Birth Defects Research Part B: Developmental and Reproductive Toxicology

Cover image for Vol. 101 Issue 3

Edited By: George P. Daston

Impact Factor: 1.971

ISI Journal Citation Reports © Ranking: 2012: 57/85 (Toxicology); 110/161 (Genetics & Heredity); 128/197 (Oncology)

Online ISSN: 1542-9741

Associated Title(s): Birth Defects Research Part A: Clinical and Molecular Teratology, Birth Defects Research Part C: Embryo Today: Reviews, Teratogenesis, Carcinogenesis, and Mutagenesis

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  • Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

    Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

    Overview of study findings on the associations between ATR/triazine herbicide (or surrogate) exposures and birth defects.

  • Developmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabbits

    Developmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabbits

    Maternal body weight (top) and food consumption (bottom) during the rabbit developmental toxicity study of atrazine. Dose groups are expressed in mg/kg bw/day. *p ≤ 0.05 compared to control. Figures redrawn from data tables in Infurna et al. ().

  • Multigeneration Reproduction and Male Developmental Toxicity Studies on Atrazine in Rats

    Multigeneration Reproduction and Male Developmental Toxicity Studies on Atrazine in Rats

    Group mean maternal body weight and food consumption during treatment on GDs 6 to 21 (A and B) or PNDs 2 to 21 (E and F). Group mean male and female pup body weights on PNDs 1 to 21, following treatment during on GDs 6 to 21 (C and D) or on PNDs 2 to 21 (G and H). An asterisk (*) below a symbol indicates a mean value significantly different from the control mean (p < 0.05) as determined by one-way ANOVA followed by Dunnett's t-test.

  • Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2-Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro

    Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2‐Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro

    Embryonic day 12 forelimbs were cultured for 3 days in the presence of increasing concentrations of either EGME or 2-MAA (0, 3, 10, or 30 mM); on day 3 the culture medium was changed without further addition of EGME or 2-MAA and the bottles were oxygenated. Limbs remained in culture for three more days. They were stained with 0.1% toluidine blue (A and B) to visualize cartilage formation and scored according to their morphology (C and D). n = 6–8. *p < 0.05, ***p < 0.005.

  • The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague-Dawley and Long Evans Rats

    The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague‐Dawley and Long Evans Rats

    Line graphs showing the mean ± SEM LH levels of plasma on the evening of proestrus after 4 days of ATR treatment of intact female (A) SD bolus, (B) LE bolus, (C) SD dietary, or (D) LE dietary animals.

  • Excessive Retinoic Acid Impaired Proliferation and Differentiation of Human Fetal Palatal Chondrocytes (hFPCs)

    Excessive Retinoic Acid Impaired Proliferation and Differentiation of Human Fetal Palatal Chondrocytes (hFPCs)

    RA inhibited cell viability of hFPCs. (A) hFPCs were treated with various concentrations of atRA for 3 days and cell viability was determined by MTT assay. (B) Cell cycle analysis of hFPCs with or without 0.5 μM atRA treatment for 3 days. (C) hFPCs were treated with or without 0.5 μM atRA for 3 days. The cell lysates were evaluated for the expression of cell cycle–related proteins by Western blot analysis. Data are shown as mean ± SD of three independent experiments. Compared with control, **p < 0.01.

  • Tripterygium Glycosides Impairs the Proliferation of Granulosa Cells and Decreases the Reproductive Outcomes in Female Rats

    Tripterygium Glycosides Impairs the Proliferation of Granulosa Cells and Decreases the Reproductive Outcomes in Female Rats

    The effect of triptolide with different concentrations on cell cycle of rat GCs. After incubation with TG (0, 0.01, 0.1, and 1 μM) for 24 hr, cells staining with PI were analyzed by flow cytometry. The proportions of cells in S stage were 8.58, 16.62, 24.12, and 26.13%, respectively. And the proportions of cells in G1 stage were 70.35 at 0 μM, 66.54% at 0.01 μM, 57.78% at 0.1 μM, and 54.46% at 1 μM. There was a comparatively distinct difference in G1/S phase (n = 4). **p < 0.01, *0.01 < p < 0.05.

  • Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence
  • Developmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabbits
  • Multigeneration Reproduction and Male Developmental Toxicity Studies on Atrazine in Rats
  • Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2‐Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro
  • The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague‐Dawley and Long Evans Rats
  • Excessive Retinoic Acid Impaired Proliferation and Differentiation of Human Fetal Palatal Chondrocytes (hFPCs)
  • Tripterygium Glycosides Impairs the Proliferation of Granulosa Cells and Decreases the Reproductive Outcomes in Female Rats

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Birth Defects Research Distinguished Scholar Awards

Birth Defects Research Distinguished Scholar AwardsCongratulations to Dr. Anick Bérard, the winner of the Birth Defects Research Distinguished Scholar Award for her paper in Birth Defects Research: Part B: First trimester exposure to paroxetine and risk of cardiac malformations in infants: The importance of dosage. Details of the Award can be read here.

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