EST | DOI: 10.1002/hep.26267

  130. Viral Hepatitis

    1. Maternal obesity programs offspring non-alcoholic fatty liver disease via innate immune dysfunction in mice

      Angelina Mouralidarane, Junpei Soeda, Clara Visconti-Pugmire, Anne-Maj Samuelsson, Joaquim Pombo, Xanthi Maragkoudaki, Adil Butt, Ruma Saraswati, Marco Novelli, Guiseppe Fusai, Lucilla Poston, Paul D Taylor and Jude A Oben

      Accepted manuscript online: 12 JAN 2013 07:12AM EST | DOI: 10.1002/hep.26248

    2. Pegylated interferon and ribavirin: A therapeutic option in patients who fail to respond to telaprevir-based triple therapy?

      Alina Pascale, Olivier Chazouillères and Lawence Serfaty

      Accepted manuscript online: 12 JAN 2013 07:12AM EST | DOI: 10.1002/hep.26247

    3. Association of tattooing and hepatitis C virus infection: A multicenter case-control study

      Kerrilynn Carney, Sameer Dhalla, Ayse Aytaman, Craig T. Tenner and Fritz Francois

      Accepted manuscript online: 12 JAN 2013 07:12AM EST | DOI: 10.1002/hep.26245

  131. Correspondence

    1. The role of biopsy of the non-tumorous liver parenchyma in patients considered for partial resection of small HCC

      David Fuks, Francois Durand and Jacques Belghiti

      Accepted manuscript online: 12 JAN 2013 07:12AM EST | DOI: 10.1002/hep.26244

  132. Autoimmune, Cholestatic and Biliary Disease

    1. Antimitochondrial antibodies may be insufficiently specific to define primary biliary cirrhosis-like disease in mouse models

      Simon Hohenester, Ulrich Beuers, Juan F Medina and Ronald P Oude Elferink

      Accepted manuscript online: 12 JAN 2013 07:12AM EST | DOI: 10.1002/hep.26243

    2. Response to: Antimitochondrial antibodies may be insufficiently specific to define primary biliary cirrhosis-like disease in mouse models

      M. Eric Gershwin, Patrick S.C. Leung, William M. Ridgway, Ross L. Coppel and Aftab A. Ansari

      Accepted manuscript online: 12 JAN 2013 07:11AM EST | DOI: 10.1002/hep.26242

  133. Correspondence

    1. Correspondence to 12-2045

      Sasan Roayaie, Josep Llovet, Myron Schwartz and Vincenzo Mazzaferro

      Accepted manuscript online: 12 JAN 2013 07:11AM EST | DOI: 10.1002/hep.26241

  134. Liver Biology and Pathobiology

    1. Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in mice

      Chad Walesky, Genea Edwards, Prachi Borude, Sumedha Gunewardena, Maura O'Neil, Byunggil Yoo and Udayan Apte

      Accepted manuscript online: 12 JAN 2013 07:11AM EST | DOI: 10.1002/hep.26251

  135. Hepatobiliary Malignancies

    1. Activation of mTORC1 and Raf/Pyk2 by growth factor-mediated EphA2 Is required for cholangiocarcinoma growth and metastasis

      Xiang-Dan Cui, Mi-Jin Lee, Jong-Hyun Kim, Pei-Pei Hao, Lan Liu, Goung-Ran Yu and Dae-Ghon Kim

      Accepted manuscript online: 11 JAN 2013 12:16PM EST | DOI: 10.1002/hep.26253

  136. Steatohepatitis and Metabolic Liver Disease

    1. Retinol binding protein 4 stimulates hepatic SREBP-1 and increases lipogenesis through PGC-1beta-dependent pathway

      Min Xia, Yan Liu, Honghui Guo, Duan Wang, Yun Wang and Wenhua Ling

      Accepted manuscript online: 8 JAN 2013 07:13PM EST | DOI: 10.1002/hep.26227

  137. Correspondence

    1. 3 Tesla diffusion-weighted mri for assessing liver fibrosis in non alcoholic fatty liver disease

      Lavrentios Papalavrentios, Emmanouil Sinakos, Chourmouzi Danai, Prodromos Hytiroglou, Konstantinos Drevelegas, Antonios Drevelegas and Evangelos Akriviadis

      Accepted manuscript online: 8 JAN 2013 05:29PM EST | DOI: 10.1002/hep.26220

  138. Steatohepatitis and Metabolic Liver Disease

    1. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

      Karima Begriche, Julie Massart, Marie-Anne Robin, Fabrice Bonnet and Bernard Fromenty

      Accepted manuscript online: 8 JAN 2013 05:28PM EST | DOI: 10.1002/hep.26226

  139. Viral Hepatitis

    1. Improvement of neurocognitive function in responders to an antiviral therapy for chronic hepatitis C

      Michael R Kraus, Arne Schäfer, Gerlinde Teuber, Heiner Porst, Kathrin Paul, Sven Wollschläger, Christian Keicher and Michael Scheurlen

      Accepted manuscript online: 8 JAN 2013 05:23PM EST | DOI: 10.1002/hep.26229

  140. Liver Failure/Cirrhosis/Portal Hypertension

    1. Reply to letter to the editor by Zheng G et al: Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

      Gitte Dam, Susanne Keiding, Ole L. Munk, Peter Ott, Hendrik Vilstrup, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe and Michael Sørensen

      Accepted manuscript online: 27 DEC 2012 05:15AM EST | DOI: 10.1002/hep.26149

  141. Steatohepatitis and Metabolic Liver Disease

    1. Brahma related gene 1 (Brg1) bridges epigenetic regulation of pro-inflammatory cytokine production to steatohepatitis

      Wenfang Tian, Huihui Xu, Fei Fang, Qi Chen, Yong Xu and Aiguo Shen

      Accepted manuscript online: 26 DEC 2012 06:58PM EST | DOI: 10.1002/hep.26207

  142. Viral Hepatitis

    1. Polymorphisms of the core, NS3 and NS5A proteins of hepatitis C 1 virus genotype 1b associate with development of hepatocellular carcinoma

      Ahmed El-Shamy, Michiko Shindo, Ikuo Shoji, Lin Deng, Tadao Okuno and Hak Hotta

      Accepted manuscript online: 24 DEC 2012 05:02AM EST | DOI: 10.1002/hep.26205

  143. Correspondence

    1. Old age and steatohepatitis: A dangerous liaison?

      Manlio Vinciguerra

      Accepted manuscript online: 22 DEC 2012 08:53AM EST | DOI: 10.1002/hep.26212

    2. Correspondence to 12-1295.R1

      Mark J. Czaja

      Accepted manuscript online: 22 DEC 2012 08:53AM EST | DOI: 10.1002/hep.26214

    3. Real-time tissue elastography in the assessment of liver stiffness

      Giovanna Ferraioli, Raffaella Lissandrin and Carlo Filice

      Accepted manuscript online: 22 DEC 2012 08:53AM EST | DOI: 10.1002/hep.26215

    4. Reply for the letter to the editor by Giovanna Ferraioli, M.D., et al.

      Yoichi Hiasa, Hironori Ochi and Masashi Hirooka

      Accepted manuscript online: 22 DEC 2012 08:53AM EST | DOI: 10.1002/hep.26216

    5. Reply

      Hiroyuki Tsuchiya, Kentaro Kogure and Goshi Shiota

      Accepted manuscript online: 22 DEC 2012 08:53AM EST | DOI: 10.1002/hep.26217

  144. Liver Injury and Regeneration

    1. High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

      Minjun Chen, Jürgen Borlak and Weida Tong

      Accepted manuscript online: 19 DEC 2012 11:42AM EST | DOI: 10.1002/hep.26208

  145. Liver Biology and Pathobiology

    1. Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted mice

      Ina Rittelmeyer, Michael Rothe, Martijn H. Brugman, Marcus Iken, Axel Schambach, Michael P. Manns, Christopher Baum, Ute Modlich and Michael Ott

      Accepted manuscript online: 19 DEC 2012 11:42AM EST | DOI: 10.1002/hep.26204

  146. Steatohepatitis and Metabolic Liver Disease

    1. Disruption of cyclophilin D-mediated calcium transfer from the ER to mitochondria contributes to hepatic ER stress and insulin resistance

      Jennifer Rieusset, Jeremy Fauconnier, Melanie Paillard, Elise Belaidi, Emily Tubbs, Marie-Agnès Chauvin, Annie Durand, Amélie Bravard, Geoffrey Teixeira, Birke Bartosch, Maud Michelet, Pierre Theurey, Guillaume Vial, Marie Demion, Emilie Blond, Fabien Zoulim, Ludovic Gomez, Hubert Vidal, Alain Lacampagne and Michel Ovize

      Accepted manuscript online: 5 DEC 2012 02:52AM EST | DOI: 10.1002/hep.26189

  147. Correspondence

    1. The prevalence of cirrhosis and hepatocellular carcinoma in patients with HIV infection: Are the data found in this sample applicable to other settings?

      Catiane Tiecher Cusinato, Ana Paula Messa Koetz, Nêmora Tregnago Barcellos and Fernando Herz Wolff

      Accepted manuscript online: 29 NOV 2012 01:33PM EST | DOI: 10.1002/hep.26172

  148. Autoimmune, Cholestatic and Biliary Disease

    1. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion

      Shi-Ying Cai, Daniël A. Lionarons, Lee Hagey, Carol J. Soroka, Albert Mennone and James L. Boyer

      Accepted manuscript online: 23 NOV 2012 04:14AM EST | DOI: 10.1002/hep.26161

  149. Liver Failure, Cirrhosis and Portal Hypertension

    1. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

      Gang Zheng, Long Jiang Zhang, Yue Cao and Guang Ming Lu

      Accepted manuscript online: 21 NOV 2012 03:01PM EST | DOI: 10.1002/hep.26148

  150. Correspondence

    1. Selenium levels in patients with HCV-related chronic hepatitis, liver cirrhosis and hepatocellular carcinoma: A pilot study

      Dominik Bettinger, Michael Schultheiß, Nadine Hennecke, Elisabeth Panther, Eva Knüppel, E. Blum, Robert Thimme and Hans Christian Spangenberg

      Accepted manuscript online: 21 NOV 2012 03:00PM EST | DOI: 10.1002/hep.26142

    2. Response to letter to Editor, re: HEP-12-1345 “circulating microrna-122 signature in NAFLD and cardiovascular disease: A new endocrine system in metabolic syndrome”

      Gyongyi Szabo and Shashi Bala

      Accepted manuscript online: 30 OCT 2012 01:39PM EST | DOI: 10.1002/hep.26111

  151. Viral Hepatitis

    1. Response to letter to the editor

      Lauren E. Holz, Joo Chun Yoon, Sukanya Raghuraman, Susan Moir, Michael C. Sneller and Barbara Rehermann

      Accepted manuscript online: 30 OCT 2012 01:39PM EST | DOI: 10.1002/hep.26112

  152. Correspondence

    1. B-cell frequency in HCV-related mixed cryoglobulinemia

      Domenico Sansonno, Sabino Russi, Vincenza Conteduca and Loredana Sansonno

      Accepted manuscript online: 30 OCT 2012 01:39PM EST | DOI: 10.1002/hep.26117

    2. Long-lived intragraft donor leukocytes or relocated donor HSPCs can cause long-term hematopoietic chimerism after liver transplantation

      Xiaolei Shi, Viviana Moroso, Herold J. Metselaar and Jaap Kwekkeboom

      Accepted manuscript online: 30 OCT 2012 01:39PM EST | DOI: 10.1002/hep.26118

  153. Viral Hepatitis

    1. Retracted: HLA-A2-/HLA-DR1-transgeneic H-2 class I-/class II-knockout mouse is an ideal animal model for study of chronic HBV infection

      Ding-Qiang Chen, Ling Yang, Jie Zhou, Liwei Lu, Yu-Chun Lone, Kwok-Yung Yuen and Bo-Jian Zheng

      Accepted manuscript online: 23 AUG 2010 11:36AM EST | DOI: 10.1002/hep.23932

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