Cover image for Vol. 34 Issue 12

Edited By: Jan A. Nolta

Impact Factor: 5.902

ISI Journal Citation Reports © Ranking: 2015: 3/21 (CELL & TISSUE ENGINEERING); 8/70 (Hematology); 14/161 (Biotechnology & Applied Microbiology); 24/213 (Oncology); 34/187 (Cell Biology)

Online ISSN: 1549-4918

Associated Title(s): STEM CELLS Translational Medicine

Author Guidelines

Author Guidelines 2016 - AlphaMed Press and Wiley

Table of Contents

General Information
Mission and Focus
Manuscript Types
Peer-Review Process
Preparation and Online Submission of Articles
Post-Acceptance Information
Article Enhancements
Author Rights
Reprints and Permission


STEM CELLS is co-published by AlphaMed Press and Wiley.

STEM CELLS, the premier journal on stem and progenitor cell biology, offers high visibility for your published research and maintains consistently high quality content dedicated to all aspects of stem cell research. Reasons to publish in STEM CELLS:

Enhanced Print and Online presentation – STEM CELLS is offered on Wiley Online Library for easy and wider access, featuring a variety of new and dynamic online functionalities.

High Quality Content – Maintained through a rigorous peer-review system and an internationally renowned group of scientists that serve as Editors and on the Editorial Board.

Rapid Publication – Posting accepted manuscripts online within 10 days of acceptance.

Enhanced Discoverability for Your Paper – Generated through CrossRef Links (enabling users to move from a reference to your article) and e-mail fTOCs (forthcoming Table of Contents) and eTOC (Table of Contents) Alerts and RSS Feeds sent to users on acceptance and publication of your paper.

Strong Impact Factor – 2014 IF of 6.523 and listed in the Cell Biology, Hematology, Oncology, and Biotechnology & Applied Microbiology categories of ISI.

Online Submission – Scholar One Manuscripts helps speed up the peer-review process.


Committee on Publication Ethics (COPE)

STEM CELLS is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE)


STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology.

STEM CELLSwelcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The Journal covers all aspects of stem cells embryonic stem cells/induced pluripotent stem cells; tissue-specific stem cells; stem cell technology: epigenetics, genomics, proteomics, and metabonomics; cancer stem cells; translational and clinical research; and regenerative medicine.


While the Publisher and Editorial Board make every effort to see that no inaccurate or misleading data, opinions, or statements appear in the Journal, they wish to state that the data and opinions in the articles and advertisements herein are the responsibility of the contributor or advertiser concerned. Accordingly, the Publisher, the Editorial Board, and their respective employees, officers and agents accept no liability whatsoever for the consequences of any inaccurate or misleading data, opinion, or statement.

Conduct Policy

As the first journal devoted to the fast-paced area of stem cells and regenerative medicine, STEM CELLS remains in the top tier of peer-reviewed monthly journals for this discipline. This mission requires ongoing, scrupulous attention to the quality and integrity of the Journal's publications, and irreproachable conduct on the part of its authors, reviewers, and editors. In pursuit of this goal, STEM CELLS has adopted a Conduct Policy that reflects and supports the Journal's unwavering commitment to the quality and integrity of work it publishes.

The Conduct Policy outlines the standards of professional behavior expected of authors, reviewers, and editors, and addresses the Journal's policy for handling potential instances of misconduct.

Please refer to the Information for Contributors to read the policy in full. For any questions or concerns, please contact the editorial office for STEM CELLS (


Original Research Articles


Reports new findings of major importance. The manuscript should include an Abstract, Introduction, Methods, Results, and a Discussion and Conclusion that place the findings in context and examines the implications for future research.

Word limit: 5,000
Display items: 7
Max References: 100
Submission Fee: $90
Publication Fee: $2000


Concise Reviews


Reviews should address the impact of new concepts or information on clinical disease management, including prognosis, treatment, prevention, or diagnosis.

Word limit: 3,000
Display items: 2
Max References: 50
Submission Fee: $90
Publication Fee: $2000


Brief Reports


Short reports of current research. The manuscript should include an Abstract, Introduction, Methods, Results, and a Discussion and Conclusion that place the findings in context and examines the implications for future research.

Word limit: 1,200
Display items: 4
Max References: 25
Submission Fee: $90
Publication Fee: $2000


Letters to the Editor


Letters to the Editor may deal with material in published papers, or they may raise new issues.

Word limit: 500
Display items: 1
Max References: 10
Submission Fee: N/A
Publication Fee: N/A


For more details, please refer to STEM CELLSInformation for Contributors.


STEM CELLS abides by a policy of anonymous peer review. As a single-blind review process, authors do not know the identity of their reviewers. The Editor and Associate Editors appoint Editorial Board members to lead the reviews and select external reviewers from a database of experts. These reviewers provide comments for the Editors and the authors, as well as a publication recommendation. Upon receiving the comments, the Associate Editor responsible for the manuscript makes a recommendation to the Editor, who must endorse all final manuscript decisions. Often, the Editors seek manuscript opinions from one another and/or discuss decisions.

Acceptance of manuscripts is based on originality and importance to the field, as assessed by the Editors. Acceptance and publication decisions are made by the Editors. For further information, see the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals,” published by the International Committee of Medical Journal Editors (ICMJE).

Based on editorial judgment, some submissions are rejected initially without external review. If review is required, authors may expect to learn of rejection or acceptance in approximately 2 weeks.

Upon completion of review, the Editors’ decision will be e-mailed to the corresponding author, along with the reviewers’ comments. The author will receive one of the following decisions:

Reject: The Editors did not select your manuscript for publication. Many factors contribute to acceptance including, but not limited to, the following:

  • Importance of the research to the field of translational medicine
  • Originality of the work
  • Quality of the study
  • Priority of the work to STEM CELLS and its readership

If an author disagrees with the editorial decision, cordial inquiry is invited. The response must be timely and include a detailed rebuttal.

Major Revision: The Editors believe that your article contained information of potential importance but a number of major issues were raised. The editors would be willing to reconsider your manuscript, but cannot guarantee acceptance, particularly if you cannot address the concerns.

Minor Revision: The Editors found your manuscript potentially acceptable for publication, provided you make some minor adjustments.

Acceptance: The Editors selected your manuscript for publication. Additional information will be provided via separate email regarding embargo policies and the production process.

Authors are given three months to complete a request for major revision and three weeks to complete minor revisions or revisions on a revised manuscript. Revisions must also contain a detailed point-by-point response to the comments of the reviewers and/or Editors. The cover letter should briefly summarize how the revised manuscript addressed these comments.


General Instructions for Online Manuscript Submission with STEM CELLS Manuscript Central

1. Please read the detailed manuscript submission instructions: Information for Contributors

2. Click on the required forms you'll need to download and return:

Submission Fee Form
Potential Conflict of Interest and Financial Disclosure Form
Copyright Assignment Form

Submission Fee Form

A nonrefundable submission fee of $90 USD is required upon online submission of the manuscript. The review process will not begin until the submission fee has been received. With your payment, include full identifying information: the corresponding author's name, address, and telephone number, as well as the title of the submitted manuscript. It can be completed on your screen and faxed or e-mailed to the contact information on the form. Please make payment in U.S. funds with a credit card (American Express, MasterCard, or Visa).

Potential Conflict of Interest and Financial Disclosure & Copyright Assignment Forms

For the initial submission, the corresponding author must complete and sign the Potential Conflict of Interest and Financial Disclosure Form, and the Copyright Assignment Form. These should be uploaded with the manuscript files at the time of submission. Forms from co-authors will be collected upon receipt of revision (if applicable).

Please be aware that ScholarOne Manuscripts will send all communications about the paper (including the request for final approval and the confirmation of submission) to the person who is checked as contact author during the submission process.

3. Then go to to submit your manuscript.

Steps for Submitting a Manuscript on Manuscript Central may be found in STEM CELLS’ Information for Contributors. You can also click here to send e-mail to the Editorial Office.

Adobe Acrobat® Reader™ is required to open the Information for Authors, as well as all supporting forms. Click here to download Adobe Acrobat® Reader™.

For technical assistance in uploading your manuscript files, there is a "Get Help Now" button in Manuscript Central.

Other documents:

Permissions Information form


Page Proofs

The corresponding authors are sent page proofs, which are to be carefully proofread for any copyediting or typesetting errors. Authors should also make sure that any renumbered tables, figures or references match text citations and that figure legends correspond with text citations and actual figures. Please also make sure that author names and institutions are correct on the title page via the color-coding to ensure correct indexing in PubMed Central (PMC). Any corrections made at the page-proof stage will be applied to the publish-ahead-of-print version of the manuscript online and to the printed version of the manuscript. Proofs must be returned within 48 hours of receipt.

Publication Fee (Required Fee)

Proffered manuscripts that are accepted for publication will be assessed a publication fee of $2,000, which includes all page charges and any applicable color charges. The author agrees to pay this fee to the Publisher within 30 days of receiving the Publisher's invoice. If an author is unable to support this publication fee, it is his or her responsibility to inform the Editorial Office at the time of manuscript submission. Letters to the Editor and invited manuscripts are exempt from the publication fee.

OnlineOpen (Optional Fee)

OnlineOpen is available to authors of primary research articles who wish to make their article freely available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a $2,000 fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see

Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website at: Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

Copyright Transfer Agreement

Manuscripts will not be published until each author has completed a copyright transfer agreement with both co-publishers. If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an e-mail from the Publisher prompting them to login into Author Service; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement:

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions:

For authors choosing OnlineOpen:

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by certain funders [e.g. The Wellcome Trust and members of the Research Councils UK (RCUK) or the Austrian Science Fund (FWF)] you will be given the opportunity to publish your article under a CC-BY license supporting you in complying your Funder requirements . For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK, Wellcome Trust, FWF authors click on the link below to preview the terms and conditions of this license:

Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

NIH Public Access Mandate

Wiley will support our authors by posting the accepted version of articles by NIH grant-holders to PubMed Central upon acceptance by the Journal. The accepted version is the version that incorporates all amendments made during peer review, but prior to the publisher’s copy-editing and typesetting. This accepted version will be made publicly available 12 months after publication. The NIH mandate applies to all articles based on research that has been wholly or partially funded by the NIH and that are accepted for publication on or after April 7, 2008.

NIH authors should be aware that they will receive an e-mail request once Wiley has posted the files of their accepted manuscript to the NIH Manuscript Submission system to approve the upload for display on the PubMed Central system. Without the author’s active consent the file upload to PubMed Central will not be completed. This is a requirement of their grant/affiliation.

For NIH employees only, we will accept the NIH Publishing Agreement.

Wellcome Trust-Funded Articles

Since October 1, 2006, Wellcome Trust grantees are required to submit an electronic copy of the final manuscripts of their research papers to PMC or UKPubMed Central (UKPMC). The Wellcome Trust requires that the author’s work be made available to the public via PMC and PMC mirror sites no later than six months after final publication. AlphaMed Press and Wiley have established a policy that will allow authors who publish in STEM CELLS to comply with these requirements.

AlphaMed Press and Wiley authorize Wellcome Trust-funded authors whose papers are accepted and published in STEM CELLS permission to deposit the author’s peer-reviewed manuscript (but not published format) in PMC and UKPMC no earlier than six months after the print publication in STEM CELLS . Additionally, the author is authorized to replace the peer-reviewed author manuscript with the final published version 12 months after print publication in STEM CELLS. Further information on the Wellcome Trust policy is available at:

Howard Hughes Medical Institute (HHMI)-Funded Articles

The Institute's policy on public access to publications takes effect for manuscripts submitted for publication on or after January 1, 2008, for which an HHMI scientist is a major author. HHMI has designated PubMed Central (PMC) as the repository for journals in the biological sciences.

The publisher facilitates the deposit of HHMI-funded articles into PMC and also makes them publicly available online within six months of publication. Further information on the HHMI policy is available at


Embargo and Press Release

Materials submitted to STEM CELLS are embargoed for release until 2 p.m. Eastern U.S. time on the day before the mailing date (for the print edition) or the date when the article is posted online, whichever comes first. This policy applies to members of the media, authors, institutions' public information officers, and the public. Authors may not discuss their work with the media until 1 week before the mailing date or 1 week before online posting of the article, whichever is earlier, and must ensure that the media representatives agree to abide by the embargo policy. STEM CELLS may refuse to publish a manuscript, despite acceptance for publication, if it has been prematurely released to the press.

If you or your institution will be issuing a press release regarding the publication of this manuscript, please notify the Editorial Office so that we may coordinate the embargo date with our Production Team.

Graphical Abstract

STEM CELLS is published with a graphical Table of Contents (TOC). A graphical abstract is a visual representation of the key concepts in the work. An attractive full color image for the graphical TOC should be sent, preferably at the time of manuscript submission; it may be specifically designed for the table of contents and it is meant to convey the broader importance of the work and thereby capture the readers’ attention. The graphical abstract should be submitted in .eps or .tif format, and the legend should be provided in the manuscript text. The image will be printed square with sides 2 inches/5 cm; the use of graphs and images consisting of several parts or panels is therefore strongly discouraged.

Search Engine Optimization (SEO)

Although all published articles are accessible online, authors can take steps to improve their article's online discoverability. Search engine optimization (SEO) techniques can help boost STEM CELLS's content to high-ranking positions in search results, resulting in greater visibility, readership, and citations for your article.

Key techniques you can use to improve your article's SEO are:

  • Carefully select at least 5 relevant key words
  • Lead with key words in the article title
  • Ensure title is short and informative (125 characters including spaces)
  • Repeat key words 3-4 times throughout the abstract
  • Link to the published article on social media, blogs, and academic websites

Because they are highly utilized by search engines when ranking search results, selecting appropriate key words (i.e., search terms) and using them frequently and appropriately in the title, abstract, and article is critical.

Video Highlights

STEM CELLS features Video Highlights on the Journal homepage for published manuscripts. Authors of accepted articles are invited to submit a short (2-5 minutes) video to discuss their research. The preferred file format is compressed Windows Media Player-compatible (.wmp or .mpg). Video file size should be kept as small as possible while maintaining good audio, resolution and screen size. Video Highlights are subject to editorial review, and upon approval, will be tagged with keywords, a description, and link to the article. This video supplement will add a new dimension to the work and is intended to draw additional readers. Authors may create their own Video Highlight or, alternatively, our co-publisher Wiley and its partner Research Square offer a service of professionally produced video abstracts. You can learn more about it, and purchase one for your article, at If you have any questions about this service, please direct them to


As an author, you are granted rights for a large number of author uses, including use by your employer (institution or company). These rights are granted and permitted without the need to obtain specific permission from the copyright holder, AlphaMed Press, provided a full credit line is prominently placed [i.e., author name(s), journal name, copyright year, volume number, inclusive pages, and copyright holder]. These author rights are granted and apply only to articles for which you are named as the author or co-author. The author rights include:

  • the right to make copies of the article for your own personal use, including for your own classroom teaching use;
  • the right to make copies and distribute copies (including via e-mail) of the article to research colleagues, for the personal use by such colleagues (but not commercially or systematically, e.g., via an e-mail list or listserv);
  • the right to present the article at a meeting or conference and to distribute copies of such paper or article to the delegates attending the meeting;
  • for the author's employer, if the article is a "work for hire," made within the scope of the author's employment, the right to use all or part of the information in (any version of) the article for other intracompany use (e.g., training);
  • patent and trademark rights and rights to any process or procedure described in the article;
  • the right to include the article in full or in part in a thesis or dissertation (provided that this is not to be published commercially);
  • the right to use the article or any part thereof in a printed compilation of works of the author, such as collected writings or lecture notes (subsequent to publication of the article in the Journal);
  • the right to prepare other derivative works, to extend the article into book-length form, or to otherwise reuse portions or excerpts in other works, with full acknowledgment of its original publication in the Journal; and
  • the right to self-archive the work by posting the work as the final peer-reviewed author's manuscript (but not published layout) on his/her own website and his/her institution's website and repository no earlier than six months after print publication in STEM CELLS provided that a link is made to the AlphaMed Press version.

Corrections to Published Articles

If you believe a correction is needed to a published article, please send an e-mail to Please include the full citation of the article, location of the error, and if possible, suggest the correction.


STEM CELLS can publish borrowed material only with written permission of the original publisher. If you use illustrations and tables in your manuscript that are obtained from other sources, you must obtain permission from the original source for each. Secure these permissions as soon as possible. To assist you in this process, click here for a helpful checklist to follow for each permission required.

Copyright Notice

STEM CELLS® (pISSN 1066-5099) and STEM CELLS Online (eISSN-1549-4918) and all contributions included therein are protected by copyright. All rights are reserved under United States and international copyright laws and other applicable laws and conventions. No copyright is claimed in any original work created by agencies or employees of the United States government.

No part of this publication may be reproduced or transmitted in any form without the prior written consent of AlphaMed Press or Copyright Clearance Center. Certain provisions of the Copyright Act of 1976, as amended, respecting fair use and reproduction by libraries and archives, 17 U.S.C. §§ 107 and 108, may be applicable.


Reprints may be purchased at


Procedure to Request Permission

Permission requests, as described below, to photocopy, distribute, and republish material from STEM CELLS should be directed to the Copyright Clearance Center (CCC):

  • Classroom handouts
  • Print and electronic coursepacks
  • Interlibrary loan
  • Library reserves
  • Business purposes (sharing information with investors, prospects, clients, and partners)
  • Republish figures, tables, abstracts, or excerpts in another book, journal, or newsletter
  • Republish figures, tables, abstracts, or excerpts in a brochure or pamphlet
  • Use of figures, tables, abstracts, or excerpts in PowerPoint
  • Use of figures, tables, abstracts, or excerpts in a dissertation or thesis paper

The CCC will grant requests only to reproduce our material exactly as it was originally published. You can submit your request to the CCC via traditional mail, fax, or e-mail. Additionally, you can secure permission online using their automated online system. Submit requests to:

Traditional mail: CCC, 222 Rosewood Drive, Danvers, Massachusetts 01923, USA
Telephone: 978-750-8400 (8:00 am-5:30 pm EST)
Fax: 978-646-8600

All other permission requests should be made in writing to the Permissions Department, c/o John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030: (201) 748-6011, fax (201) 748-6008, E-mail:, and should include a statement of intended use, as well as explicit specifications of the materials to be reproduced. When submitting your permission request, please include the following information:

  • A complete citation of the requested material (title of journal, volume number, issue number, year, author name, article title, specific page numbers)
  • The intended use of the material (for publication, slides, handouts, etc.)
  • If for handouts: the number of copies being made
  • If for republication: the publisher and the name of the new publication
  • How the material will be reproduced and distributed
  • Complete contact details (name, institution/company name, address, telephone, fax, e-mail)

Internet sites interested in linking to information published by John Wiley & Sons must submit a written request and include the following information: Originating website URL, company business focus, complete contact information, and description of the specific page or material to be linked.