Birth Defects Research Part A: Clinical and Molecular Teratology

Cover image for Vol. 100 Issue 12

Edited By: Michel Vekemans

Impact Factor: 2.211

ISI Journal Citation Reports © Ranking: 2013: 27/41 (Developmental Biology); 48/87 (Toxicology)

Online ISSN: 1542-0760

Associated Title(s): Birth Defects Research Part B: Developmental and Reproductive Toxicology, Birth Defects Research Part C: Embryo Today: Reviews

Featured

  • Dissecting aortic aneurysm induced by N-(2-aminoethyl) ethanolamine in rat: Role of defective collagen during development

    Dissecting aortic aneurysm induced by N‐(2‐aminoethyl) ethanolamine in rat: Role of defective collagen during development

    Thoracic vessels of newborn rats (PDN1) from dams treated with AEEA by gavage (150 mg/kg) showed extensive dissections. Dissecting aortic aneurysm was observed in aortic root (A), ascending aorta (B, right vessel), pulmonary artery (B, left vessel), and descending aorta (C). Multiple dissections in branches of pulmonary arteries are shown in (D).

  • Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice

    Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice

    Craniofacial phenotype after in utero treatment with citalopram. A: Results of the canonical variate analysis for differences in shape variation between pups exposed in utero to citalopram and pups from untreated mothers imaged at 15 days postnatal. B,D: Lateral and superior views of the shape variation associated with the untreated pups. C,E: Lateral and superior views of pups exposed to citalopram. The remaining images (F–K) show examples of anomalies found among the citalopram exposed pups; the arrows highlight the anatomical region of interest. F: 3D reconstruction of a citalopram exposed pup with an ectopic suture dividing the parietal bone. G: Sagittal CT slice showing the parietal defect from the same pup. H: 3D reconstruction of one of two pups born with a single maxillary incisor. I: Coronal CT slice showing an absence of the left maxillary incisory root. J: Superior view of a citalopram exposed pup with a deviated snout. K: 45-degree frontal view of the same animal shown in J.

  • Pediatric inpatient hospital resource use for congenital heart defects

    Pediatric inpatient hospital resource use for congenital heart defects

    Total costs of hospitalizations with critical congenital heart defects as a percentage of total costs of all hospitalizations with any congenital heart defect; total hospitalizations with a critical congenital heart defect as a percentage of total hospitalizations with any congenital heart defect, by age. CHD, congenital heart defect; HLHS, hypoplastic left heart syndrome; Coarc, coarctation of the aorta; ToF, tetralogy of Fallot; DORV, double outlet right ventricle; TGA, transposition of the great arteries; Single, single ventricle; Pulm Atr, pulmonary atresia; Aortic, interruption or hypoplasia of aortic arch; Tric Atr, tricuspid atresia; TAPVR, total anomalous pulmonary venous return; Truncus, truncus arteriosus; Ebstein, Ebstein anomaly

  • Analysis of chromosomal structural variation in patients with congenital left-sided cardiac lesions

    Analysis of chromosomal structural variation in patients with congenital left‐sided cardiac lesions

    Flow chart depicting quality control measures and progression of data analysis.

  • Promoter methylation and expression of the VANGL2 gene in the myocardium of pediatric patients with Tetralogy of Fallot

    Promoter methylation and expression of the VANGL2 gene in the myocardium of pediatric patients with Tetralogy of Fallot

    The CpG island in the promoter region of the VANGL2 gene. A: Location of the CpG island. B: The schematic represents the distribution of the CpG site in the CpG island. Three pairs of primers were designed for bisulfite sequencing PCR. C: The sequence shown here represents the 546 base pair fragment which comprises 56 CpG sites. TSS, transcription start site; bp, base pair; B, bisulfite sequencing PCR; F, forward primer; R, reverse primer.

  • Severe neonatal presentation of Kleefstra syndrome in a patient with hypoplastic left heart syndrome and 9q34.3 microdeletion

    Severe neonatal presentation of Kleefstra syndrome in a patient with hypoplastic left heart syndrome and 9q34.3 microdeletion

    UCSC Genome Browser plot showing a 2.1 Mb deletion at 9q34.3. (http//genome.ucsc.edu).

  • Dissecting aortic aneurysm induced by N‐(2‐aminoethyl) ethanolamine in rat: Role of defective collagen during development
  • Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice
  • Pediatric inpatient hospital resource use for congenital heart defects
  • Analysis of chromosomal structural variation in patients with congenital left‐sided cardiac lesions
  • Promoter methylation and expression of the VANGL2 gene in the myocardium of pediatric patients with Tetralogy of Fallot
  • Severe neonatal presentation of Kleefstra syndrome in a patient with hypoplastic left heart syndrome and 9q34.3 microdeletion

Recently Published Issues

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Special Issue: Abstracts from the 2nd International Joined OTIS - ENTIS Conference

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Open Access Articles in BDRA: Clinical and Molecular Teratology

Click below to read this OnlineOpen content in BDRA: Clinical and Molecular Teratology for FREE:

Corticosteroid use and risk of orofacial clefts
Hildur Skuladottir, Allen J. Wilcox, Chen Ma, Edward J. Lammer, Sonja A. Rasmussen, Martha M. Werler, Gary M. Shaw, Suzan L. Carmichael
Volume 100, Issue 6, June 2014

Nuclear factor-kappa-B signaling in lung development and disease: One pathway, numerous functions
Cristina M. Alvira
Volume 100, Issue 3, March 2014

Sex prevalence of major congentical anomalies in the United Kingdom: A national population-based study and international comparison meta-analysis
Rachel Sokal, Laila J. Tata, Kate M. Fleming
Volume 100, Issue 2, February 2014

Knowledge and periconceptual use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: Systematic review and meta-analysis
Jordana N. Peake, Andrew J. Copp, Jill Shawe
Volume 97, Issue 7, July 2013

Announcements

5 Year Impact Factor announced: 2.666!

Birth Defects Research Distinguished Scholar AwardsCongratulations to Dr. Bengt Källen, the winner of the Birth Defects Research Distinguished Scholar Award for his paper in Birth Defects Research: Part A: In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods. Details of the Award can be read here.

Now in EarlyView

Now Available Online:

Prevention of orofacial clefts caused by smoking: Implications of the Surgeon General's report
Margaret A. Honein, Owen Devine, Scott D. Grosse and Jennita Reefhuis

Immortal time bias in observational studies of drug effects in pregnancy
Ilan Matok, Laurent Azoulay, Hui Yin and Samy Suissa

Mitochondrial one-carbon metabolism and neural tube defects
Jessica Momb and Dean R. Appling

Limb-body wall defect: Experience of a reference service of fetal medicine from Southern Brazil
Sibele Nascimento de Aquino, Ryuichi Hoshi, Elizabete Bagordakis, Maria Giulia Rezende Pucciarelli, Ana Camila Messetti, Helenara Moreira, Andreia Bufalino, Andréa Borges, Ana Lucia Rangel, Luciano Abreu Brito, Mario Sergio Oliveira Swerts, Hercilio Martelli-Junior, Sergio R. Line, Edgard Graner, Sílvia R.A. Reis, Maria Rita Passos-Bueno and Ricardo D. Coletta

Population-based study to determine mortality in spina bifida: New York State congenital malformations registry, 1983 to 2006
Vijaya Kancherla, Charlotte M. Druschel and Godfrey P. Oakley Jr.


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