The Journal of Clinical Pharmacology

Cover image for Vol. 54 Issue 12

Edited By: Joseph S. Bertino, Jr., Schenectady, NY

Impact Factor: 2.472

ISI Journal Citation Reports © Ranking: 2013: 116/254 (Pharmacology & Pharmacy)

Online ISSN: 1552-4604

Associated Title(s): Clinical Pharmacology in Drug Development

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Clopidogrel (Aug 2014)


While clopidogrel has been available for patient use since the late 1990’s the controversy surrounding the pharmacogenomics of the drug has continued. While major regulatory agencies have made the manufacturer revise the label to include warnings concerning the use of the drug with concurrent omeprazole/esomeprazole along with the potential for reduced efficacy in individuals possessing CYP2C19 null alleles, the data to support these recommendations is controversial.
This themed issue presents some interesting data to investigate these issues further. While the papers presented here may not put these issues to rest, they should provide food for thought to the prescribing community and to regulatory agencies.

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Final version of the article available online roughly 30 days after acceptance via Early View