Cover image for Vol. 33 Issue 8

Stem Cells Express (Accepted Articles - Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Jan A. Nolta

Impact Factor: 6.523

ISI Journal Citation Reports © Ranking: 2014: 2/21 (CELL & TISSUE ENGINEERING); 4/68 (Hematology); 10/162 (Biotechnology & Applied Microbiology); 19/211 (Oncology); 32/184 (Cell Biology)

Online ISSN: 1549-4918


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  1. Translational and Clinical Research

    1. Human adipose-derived mesenchymal stem cells modulate experimental autoimmune arthritis by modifying early adaptive t cell responses

      Mercedes Lopez-Santalla, Pablo Mancheño-Corvo, Ramon Menta, Juan Lopez-Belmonte, Olga DelaRosa, Juan A. Bueren, Wilfried Dalemans, Eleuterio Lombardo and Marina I. Garin

      Accepted manuscript online: 22 JUL 2015 05:25PM EST | DOI: 10.1002/stem.2113

  2. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. CHD1L regulated PARP1-driven Pluripotency and Chromatin Remodeling during the Early-stage Cell Reprogramming

      Bo-Hua Jiang, Wei-Yi Chen, Hsin-Yang Li, Yueh Chien, Wei-Chao Chang, Pei-Chen Hsieh, Ping Wu, Chieh-Yu Chen, Hui-Yung Song, Chian-Shiu Chien, Yen-Jen Sung and Shih-Hwa Chiou

      Accepted manuscript online: 22 JUL 2015 05:25PM EST | DOI: 10.1002/stem.2116

  3. Cancer Stem Cells

    1. Stem cells in pancreatic cancer – from concept to translation

      Deepak Raj, Alexandra Aicher and Christopher Heeschen

      Accepted manuscript online: 22 JUL 2015 05:25PM EST | DOI: 10.1002/stem.2114

  4. Translational and Clinical Research

    1. Treatment of Lateral Epicondylosis by Using Allogeneic Adipose-Derived Mesenchymal Stem Cells: A Pilot Study

      Sang Yoon Lee, Won Kim, Chaiyoung Lim and Sun G. Chung

      Accepted manuscript online: 21 JUL 2015 09:01PM EST | DOI: 10.1002/stem.2110

  5. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity

      Benjamin Soibam, Ashley Benham, Jong Kim, Kuo-Chan Weng, Litao Yang, Xueping Xu, Matthew Robertson, Alon Azares, Austin J Cooney, Robert J. Schwartz and Yu Liu

      Accepted manuscript online: 21 JUL 2015 03:57AM EST | DOI: 10.1002/stem.2111

    2. Cytostatic effect of repeated exposure to simvastatin, a mechanism for chronic myotoxicity revealed by the use of mesodermal progenitors derived from human pluripotent stem cells

      Delphine Peric, Isabel Barragan, Karine Giraud-Triboult, Anne-Laure Egesipe, Laurène Meyniel-Schicklin, Christelle Cousin, Vincent Lotteau, Vincent Petit, Jawida Touhami, Jean-Luc Battini, Marc Sitbon, Christian Pinset, Magnus Ingelman-Sundberg, Delphine Laustriat and Marc Peschanski

      Accepted manuscript online: 17 JUL 2015 01:36AM EST | DOI: 10.1002/stem.2107

  6. Tissue-Specific Stem Cells

    1. Mesenchymal stromal cells prevent allostimulation in vivo and control checkpoints of Th1 priming: Migration of human DC to lymph nodes and NK cell activation

      C. Consentius, L. Akyüz, J. A. Schmidt-Lucke, C. Tschöpe, L. Pinzur, R. Ofir, P. Reinke, H.-D. Volk and K. Juelke

      Accepted manuscript online: 17 JUL 2015 01:34AM EST | DOI: 10.1002/stem.2104

  7. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice

      Yue-Qi Sun, Yuelin Zhang, Xin Li, Meng-Xia Deng, Wen-Xiang Gao, Yin Yao, Sin-Ming Chiu, Xiaoting Liang, Fei Gao, Camie W. Chan, Hung-Fat Tse, Jianbo Shi, Qing-Ling Fu and Qizhou Lian

      Accepted manuscript online: 14 JUL 2015 10:52AM EST | DOI: 10.1002/stem.2094

      Thumbnail image of graphical abstract

      Low expression of HLA molecules in human iPSC-MSCs under the stimulation of IFN-γ in vitro, and less inflammation and more cell survival after be transplanted into humanized mice. After the stimulation of IFN-γ, a low amount of STAT1 is phosphorylated and there is low IRF-1 and CIITA expression in human iPSC-MSCs. Next, low levels of CIITA are transcripted due to the low level of IRF-1 and the low number of p-STAT1 dimers. Consequently, there is an insufficient amount of CIITA proteins to induce the expression of HLA-II molecules. Less inflammation and more cell survival are found after the transplantation of human iPSC-MSCs into humanized mice.

  8. Tissue-Specific Stem Cells

    1. A role for mospd1 in mesenchymal stem cell proliferation and differentiation

      Madina Kara, Richard A. Axton, Melany Jackson, Sahar Ghaffari, Katrin Buerger, Alistair J. Watt, A. Helen Taylor, Brigid Orr, Winters R. Hardy, Bruno Peault and Lesley M. Forrester

      Accepted manuscript online: 14 JUL 2015 10:47AM EST | DOI: 10.1002/stem.2102

  9. Translational And Clinical Research

    1. hPSCs and NELL-1 Synergistically Enhance Spinal Fusion in Osteoporotic Rats

      Soonchul Lee, Xinli Zhang, Jia Shen, Aaron W. James, Choon G. Chung, Reef Hardy, Chenshuang Li, Caroline Girgius, Yulong Zhang, David Stoker, Huiming Wang, Benjamin M. Wu, Bruno Peault, Kang Ting and Chia Soo

      Accepted manuscript online: 14 JUL 2015 10:47AM EST | DOI: 10.1002/stem.2103

  10. Tissue-Specific Stem Cells

    1. Pharyngeal satellite cells undergo myogenesis under basal conditions and are required for pharyngeal muscle maintenance

      Matthew E. Randolph, Brittany L. Phillips, Hyo-Jung Choo, Katherine E. Vest, Yandery Vera and Grace K. Pavlath

      Accepted manuscript online: 14 JUL 2015 10:29AM EST | DOI: 10.1002/stem.2098

    2. Intranuclear Actin Regulates Osteogenesis

      Buer Sen, Zhihui Xie, Gunes Uzer, William R. Thompson, Maya Styner, Xin Wu and Janet Rubin

      Accepted manuscript online: 3 JUL 2015 05:36AM EST | DOI: 10.1002/stem.2090

      Thumbnail image of graphical abstract

      Graphical Abstract “In marrow MSC, depolymerization of cytoplasmic actin leads to its cofilin dependent translocation into the nucleus where it forms actin rods. Intranuclear actin results in YAP export and RUNX2 dependent osteogenesis.”

  11. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Barriers for Deriving Transgene-free Pig iPS Cells with Episomal Vectors

      Xuguang Du, Tao Feng, Dawei Yu, Yuanyuan Wu, Huiying Zou, Shuangyu Ma, Chong Feng, Yongye Huang, Hongsheng Ouyang, Xiaoxiang Hu, Dengke Pan, Ning Li and Sen Wu

      Accepted manuscript online: 2 JUL 2015 10:52AM EST | DOI: 10.1002/stem.2089

  12. Translational And Clinical Research

    1. You have free access to this content
      Bone Marrow Therapies for Chronic Heart Disease

      Iman Saramipoor Behbahan, Armand Keating and Robert Peter Gale

      Accepted manuscript online: 18 JUN 2015 07:52AM EST | DOI: 10.1002/stem.2080

  13. Tissue-Specific Stem Cells

    1. SWI/SNF-mediated lineage determination in mesenchymal stem cells confers resistance to osteoporosis

      Kevin Hong Nguyen, Fuhua Xu, Stephen Flowers, Edek A.J. Williams, J. Christopher Fritton and Elizabeth Moran

      Accepted manuscript online: 8 JUN 2015 05:59AM EST | DOI: 10.1002/stem.2064

      Thumbnail image of graphical abstract

      Deficiency of BRM-SWI/SNF favors osteoblast lineage selection and confers resistance to osteoporosis. The SWI/SNF chromatin-remodeling complex contains either brahma-related gene-1 (BRG1) or brahma (BRM) as the catalytic ATPase, and functions as a master regulator of gene expression. BRG1 is required for tissue-specific gene expression throughout development, but comparatively little is known about the alternative ATPase, BRM, because BRM-null mice develop normally. The present study now indicates that BRM-SWI/SNF plays a key role in lineage selection at the osteoblast vs adipocyte decision point. Rather than favoring tissue-specific gene expression generally, BRM-SWI/SNF represses osteogenic gene expression and promotes adipogenic gene expression. The bone marrow stromal cell (BMSC) population in BRM-null mice contains an increased percentage of osteoblast precursors, at the expense of cells able to differentiate along the adipocyte lineage. This is significant in conditions of osteoblast insufficiency, such that BRM-null mice are resistant to age-related osteoporosis.


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