Integrated Environmental Assessment and Management

Cover image for Vol. 12 Issue 4

Edited By: Richard J Wenning, Editor-in-Chief

Impact Factor: 1.53

ISI Journal Citation Reports © Ranking: 2015: 72/90 (Toxicology); 126/225 (Environmental Sciences)

Online ISSN: 1551-3793

Associated Title(s): Environmental Toxicology and Chemistry

IEAM Podcast 1

Discussing the Tissue Residue Approach with Guest Editor Jim Meador

Link to IEAM podcast episode 1, part 1. [.mp3 file]
Link to IEAM podcast episode 1, part 2. [.mp3 file]
Link to IEAM podcast episode 1 transcript. [.pdf file]


Join us as we chat with Dr. James Meador, Guest Editor of the Tissue Residue Approach Special Series. The series consists of six articles that are featured in the January 2011 issue of IEAM (volume 7, issue 1).

In 2007, Dr. Meador organized and chaired a Society of Environmental Toxicology and Chemistry (SETAC) Pellston workshop entitled “The Tissue Residue Approach for Toxicity Assessment (TRA).” A group of 39 scientists from 9 countries convened in Leavenworth, Washington, USA to evaluate the theory and application of tissue concentrations (internal concentrations) as the dose metric for characterizing toxic effects. An important consensus of the experts at the workshop was that the TRA can enhance the scientific understanding of the interaction between exposure and consequent effects, which will strengthen our ability to assess and manage risks from chemical contamination. The workshop participants also felt that appropriate application of the TRA can reduce variability, diminish uncertainties, and improve interpretation of causality as compared to both traditional toxicity testing and assessments based solely on concentrations in exposure media.

Bio for James Meador

Dr. James Meador

Dr. James Meador is an environmental toxicologist with the National Marine Fisheries Service in Seattle, Washington, USA, which is part of the National Oceanic and Atmospheric Administration (NOAA). His area of expertise includes the environmental factors that affect the bioavailability and bioaccumulation of contaminants, the role of toxicokinetics in predicting bioaccumulation, and the differences that species exhibit in their response to toxicants. Jim’s interests evolved over the last several years to include evaluation of toxic responses as a function of tissue concentrations. His research currently focuses on alterations to growth and energetics in fish exposed to a variety of contaminants. He has published numerous research articles and book chapters on these topics and has studied a wide range of species including algae, polychaete worms, amphipods, fish, and marine mammals.


Meador et al., The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop, IEAM 7#1:2–6.

McCarty et al., Advancing environmental toxicology through chemical dosimetry: External exposures versus tissue residues, IEAM 7#1:7–27.

Escher et al., Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals, IEAM 7#1:28–49.

McElroy et al., A review of the tissue residue approach for organic and organometallic compounds in aquatic organisms, IEAM 7#1:50–74.

Adams et al., Utility of tissue residues for predicting effects of metals on aquatic organisms, IEAM 7#1:75–98.

Dyer et al., Tissue residue approach for chemical mixtures, IEAM 7#1:99–115.

Sappington et al., Application of the tissue residue approach in ecological risk assessment, IEAM 7#1:116–140.

All articles are a part of the Tissue Residue Approach Special Series, published as Volume 7, Issue 1.