Pediatric Blood & Cancer

Cover image for Vol. 63 Issue 10

Edited By: Editor-in-Chief: Peter E. Newburger, M.D. | Deputy Editor: Thomas Gross, M.D., Ph.D.

Impact Factor: 2.634

ISI Journal Citation Reports © Ranking: 2015: 20/120 (Pediatrics); 36/70 (Hematology); 124/213 (Oncology)

Online ISSN: 1545-5017

Featured Cover Images

  • Volume 63, Issue 10 Cover Image

    Volume 63, Issue 10 Cover Image

    The cover figure is from Figure 1 in Egeler, et al. and depicts interactingmolecular pathways and cellular processes affected by mutant V600E BRAF in LCH cells. Signaling from the cell surface utilizes RAF or PI3K pathways to converge on ERKwhich, in turn, activates signals that influence a wide variety of cellular behaviors, some of which are involved in neoplastic pathophysiology. (RTK-receptor tyrosine kinase; GF – growth factor;MEK– mitogen activated protein kinase kinase; ERK – extracellular signal regulated kinase; DUSP – dual-specificity phosphatases; MEK – mitogen activated protein kinase kinase; ERK – extracellular regulated kinase; PI3K – phosphoinositide 3-kinase; PIP3 – phosphatidylinositol (3,4,5)- trisphosphate; AKT – Protein kinase B; GSK3 – glycogen synthase kinase 3; mTOR – mammalian target of rapamycin.

  • Volume 63, Issue 9 Cover Image

    Volume 63, Issue 9 Cover Image

    The cover figure is from Figure 1 in Lam, et al. Lymphoma cells in primary effusion lymphoma-like lymphoma in a child with congential immunodeficiency.

  • Volume 63, Issue 8 Cover Image

    Volume 63, Issue 8 Cover Image

    The cover figure is from Figure 1 in Alexander, et al. Representative photomicrographs of colonic polyps from a patient with constitutional mismatch repair deficiency syndrome, metachronous lymphomas, and colonic polyposis. A: (20x magnification) Hematoxylin and eosin stained sections of polyps showed tubular adenoma, B: (400x magnification) with characteristic pseudostratified dysplastic nuclei, C and D: (400x magnification) Paraffin immunohistochemistry for MLH1 (C) and PMS2 (D) showed loss of expression of the latter. Retained expression similar to MLH1 was seen for MSH2 and MSH6.

  • Volume 63, Issue 7 Cover Image

    Volume 63, Issue 7 Cover Image

    This heat map, from Borss´en, et al. (page 1186), shows the methylation status (y-axis, green colorunmethylated, red-methylated) of the 1293 CpG sites in a CpG Island Methylator Phenotype (CIMP) panel for 65 samples at diagnosis of pediatric T-cell acute lymphoblastic leukemia (T-ALL) and for sorted normal CD34+/CD38– and CD3+ cells (x-axis). The study suggests that CIMP classification, in combination with minimal residual disease during induction therapy, is a strong candidate for risk classification in T-ALL.

  • Volume 63 Issue 6 Cover Image

    Volume 63 Issue 6 Cover Image

    The cover figure is from Figure 1 in Rayes, et al. Blast morphology prior to blinatumomab was typical for B lymphoblastic leukemia.

  • Volume 63 Issue 5 Cover Image

    Volume 63 Issue 5 Cover Image

    The cover figure is from Figure 1 in Lo, et al, in this issue of PBC. Magnetic resonance angiogram of a patient who received radiotherapy for craniopharyngioma, showing a small supraclinoid right internal carotid artery and M1 segment (arrow).

  • Volume 63 Issue 4 Cover Image

    Volume 63 Issue 4 Cover Image

    The cover figure is from Figure 1 in Kaye, Friebert, and Baker. Three tiers of pediatric palliative care services within an institution.

  • Volume 63 Issue 3 Cover Image

    Volume 63 Issue 3 Cover Image

    The cover figure is from Figure 1 in Hagelstrom and Ford et al, in this issue of PBC. FISH image of breast tumor demonstrating 4-5 signals for each locus tested (shown here with the PDGFRB probe), and two copies of PTEN.

  • Volume 63 Issue 2 Cover Image

    Volume 63 Issue 2 Cover Image

    The cover figure is from Figure 1 in Engelholm, et al. The figure shows an example of treatment delivered using conventional photon therapy photon (left) and proton therapy (right) plans for cranio-spinal irradiation at the same institution.

  • Volume 63 Issue 1 Cover Image

    Volume 63 Issue 1 Cover Image

    The cover figure is from Figure 1 in Weyand, et al. Photo microscopy (1000x) of the initial bone marrow aspirate demonstrating marked eosinophilia, tri-lineage hematopoietic maturation, and no increased blast population in a patient with severe hypereosinophilic syndrome.

  • Volume 62 Issue 12 Cover Image

    Volume 62 Issue 12 Cover Image

    The cover figure is from Figure 1 in Bhattad et al, in this issue of PBC. Distended abdomen with dilated veins due to Budd-Chiari syndrome in a child with leukocyte adhesion defect.

  • Volume 62 Issue 11 Cover Image

    Volume 62 Issue 11 Cover Image

    The cover figure is from Figure 1 in Olbrich et al, in this issue of PBC. Clinical presentation of marked lymphadenopathies in a child with complete Interferon-γ Receptor 1 deficiency.

  • Volume 62 Issue 10 Cover Image

    Volume 62 Issue 10 Cover Image

    The cover figure is from Figure 2 in Alvarez et al, in this issue of PBC. Photomicrographs of medullary carcinoma of the kidney in a patient with sickle cell trait. A. Hematoxylin and eosin-stained section depicts carcinoma cells within renal tubules. Glomeruli are uninvolved. B. Immunohistochemistry for keratin stains carcinoma dark brown.

  • Volume 62 Issue 9 Cover Image

    Volume 62 Issue 9 Cover Image

    The cover figure is from Figure 1 in Tsouana et al, in this issue of PBC. Hybrid 18F-fluroethyl-choline positron emission tomography/magnetic resonance imaging of the brain at the baseline (A) and after treatment (B) in an 18 year-old male with a pineal NGGCT. Good response after chemotherapy with decreased size and uptake.

  • Volume 63, Issue 10 Cover Image
  • Volume 63, Issue 9 Cover Image
  • Volume 63, Issue 8 Cover Image
  • Volume 63, Issue 7 Cover Image
  • Volume 63 Issue 6 Cover Image
  • Volume 63 Issue 5 Cover Image
  • Volume 63 Issue 4 Cover Image
  • Volume 63 Issue 3 Cover Image
  • Volume 63 Issue 2 Cover Image
  • Volume 63 Issue 1 Cover Image
  • Volume 62 Issue 12 Cover Image
  • Volume 62 Issue 11 Cover Image
  • Volume 62 Issue 10 Cover Image
  • Volume 62 Issue 9 Cover Image

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Journal News

Pediatric Blood & Cancer Special Series

New Section!

The journal is pleased to announce a new submission type—On Children, Blood, and Cancer. These submissions will provide personal perspectives on the experiences of children with cancer or blood disorders, or of caring for these children. The section will be led by Dr. David N. Korones, of the University of Rochester. For more information, visit our Author Guidelines page.

Standards for Psychosocial Care for Children With Cancer and Their Families

This Special Issue is dedicated to the memory of Robert J. Arceci, M.D., Ph.D. Dr. Arceci, an internationally prominent pediatric oncologist and the former editor of this Journal, was, throughout his life, committed to a biopsychosocial approach and to advancing the behavioral health of children with cancer and their families. While working tirelessly to cure pediatric cancer, he also strongly believed that children and families deserve effective psychosocial care to alleviate suffering until cures without costs emerge. Dr. Arceci championed publication of the Standards for the Psychosocial Care of Children with Cancer and their Families in this Pediatric Blood and Cancer Special Issue until his death on June 8, 2015. We are grateful for and will miss his passionate enthusiasm, his support and his friendship.

Publication of this supplement is made possible by the Mattie Miracle Foundation.

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