Pediatric Blood & Cancer

Cover image for Vol. 61 Issue 6

Edited By: Robert J. Arceci, M.D., Ph.D.

Impact Factor: 2.353

ISI Journal Citation Reports © Ranking: 2012: 27/122 (Pediatrics); 36/67 (Hematology); 109/197 (Oncology)

Online ISSN: 1545-5017

Author Guidelines

NIH Public Access Mandate
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Wiley Author Licensing Services (WALS)

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

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If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

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Author Guidelines

Wiley's Journal Styles

Submission and Contact Information
Pediatric Blood & Cancer welcomes submitted manuscripts online at: Pediatric Blood & Cancer employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works.

COVER LETTER. The online submission program requires an author cover letter to the journal’s Editor in Chief which should state what significant, new information the submission provides from that previously published in medical literature. It should should contain the manuscript title and all author names, provide a brief summary of the findings and why they are important and appropriate for this journal. State what manuscript classification it fits, i.e., Research Article, Brief Report, Letter to the Editor, etc. State that the manuscript has not been submitted elsewhere nor previously published. State any conflicts of interest. List names of 3 potential reviewers along with their contact information including their professional email address who are experts in the field and who are not from the authors’ institutions and have no other conflicts of interest. State who and why any colleagues should not be asked to review. State that all authors have contributed to the manuscript in significant ways, have reviewed and agreed upon the manuscript content.

The manuscript text must be provided in a Word file with a .doc extension. The title page should contain the complete title of the manuscript, the names, degrees, and affiliations of all authors, as well as the name, address, phone, fax and email of the person to whom all correspondence should be addressed. While the number of authors should usually not exceed six, exceptions will be granted with adequate justification. The title page should also include the abstract word count, text word count (minus word count on title page, abstract, references, tables, figures), the number of tables and figures, a short running title, and three to six keywords to index the content. The length of the abstract text body as well as the number of figures and tables (not including supplemental information) must not exceed Author Guidelines for the classification of manuscript being submitted. The short running title should be the same as that provided in the online “box” where it is requested and cannot exceed 45 characters, including spaces.

Wiley suggests that authors from non-English speaking countries have their manuscript reviewed and corrected by English Language Services before submission. Please see the following link from Wiley-Blackwell as we have adopted their policy:

Authors are encouraged to check for an existing account. If you are submitting for the first time, and you do not have an existing account, then create a new account. Once you have logged in, you will be presented with the Main Menu and a link to your Author Center. Enter your Author Center to submit your manuscript. At the end of a successful submission, a confirmation screen with manuscript number will appear and you will receive an e-mail confirming that the manuscript has been received by the journal. If this does not happen, please check your submission and/or contact the Help Desk, listed on the website.

Editorial Office: Julie Nash, Managing Editor, Pediatric Blood & Cancer , 320 North Salem Street, Apex, NC 27502; Tel: 919-267-6831; E-mail:

Submission Requirements

All manuscripts submitted to Pediatric Blood & Cancer must be submitted solely to this journal, may not have been published in any part or form in another publication of any type, professional or lay, and become the property of the publisher. Any material reproduced or adapted from any other published or unpublished source must be duly acknowledged. It is the author's responsibility to obtain permission to reproduce copyrighted material. Upon submission of a manuscript for publication, the author will be requested to sign an agreement transferring copyright to the publisher, who reserves copyright. Material published in this journal may not be reproduced or published elsewhere without the written permission of the publisher and the author. All statements in, or omissions from, published manuscripts are the responsibility of the author who will assist the editor and publisher by reviewing proofs. No page charges will be levied against authors or their institutions for publication in this journal. All authors should have contributed in a significant manner and be in agreement with all content in a manuscript. The corresponding author will take responsibility for this requirement being met.

DISCLOSURE STATEMENT. All authors must disclose in a statement following Acknowledgments under the title, "Conflict of Interest Statement," any affiliations that they consider to be relevant and important with any organization that to any author's knowledge has a direct interest, particularly a financial interest, in the subject matter discussed. Such affiliations include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products. Other areas of real or perceived conflict of interest would include receiving honoraria or consulting fees or receiving grants or funds from such corporations or individuals representing such corporations. This requirement will apply to every sort of article submitted to the Journal, including original research, reviews, editorials, letters to the editor, and any others, and should be disclosed at the time of submission. The simplest remedy for conflict of interest is disclosure. This information will be held in confidence while the paper is under review. It will not be shared with peer reviewers, and it will not influence the editorial decision to accept or reject the manuscript. When an article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be presented.

ARTICLES. Articles should represent original and in-depth studies involving all aspects of clinical or laboratory investigations. Articles should be less than 3,500 words in length. That word count excludes the title page, abstract, references, tables, figures. References are recommended to be less than 50. The number of figures and tables combined should be not be greater than 6 (excluding supplemental material), and be appropriate for the data presented; tables and figures should not simply repeat information in the text. All images of a composite figure should be uploaded in 1 composite .tif file with each subcomponent labeled clearly as A, B, etc. Figures that contain only one image should each be uploaded in either a .tif file or .eps file. Arrows should be included in radiographs or histology figures to point out areas of interest described in the figure legends below the figures. The manuscript file must contain line numbering.

Supporting Information: Supporting information will be published as submitted and will not be corrected or checked for scientific content, typographical errors or functionality. The responsibility for scientific accuracy and file functionality remains entirely with the authors. A disclaimer will be displayed to this effect with any supporting information published. Supporting information should always be provided in its final format, as it will not be copyedited or changed from its original format. It will not be available for review prior to publication. Supporting tables or figures may be made cited within the text and will be made available to readers at an online link; those additional files should be classified as supplemental files for review when the paper is submitted online.

TITLE PAGE. The title page should include the abstract word count, text word count, the number of tables and figures, a short running title, and three to six keywords to index the content.

Abstract. This should be a summary in not more than 250 words, and organized under headings as follows: Background (to include purpose of the work being reported); Procedure (to include Materials and Methods); Results; and Conclusions. Do not include material in the abstract that is not described in the body of the manuscript.

Text. The text should follow the format: Introduction, Methods, Results, and Discussion. Place Acknowledgments as the last element of text, before references. Use subheadings and paragraph titles whenever possible. Authors whose first language is not English should arrange for their manuscripts to be written in idiomatic English and reviewed prior to submission by an editor facile in medical English. This will avoid disappointing delays before a paper can be sent out for review. Either American or British style is acceptable. For the former consult Merriam-Webster's ; for the latter, consult the Oxford Shorter Dictionary. Abbreviations should follow the guidelines in the CBE Style Manual, 5th Edition (available from the Council of Biology Editors,Inc., One Illinois Center, Suite 200, 111 East Wacker Drive, Chicago, IL60601-4298). All measurements must be in metric units. Patients should be referred to only by subject numbers and not with names, initials, or other potentially identifying characters. Manuscripts reporting the results of experimental investigations on human subjects must include a statement to the effect that procedures had received official institutional approval. Text should be written using past tense verbs throughout as a general approach. The manuscript file must contain line numbering.

There should be no dates in the text or on radiographs as these are potential patient identifiers. Avoid the inclusion of lists of information in the text file. Use uncapitalized generic names (e.g., cyclophosphamide) for all drugs and pharmaceutical preparations. Trade names (capitalized) for appliances, etc., may be used in the Methods section, and the manufacturers identified by name and address. Disease names should be written as Wilms tumor, Burkitt lymphoma, Hodgkin disease, Ewing sarcoma -- without apostrophes. Decimal numbers should have a zero preceding the decimal point. Sentences should not start with a number. Decimal points should be periods and not commas. Gene and protein designations should be written in the international style approved by the HUGO Gene Nomenclature Committee at

The statement ‘data not shown’ is not allowed within the manuscript text as readers cannot evaluate if the data are not shown. Such information should either be included in the manuscript or provided as supplemental material in a separate Word file that is titled as Supplemental Appendix I (or II, etc.) or Supplemental Table I (or II, etc.) and is cited within the text as same. When uploading that separate file, select the file classification of Supplemental Material for Review.

References. Authors are responsible for the accuracy of references. In the text, cite references consecutively as numerals in brackets; all references must be cited in either text or tables. Abstracts, unpublished data, and personal communications should not be listed as references. Arrange the references in numerical order, and include the names of all authors up to four in number. If more than four, list the first three followed by "et al." The complete title of the article cited and inclusive page numbers follow. Abbreviate journal names according to Index Medicus.

In the following examples, notice the punctuation and order of information, do not use all capitals, and do not underline:

Journal articles:
1. Nathan PC, Maze R, Spiegler B, et al. CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation. Pediatr Blood Cancer 2004:42:24-29.

2. Bricker JT, Green DM, D'Angio GJ, editors. Cardiac toxicity after treatment for childhood cancer. New York: Wiley-Liss, Inc.; 1993. 1223 p.

Articles in Books:
3. Gerber JE. The role of genetic counseling in the management of long-term survivors of childhood cancer. In: Bricker JT, Green DM, D'Angio GJ, editors. Cardiac toxicity after treatment for childhood cancer. New York: Wiley-Liss, Inc.; 1993. p 121-150.

Online-Only Journal Articles:
4. Angelico F, Burattin M, Alessandri C, Del Ben M, Lirussi F. Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis. Cochrane Database Syst Rev 2007:CD005166.

5. Willberg CW, Ward SM, Clayton RF, et al. Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha. PloS ONE 2007;2:e791. doi:10.1371/journal.pone.0000791.

E-Pub Ahead of Print:
6. Salerno F, Gerbes A, Gines P, Wong F, Arroyo V. Diagnosis, prevention and treatment of the hepatorenal syndrome in cirrhosis. A consensus workshop of the international ascites club. Gut 2009; doi:10.1136/gut.2006.107789.

7. Lindor KD, Gores GA. Future course of hepatology research. Hepatology 2009; doi:10.1002/hep.22749.

Information from a URL:
8. Centers for Disease Control and Prevention. Viral hepatitis C fact sheet. Division of Viral Hepatitis home page. Published April 22, 2006. Accessed August 10, 2008.

9. Levin J. Viramidine phase III study-did not meet efficacy endpoint. Valeant looking at weight-based dosing of viramidine based on post-hoc analysis [NATAP conference report on Benhamou et al., J Hepatol 2006;44(Suppl 2):S293.]. Accessed May 12, 2009.

MANUSCRIPT. For optimal production, prepare double spaced manuscript text in either Times New Roman or Arial 12 point font on 8-1/2 x 11 inch page, with at least 1 inch margins on all sides. When uploading the manuscript files into the journal's online program, the text file should be uploaded first, followed by each table in a separate Word file in numerical order with the figure files following in numerical order. Tables and figures should not be in the same file as the manuscript text. The manuscript file must contain line numbering.

Tables. Tables should be numbered consecutively with Roman numerals. The table number, followed by a period, and title should be placed above the table and abbreviations placed below the table in paragraph form and not in lists.

Figures. The figure number and legend should be placed either below each figure in the figure file or at the end of the main text file. When preparing digital art, consider the following: Figures and text within a figure should not be surrounded by boxed lines unless critical for clarity.

Resolution: The minimum requirements for resolution are:

• 1200 DPI/PPI for black and white images, such as line drawings or graphs
• 300 DPI/PPI for picture-only photographs
• 600 DPI/PPI for photographs containing pictures and line elements, i.e., text labels, thin lines, arrows

These resolutions refer to the output size of the file; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.

Formats. For the entire submission/acceptance process, .tif or .eps files for figures are required. Figures should be numbered using Arabic numerals, i.e., Figure 1, Figure 2, etc., and cited with the manuscript text as same. For the editorial review process, color images may be submitted in RGB color; upon acceptance, CMYK color will be required. Delivery of production-quality files early in the review process may facilitate smooth and rapid publication once a manuscript has been accepted. Legends should be placed at the end of the manuscript text file or below each figure.

All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print. Authors are encouraged to submit color illustrations that highlight the text and convey essential scientific information. For best reproduction, bright, clear colors should be used. Dark colors against a dark background do not reproduce well; please place your color images against a white background wherever possible. Please contact Jessica Rodwick at for further information.

PRIORITY REPORTS. At the recommendation of the journal’s Editor-in-Chief and with recommendations from members of the Editorial Board, certain high-impact research articles will selected to be fast-tracked for online publication within 4 weeks after final acceptance and print publication within 2 months of final acceptance. The structured abstract should be less than 150 words, the text length of less than 2,000 words with less than 25 references with figures and/or tables totaling no more than 4. Additional tables or figures may be made cited within the text and will be made available to readers at an online link; those additional files should be classified as supplemental files for review when the paper is submitted online.

BRIEF REPORTS. Brief reports may include descriptions of single or several patients that demonstrate novel findings or add in a significant way to already existing literature. Brief reports may also include novel laboratory observations relating to clinical questions or advances in laboratory methodologies. Text should begin with an abstract of 100 words or less that does not include headings, and be followed by a brief introduction. Total text length should be less than 1,200 words. That word count excludes the title page, abstract, references, tables, figures. There should be no more than twenty references. There should be no more than 2 figures or 2 tables or any combination not to exceed 2. The title page should contain the complete title of the manuscript, the names, degrees, and affiliations of all authors as well as the name, address, phone, fax and email of the person to whom all correspondence should be addressed. While the number of authors should usually not exceed six, exceptions will be granted with adequate justification. The title page should also include the abstract word count, text word count, the number of tables and figures, a short running title, and three to six keywords to index the content.

Beginning in 2013, Brief Reports will be published in electronic-only pages of the journal. Electronic-only articles are indexed in PubMed and other indexing services and can be cited as any other article. Additionally, Brief Reports will be listed in the journal’s table of contents with assigned e-pages. Please see instructions above for formatting a reference to an online-only article.

CRITICAL REVIEWS. Reviews of important and timely subjects can be invited through the editorial board or submitted independently. In the latter case, it is usually helpful for the corresponding author to consult the Editor-in-Chief prior to submission. Reviews should focus on the critical aspects of a subject, linking what is know to what areas remain controversial or unanswered. Historical accounts of important events relating to pediatric hematology/oncology are also acceptable. Reviews should normally be less than 3,500 words, contain an unstructured abstract of 100 words or less, and fewer than 100 references; illustrations and tables should be used only to provide summaries or a synthesis of ideas and/or data not also included in the text. Requests for permission to submit manuscripts of greater length should be emailed to the Editor-in-Chief at prior to manuscript submission.

REVIEWS OF BOOKS AND OTHER MEDIA FORMATS. Reviews of books, films or other media formats relevant to the scientific or clinical practice of medicine with particular importance to pediatric hematology/oncology can be invited or submitted independently. In the latter case, consultation with the Editor-in-Chief should be made prior to submission. The text length should be less than 1,000 words.

CORRESPONDENCE AND LETTERS. Letters to the Editor should usually be in reference to previously published manuscripts in Pediatric Blood and Cancer. However, correspondence relating to important and timely publications or topics from other sources may also be appropriate. Brief descriptions of interesting laboratory or clinical observations may also be appropriate. The length of Letters to the Editor should be less than 500 words and should contain references and illustrations or tables only when absolutely necessary but not to exceed more than one total.

HIGHLIGHTS. Highlights are submitted only at the invitation of the Editor-in-Chief. The Highlight should be less than 1,000 words and 10 references or less and summarize findings from the accepted paper as well as put them into perspective in terms of past work and future challenges. Controversial areas should be included.

COMMENTARY. Commentaries are usually invited but may be submitted independently after consultation with the Editor-in-Chief. Please limit the text to 1,200 words and fewer than 10 references. Commentaries should focus on a controversial subject arising from a recently published Pediatric Blood & Cancer manuscript but may also focus on independent and timely topics of relevance to the journal’s readership. Illustrations and Tables are allowed only if they highlight or clarify points made in the text. Commentaries will be reviewed and may require changes or be rejected.

MEETING REPORTS AND SUPPLEMENTS. Concise summaries of meetings that have important information to convey to the readers of Pediatric Blood & Cancer are welcomed but consultation with the Editor-in-Chief should occur before submission. Summaries should emphasize the issues discussed at the meeting along with why they are important or controversial. Summaries should be less than 1,500 words of text. Illustrations and tables can be included but only when they significantly add to the text content. More extensive meeting reports with manuscripts from the speakers at the meeting are also welcomed but early consultation with the Editor-in-Chief must take place in order to determine the type and number of manuscripts, expected pages to be published, the review process as well as procurement of additional funding if required.

HISTORICAL PERSPECTIVE. A Historical Perspective should be submitted only after consultation with the journal’s Editor-in-Chief. This occasionally-appearing series focuses on the history of hematology/oncology. The text should be less than 1000 words, have less than 5 references and no more than 2 figures if necessary. No abstract required.

SPECIAL REPORT. To be submitted only after consultation with the journal’s Editor-in-Chief, the report should focus on a subject of current interest in developing countries. There should be an abstract of 100 words or less without subheadings, a text of 2,500 words or less, 20 references or less and either 2 tables OR 2 figures OR 1 table and 1 figure only.

ONLINE OPEN. OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website at: Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

CLINICAL PRACTICE GUIDELINES (CPG) should concern important and timely subjects. They must receive pre-submission from the Editor-in-Chief. CPGS should normally be less than 4,500 words, be based on best available evidence with documentation of the leve of evidence, contain a unstructured abstract of 100 words or less and fewer than 150 references. Illustrations, tables, and clinical care algorithms are encouraged to augment the text. The Institute of Medicine has defined a CPG as a "systematically developed statement to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances." An excellent resource for preparing a CPG is the manuscript by Turner et al., Development of evidence-based clinical practice guidelines (CPG's: comparing approaches, Implementation Science, 3:1-8; 2008.


*Abstract text should be 300 words or less.  That word count excludes the abstract title, author names and affiliations.

*There should be 4 sections to the abstract: Background/Objectives, Design/Methods, Results, Conclusion.  All text should include a single paragraph and contain no lists.

*Abstract text should be written in complete sentences and in correct English.

*There should be a mark of end punctuation at the end of all sentences.

*Tables and figures, only when critical to the content, should be included and must comply in terms of format with PBC Author Guidelines.

*Abstract titles should be in all capital letters, e.g., INDUCTION OUTCOMES IN CHILDREN WITH ALL

*Author names should be listed below the abstract title and underlined.  The first and last names of authors should be written in upper and lower case letters and should be underlined.  No degrees of authors should be included.

*Author affiliations should be written in upper and lower case letters, e.g., Tata Memorial Centre

*Names of cities and countries with 2 words should be written in upper and lower case letters, e.g., Czech Rep, South Africa, Los Angeles, St. Louis.

*Periods should be used in numbers for decimal points, not commas, e.g., P=0.015, and numbers beginning with a decimal point should be preceded by a zero.

*Disease names should be written without apostrophes, e.g., Hodgkin lymphoma, Non-Hodgkin lymphoma, Burkitt lymphoma, Ewing sarcoma

*The X and Y axis of graphs must be labeled as per PBC Author Guidelines.

*There should be no extraneous writing on radiographic scans, which, for instance, could be patient identifiers.

*Numbers containing more than 3 digits should have a comma, e.g., 3,000.

*Abbreviations should be defined on first usage, then using of abbreviation alone is acceptable: e.g., Wilms Tumor (WT), then referred to as WT in subsequent mention, no quotation marks, however.

*Abstracts need to be corrected for all spelling and grammatical errors.

*Abstracts that do not satisfy publication instructions will not be published.


??? Production Questions ???

Jessica Rodwick
Tel.: 201-748-6670