STEM CELLS

Cover image for Vol. 34 Issue 9

Stem Cells Express (Accepted Articles - Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Jan A. Nolta

Impact Factor: 5.902

ISI Journal Citation Reports © Ranking: 2015: 3/21 (CELL & TISSUE ENGINEERING); 8/70 (Hematology); 14/161 (Biotechnology & Applied Microbiology); 24/213 (Oncology); 34/187 (Cell Biology)

Online ISSN: 1549-4918

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  1. Tissue-Specific Stem Cells

    1. Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression

      Lindsay C. Davies, Nina Heldring, Nadir Kadri and Katarina Le Blanc

      Accepted manuscript online: 27 SEP 2016 07:16AM EST | DOI: 10.1002/stem.2509

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      Stem Cell Population Biology: Insights from Haematopoiesis

      Adam L MacLean, Cristina Lo Celso and Michael PH Stumpf

      Accepted manuscript online: 27 SEP 2016 07:12AM EST | DOI: 10.1002/stem.2508

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      Graphical Abstract

      Population dynamics can explain the maintenance, dominance, and extinction of stem cells and their progeny, through careful use of mathematical models. In the haematopoietic stem cell niche, competition between healthy and leukemic stem cells impacts cancer incidence and progression. Grey arrows: cell production by differentiation; red dashed arrows: possible regulatory interactions.

  2. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Depletion of the fragile X mental retardation protein in embryonic stem cells alters the kinetics of neurogenesis

      Olfa Khalfallah, Marielle Jarjat, Laetitia Davidovic, Nicolas Nottet, Sandrine Cestèle, Massimo Mantegazza and Barbara Bardoni

      Accepted manuscript online: 24 SEP 2016 05:10AM EST | DOI: 10.1002/stem.2505

    2. Concise Review: Lessons from Naïve Human Pluripotent Cells

      Carol B. Ware

      Accepted manuscript online: 24 SEP 2016 05:10AM EST | DOI: 10.1002/stem.2507

  3. Tissue-Specific Stem Cells

    1. Advanced glycation endproducts impair endothelial progenitor cell migration and homing via syndecan 4 shedding

      Jun Xie, Ran Li, Han Wu, Jianzhou Chen, Guannan Li, Qinhua Chen, Zhonghai Wei, Guixin He, Lian Wang, Albert Ferro and Biao Xu

      Accepted manuscript online: 24 SEP 2016 05:10AM EST | DOI: 10.1002/stem.2506

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      Graphical Abstract

      AGEs induce syndecan 4(synd4) shedding from late EPCs. The synd4 was an important receptor on the cell surface to mediate cell migration. (A) Schematic showing the antibody against the cytoplasmic epitope of synd4. (B) Representative immunoblots showing synd4 expression in late EPCs incubated with 200 μg/l AGEs for 12 h using antibody against cyt-synd4. The fragment of about 10 kDa was increased, representing the residual fragment of synd4 after shedding; in parallel, the full length fragment (40 kDa) of synd4 was decreased. N=3. (C) Representative flow cytometric showing that surface ext-synd4 expression was decreased in CD34+ PMNC from T2DM patients compared with those from controls. N=6. (D) Late EPCs were treated with Lv null, Lv si-synd4, or Lv null together with AGEs, and their migration was examined in an SDF-1 gradient (0-5 ng/ml) by fluorescence microscopy. Forty cells of each group were selected randomly, tracked and analyzed. Inhibition of synd4 reduces the migration of late EPCs. N=3.

  4. Regenerative Medicine

    1. Reactive oxygen species impair the function of cd90+ hematopoietic progenitors generated from human pluripotent stem cells

      Roger E. Rönn, Carolina Guibentif, Shobhit Saxena and Niels-Bjarne Woods

      Accepted manuscript online: 19 SEP 2016 04:12AM EST | DOI: 10.1002/stem.2503

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      Graphical Abstract. Reactive Oxygen Species Impair the Function of CD90+ Hematopoietic Progenitors Generated from Human Pluripotent Stem Cells

      Elevated levels of ROS correlates with reduced functionality in hPSC-derived hematopoietic progenitors. Strategies aimed at reducing the level of ROS specifically benefit the more primitive hPSC-derived hematopoietic cell fraction resulting in increased functionality in terms of growth potential.

    2. Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts

      Clara T. Nicolas, Raymond D. Hickey, Harvey S. Chen, Shennen A. Mao, Manuela Lopera Higuita, Yujia Wang and Scott L. Nyberg

      Accepted manuscript online: 19 SEP 2016 03:48AM EST | DOI: 10.1002/stem.2500

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      Graphic Abstract

      De- and recellularization process for the creation of bioengineered livers: along with cell transplantation and bioartificial liver systems, the most promising alternative to orthotopic, allogeneic whole-organ liver transplantation that regenerative medicine has to offer.

  5. Translational and Clinical Research

    1. The use of Adipose-derived Stromal Vascular Fraction Cells and Platelet Rich Plasma in Regenerative Plastic Surgery

      Pietro Gentile, Maria Giovanna Scioli, Alessandra Bielli, Augusto Orlandi and Valerio Cervelli

      Accepted manuscript online: 19 SEP 2016 03:48AM EST | DOI: 10.1002/stem.2498

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      Graphical Abstract

      The use of autologous stem cells, growth factors and biomaterials in regenerative medicine.

  6. Regenerative Medicine

    1. Organ Engineering: Design, Technology, and Integration

      Gaurav Kaushik, Jeroen Leijten and Ali Khademhosseini

      Accepted manuscript online: 19 SEP 2016 03:48AM EST | DOI: 10.1002/stem.2502

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      Table of Content Abstract

      Organ engineering offers tremendous promise for regenerative medicine on multiple fronts, including transplants for patients and improved preclinincal diagnostic modeling. This review encompasses integrative approaches in engineering in an accessible manner. In addition to its core subject, improved culture systems are discussed which could benefit biologists across fields, not just stem cell biology and regenerative medicine.

  7. Original Research

    1. An LPA1/3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells (MSCs) and Promotes Growth and Vascularization of Multiple Myeloma

      Masahiko Kanehira, Tohru Fujiwara, Shinji Nakajima, Yoko Okitsu, Yasushi Onishi, Noriko Fukuhara, Ryo Ichinohasama, Yoshinori Okada and Hideo Harigae

      Accepted manuscript online: 19 SEP 2016 03:48AM EST | DOI: 10.1002/stem.2499

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      Legend for graphical TOC

      The signaling through lysophosphatidic acid receptor 1 (LPA1) and 3 (LPA3) in bone marrow mesenchymal stromal cells (MSCs) is an important determinant in multiple myeloma (MM) progression. LPA3-silenced MSCs exhibit pro-senescent phenotypes and promote MM progression and tumor-related angiogenesis via transdifferentiation into tumor-associated fibroblasts (TAFs) and FGF2 production. Conversely, LPA1-silenced MSCs exhibit anti-senescent phenotypes and delay MM progression. These results suggest that LPA1/3 axis is a crucial regulator of formation of tumor microenvironment and a novel conceptual target for MM therapy.

  8. Tissue-Specific Stem Cells

    1. The Cellular Prion Protein Controls Notch Signalling in Neural Stem/Progenitor Cells

      Séverine Martin-Lannerée, Sophie Halliez, Théo Z. Hirsch, Julia Hernandez-Rapp, Bruno Passet, Céline Tomkiewicz, Ana Villa-Diaz, Juan-Maria Torres, Jean-Marie Launay, Vincent Béringue, Jean-Luc Vilotte and Sophie Mouillet-Richard

      Accepted manuscript online: 19 SEP 2016 03:48AM EST | DOI: 10.1002/stem.2501

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      Legend to graphical abstract

      Model for PrPC action on Notch and stemness in neural progenitors:

      PrPC positively regulates the expression of Notch ligands and that of the Notch receptors and its ablation compromises Notch signalling;

      Proper Notch signalling supports N-cadherin-mediated cell-cell contacts as well as the expression of NSC markers and exerts a positive feedback action on PrPC;

      Downstream from PrPC, Notch signalling additionally upregulates the expression of EGFR, which, when activated, negatively regulates both PrPC and Notch.

      Thus, PrPC, the Notch pathway and EGFR belong to a gene regulatory network, whose imbalance may shift towards “more stemness” (higher Notch activity induces higher PrPC expression and vice-versa) or “less stemness” (EGFR activation dampens Notch signalling and PrPC expression).

    2. H/ACA Box Small Nucleolar RNA 7A promotes the Self-Renewal of Human Umbilical Cord Mesenchymal Stem Cells

      Yan Zhang, Chen Xu, Daolan Gu, Minjuan Wu, Binghao Yan, Zhenyu Xu, Yue Wang and Houqi Liu

      Accepted manuscript online: 30 AUG 2016 03:41AM EST | DOI: 10.1002/stem.2490

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