Hepatology

Cover image for Vol. 59 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Michael H. Nathanson

Impact Factor: 12.003

ISI Journal Citation Reports © Ranking: 2012: 2/74 (Gastroenterology & Hepatology)

Online ISSN: 1527-3350

Associated Title(s): Clinical Liver Disease, Liver Transplantation

VIEW

  1. 1 - 71
  1. Liver Biology and Pathobiology

    1. T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

      Angélique Gougelet, Cyril Torre, Philippe Veber, Chiara Sartor, Laura Bachelot, Pierre-Damien Denechaud, Cécile Godard, Marthe Moldes, Anne-Françoise Burnol, Céline Dubuquoy, Benoit Terris, François Guillonneau, Tao Ye, Michael Schwarz, Albert Braeuning, Christine Perret and Sabine Colnot

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26924

  2. Reviews

    1. Is genotype 3 of the hepatitis C virus the new villain?

      Nicolas Goossens and Francesco Negro

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26905

  3. Liver Injury and Regeneration

    1. Tri-iodothyronine induces hepatocyte proliferation by protein kinase a-dependent β-catenin activation in rodents

      Maura Fanti, Sucha Singh, Giovanna M. Ledda-Columbano, Amedeo Columbano and Satdarshan P. Monga

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26775

  4. Correspondence

    1. Renal impairment is frequent in chronic hepatitis C patients under triple therapy with telaprevir or boceprevir

      Véronique Loustaud-Ratti, Paul Carrier, Chanlina Vong and Marie Essig

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26730

  5. Viral Hepatitis

    1. Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study

      Chiun Hsu, Hsiao-Hui Tsou, Shyh-Jer Lin, Ming-Chung Wang, Ming Yao, Wen-Li Hwang, Woei-Yau Kao, Chang-Fang Chiu, Sheng-Fung Lin, Johnson Lin, Cheng-Shyong Chang, Hwei-Fang Tien, Tsang-Wu Liu, Pei-Jer Chen, Ann-Lii Cheng and on behalf of the Taiwan Cooperative Oncology Group

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26718

  6. Correspondence

    1. Reply

      Christophe Bureau and Jean-Pierre Vinel

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26966

    2. Reply

      Stuart C Gordon, Eduardo Bruno Martins and Leland J. Yee

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26902

  7. Liver Failure, Cirrhosis and Portal Hypertension

    1. Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

      Len Verbeke, Ricard Farre, Jonel Trebicka, Mina Komuta, Tania Roskams, Sabine Klein, Ingrid Vander Elst, Petra Windmolders, Tim Vanuytsel, Frederik Nevens and Wim Laleman

      Article first published online: 14 APR 2014 | DOI: 10.1002/hep.26939

  8. Hepatology Elsewhere

  9. Editorial

  10. Concise Reviews

  11. Hepatology Elsewhere

    1. Beyond liver fibrosis: Hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome

      Nicholas A. Shackel, Mathew A. Vadas, Jennifer R. Gamble and Geoffrey W. McCaughan

      Article first published online: 9 APR 2014 | DOI: 10.1002/hep.26932

  12. Correspondence

    1. Reply

      Markus Peck-Radosavljevic, Wolfgang Sieghart, Florian Hucke and for the Vienna HCC Study Group

      Article first published online: 4 APR 2014 | DOI: 10.1002/hep.26765

  13. Hepatobiliary Malignancies

    1. Opposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle-aged and elderly

      Chien-Hsieh Chiang, Long-Teng Lee, Shou-Hung Hung, Wen-Yuan Lin, Hui-Fang Hung, Wei-Shiung Yang, Pei-Kun Sung and Kuo-Chin Huang

      Article first published online: 3 APR 2014 | DOI: 10.1002/hep.27014

  14. Autoimmune, Cholestatic and Biliary Disease

    1. IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy

      Chen-Yen Yang, Xiong Ma, Koichi Tsuneyama, Shanshan Huang, Toru Takahashi, Naga P. Chalasani, Christopher L. Bowlus, Guo-Xiang Yang, Patrick S.C. Leung, Aftab A. Ansari, Linda Wu, Ross L. Coppel and M. Eric Gershwin

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26979

  15. Steatohepatitis and Metabolic Liver Disease

    1. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ

      Elaine Xu, Marie-Pier Forest, Michael Schwab, Rita Kohen Avramoglu, Emmanuelle St-Amand, Annabelle Z. Caron, Kerstin Bellmann, Michaël Shum, Gregory Voisin, Marilene Paquet, Alain Montoudis, Emile Lévy, Katherine A. Siminovitch, Benjamin G. Neel, Nicole Beauchemin and André Marette

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26957

    2. Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis (pages 1–11)

      Jiesi Xu, Yuanyuan Li, Wei-Dong Chen, Yang Xu, Liya Yin, Xuemei Ge, Kavita Jadhav, Luciano Adorini and Yanqiao Zhang

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26714

  16. Autoimmune, Cholestatic and Biliary Disease

    1. Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4

      Edward J. Andress, Michael Nicolaou, Marta R. Romero, Sandhia Naik, Peter H. Dixon, Catherine Williamson and Kenneth J. Linton

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26970

  17. Liver Injury and Regeneration

    1. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high-mobility group box 1 in cellular protection

      Hai Huang, Gary W. Nace, Kerry-Ann McDonald, Sheng Tai, John R. Klune, Brian R. Rosborough, Qing Ding, Patricia Loughran, Xiaorong Zhu, Donna Beer-Stolz, Eugene B. Chang, Timothy Billiar and Allan Tsung

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26976

  18. Viral Hepatitis

  19. Hepatobiliary Malignancies

    1. You have full text access to this OnlineOpen article
      Evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in Taiwan

      Yen-Po Yeh, Tsung-Hui Hu, Po-Yuan Cho, Hsiu-Hsi Chen, Amy Ming-Fang Yen, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Wei-Wen Su, Yi-Jen Fang, Shih-Tien Chen, Hsiao-Ching San, Hung-Pin Chen, Chao-Sheng Liao and Changhua Community-Based Abdominal Ultrasonography Screening Group

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26703

  20. Liver Biology and Pathobiology

    1. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

      Partha Mukhopadhyay, Mohanraj Rajesh, Zongxian Cao, Béla Horváth, Ogyi Park, Hua Wang, Katalin Erdelyi, Eileen Holovac, Yuping Wang, Lucas Liaudet, Nabila Hamdaoui, Fouad Lafdil, György Haskó, Csaba Szabo, A. Hamid Boulares, Bin Gao and Pal Pacher

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26763

  21. Autoimmune, Cholestatic and Biliary Disease

    1. Serum immunoglobulin G4 and immunoglobulin G1 for distinguishing immunoglobulin G4-associated cholangitis from primary sclerosing cholangitis

      Kirsten Boonstra, Emma L. Culver, Lucas Maillette de Buy Wenniger, Marianne J. van Heerde, Karel J. van Erpecum, Alexander C. Poen, Karin M.J. van Nieuwkerk, B.W. Marcel Spanier, Ben J.M. Witteman, Hans A.R.E. Tuynman, Nan van Geloven, Henk van Buuren, Roger W. Chapman, Eleanor Barnes, Ulrich Beuers and Cyriel Y. Ponsioen

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26977

  22. Rapid Communication

    1. You have full text access to this OnlineOpen article
      Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

      Hiromitsu Kumada, Yoshiyuki Suzuki, Kenji Ikeda, Joji Toyota, Yoshiyasu Karino, Kazuaki Chayama, Yoshiiku Kawakami, Akio Ido, Kazuhide Yamamoto, Koichi Takaguchi, Namiki Izumi, Kazuhiko Koike, Tetsuo Takehara, Norifumi Kawada, Michio Sata, Hidetaka Miyagoshi, Timothy Eley, Fiona McPhee, Andrew Damokosh, Hiroki Ishikawa and Eric Hughes

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.27113

  23. Steatohepatitis and Metabolic Liver Disease

  24. Viral Hepatitis

    1. Cost-effectiveness of sofosbuvir-based triple therapy for untreated patients with genotype 1 chronic hepatitis C

      Salvatore Petta, Giuseppe Cabibbo, Marco Enea, Fabio Salvatore Macaluso, Antonella Plaia, Raffaele Bruno, Antonio Gasbarrini, Antonio Craxì, Calogero Cammà and on Behalf of the WEF Study Group

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.27010

  25. Hepatobiliary Malignancies

    1. Left-liver hypertrophy after therapeutic right-liver radioembolization is substantial but less than after portal vein embolization

      Benjamin Garlipp, Thierry de Baere, Robert Damm, Romy Irmscher, Mark van Buskirk, Patrick Stübs, Frederic Deschamps, Frank Meyer, Ricarda Seidensticker, Konrad Mohnike, Maciej Pech, Holger Amthauer, Hans Lippert, Jens Ricke and Max Seidensticker

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26947

  26. Editorial

  27. Hepatobiliary Malignancies

    1. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

      Tony Gutschner, Monika Hämmerle, Nikolaos Pazaitis, Nadine Bley, Evgenij Fiskin, Hannah Uckelmann, Andreas Heim, Matthias Groβ, Nina Hofmann, Robert Geffers, Britta Skawran, Thomas Longerich, Kai Breuhahn, Peter Schirmacher, Britta Mühleck, Stefan Hüttelmaier and Sven Diederichs

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26997

  28. Editorial

  29. Hepatobiliary Malignancies

    1. MicroRNA-26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor-cMet pathway

      Xin Yang, Xiao-Fei Zhang, Xu Lu, Hu-Liang Jia, Lei Liang, Qiong-Zhu Dong, Qing-Hai Ye and Lun-Xiu Qin

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26941

  30. New Horizons

  31. Liver Biology and Pathobiology

    1. Novel Death Defying Domain in met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes

      Jihong Ma, Chunbin Zou, Lida Guo, Danushka S. Seneviratne, Xinping Tan, Yong-Kook Kwon, Jiyan An, Robert Bowser, Marie C. DeFrances and Reza Zarnegar

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26769

  32. Viral Hepatitis

    1. You have full text access to this OnlineOpen article
      Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

      Koichi Watashi, Ann Sluder, Takuji Daito, Satoko Matsunaga, Akihide Ryo, Shushi Nagamori, Masashi Iwamoto, Syo Nakajima, Senko Tsukuda, Katyna Borroto-Esoda, Masaya Sugiyama, Yasuhito Tanaka, Yoshikatsu Kanai, Hiroyuki Kusuhara, Masashi Mizokami and Takaji Wakita

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26982

  33. Liver Failure, Cirrhosis and Portal Hypertension

    1. Ascites and serum sodium are markers of increased waiting list mortality in children with chronic liver failure

      Renata Pugliese, Eduardo A. Fonseca, Gilda Porta, Vera Danesi, Teresa Guimaraes, Adriana Porta, Irene K. Miura, Cristian Borges, Helry Candido, Marcel Benavides, Flavia H. Feier, Andre Godoy, Rita Antonelli Cardoso, Mario Kondo, Paulo Chapchap and Joao Seda Neto

      Article first published online: 1 APR 2014 | DOI: 10.1002/hep.26776

  34. Special Articles

  35. Liver Injury and Regeneration

    1. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling

      Juan L. García-Rodríguez, Lucía Barbier-Torres, Sara Fernández-Álvarez, Virginia Gutiérrez-de Juan, María J. Monte, Emina Halilbasic, Daniel Herranz, Luis Álvarez, Patricia Aspichueta, Jose J.G. Marín, Michael Trauner, Jose M. Mato, Manuel Serrano, Naiara Beraza and María Luz Martínez-Chantar

      Article first published online: 31 MAR 2014 | DOI: 10.1002/hep.26971

  36. Autoimmune, Cholestatic and Biliary Disease

    1. Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis

      Simon C. Afford, Elizabeth H. Humphreys, Danielle T. Reid, Clare L. Russell, Vanessa M. Banz, Ye Oo, Tina Vo, Craig Jenne, David H. Adams and Bertus Eksteen

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26965

  37. Hepatobiliary Malignancies

    1. Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B

      Seok Won Jung, Neung Hwa Park, Jung Woo Shin, Bo Ryung Park, Chang Jae Kim, Jong-Eun Lee, Eun-Soon Shin, Jeong A Kim and Young-Hwa Chung

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26655

  38. Steatohepatitis and Metabolic Liver Disease

    1. FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis

      Chunjiong Wang, Yujing Chi, Jing Li, Yifei Miao, Sha Li, Wen Su, Shi Jia, Zhenzhen Chen, Shengnan Du, Xiaoyan Zhang, Yunfeng Zhou, Wenhan Wu, Mingyan Zhu, Zhiwei Wang, Huaqian Yang, Guoheng Xu, Shiqiang Wang, Jichun Yang and Youfei Guan

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26945

  39. Hepatobiliary Malignancies

    1. EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

      Rossella Pellegrino, Diego F. Calvisi, Olaf Neumann, Venkatesh Kolluru, Josephine Wesely, Xin Chen, Chunmei Wang, Torsten Wuestefeld, Sara Ladu, Nahla Elgohary, Justo Lorenzo Bermejo, Bernhard Radlwimmer, Martin Zörnig, Lars Zender, Frank Dombrowski, Matthias Evert, Peter Schirmacher and Thomas Longerich

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26954

  40. Editorial

  41. Steatohepatitis and Metabolic Liver Disease

    1. You have full text access to this OnlineOpen article
      IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

      Isaac T.W. Harley, Traci E. Stankiewicz, Daniel A. Giles, Samir Softic, Leah M. Flick, Monica Cappelletti, Rachel Sheridan, Stavra A. Xanthakos, Kris A. Steinbrecher, R. Balfour Sartor, Rohit Kohli, Christopher L. Karp and Senad Divanovic

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26746

  42. Editorial

  43. Viral Hepatitis

    1. T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis

      Jiacheng Bi, Qing Zhang, Dan Liang, Lei Xiong, Haiming Wei, Rui Sun and Zhigang Tian

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26968

  44. Correspondence

    1. Improving the quality of clinical practice guidelines for clinicians and patients

      Ian A. Rowe, Richard Parker, Matthew J. Armstrong, Andrew L. King, Diarmaid D. Houlihan and David J. Mutimer

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26756

  45. Editorial

  46. Hepatology Elsewhere

  47. Steatohepatitis and Metabolic Liver Disease

    1. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

      Song-iee Han, Yoko Komatsu, Akiko Murayama, Knut R. Steffensen, Yoshimi Nakagawa, Yuka Nakajima, Michiko Suzuki, Shohei Oie, Paolo Parini, Lise-Lotte Vedin, Hiroyuki Kishimoto, Hitoshi Shimano, Jan-Åke Gustafsson and Junn Yanagisawa

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26951

  48. Editorials

  49. Clinical Observations in Hepatology

  50. Hepatobiliary Malignancies

    1. c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma

      Lei Wang, Xiang Zhang, Lin-Tao Jia, Si-Jun Hu, Jing Zhao, Jian-Dong Yang, Wei-Hong Wen, Zhe Wang, Tao Wang, Jun Zhao, Rui-An Wang, Yan-Ling Meng, Yong-Zhan Nie, Ke-Feng Dou, Si-Yi Chen, Li-Bo Yao, Dai-Ming Fan, Rui Zhang and An-Gang Yang

      Article first published online: 27 MAR 2014 | DOI: 10.1002/hep.26720

  51. Steatohepatitis and Metabolic Liver Disease

    1. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade

      Seong Chul Kim, Chun-Ki Kim, David Axe, Aaron Cook, Mikang Lee, Tiangang Li, Nicole Smallwood, John Y.L. Chiang, James P. Hardwick, David D. Moore and Yoon Kwang Lee

      Article first published online: 26 MAR 2014 | DOI: 10.1002/hep.26699

  52. Correspondence

    1. Reply

      Tetsuya Hosaka, Fumitaka Suzuki and Hiromitsu Kumada

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26774

  53. Liver Biology and Pathobiology

    1. Glucose sensing O-GlcNacylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

      Wahiba Berrabah, Pierrette Aumercier, Céline Gheeraert, Hélène Dehondt, Emmanuel Bouchaert, Jérémy Alexandre, Maheul Ploton, Claire Mazuy, Sandrine Caron, Anne Tailleux, Jérôme Eeckhoute, Tony Lefebvre, Bart Staels and Philippe Lefebvre

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26710

  54. Correspondence

    1. Reply

      Sheida Moghadamrad, Matteo Montani and Andrea De Gottardi

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26742

    2. Beta-blockers in cirrhosis patients with refractory ascites

      Anne Robins, Anne Bowden, William Watson, Fiona Smith, William Gelson and William Griffiths

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26676

  55. Steatohepatitis and Metabolic Liver Disease

    1. Relationship between sarcopenia and nonalcoholic fatty liver disease: The Korean Sarcopenic Obesity Study

      Ho Cheol Hong, Soon Young Hwang, Hae Yoon Choi, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi and Kyung Mook Choi

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26716

  56. Editorial

    1. How sweet it is to activate FXR

      Peter L.M. Jansen and Frank G. Schaap

      Article first published online: 24 MAR 2014 | DOI: 10.1002/hep.26778

  57. Correspondence

  58. Special Articles

  59. Liver Failure, Cirrhosis and Portal Hypertension

    1. Idiopathic portal hypertension: Natural history and long-term outcome

      Sith Siramolpiwat, Susana Seijo, Rosa Miquel, Annalisa Berzigotti, Angeles Garcia-Criado, Anna Darnell, Fanny Turon, Virginia Hernandez-Gea, Jaume Bosch and Juan Carlos Garcia-Pagán

      Article first published online: 28 FEB 2014 | DOI: 10.1002/hep.26904

  60. Autoimmune, Cholestatic and Biliary Disease

    1. Withholding parenteral nutrition during critical illness increases plasma bilirubin but lowers the incidence of biliary sludge

      Yoo-Mee Vanwijngaerden, Lies Langouche, Richard Brunner, Yves Debaveye, Marijke Gielen, Michael Casaer, Christopher Liddle, Sally Coulter, Pieter J. Wouters, Alexander Wilmer, Greet Van den Berghe and Dieter Mesotten

      Article first published online: 26 FEB 2014 | DOI: 10.1002/hep.26928

  61. Steatohepatitis and Metabolic Liver Disease

    1. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

      Samuele De Minicis, Chiara Rychlicki, Laura Agostinelli, Stefania Saccomanno, Cinzia Candelaresi, Luciano Trozzi, Eleonora Mingarelli, Bruna Facinelli, Gloria Magi, Claudio Palmieri, Marco Marzioni, Antonio Benedetti and Gianluca Svegliati-Baroni

      Article first published online: 25 FEB 2014 | DOI: 10.1002/hep.26695

  62. Hepatology Elsewhere

    1. A new role for IKK-α in hepatitis C virus-induced lipogenesis

      Mark W. Douglas, Saeed Esmaili and Jacob George

      Article first published online: 18 FEB 2014 | DOI: 10.1002/hep.26887

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