Birth Defects Research Part B: Developmental and Reproductive Toxicology

Cover image for Vol. 101 Issue 6

Edited By: George P. Daston

Impact Factor: 1.168

ISI Journal Citation Reports © Ranking: 2013: 71/87 (Toxicology); 141/164 (Genetics & Heredity); 173/202 (Oncology)

Online ISSN: 1542-9741

Associated Title(s): Birth Defects Research Part A: Clinical and Molecular Teratology, Birth Defects Research Part C: Embryo Today: Reviews, Teratogenesis, Carcinogenesis, and Mutagenesis

Featured

  • Imbalance of Caveolin-1 and eNOS Expression in the Pulmonary Vasculature of Experimental Diaphragmatic Hernia

    Imbalance of Caveolin‐1 and eNOS Expression in the Pulmonary Vasculature of Experimental Diaphragmatic Hernia

    Immunofluorescence evaluation of pulmonary tissue for Cav-1 (A) and eNOS (B) as well as α-SMA (A, B). There was marked increase in medial and adventitial thickness in pulmonary arteries of all sizes in the CDH(+) group compared to controls. α-SMA was used to identify pulmonary arteries. Confocal microscopy further revealed decreased vascular Cav-1 and increased eNOS protein expression in the pulmonary vasculature of nitrofen-exposed lungs compared to normal lung tissue (A, B).

  • Treatment of Mid-Pregnant Mice with KRN633, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Induces Abnormal Retinal Vascular Patterning in Their Newborn Pups

    Treatment of Mid‐Pregnant Mice with KRN633, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Induces Abnormal Retinal Vascular Patterning in Their Newborn Pups

    The vascular basement membrane and pericytes in retinas from 8-day-old pups. Confocal microscopy images of retinal flat-mounts stained for endothelial cells (CD31; green) and type IV collagen (red, A), NG2 (red, B), or αSMA (red, C) from pups of control mice and mice treated with KRN633 (5 mg/kg) during mid-pregnancy. Higher magnification of the insets (pink, artery; blue, vein) shown in the right panels. Arrowheads (A) and arrows (B) indicate the basement membrane sleeves and pericytes, respectively. Scale bar, 100 μm (a–f); 30 μm (c′, c″, f′, f″).

  • Evaluation of Developmental Toxicity of Propylthiouracil and Methimazole

    Evaluation of Developmental Toxicity of Propylthiouracil and Methimazole

    PTU treatment induced lower body weights at GD 20 in rat dams. Dam weights were measured at GD 0, 6, 9, 12, 15, 18, and 20 in dams treated from GD 6 to 19 with vehicle, PTU, or MMI. (A) Dam body weights were measured during pregnancy and at GD 20 they were significantly lower in PTU-treated dams compared to vehicle controls. (B) Changes in dam body weight from GD 6 to 20 revealed that PTU-treated dams gained less weight over the treatment period. (C) Examining the adjusted body weights (total dam weight-gravid uterus weight) showed no difference in weight among all treatment groups. Pregnant rats were treated with vehicle (n = 9), 50 mg/kg PTU (n = 11), 100 mg/kg PTU (n = 8), 10 mg/kg MMI (n = 10), and 20 mg/kg MMI (n = 10). *p ≤ 0.0001.

  • Primary Cell Cultures for Understanding Rat Epididymal Inflammation

    Primary Cell Cultures for Understanding Rat Epididymal Inflammation

    Photomicrograph of the distal corpus epididymis of a rat treated with a drug candidate, showing the infiltration of the interstitium by macrophages and neutrophils. H&E staining. Original magnification: 100×.

  • The Microbiome in Early Life: Self-Completion and Microbiota Protection as Health Priorities

    The Microbiome in Early Life: Self‐Completion and Microbiota Protection as Health Priorities

    The infant's microbiota is a front-line of environmental exposure to both environmental pollutants and drugs. The commensal microbes can respond to the exposure in different ways (depicted) depending upon the specific microbiota composition of the individual. For this reason, chemical and drug metabolism can vary significantly among individuals with different microbiota.

  • Imbalance of Caveolin‐1 and eNOS Expression in the Pulmonary Vasculature of Experimental Diaphragmatic Hernia
  • Treatment of Mid‐Pregnant Mice with KRN633, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Induces Abnormal Retinal Vascular Patterning in Their Newborn Pups
  • Evaluation of Developmental Toxicity of Propylthiouracil and Methimazole
  • Primary Cell Cultures for Understanding Rat Epididymal Inflammation
  • The Microbiome in Early Life: Self‐Completion and Microbiota Protection as Health Priorities

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Open Access Articles in BDRB: Developmental and Reproductive Toxicology

Click below to read these OnlineOpen Articles in BDRB: Developmental and Reproductive Toxicology for FREE:

Developmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabitts
Anthony R. Scialli, John M. DeSesson, Charles B. Breckenridge

Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence
Michael Goodman, Jack S. Mandel, John M. DeSesso

Effects of Ethylene Glyocol Monomethyl Ether and Its Metabolite, 2-Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs in Vitro
Caroline Dayan, Barbara F. Hales

The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague-Dawley and Long Evans Rats
Chad D. Foradori, Prägati Sawhney Coder, Merrill Tisdel, Kun Don Yi, James W. Simpkins, Robert J. Handa and Charles B. Breckenridge

Top Downloaded Articles

Check out these top downloaded articles FREE for a limited time!

NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Hayward, S. W., Lees, P. S.J., McIntyre, B. S., Portier, K. M., Schnorr, T. M., Selevan, S. G., Vandenbergh, J. G. and Woskie, S. R.

Evaluation of the reproductive and developmental risks of caffeine
Brent, R. L., Christian, M. S. and Diener, R. M.

Interpreting Estrogen Screening Assays in the Context of Potency and Human Exposure Relative to Natural Exposures to Phytoestrogens
Becker, R. A., Hays, S. M., Kirman, C. R., Aylward, L. L. and Wise, K.

Considerations in assessing the developmental and reproductive toxicity potential of biopharmaceuticals
Martin, P. L., Breslin, W., Rocca, M., Wright, D. and Cavagnaro, J

Key Learnings from Performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 In Vitro Assays
LeBaron, M. J., Coady, K. K., O'Connor, J. C., Nabb, D. L., Markell, L. K., Snajdr, S. and Sue Marty, M

Birth Defects Research Distinguished Scholar Awards

Birth Defects Research Distinguished Scholar AwardsCongratulations to Dr. Anick Bérard, the winner of the Birth Defects Research Distinguished Scholar Award for her paper in Birth Defects Research: Part B: First trimester exposure to paroxetine and risk of cardiac malformations in infants: The importance of dosage. Details of the Award can be read here.

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