Birth Defects Research Part B: Developmental and Reproductive Toxicology

Cover image for Vol. 101 Issue 2

Edited By: George P. Daston

Impact Factor: 1.971

ISI Journal Citation Reports © Ranking: 2012: 57/85 (Toxicology); 110/161 (Genetics & Heredity); 128/197 (Oncology)

Online ISSN: 1542-9741

Associated Title(s): Birth Defects Research Part A: Clinical and Molecular Teratology, Birth Defects Research Part C: Embryo Today: Reviews, Teratogenesis, Carcinogenesis, and Mutagenesis

Featured

  • Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture

    Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture

    Examples of embryonic erythroblasts; treatment for 2 to 12 hr (treated ∼Day 11 pc). (A) Normal, Type II–III (arrows). (B) Asymmetric binuclear (arrows), early phenotype (Type I or earlier), arrowhead. (C) Symmetrically binuclear (arrows). (D) Fragmented nuclei (arrowhead), trinuclear (arrow) all H&E, 60×.

  • Difference in Developmental Toxicity Among Structurally Similar N-Phenylimide Herbicides in Rats and Rabbits

    Difference in Developmental Toxicity Among Structurally Similar N‐Phenylimide Herbicides in Rats and Rabbits

    Chemical structures of N-phenylimide herbicides.

  • Placental Transfer of Fc-Containing Biopharmaceuticals across Species, an Industry Survey Analysis

    Placental Transfer of Fc‐Containing Biopharmaceuticals across Species, an Industry Survey Analysis

    Cross-species placental transfer comparison of monoclonal antibodies binding to either membrane-bound or soluble targets. Fetal/maternal serum concentration ratios are shown for each monoclonal antibody examined in the rabbit, rat, mouse, or NHP and demonstrated no remarkable difference between ratios for soluble compared to membrane-bound targets.

  • Placental Transfer of Fc-Containing Biopharmaceuticals across Species, an Industry Survey Analysis

    Placental Transfer of Fc‐Containing Biopharmaceuticals across Species, an Industry Survey Analysis

    Fetal serum concentrations of Fc-containing biopharmaceuticals (microgram per milliliter) in animals compared to human during the gestation milestones of (A) organogenesis, (B) the end of organogenesis, (C) in-between the end of organogenesis, and (D) the end of gestation. The definitions of gestation milestones are described in Table . The data show a general trend toward an increase in fetal concentration to maternally administered Fc-containing biopharmaceuticals with gestation for rabbit and NHP between the end of organogenesis and end of gestation, whereas the limited data in rats appear similar across gestation milestones. It should be noted that the concentrations during organogenesis represent concentration of Fc biopharmaceutical in rat serum and concentration of total IgG in human coelomic fluid. There have been no adjustments for dose administered, time since last dose or for maternal exposure in this series of graphs. In addition, not illustrated here are the mouse and rabbit tissue levels observed during organogenesis in these species (Figs. B and B, respectively).

  • Effect of NSAIDs and Diuretics on Nephrogenesis in an Ex Vivo Embryogenic Kidney Model

    Effect of NSAIDs and Diuretics on Nephrogenesis in an Ex Vivo Embryogenic Kidney Model

    Representative immunohistochemic staining of ureteric bud development in metanephroi cultured for 24 hr (amplification 200×).

  • Ochratoxin A: Developmental and Reproductive Toxicity—An Overview

    Ochratoxin A: Developmental and Reproductive Toxicity—An Overview
  • Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture
  • Difference in Developmental Toxicity Among Structurally Similar N‐Phenylimide Herbicides in Rats and Rabbits
  • Placental Transfer of Fc‐Containing Biopharmaceuticals across Species, an Industry Survey Analysis
  • Placental Transfer of Fc‐Containing Biopharmaceuticals across Species, an Industry Survey Analysis
  • Effect of NSAIDs and Diuretics on Nephrogenesis in an Ex Vivo Embryogenic Kidney Model
  • Ochratoxin A: Developmental and Reproductive Toxicity—An Overview

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The Teratology Society 54th Annual Meeting

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Evaluation of the reproductive and developmental risks of caffeine
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Developmental toxicitiy testing for safety assessment: new approaches and technologies
Thomas B. Knudsen, Robert J. Kavlock, George P. Daston, Donald Stedman, Mary Hixon, James H. Kim

Incidence and nature of testicular toxicity findings in pharmaceutical development
Jenifer C. Sasaki, Robert E. Chapin, David Gregory Hall, William Breslin, Jeffrey Moffit, Louise Saldutti, Brian Enright, Monica Seger, Keith Jarvi, Mary Hixon, Terri Mitchard, James H. Kim

The Effects of Interleukin-6 Signal Blockade on Immune System, Reproductive and Skeletal Development in Juvenile Mice
Takayuki Sakurai, Ryo Takai, Heinrich Bürgin, Akifumi Shioda, Yuichior Sakamoto, Jun Amano, Hans Peter Grimm, Wolfgang F. Richter, Yoshinobu Higuchi, Shuichi Chiba, Akinori Kawamura, Masami Suzuki, Lutz Müller

Maternal exposure to multi-wall carbon nanotubes does not induce embryo-fetal developmental toxicity in rats
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Evaluation of the reproductive and developmental risks of caffeine
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Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature
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Developmental Toxicity Testing for Safety Assessment: New Approaches and Technologies
Thomas B. Knudsen, Robert J. Kavlock, George P. Daston, Donald Stedman, Mary Hixon, James H. Kim

Incidence and nature of testicular toxicity findings in pharmaceutical development
Jennifer C. Sasaki, Robert E. Chapin, David Gregory Hall, William Breslin, Jeffrey Moffit, Louise Saldutti, Keith Jarvi, Mary Hixon, Terri Mitchard, James H. Kim

Current and Future Needs for Developmental Toxicity Testing
Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl
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