STEM CELLS

Cover image for Vol. 34 Issue 1

Stem Cells Express (Accepted Articles - Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Jan A. Nolta

Impact Factor: 6.523

ISI Journal Citation Reports © Ranking: 2014: 2/21 (CELL & TISSUE ENGINEERING); 4/68 (Hematology); 10/163 (Biotechnology & Applied Microbiology); 20/211 (Oncology); 33/184 (Cell Biology)

Online ISSN: 1549-4918

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  1. 1 - 23
  1. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B-Cells into Induced Pluripotent Stem Cells

      Álvaro Muñoz-López, Eddy. H. J. van Roon, Damià Romero-Moya, Belén López-Millan, Ronald Stam, Dolors Colomer, Mahito Nakanishi, Clara Bueno and Pablo Menendez

      Accepted manuscript online: 6 FEB 2016 05:24AM EST | DOI: 10.1002/stem.2303

      Thumbnail image of graphical abstract

      Graphical abstract. Cellular hierarchy and ontogeny influence the reprogramming efficiency of the B-cell compartment into iPSCs. Human B-cell progenitors are reprogrammed into iPSCs significantly easier than committed Blymphocytes. Similarly, human fetal B-cells are reprogrammed into iPSCs at much higher efficiency than neonatal (cord blood) and adult (peripheral blood) B-cells, highlighting how cellular hierarchy and ontogeny impact reprogramming into pluripotency. Early ontogeny and immature phenotype are associated to higher proliferation rates, a key mechanism underlying reprogramming.

  2. Tissue-Specific Stem Cells

    1. MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2–Lin28/let-7 Signaling Pathway

      Ana L. Morgado, Cecília M. P. Rodrigues and Susana Solá

      Accepted manuscript online: 6 FEB 2016 05:24AM EST | DOI: 10.1002/stem.2309

    2. Peribiliary Glands as a Niche of Extra-Pancreatic Precursors Yielding Insulin-Producing Cells in Experimental and Human Diabetes

      Guido Carpino, Rosa Puca, Vincenzo Cardinale, Anastasia Renzi, Gaia Scafetta, Lorenzo Nevi, Massimo Rossi, Pasquale B. Berloco, Stefano Ginanni Corradini, Lola M. Reid, Marella Maroder, Eugenio Gaudio and Domenico Alvaro

      Accepted manuscript online: 6 FEB 2016 05:23AM EST | DOI: 10.1002/stem.2311

      Thumbnail image of graphical abstract

      Graphical Abstract

      Peribiliary glands (PBGs) are located throughout the extrahepatic biliary tree and represent the niche of multipotent (Sox9+) biliary tree stem/progenitor cells (BTSC). In our experimental models, streptozotocin (STZ) administration determined the reduction of pancreatic islets and a correlated increase of PBG mass; in STZ models, PBGs are characterized by the expansion of Sox9+ proliferating cells, the increase of mucinous cells, and the appearance of insulinproducing cells. In parallel, at the level of hepato-pancreatic ampulla, Type 2 Diabetic (T2D) patients showed PBG hyperplasia, proliferation, and signs of endocrine pancreatic commitment in comparison with normal subjects. In summary, our findings indicated that cells in PBGs respond to diabetes with proliferation and differentiation towards insulin-producing cells.

    3. The Slicer Endonuclease Argonaute 2 is a Negative Regulator of Hematopoietic Stem Cell Quiescence

      Kenneth Lu, Masahiro Marshall Nakagawa, Keyur Thummar and Chozha Vendan Rathinam

      Accepted manuscript online: 6 FEB 2016 05:23AM EST | DOI: 10.1002/stem.2302

      Thumbnail image of graphical abstract

      Graphical Abstract

      A deficiency of the slicer endonuclease Argonaute (Ago) 2, a key enzyme involved in the miRNA biogenesis pathway, in HSCs causes defective self-renewal, reduced proliferation and augmented myeloid differentiation due to alterations in the molecular signature and Transcription Factor networks.

    4. Manipulating Stem Cells to Treat Calcification Pharmacological Regulation of in-situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment

      Jia-Jie Hu, Zi Yin, Wei-Liang Shen, Yu-Bin Xie, Ting Zhu, Ping Lu, You-Zhi Cai, Min-Jian Kong, Boon Chin Heng, Yi-Ting Zhou, Wei-Shan Chen, Xiao Chen and Hong-Wei Ouyang

      Accepted manuscript online: 6 FEB 2016 05:21AM EST | DOI: 10.1002/stem.2306

  3. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Jun-Mediated Changes in Cell Adhesion Contribute to Mouse Embryonic Stem Cell Exit from Ground State Pluripotency

      Giulia Veluscek, Yaoyong Li, Shen-Hsi Yang and Andrew D. Sharrocks

      Accepted manuscript online: 6 FEB 2016 05:21AM EST | DOI: 10.1002/stem.2294

  4. Stem Cell Technology: Epigenetics, Genomics, Proteomics And Metabonomics

    1. Knockdown of Dnmt1 and Dnmt3a Promotes the Angiogenesis of hMSCs Leading to Arterial Specific Differentiation

      Rui Zhang, Nan Wang, Li-Nan Zhang, Na Huang, Tie-Feng Song, Zheng-Zheng Li, Man Li, Xue-Gang Luo, Hao Zhou, Hong-Peng He, Xiao-yu Zhang, Wenjian Ma and Tong-Cun Zhang

      Accepted manuscript online: 6 FEB 2016 05:21AM EST | DOI: 10.1002/stem.2288

  5. Regenerative Medicine

    1. Cell therapies for stroke and traumatic brain injury: Targeting microglia

      Sean I. Savitz and Charles S. Cox

      Accepted manuscript online: 4 FEB 2016 05:46PM EST | DOI: 10.1002/stem.2253

    2. Wnt3a, a protein secreted by Mesenchymal Stem Cells is neuroprotective and promotes neurocognitive recovery following Traumatic Brain Injury

      Yuhai Zhao, Stuart L. Gibb, Jing Zhao, Anthony N. Moore, Michael J Hylin, Tyler Menge, Hasen Xue, Gyulnar Baimukanova, Daniel Potter, Evan M. Johnson, John B. Holcomb, Charles S. Cox Jr, Pramod K. Dash and Shibani Pati

      Accepted manuscript online: 3 FEB 2016 05:38PM EST | DOI: 10.1002/stem.2310

  6. Tissue-Specific STEM Cells

    1. Systems genetics analysis of a recombinant inbred mouse cell culture panel reveals Wnt pathway member Lrp6 as a regulator of adult hippocampal precursor cell proliferation

      Suresh Kannan, Zeina Nicola, Rupert W. Overall, Muhammad Ichwan, Gerardo Ramírez-Rodríguez, Anna Grzyb, Giannino Patone, Kathrin Saar, Norbert Hübner and Gerd Kempermann

      Accepted manuscript online: 3 FEB 2016 05:38PM EST | DOI: 10.1002/stem.2313

  7. Regenerative Medicine

    1. Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

      Aleksandra Leszczynska, Aideen O'Doherty, Eric Farrell, Jana Pindjakova, Fergal J. O'Brien, Timothy O'Brien, Frank Barry and J. Mary Murphy

      Accepted manuscript online: 3 FEB 2016 05:38PM EST | DOI: 10.1002/stem.2315

  8. Translational and Clinical Research

    1. Cell-based therapies and other non-traditional approaches for Type 1 diabetes

      Remi J. Creusot, Manuela Battaglia, Maria-Grazia Roncarolo and C. Garrison Fathman

      Accepted manuscript online: 3 FEB 2016 05:37PM EST | DOI: 10.1002/stem.2290

  9. Tissue-Specific STEM Cells

    1. When colonies are not clones: Evidence and implications of intracolony heterogeneity in mesenchymal stem cells

      Deena A. Rennerfeldt and Krystyn J. Van Vliet

      Accepted manuscript online: 3 FEB 2016 05:37PM EST | DOI: 10.1002/stem.2296

  10. Translational and Clinical Research

  11. Regenerative Medicine

    1. Human stem cells overexpressing miR-21 promote angiogenesis in critical limb ischemia by targeting CHIP to enhance HIF-1α activity

      Yong Zhou, Youming Zhu, Li Zhang, Tao Wu, Tingting Wu, Wenjie Zhang, AM Decker, Jiacai He, Jie Liu, Yiqun Wu, Xinqun Jiang, Zhiyuan Zhang, Chaozhao Liang and Duohong Zou

      Accepted manuscript online: 3 FEB 2016 04:52PM EST | DOI: 10.1002/stem.2321

  12. Tissue-Specific Stem Cells

    1. A novel selectable ISL-1 positive progenitor cell reprogrammed to expandable and functional smooth muscle cells

      E.C. Turner, C.L. Huang, N. Sawhney, K. Govindarajan, A.J.P. Clover, K. Martin, T.C. Browne, A.H.S. Kumar, J.J. Mackrill, D. Whelan, S. Wang, J. Schmeckpeper, A. Stocca, W.G. Pierce, A.L. Leblond, L. Cai, C.K. Buneker, J. Choi, J. MacSharry, Y. Ikeda, S.J. Russell and N.M. Caplice

      Accepted manuscript online: 3 FEB 2016 04:48PM EST | DOI: 10.1002/stem.2319

  13. Cancer Stem Cells

    1. IGF/STAT3/NANOG/Slug signaling axis simultaneously controls epithelial-mesenchymal transition and stemness maintenance in colorectal cancer

      Chao Yao, Li Su, Juanjuan Shan, Chuanlin Zhu, Limei Liu, Chungang Liu, Yanmin Xu, Zhi Yang, Xiuwu Bian, Jimin Shao, Jianming Li, Maode Lai, Junjie Shen and Cheng Qian

      Accepted manuscript online: 3 FEB 2016 04:46PM EST | DOI: 10.1002/stem.2320

  14. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes

      Erin Lambers, Baron Arnone, Anees Fatima, Gangjian Qin, J. Andrew Wasserstrom and Tsutomu Kume

      Accepted manuscript online: 29 JAN 2016 10:54AM EST | DOI: 10.1002/stem.2301

  15. Regenerative Medicine

    1. Cell-surface MMP-9 protein is a novel functional marker to identify and separate pro-angiogenic cells from early endothelial progenitor cells derived from CD133+ cells

      Toshie Kanayasu-Toyoda, Takeshi Tanaka, Yutaka Kikuchi, Eriko Uchida, Akifumi Matsuyama and Teruhide Yamaguchi

      Accepted manuscript online: 29 JAN 2016 10:53AM EST | DOI: 10.1002/stem.2300

  16. Cancer Stem Cells

    1. A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche

      Kouichi Tabu, Nozomi Muramatsu, Christian Mangani, Mei Wu, Rong Zhang, Taichi Kimura, Kazuo Terashima, Norihisa Bizen, Ryosuke Kimura, Wenqian Wang, Yoshitaka Murota, Yasuhiro Kokubu, Ikuo Nobuhisa, Tetsushi Kagawa, Issay Kitabayashi, Mark Bradley and Tetsuya Taga

      Accepted manuscript online: 29 JAN 2016 02:44AM EST | DOI: 10.1002/stem.2299

  17. Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics

    1. You have full text access to this OnlineOpen article
      Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via NFkB Signaling

      Johnathon D. Anderson, Henrik J. Johansson, Calvin S. Graham, Mattias Vesterlund, Missy T. Pham, Charles S. Bramlett, Elizabeth N. Montgomery, Matt S. Mellema, Renee L. Bardini, Zelenia Contreras, Madeline Hoon, Gerhard Bauer, Kyle D. Fink, Brian Fury, Kyle J. Hendrix, Frederic Chedin, Samir EL-Andaloussi, Billie Hwang, Michael S. Mulligan, Janne Lehtiö and Jan A. Nolta

      Accepted manuscript online: 19 JAN 2016 08:08AM EST | DOI: 10.1002/stem.2298

      Thumbnail image of graphical abstract

      Graphical Abstract

      Mesenchymal stem cells (MSCs) exposed to peripheral arterial disease-like (PAD) conditions increase expression of a diverse profile of angiogenic proteins which are subsequently packaged into exosome for secretion and induce angiogenesis in endothelial cells.

  18. Tissue-Specific Stem Cells

    1. The Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation

      Tareq Hossan, Sankari Nagarajan, Simon J. Baumgart, Wanhua Xie, Roberto Tirado Magallanes, Céline Hernandez, Pierre-Marie Chiaroni, Daniela Indenbirken, Melanie Spitzner, Morgane Thomas-Chollier, Marian Grade, Denis Thieffry, Adam Grundhoff, Florian Wegwitz and Steven A. Johnsen

      Accepted manuscript online: 11 JAN 2016 03:40AM EST | DOI: 10.1002/stem.2287

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