STEM CELLS

Cover image for Vol. 34 Issue 12

Stem Cells Express (Accepted Articles - Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Jan A. Nolta

Impact Factor: 5.902

ISI Journal Citation Reports © Ranking: 2015: 3/21 (CELL & TISSUE ENGINEERING); 8/70 (Hematology); 14/161 (Biotechnology & Applied Microbiology); 24/213 (Oncology); 34/187 (Cell Biology)

Online ISSN: 1549-4918

Associated Title(s): STEM CELLS Translational Medicine

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  1. Translational and Clinical Research

    1. A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells

      Gisela Pachón-Peña, Conor Donnelly, Catalina Ruiz-Cañada, Adam Katz, Sonia Fernández-Veledo, Joan Vendrell and Robert Sackstein

      Accepted manuscript online: 26 NOV 2016 05:50AM EST | DOI: 10.1002/stem.2549

    2. Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction following Trauma or Sepsis

      Michael A. Matthay, Shibani Pati and Jae-Woo Lee

      Accepted manuscript online: 26 NOV 2016 04:07AM EST | DOI: 10.1002/stem.2551

  2. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival

      Hadar Amir, Thomas Touboul, Karen Sabatini, Divya Chhabra, Ibon Garitaonandia, Jeanne F. Loring, Robert Morey and Louise C. Laurent

      Accepted manuscript online: 26 NOV 2016 04:07AM EST | DOI: 10.1002/stem.2550

      Thumbnail image of graphical abstract

      Phenotypes altered by single-copy deletion of TP53 in human embryonic stem cells.

  3. Tissue-Specific Stem Cells

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      Cutting Edge Advances in Stem Cell Biology and Therapy

      Jan A. Nolta

      Accepted manuscript online: 22 NOV 2016 03:40AM EST | DOI: 10.1002/stem.2547

  4. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Abrogation Of Gap Junctional Communication In Es Cells Results In A Disruption Of Primitive Endoderm Formation In Embryoid Bodies

      Philipp Wörsdörfer, Felicitas Bosen, Martina Gebhardt, Nicole Russ, Katrin Zimmermann, David Komla Kessie, Thileepan Sekaran, Angela Egert, Süleyman Ergün, Hubert Schorle, Alexander Pfeifer, Frank Edenhofer and Klaus Willecke

      Accepted manuscript online: 21 NOV 2016 08:50AM EST | DOI: 10.1002/stem.2545

      Thumbnail image of graphical abstract

      Graphical abstract

      Our study set out to identify the functional role of gap junctional intercellular communication (GJIC) in ES cells. The deletion of Connexin43 and Connexin45 leads to an abrogation of GJIC, which resulted in defective primitive endoderm formation in embryoid bodies (EBs). We assume that IP3 diffuses via gap junction conduits to coordinate and sustain NFATc3 activation in a synchronized manner. As a consequence of Cx43/45 deletion the IP3 mediated synchronization breaks down and the development of primitive endoderm is impaired. A similar phenotype is observed upon blocking NFAT signaling using the calcineurin inhibitor Cyclosporin A (CSA). The fluorescence pictures show Ebs on day6 of differentiation. The primitive endoderm marker Gata6 is shown in red, the pluripotency marker Nanog in green. Scale: 20 μm.

  5. Tissue-Specific Stem Cells

    1. Mesenchymal stem cell-derived microvesicles modulate LPS-induced inflammatory responses to microglia cells

      Yarúa Jaimes, Yahaira Naaldijk, Kerstin Wenk, Christiane Leovsky and Frank Emmrich

      Accepted manuscript online: 16 NOV 2016 03:10AM EST | DOI: 10.1002/stem.2541

      Thumbnail image of graphical abstract

      GRAPHICAL ABSTRACT

      Mesenchymal stem cell-derived microvesicles (MSC-MVs) prevent the activation of LPS-stimulated BV-2 cells. Microglia cells display an elongated and ramified morphology in the resting state, whereas activated cells show amoeboid morphology. Representative immunofluorescence image of BV-2 cells without stimulation (NC), in presence of pure MSC-MV, stimulated with Lipopolysaccharides (LPS) and stimulated with LPS in the presence of MSC-MVs (LPS+MSCMV). The higher panel shows BV-2 cells labelled with CFSE (green) and Hoechst 33258 (Blue). The lower panel represents bright field microscopy pictures with arrows pointing to the elongated structures formed by the cell membrane in resting cells. The scale bar is equivalent to 50μm.

  6. Regenerative Medicine

    1. Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and MCP-1 Synergistically Regenerate Transected Rat Peripheral Nerves by Altering Macrophage Polarity

      Fumiya Kano, Kohki Matsubara, Minoru Ueda, Hideharu Hibi and Akihito Yamamoto

      Accepted manuscript online: 10 NOV 2016 02:10AM EST | DOI: 10.1002/stem.2534

      Thumbnail image of graphical abstract

      MCP-1 and sSiglec-9 secreted from dental pulp stem cells polarized bone marrow-derived macrophages toward tissue reparative M2, which expressed multiple trophic factors that enhanced proliferation, migration, and differentiation of Schwann cells, blood vessel formation, and nerve fiber extension. Transection of facial nerve involving a nerve gap overwhelms their repairing activity, however MCP-1/sSiglec-9 treatment restored nerve function through the induction of M2 in the nerve gap. The M2 promoted recruitment of a number of de-differentiated SCs, formation of a SC bridge and extension of the transected nerve fiber. Our study demonstrates the remarkable therapeutic benefits of the stem cell-derived M2 inducers, MCP-1 and sSiglec-9, for regenerating severely injured peripheral nerves.

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