Birth Defects Research Part A: Clinical and Molecular Teratology

Cover image for Vol. 103 Issue 7

Edited By: Michel Vekemans

Impact Factor: 2.089

ISI Journal Citation Reports © Ranking: 2014: 32/41 (Developmental Biology); 53/87 (Toxicology)

Online ISSN: 1542-0760

Associated Title(s): Birth Defects Research Part B: Developmental and Reproductive Toxicology, Birth Defects Research Part C: Embryo Today: Reviews

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  • CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition

    CMV‐induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition

    mCMV induces notable changes in the cell-specific distribution of FGFR3 and Notch proteins compared with controls. A–D: FGFR3 immunolocalization: In control E15 + 6 (A) and E15 + 9 (C) organs of Corti (OC, white bracket), nuclear-localized FGFR3 (white arrowheads) is found in pillar cells surrounding the tunnel of Corti (*) and in other SCs. mCMV induced a marked reduction in nuclear-localized FGFR3 in mCMV-infected E15 + 6 (B) and E15 + 9 (D) OCs compared with controls (compare B, D with A, C). E–H: Notch localization: In control E15 + 6 (E) and E15 + 9 (G) OCs, Notch is found in the nuclei and cytoplasm of SCs (black arrowheads), being relatively absent in HCs. mCMV infection induced a notable reduction in nuclear- and cytoplasmic-localized Notch in the densely packed and misaligned HCs and SCs on days 6 (F) and 9 (H) compared with controls (compare F, H with E, G). On day 9, Notch is also seen in a subset of HCs (white arrows) in mCMV-infected OCs. Nuclei were stained with DAPI. Scale bar = 50 μm.

  • In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model

    In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model

    HDAC activity is decreased in brain and lung with nicotine exposure. Nuclear extracts from brain and lung of nicotine exposed offspring reveals a significant decrease in HDAC activity compared with control offspring. Error bars represent standard error of the mean.

  • Register based study of anorectal anomalies over 26 years: Associated anomalies, prevalence, and trends

    Register based study of anorectal anomalies over 26 years: Associated anomalies, prevalence, and trends

    Map of the United Kingdom showing the area covered by the Northern Congenital Abnormality Survey.

  • What we don't know can hurt us: Nonresponse bias assessment in birth defects research

    What we don't know can hurt us: Nonresponse bias assessment in birth defects research

    Estimated prevalence of barrier (%).

  • Unusual trend in the prevalence of trisomy 13 in mothers aged 35 and older: A population based study of national congenital anomaly data

    Unusual trend in the prevalence of trisomy 13 in mothers aged 35 and older: A population based study of national congenital anomaly data

    Trisomy 13, 18, 21 temporal trends in prevalence by maternal age, 3-year rolling rates per 10,000 births, Wales, 1998 to 2012.

  • EFTUD2 deficiency in vertebrates: Identification of a novel human mutation and generation of a zebrafish model

    EFTUD2 deficiency in vertebrates: Identification of a novel human mutation and generation of a zebrafish model

    Phenotypic analysis of eftud2 mutants. A–H: Morphology (A–D) and TUNEL staining (E–H) of wild-type embryos at 30 and 38 to 42 hpf (as indicated). A′–H′: Morphology (A′–D′) and TUNEL staining (E′–H′) of eftud2 mutant embryos at 30 and 38 to 42 hpf. Please note microcephaly and coloboma in mutant embryos. I–P: Enlarged whole mount images of TUNEL staining in eftud2 mutant embryos in representative embryonic regions. Please note increase in TUNEL positive cells throughout the embryo, particularly in the eye, branchial arches, tectum, and spinal cord. The black lines in B, B′, D, D′, I and M indicate the retinal edges and highlight the presence of coloboma in mutant embryos; arrowheads in I and M indicate thinning of the ventral portion of the retina in mutants; b, brain; e, eye; f, forebrain; le, lens; pa, pharyngeal arches; r, retina; sc, spinal cord; t, tectum.

  • Using the electronic medical record to refer women taking category D or X medications for teratogen and contraceptive counseling

    Using the electronic medical record to refer women taking category D or X medications for teratogen and contraceptive counseling

    Participant flowchart.

  • CMV‐induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition
  • In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model
  • Register based study of anorectal anomalies over 26 years: Associated anomalies, prevalence, and trends
  • What we don't know can hurt us: Nonresponse bias assessment in birth defects research
  • Unusual trend in the prevalence of trisomy 13 in mothers aged 35 and older: A population based study of national congenital anomaly data
  • EFTUD2 deficiency in vertebrates: Identification of a novel human mutation and generation of a zebrafish model
  • Using the electronic medical record to refer women taking category D or X medications for teratogen and contraceptive counseling

Recently Published Issues

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Special Issue: Abstracts from the 2nd International Joined OTIS - ENTIS Conference

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Open Access Articles in BDRA: Clinical and Molecular Teratology

Click below to read this OnlineOpen content in BDRA: Clinical and Molecular Teratology for FREE:

Corticosteroid use and risk of orofacial clefts
Hildur Skuladottir, Allen J. Wilcox, Chen Ma, Edward J. Lammer, Sonja A. Rasmussen, Martha M. Werler, Gary M. Shaw, Suzan L. Carmichael
Volume 100, Issue 6, June 2014

Nuclear factor-kappa-B signaling in lung development and disease: One pathway, numerous functions
Cristina M. Alvira
Volume 100, Issue 3, March 2014

Sex prevalence of major congentical anomalies in the United Kingdom: A national population-based study and international comparison meta-analysis
Rachel Sokal, Laila J. Tata, Kate M. Fleming
Volume 100, Issue 2, February 2014

Knowledge and periconceptual use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: Systematic review and meta-analysis
Jordana N. Peake, Andrew J. Copp, Jill Shawe
Volume 97, Issue 7, July 2013

5 Year Impact Factor announced: 2.666!

5 Year Impact Factor announced: 2.666!

Birth Defects Research Distinguished Scholar AwardsCongratulations to Dr. Mark A. Canfield, Dr. Adolfo Correa, and Dr. Russell S. Kirby, recipients of the 2015 Birth Defects Research Distinguished Scholar Award for their research associated with national prevalence estimates for selected birth defects published in Birth Defects Research: Part A: National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999–2001; and Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006.

Now in EarlyView

Now Available Online:

Prevention of orofacial clefts caused by smoking: Implications of the Surgeon General's report
Margaret A. Honein, Owen Devine, Scott D. Grosse and Jennita Reefhuis

Immortal time bias in observational studies of drug effects in pregnancy
Ilan Matok, Laurent Azoulay, Hui Yin and Samy Suissa

Mitochondrial one-carbon metabolism and neural tube defects
Jessica Momb and Dean R. Appling

Limb-body wall defect: Experience of a reference service of fetal medicine from Southern Brazil
Sibele Nascimento de Aquino, Ryuichi Hoshi, Elizabete Bagordakis, Maria Giulia Rezende Pucciarelli, Ana Camila Messetti, Helenara Moreira, Andreia Bufalino, Andréa Borges, Ana Lucia Rangel, Luciano Abreu Brito, Mario Sergio Oliveira Swerts, Hercilio Martelli-Junior, Sergio R. Line, Edgard Graner, Sílvia R.A. Reis, Maria Rita Passos-Bueno and Ricardo D. Coletta

Population-based study to determine mortality in spina bifida: New York State congenital malformations registry, 1983 to 2006
Vijaya Kancherla, Charlotte M. Druschel and Godfrey P. Oakley Jr.


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