American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Cover image for Vol. 168 Issue 8

Edited By: Ming T. Tsuang and Stephen V. Faraone

Impact Factor: 3.416

ISI Journal Citation Reports © Ranking: 2014: 42/140 (Psychiatry); 53/167 (Genetics & Heredity)

Online ISSN: 1552-485X

Associated Title(s): American Journal of Medical Genetics Part A, American Journal of Medical Genetics Part C: Seminars in Medical Genetics

Author Guidelines

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Author Guidelines

Neuropsychiatric Genetics


Neuropsychiatric Genetics welcomes and encourages the online submissionand peer-review of articles. Authors who would like to submit and be reviewedonline are directed to where detailed instructions for this process are given.


Neuropsychiatric Genetics is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE) (

Conflict of Interest Disclosure
Wiley-Blackwell requires that all authors disclose any potential sources of conflict of interest. Any interest or relationship, financial or otherwise, that might be perceived as influencing an author’s objectivity is considered a potential source of conflict of interest. These must be disclosed when directly relevant or indirectly related to the work that the authors describe in their manuscript. Potential sources of conflict of interest include but are not limited to patent or stock ownership, membership of a company board of directors, membership of an advisory board or committee for a company, and consultancy for or receipt of speaker’s fees from a company. The existence of a conflict of interest does not preclude publication in this journal.

If the authors have no conflict of interest to declare, they must also state this at submission. It is the responsibility of the corresponding author to review this policy with all authors and to collectively list in the cover letter to the Editor-in-Chief, in the manuscript (under the Acknowledgments section), and in the online submission system ALL pertinent commercial and other relationships.

Editorial Features

  1. Research Articles. Reports of novel research on the genetic mechanisms underlying psychiatric and neurological disorders. An Abstract, Materials, Methods, and Results sections are required. There are no restrictions on the number of pages or figures.

  2. Review Articles review a specific field through an appropriate literature survey. An Abstract is required. Materials and Methods and Results sections are not required. Although there are no restrictions on the number of pages or figures, the Review should be concise as possible.

  3. Editorials (on general matters) and (invited) Editorial Comments. Although Editorials are usually on a matter published in the same issue of the journal, speculative discussions, and proposals of hypotheses amenable for testing may also be submitted for consideration. Editorials should be accompanied by a list of key words for indexing purposes; if necessary, additional words can be circled on page proofs for that purpose. Speculative discussions, and proposals of hypotheses amenable for testing may be submitted for consideration.

  4. Letters to the Editor are welcomed from all scientists who wish to comment on papers previously published in Neuropsychiatric Genetics. Letters to the Editor represent the personal opinions of the authors, and do not necessarily reflect those of the Editor or the Publisher. Space limitations do not enable the journal to publish all letters received; submissions may be altered for space and clarity.

  5. Rapid Publications. The Journal will publish rapid communications of full-length, critically reviewed papers that report new and important advances in neuropsychiatric genetics. In order to have a manuscript considered for rapid publication, authors must write a letter of intent prior to submission and send an abstract to the Editors for consideration. The letter of intent should outline the author's rationale for publishing the article as a rapid publication. The Editors will respond to the author with a decision on whether the article is eligible for processing as a rapid communication within 48 hours. At that time the author will also be informed of the anticipated length of time from acceptance to publication for the article.

    Manuscripts accepted for publication as Rapid articles must adhere to the format of the Journal as specified in the Instructions for Contributors.

    Please note that Rapids will not go through the usual copyediting process as do the regular articles. Therefore, it is the author's responsibility to ensure that all the data in tables, figure legends, and references are complete and accurate. Galley proofs will be sent to the author for review approximately 1 - 2 weeks after acceptance. Authors are allowed to correct typesetting errors only. Any extensive corrections made at this stage will result in a publication delay. If extensive corrections are made, the Rapid will be treated as a regular manuscript. The author should fax his/her corrections to the production editor within 24 - 48 hours of receipt.

    Please contact the Journal Editorial Office should you need further information.

Editorial Policy on Association Studies

Because Neuropsychiatric Genetics receives a large number of association studies, the Editors and Associate Editors have crafted guidelines to help authors understand the considerations that enter into our decisions about whether to accept or reject such studies. These guidelines are as follows:

  1. As a field we have systematically underestimated the sample sizes needed to achieve sufficient statistical power and replicable results. Therefore, we give priority to large studies, having a minimum of 500 cases and 500 controls (or equivalent). These numbers are likely to increase in the future. We understand that somewhat smaller samples may be suitable for some applications (e.g., imaging studies, other traits believed to have high effect sizes, studies in special populations, etc.). Smaller studies will be considered but the sample size would need to be justified in the Method section. 

  2. Ideally, any positive finding would include an adequately powered replication sample.

  3. As a field, genotyping coverage has usually been inadequate. With the dramatic decreases in genotyping costs since 2001, it is now within the means of most groups to conduct comprehensive genotyping. The genomic coverage for the genomic region(s) being studied should be justified. Ideally, tagging SNPs will be chosen to cover the complete gene, although replication studies could focus on fewer variants.

  4. P-values should be corrected for multiple comparisons.

  5. Effect sizes should be presented, especially when claiming a failure to replicate a prior finding.

Manuscript Submissions

Manuscripts should be submitted online at:

Editorial office contact information:

Karen Irwin, Editorial Assistant
Neuropsychiatric Genetics
17 Manomet Road
Sagamore Beach, MA 02562
Phone: (508) 888-0199
Fax: (508) 338-4067

Submit all new manuscripts online. Launch your web browser and go to . Check for an existing account. If you are submitting for the first time, create a new account. Follow all instructions. At the end of a successful submission, a confirmation screen with manuscript number will appear and you will receive an email confirming that the manuscript has been received by the journal. If this does not happen, please check your submission and/or contact tech support at .

Manuscripts submitted to the American Journal of Medical Genetics that fall within the scope of Neuropsychiatric Genetics may, at the discretion of the Editor, be forwarded to the Editor for consideration, in which case the authors will be notified.

Manuscripts for consideration by Neuropsychiatric Genetics must be submitted solely to this journal, and in submitting a manuscript the corresponding author warrants that it has been approved for publication by all co-authors and institutions at which the work was performed, and has not been published, either in whole or in part, in another publication of any type, professional or lay.

Research performed on human subjects must be accompanied by a statement of compliance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) and the standards established by the author's Institutional Review Board and granting agency. If photographs or any other identifiable data are included, a copy of the signed consent must accompany the manuscript. All statements in, or omissions from, published manuscripts are the responsibility of the authors, who will be asked to review proofs prior to publication. Reprint order forms will be sent with the page proofs. No page charges will be levied against authors or their institutions for publication in the journal.

PRE-SUBMISSION ENGLISH-LANGUAGE EDITING: Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at

All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.


If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement:
If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions

For authors choosing OnlineOpen: If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of this license:
Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

Early View. Beginning with calendar 2001 issues, we are pleased to announce the introduction of Early View ® for AJMG. Online publication of individual articles in full text HTML and PDF format before release of the compiled print issue of the journal. All articles posted online in Early View ® are peer-reviewed, copyedited, author corrected, and fully citable. This exciting new feature combines the benefits of fast online availability and issue-based archiving. The official publication date for each article is the date of online posting to facilitate rapid dissemination and will be available approximately 5-6 weeks prior to the print journal.

Format of Manuscript Elements

Manuscripts should contain each of the following elements in sequence:

Title Page. The title page should contain the complete title of the manuscript, names and affiliations of all authors, institution(s) where the work was performed, and the name, address, telephone and telefax numbers of the author responsible for correspondence. Authors should also provide a short title of not more than 45 characters to be used as a running head title.

Abstract. Abstracts, which are not to exceed 250 words, should be a succinct condensation of the contents of the article and the significance of the conclusions.

Key Words. Include up to five key words that reflect the topic of the article, without repeating terms used in the title.

Text. Research articles are not limited in length. The text should include the following sections: Introduction, Materials and Methods, Results, and Discussion. The last element of the text before the References is the Acknowledgments. The use of subheads and paragraph titles is encouraged. Initial definitions should be provided for unusual abbreviations. Units of measurement should be abbreviated according to the Style Manual for Biological Journals, available from the American Institute for Biological Sciences, 1401 Wilson Boulevard, Arlington, VA 22209. All measurements should be in metric units or other internationally accepted units. Authors should use the approved list of pedigree symbols presented at the end of these instructions. Caution should be exercised in using the unmarried/illegitimate dashed lines in identifying such offspring in pedigrees.


References within the text should be cited by author and year of publication. When referring to a work with more than two authors, the name of the first author should be given, followed by et al. (e.g., Smith, 1991; Smith and Black, 1991; Smith et al., 1989a,b). If several papers by the same author are cited, list in chronological order.
Citations in the reference list are to be arranged alphabetically in the following style: author's name (or names), year of publication, complete title, volume, and inclusive pages. Abbreviations for journals used in the reference list should conform to Index Medicus. Refer to the following examples when preparing citations:

Chitayat D, Hodgkinson KA, Ginsburg O, Dimmick J, Watters GV. 1992. King syndrome: a genetically heterogeneous phenotype due to congenital myopathies. Am J Med Genet 43:954-956.

Wright P, Gill M, Murray RM. 1993. Schizophrenia: genetics and the maternal immune response to viral infection. Am J Med Genet (Neuropsychiatr Genet) 1:40-46.

Wilkins AS. 1993. Genetic analysis of animal development. New York: Wiley-Liss. 1223 p.

Chapter in Book:
Whyte MP. 1993. Osteoporosis and the heritable forms of rickets. In: Royce PM, Steinmann B, editors. Connective tissue and its heritable disorders. New York: Wiley- Liss. p 563-589.

Tables. Each table must have a title and should be self-explanatory. Avoid duplicating information in the text. Number tables with Roman numerals in order of their appearance in the text.

Illustrations. Illustrations should be numbered consecutively using Arabic numerals. Figures not properly prepared will be returned for revision. Each figure requires a corresponding legend. Each legend should describe briefly the information presented.

Abbreviations used in figures and photographs must match exactly those used in the text. All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print (upon acceptance of the manuscript, the publisher will provide price quotes). Authors are encouraged to submit color illustrations that highlight the text and convey essential scientific information. For best reproduction, bright, clear colors should be used. Dark colors against a dark background do not reproduce well; please place your color images against a white background wherever possible.

Supplementary online material. Authors are invited to submit supplementary material for their articles to be posted in the electronic version of the JOURNAL on Wiley Online Library. Supplementary material may include (but is not limited to) video clips, large sections of tabular data, program code, or electronic graphical files that are otherwise not suitable for print media. When submitting material for consideration please follow the guidelines below.

1. Peer review. Supplementary material must be submitted at the time of peer review. Submit a paper copy of the material (in the case of material that exists in electronic form only, please consult the Editor).

2. Data file types. Manuscript files AND tables must be submitted in either Microsoft Word (.doc or .docx) or Rich Text Format (.rtf). Images (ie: figures, drawings, etc) must be submitted either as .eps or .tiff.

3. Publication and Access. Supplementary material for published articles will be made available via the online edition of the JOURNAL ( ). From the table of contents listing, any article that has supplementary material will be noted by a hyperlink that links to a page that describes the material in detail, and to the material itself.

Linking to Databases. Authors may submit genetic and protein database information with their manuscript for the databases listed below and a hypertext link will appear in the online version of the article.
The databases listed below allow hypertext links to records in the database. Authors may submit genetic and protein database information with their manuscript for these databases and a hypertext link will appear in the online version of the article.

The Genome Database (GDB)
Protein Databank (PDB)
Online Mendelian Inheritance in Man (OMIM)
Molecular Modeling Database (MMDB)
Entrez Genomes
Entrez Proteins
European Molecular Biology Laboratory (EMBL)

Note to NIH Grantees. Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see .

Sequence Data and Mutation Nomenclature

Reference sequences. Variants must be reported in the context of a defined reference sequence. Authors should always include the GenBank Accession Number of the relevant reference sequence(s), with version number (e.g., RefSeq NM_123456.3 or GenBank U654321.1), in the Materials and Methods section and as a footnote in tables listing variants. Authors are encouraged to use the Locus Reference Genomic (LRG) reference sequence ( which dispenses with the need for sequence versions, if a record exists for the gene in question (e.g., LRG_1).

Variant nomenclature. The most current guidelines are summarized on the Mutation Nomenclature Homepage at the HGVS website ( Examples of acceptable nomenclature are also provided. If alternative nomenclature schemes (e.g., for legacy exon- or amino-acid numbering) are commonly found in the literature, they may also be used in addition to approved nomenclature, but they must be defined clearly. Variants may be described using dbSNP identifiers (e.g., rs123456:A>G). Authors should also refer to den Dunnen and Antonarakis, 2000, Hum Mutat 15:7–12 and to den Dunnen and Paalman, 2003, Hum Mutat 22:181-182 for additional information.
Complex rearrangements can be described using the HGVS nomenclature (Taschner and den Dunnen, 2011, Hum Mutat 32:507-511) and the nomenclature is being adapted to accommodate the reporting of chromosomal variants detected by several technologies.

Variant checking. Authors are advised to check sequence variant descriptions using the Mutalyzer program ( Using batch mode, several variants can be analysed at once. Please see the article by Wildeman et al., 2008, Hum Mutat 29:6-13 for more information.

Submission of variants to databases. Authors must confirm the status of database submission in their covering letter. In addition, authors should note in the manuscript (e.g., in the methods section) the database(s) to which they have submitted their variants and provide the URL(s). We encourage the use of widely accessible genetics databases as repositories for human gene sequence variation information. Links to gene variant databases can be obtained from the Human Genome Variation Society web site ( or using the url "GeneSymbol" (e.g., ClinVar ( and dbSNP ( are acceptable alternatives.

Electronic Proofing

To expedite our publication schedule, page proofs are available in .pdf format. Files in this format are viewed using Adobe Acrobat Reader, which is available as a free download at Page proofs will be available for review approximately 4 weeks from acceptance. You will receive information about file access (via ftp or Internet browser) directly from the typesetters. If you do not wish to receive page proofs in .pdf format, traditional, hard-copy page proofs will be sent via express service. In either case, proof corrections should be returned immediately by fax, e-mail, or express mail. Please notify us of your preferred proof delivery method when submitting your final manuscript. Indicate in your cover letter your page proof choice: ELECTRONIC (pdf) or TRADITIONAL (paper).

Guidelines for Electronic Submission

Microsoft Word (.doc or .docx) or Rich Text Format (.rtf)

Microsoft Word (.doc or .docx) or Rich Text Format (.rtf)

Please note: This journal now accepts Microsoft WORD 2007 and 2010 documents. Please use WORD’s “Save As” option to save your document as .doc, .docx, or .rtf file type.

Software and format . All image files should be in TIFF or EPS (with preview) formats. Do not submit native application formats.

All print reproduction requires files for full color images to be in a CMYK color space. If possible, ICC or ColorSync profiles of your output device should accompany all digital image submissions.

Resolution . Journal quality reproduction will require greyscale and color files at resolutions yielding approximately 300 ppi. Bitmapped line art should be submitted at resolutions yielding 600-1200 ppi. These resolutions refer to the output size of the file; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.

File names . Illustration files should be given the 2- or 3-letter extension that identifies the file format used (i.e., .tif, .eps).

Submit the text, tables, figures, etc. of each manuscript in individual files.

MGGM This journal works together with Wiley's Open Access Journal, Molecular Genetics & Genomic Medicine (MGGM), to enable rapid publication of good quality research that is unable to be accepted for publication by our journal. Authors may be offered the option of having the paper, along with any related peer reviews, automatically transferred for consideration by the Editor of MGGM. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place. The Editor of MGGM will accept submissions that report well-conducted research which reaches the standard acceptable for publication. MGGM is a Wiley Open Access journal and article publication fees apply. For more information please do to

Reprints: Reprints may be purchased at

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