The Journal of Clinical Pharmacology
© American College of Clinical Pharmacology
Edited By: Joseph S. Bertino, Jr., Schenectady, NY
Online ISSN: 1552-4604
Associated Title(s): Clinical Pharmacology in Drug Development
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Featured issues and articles
April Editor’s Choice article - Allometry Is a Reasonable Choice in Pediatric Drug Development
Free Online access
Tao Liu, Parima Ghafoori and Jogarao V. S. Gobburu
During drug development, children present a challenge in terms of drug dosing. Under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act amendment, drug development in children was supported and promoted. This month’s Editor’s Choice article examines the use of allometry in developing dosing regimens through the use of pharmacokinetics, for the pediatric patient. The methodology presented shows that it is accurate to develop pharmacokinetic study design in children ages 2 and greater.
Special Issue – Transporters
Free Online access
Knowledge about the role and importance of transporters has increased dramatically in the last decade. Transporters play an important role in determining pharmacokinetics and pharmacodynamics of drugs. We appreciate the pharmacogenomic and environmental effects determining transporter activity. This issue examines the role of transporters in drug development and in the clinical care of patients. A discussion of transporters in various organ systems and drug-drug interactions involving transporters highlight this issue. Our evolving knowledge of transporters and their functions will assist in the quest to personalize medicine for specific patients in the future. While our knowledge is still evolving, science has made great strides in explaining the importance of transporters in drug therapy.
Final version of the article available online roughly 30 days after acceptance via Early View