The Journal of Clinical Pharmacology

Cover image for Vol. 55 Issue 5

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Joseph S. Bertino, Jr., Schenectady, NY

Impact Factor: 2.472

ISI Journal Citation Reports © Ranking: 2013: 116/256 (Pharmacology & Pharmacy)

Online ISSN: 1552-4604

Associated Title(s): Clinical Pharmacology in Drug Development


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  1. Original Articles

    1. Effects of OM-85 BV in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

      Lei Pan, Xue-Ge Jiang, Jun Guo, Yuan Tian and Chang-Ting Liu

      Accepted manuscript online: 23 APR 2015 02:26AM EST | DOI: 10.1002/jcph.518

    2. Long term cardiac safety and tolerability of Fingolimod in Multiple Sclerosis: A post-marketing study

      Damiano Paolicelli, Alessia Manni, Vita Direnzo, Mariangela D'Onghia, Carla Tortorella, Stefano Zoccolella and Maria Trojano

      Accepted manuscript online: 23 APR 2015 02:26AM EST | DOI: 10.1002/jcph.519

    3. Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology

      Akshanth R. Polepally, Rory P. Remmel, Richard C. Brundage, Ilo E. Leppik, John O. Rarick, R. Eugene Ramsay and Angela K. Birnbaum

      Accepted manuscript online: 23 APR 2015 02:26AM EST | DOI: 10.1002/jcph.522

  2. Brief Reports

    1. Antiretroviral therapy-induced toxicity is associated with increased mRNA expression of telomerase

      Min Li, Yram Foli, Nana Y Amakye, Taline Klein, Shanmugapriya Selvaraj, Lingeng Lu and Elijah Paintsil

      Accepted manuscript online: 23 APR 2015 02:25AM EST | DOI: 10.1002/jcph.520

  3. Original Articles

    1. Predicting neonatal pharmacokinetics from prior data using population pharmacokinetic modeling

      Jian Wang, Andrea N. Edginton, Debbie Avant and Gilbert J. Burckart

      Accepted manuscript online: 22 APR 2015 04:53AM EST | DOI: 10.1002/jcph.524

    2. Comparison of different QT interval correction methods for heart rate and QT beat-to-beat method in a thorough QT study of a triple monoamine reuptake inhibitor BMS-820836

      Ming Zheng, David Burt, Wai Chan, Dara Hawthorne, Maciej Gasior, Zubin Bhagwagar, Sanjay Keswani, Malaz AbuTarif and Richard Bertz

      Accepted manuscript online: 22 APR 2015 04:52AM EST | DOI: 10.1002/jcph.528

    3. Assessment of hemoglobin responsiveness to Epoetin alfa in patients on hemodialysis using a population pharmacokinetic pharmacodynamic model

      Liviawati Wu, Diane R Mould, Juan Jose Perez Ruixo and Sameer Doshi

      Accepted manuscript online: 22 APR 2015 04:52AM EST | DOI: 10.1002/jcph.527

    4. Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects

      Linh Nguyen, Jaymes Holland, Richard Mamelok, Marie-Kristine Laberge, Julie Grenier, Dennis Swearingen, Danielle Armas and Steven Lacy

      Accepted manuscript online: 22 APR 2015 04:52AM EST | DOI: 10.1002/jcph.526

    5. Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects

      Naoto Uemura, Jacqueline McCrea, Hong Sun, Mardik Donikyan, Gary Zammit, Rong Liu, Bonnie Louridas, Sabrina Marsilio, Christopher Lines, Matthew D. Troyer and John Wagner

      Accepted manuscript online: 21 APR 2015 05:12AM EST | DOI: 10.1002/jcph.523

  4. Commentaries

  5. Original Articles

    1. Effect of Multiple Intravenous Doses of Lanicemine (AZD6765) on the Pharmacokinetics of Midazolam in Healthy Subjects

      Khanh H. Bui, Diansong Zhou, Felix Agbo and Jian Guo

      Accepted manuscript online: 15 APR 2015 04:25AM EST | DOI: 10.1002/jcph.515

    2. Pharmacokinetic and Pharmacodynamic Interactions Between Palifermin and Heparin

      Bing-Bing Yang, Brad Gillespie, Brian Smith, William Smith, Agneta Lissmats, Mattias Rudebeck, Torbjörn Kullenberg and Birgitta Olsson

      Accepted manuscript online: 15 APR 2015 04:25AM EST | DOI: 10.1002/jcph.516

  6. Commentary

    1. The cannabis conundrum: Thinking outside the THC box

      Sarah L. Hagerty, Sophie L. YorkWilliams, Vijay A. Mittal and Kent E. Hutchison

      Accepted manuscript online: 8 APR 2015 11:47PM EST | DOI: 10.1002/jcph.511

  7. Original Articles

    1. Pharmacokinetics of Hepatitis C Virus NS5A Inhibitor, JNJ-56914845 (GSK2336805), in Subjects with Hepatic Impairment

      Kimberly K Adkison, Jianjun Gan, Cindy Elko-Simms, Stephen Gardner, Etienne Dumont, Lori S Jones, Joanne Saunders, Thomas Marbury, William Smith, Jolene Berg, Christopher Galloway and Patrick J Stump

      Accepted manuscript online: 8 APR 2015 11:46PM EST | DOI: 10.1002/jcph.512

    2. Effect of ceralifimod (ONO-4641) on lymphocytes and cardiac function: Randomized, double-blind placebo-controlled trial with an open-label fingolimod arm

      Sonja Krösser, Peter Wolna, Tanya Z. Fischer, Ursula Boschert, Randall Stoltz, Meijian Zhou and Borje Darpo

      Accepted manuscript online: 8 APR 2015 04:08PM EST | DOI: 10.1002/jcph.513

    3. Coenzyme q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxdiation in chronic gastritis associated with H. pylori infection

      Asghar Rahmani, Ghobad Abangah, Atefeh Moradkhani, Mohammad Reza Hafezi Ahmadi and Khairollah Asadollahi

      Accepted manuscript online: 8 APR 2015 04:03PM EST | DOI: 10.1002/jcph.508

    4. Clinical Assessment of Drug-Drug Interactions of Tasimelteon, a Novel Dual Melatonin Receptor Agonist

      Brian W. Ogilvie, Rosarelis Torres, Marlene A. Dressman, William G. Kramer and Paolo Baroldi

      Accepted manuscript online: 6 APR 2015 02:06AM EST | DOI: 10.1002/jcph.507

    5. In vitro metabolism of canagliflozin in human liver, kidney, intestine microsomes and recombinant uridine diphosphate glucuronosyltransferases (UGT), and the effect of genetic variability of UGT enzymes on the pharmacokinetics of canagliflozin in humans

      Stephan Francke, Rao N. V. S. Mamidi, Bhavna Solanki, Ellen Scheers, Andrew Jadwin, Reyna Favis and Damayanthi Devineni

      Accepted manuscript online: 31 MAR 2015 11:26AM EST | DOI: 10.1002/jcph.506

    6. Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and non-obese patients

      Eun Kyoung Chung, S. Christian Cheatham, Megan R. Fleming, Daniel P. Healy, Katherine M. Shea and Michael B. Kays

      Accepted manuscript online: 30 MAR 2015 05:10AM EST | DOI: 10.1002/jcph.505

    7. The Pharmacokinetics and Safety of Idelalisib in Subjects With Moderate or Severe Hepatic Impairment

      F. Jin, M. Robeson, H. Zhou, G. Hisoire and S. Ramanathan

      Accepted manuscript online: 27 MAR 2015 04:08PM EST | DOI: 10.1002/jcph.504

    8. Post-Gastrectomy Pharmacokinetic Changes of S-1 in Patients with Localized Advanced Gastric Cancer

      Hyeong-Seok Lim, Keun Won Ryu, Jun Ho Lee, Young-Woo Kim, Il Ju Choi, Mi-Jung Kim, Young-Iee Park, Aekyung Hwang and Sook Ryun Park

      Accepted manuscript online: 24 MAR 2015 05:18PM EST | DOI: 10.1002/jcph.499

    9. Pharmacists' and General Practitioners' Pharmacology Knowledge and Pharmacotherapy Skills

      Carolina J P W Keijsers, Anne J Leendertse, Adrianne Faber, Jacobus R B J Brouwers, Dick J de Wildt and Paul A F Jansen

      Accepted manuscript online: 23 MAR 2015 05:52PM EST | DOI: 10.1002/jcph.500

  8. Reviews

    1. Imatinib induced agranulocytosis in patients with gastrointestinal stromal tumors

      Sheima Farag, Arjan J. Verschoor, Jacob W. Bosma, Prof Hans Gelderblom, J. Martijn Kerst, Prof Stefan Sleijfer and N. Steeghs

      Accepted manuscript online: 23 MAR 2015 05:52PM EST | DOI: 10.1002/jcph.498

  9. Original Articles

    1. Multiple dose pharmacokinetics of inhaled loxapine in subjects on chronic, stable antipsychotic regimens

      Daniel A. Spyker, Robert A. Riesenberg and James V. Cassella

      Accepted manuscript online: 21 MAR 2015 09:17AM EST | DOI: 10.1002/jcph.502

    2. Clinical drug interaction profile of idelalisib in healthy subjects

      F. Jin, M. Robeson, H. Zhou, C. Moyer, S. Wilbert, B. Murray and S. Ramanathan

      Accepted manuscript online: 11 MAR 2015 05:41AM EST | DOI: 10.1002/jcph.495

    3. Prediction of Drug Clearance in Children

      Frantz Foissac, Naïm Bouazza, Elodie Valade, Mailys De Sousa Mendes, Floris Fauchet, Sihem Benaboud, Déborah Hirt, Jean-Marc Tréluyer and Saïk Urien

      Accepted manuscript online: 26 FEB 2015 11:22AM EST | DOI: 10.1002/jcph.488

  10. Reviews

    1. Management of lipid disorders in patients living with HIV

      Merle Myerson, Carlos Malvestutto and Judith A. Aberg

      Accepted manuscript online: 4 FEB 2015 05:15AM EST | DOI: 10.1002/jcph.473


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