STEM CELLS

Cover image for Vol. 34 Issue 8

Stem Cells Express (Accepted Articles - Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Jan A. Nolta

Impact Factor: 5.902

ISI Journal Citation Reports © Ranking: 2015: 3/21 (CELL & TISSUE ENGINEERING); 8/70 (Hematology); 14/161 (Biotechnology & Applied Microbiology); 24/213 (Oncology); 34/187 (Cell Biology)

Online ISSN: 1549-4918

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  1. Tissue-Specific Stem Cells

    1. Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone in vitro and in vivo

      Jose A. Morales-Garcia, Victor Echeverry-Alzate, Sandra Alonso-Gil, Marina Sanz-SanCristobal, Jose A. Lopez-Moreno, Carmen Gil, Ana Martinez, Angel Santos and Ana Perez-Castillo

      Accepted manuscript online: 19 AUG 2016 04:52AM EST | DOI: 10.1002/stem.2480

      Thumbnail image of graphical abstract

      The phosphodiesterase 7 (PDE7) enzyme is one of the enzymes responsible for controlling intracellular levels of cAMP in central nervous system. Here we described that PDE7 inhibition controls, in vitro and in animal models, stem cell expansion in the two main adult neurogenic niches: the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the subventricular zone (SVZ) in the adult rat brain. Adult rats orally treated with an inhibitor of PDE7, presented in the SGZ and the SVZ elevated numbers of proliferating progenitor cells, migrating precursors and finally a significant increase in newly generated neurons in the olfactory bulb and the hippocampus together with a better performance in memory tests. Our results indicate for the first time that inhibition of PDE7 directly regulates proliferation, migration and differentiation of neural stem cells, improving spatial learning and memory tasks.

  2. Translational and Clinical Research

    1. Implantation of Stromal Vascular Fraction Progenitors At Bone Fracture Sites: From A Rat Model To A First-In-Man Study

      Franziska Saxer, Arnaud Scherberich, Atanas Todorov, Patrick Studer, Sylvie Miot, Simone Schreiner, Sinan Güven, Laurent AH Tchang, Martin Haug, Michael Heberer, Dirk J Schaefer, Daniel Rikli, Ivan Martin and Marcel Jakob

      Accepted manuscript online: 19 AUG 2016 04:00AM EST | DOI: 10.1002/stem.2478

  3. Tissue-Specific Stem Cells

    1. Enhanced hematopoietic stem cell self-renewal-promoting ability of clonal primary MSC versus their osteogenic progeny

      Qiling He, C. Scott Swindle, Chao Wan, Robert J. Flynn, Robert A. Oster, Dongquan Chen, Fengjie Zhang, Yinglan Shu and Christopher A. Klug

      Accepted manuscript online: 19 AUG 2016 04:00AM EST | DOI: 10.1002/stem.2481

      Thumbnail image of graphical abstract

      By assessing multiple positive and negative markers of forebrain progenitors and neurons, the authors show that now-standard, partially directed neocortical differentiation of mouse embryonic stem cells generates neurons that most closely resemble neocortical projection neurons during mid-corticogenesis. These neurons are “stalled” in subtype-specific molecular refinements, as compared to primary, dissociated E15.5 neocortical neurons cultured under the same in vitro conditions.

  4. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Inhibition of MicroRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells

      Jialiang Liang, Wei Huang, Wenfeng Cai, Lei Wang, Linlin Guo, Christian Paul, Xi-Yong Yu and Yigang Wang

      Accepted manuscript online: 19 AUG 2016 03:57AM EST | DOI: 10.1002/stem.2477

      Thumbnail image of graphical abstract

      The inhibition of miR-495 in hiPSCs reversed the expression of its target genes such as VEZF1 and then increased the EC differentiation efficiency as well as the yield of ECs. The in vitro angiogenic functions including vessel sprouting, migration, proliferation, and growth factor expression in hiPSC-derived ECs were enhanced by miR-495 inhibition. The in vivo transplantation of the derived ECs significantly enhanced angiogenesis in infarcted heart and prevented the functional worsening.

  5. Translational and Clinical Research

    1. Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and are Safe for Single-stage Cartilage repair in Humans Upon Mixture with recycled Autologous Chondrons

      Tommy S. de Windt, Lucienne A. Vonk, Ineke C.M. Slaper-Cortenbach, Marcel P.H. van den Broek, Razmara Nizak, Mattie H.P. van Rijen, Roel A. de Weger, Wouter J.A. Dhert and Daniel B.F. Saris

      Accepted manuscript online: 10 AUG 2016 04:06AM EST | DOI: 10.1002/stem.2475

  6. Tissue-Specific Stem Cells

    1. Quiescent bone lining cells are a major source of osteoblasts during adulthood

      Igor Matic, Brya G. Matthews, Xi Wang, Nathaniel A. Dyment, Daniel L. Worthley, David W. Rowe, Danka Grcevic and Ivo Kalajzic

      Accepted manuscript online: 10 AUG 2016 04:06AM EST | DOI: 10.1002/stem.2474

    2. PGE2/EP4 signaling controls the transfer of the mammary stem cell state by lipid rafts in extracellular vesicles

      Meng-Chieh Lin, Shih-Yin Chen, Ho-Min Tsai, Pei-Lin He, Yen-Chun Lin, Harvey Herschman and Hua-Jung Li

      Accepted manuscript online: 10 AUG 2016 04:05AM EST | DOI: 10.1002/stem.2476

      Graphical Abstract Figure legend

      The proposed regulation of PGE2/EP4 signaling in basal MaSCs. Blocking PGE2/EP4 signaling causes the relocation of signaling receptors, mediators, and integrins into lipid rafts/caveolae. Following endocytosis, EP4 antagonism induces Rab27B and Rab35, which promote the docking of multi-vesicular endosomes at the plasma membrane and the subsequent release of EVs/exosomes. Eliciting EV/exosome release by blocking PGE2/EP4 signaling decreases basal MaSC lipid raft-associated surface receptors, stem cell surface markers, and signaling mediators; as a result, stem cell properties are lessened in basal MaSCs by transfer of these stem cell-related proteins out of the cell by EVs/exosomes. Ingestion by mammary luminal cells of EVs containing these abundant lipid raft-associated factors can elicit basal MaSC properties. EV: extracellular vesicles. bMaSCs: basal mammary stem cells. LRF: lipid raft fraction.

    3. The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells (CMCs) through a p53-Dependent Mechanism

      Joseph B. Moore IV, John Zhao, Matthew C. L. Keith, Alok R. Amraotkar, Marcin Wysoczynski, Kyung U. Hong and Roberto Bolli

      Accepted manuscript online: 9 AUG 2016 03:47AM EST | DOI: 10.1002/stem.2471

      Thumbnail image of graphical abstract

      Graphical Abstract

      HDAC1 Regulates the Expression of a Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells (CMCs) through a p53-Dependent Mechanism. CMCs depleted of HDAC1 exhibited induction of a cardiogenic transcriptional program characterized by enhanced expression of cardiomyogenic (MEF2C, NKX2.5, and TBX5)- and vasculogenic (CD31) factors. This phenomenon required and correlated with enhanced acetylation and stabilization of the tumor suppressor protein p53. Cardiogenic gene activation and elevated p53 expression levels observed in HDAC1-depleted CMCs were associated with heightened proclivity to assume a cardiomyogenic/vasculogenic cell-like fate in vitro. These results indicate HDAC1 depletion-induced p53 expression alters CMC cell fate decisions and identify HDAC1 as a potential exploitable target to facilitate CMC-mediated myocardial repair in ischemic cardiomyopathy.

  7. Cancer Stem Cells

    1. Response to the Letter: On the Growth of Hematopoietic Stem Cells and Childhood Leukeamias

      Benjamin Werner, Arne Traulsen and David Dingli

      Accepted manuscript online: 4 AUG 2016 12:26AM EST | DOI: 10.1002/stem.2469

    2. Letter to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukaemias

      Ion Udroiu and Antonella Sgura

      Accepted manuscript online: 4 AUG 2016 12:26AM EST | DOI: 10.1002/stem.2468

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