American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Virtual Issue: Genetics of Bipolar Disorder

Bipolar disorder is a mood disorder which onsets throughout the lifespan. Genome-wide association studies (GWAS) have shown that some of its high heritability can be attributed to common SNP variants. This virtual issue presents replication and follow-up of prior GWAS findings along with two GWAS of age at onset of the disorder. It also highlights several studies about the functional consequences of genetic variants implicated in bipolar disorder along with several studies of candidate genes. Please contact authors directly for reprints or for additional information described within the articles appearing in this issue. These virtual issue articles are freely available online.

Fine Mapping of Candidate Regions for Bipolar Disorder Provides Strong Evidence for Susceptibility Loci on Chromosomes 7q
Xu, Haiyan; Cheng, Rong; Juo, Suh-Hang; Liu, Jianjun; Loth, Jo Ellen; Endicott, Jean; Gilliam, Conrad; Baron, Miron. 2011. AJMG PART B 156B:168-176.

Genetic Association and Sequencing of the Insulin-Like Growth Factor 1 Gene in Bipolar Affective Disorder
Pereira, Ana C. Parente; McQuillin, Andrew; Puri, Vinay; Anjorin, Adebayo; Bass, Nicholas; Kandaswamy, Radhika; Lawrence, Jacob; Curtis, David; Sklar, Pamela; Purcell, Shaun M.; Gurling, Hugh M. D. 2011. AJMG PART B 156B:177-187.

Association of ANK3 With Bipolar Disorder Confirmed in East Asia
Takata, Atsushi; Kim, Se Hyun; Ozaki, Norio; Iwata, Nakao; Kunugi, Hiroshi; Inada, Toshiya; Ujike, Hiroshi; Nakamura, Kazuhiko; Mori, Norio; Ahn, Yong Min; Joo, Eun-Jeong; Song, Joo Yun; Kanba, Shigenobu; Yoshikawa, Takeo; Kim, Yong Sik; Kato, Tadafumi. 2011. AJMG PART B 156B:312-315.

Genome-Wide Association Analysis of Age at Onset and Psychotic Symptoms in Bipolar Disorder
Mahon, Pamela Belmonte; Pirooznia, Mehdi; Goes, Fernando S.; Seifuddin, Fayaz; Steele, Jo; Lee, Phil Hyoun; Huang, Jie; Hamshere, Marian L.; DePaulo, J. Raymond, Jr.; Kelsoe, John R.; Rietschel, Marcella; Noethen, Markus; Cichon, Sven; Gurling, Hugh; Purcell, Shaun; Smoller, Jordan W.; Craddock, Nick; Schulze, Thomas G.; McMahon, Francis J.; Potash, James B.; Zandi, Peter P. 2011. AJMG PART B 156B:370-378.

Using Linkage Information to Weight a Genome-Wide Association of Bipolar Disorder
Howrigan, D. P.; Laird, N. M.; Smoller, J. W.; Devlin, B.; McQueen, M. B. 2011. AJMG PART B 156B:462-471.

Hypomethylation of the Serotonin Receptor Type-2A Gene (HTR2A) at T102C Polymorphic Site in DNA Derived From the Saliva of Patients With Schizophrenia and Bipolar Disorder
Ghadirivasfi, Mohammad; Nohesara, Shabnam; Ahmadkhaniha, Hamid-Reza; Eskandari, Mohammad-Reza; Mostafavi, Siavash; Thiagalingam, Sam; Abdolmaleky, Hamid Mostafavi. 2011. AJMG PART B 156B:536-545.

Functional Assessment of a Promoter Polymorphism in S100B, a Putative Risk Variant for Bipolar Disorder
Dagdan, Elif; Morris, Derek W.; Campbell, Matthew; Hill, Matthew; Rothermundt, Matthias; Kaestner, Florian; Hohoff, Christa; von Eiff, Christof; Krakowitzky, Petra; Gill, Michael; McKeon, Patrick; Roche, Siobhan. 2011. AJMG PART B 156B:691-699.

Association Analysis of ANK3 Gene Variants in Nordic Bipolar Disorder and Schizophrenia Case-Control Samples
Tesli, Martin; Koefoed, Pernille; Athanasiu, Lavinia; Mattingsdal, Morten; Gustafsson, Omar; Agartz, Ingrid; Rimol, Lars M.; Brown, Andrew; Wirgenes, Katrine V.; Smorr, Lisa-Lena; Kahler, Anna K.; Werge, Thomas; Mors, Ole; Mellerup, Erling; Jonsson, Erik G.; Melle, Ingrid; Morken, Gunnar; Djurovic, Srdjan; Andreassen, Ole A. 2011. AJMG PART B 156B:969-974.

GRIK4/KA1 protein expression in human brain and correlation with Bipolar disorder risk variant status
Knight, Helen M.; Walker, Robert; James, Rachel; Porteous, David J.; Muir, Walter J.; Blackwood, Douglas H. R.; Pickard, Benjamin S. 2012. AJMG PART B 159B:21-29.

Tests of linkage and allelic association between markers in the 1p36 PRKCZ (Protein Kinase C Zeta) gene region and Bipolar affective disorder
Kandaswamy, Radhika; McQuillin, Andrew; Curtis, David; Gurling, Hugh. 2012. AJMG PART B 159B:201-209.

Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in Bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G
Dedman, Alexandra; McQuillin, Andrew; Kandaswamy, Radhika; Sharp, Sally; Anjorin, Adebayo; Gurling, Hugh. 2012. AJMG PART B 159B:328-335.

Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of Bipolar disorder or Schizophrenia
Whalley, Heather C.; Sussmann, Jessika E.; Johnstone, Mandy; Romaniuk, Liana; Redpath, Holly; Chakirova, Goultchira; Mukherjee, Prerona; Hall, Jeremy; Johnstone, Eve C.; Lawrie, Stephen M.; McIntosh, Andrew M. 2012. AJMG PART B 159B:343-353.

Genetic overlap of Schizophrenia and Bipolar disorder in a high-density linkage survey in the Portuguese Island population
Fanous, Ayman H.; Middleton, Frank A.; Gentile, Karen; Amdur, Richard L.; Maher, Brion S.; Zhao, Zhongming; Sun, Jingchun; Medeiros, Helena; Carvalho, Celia; Ferreira, Susana R.; Macedo, Antonio; Knowles, James A.; Azevedo, Maria H.; Pato, Michele T.; Pato, Carlos N. 2012. AJMG PART B 159B:383-391.

Identification of a CACNA2D4 deletion in late onset Bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders
Van Den Bossche, Maarten J.; Strazisar, Mojca; De Bruyne, Stephan; Bervoets, Chris; Lenaerts, An-Sofie; De Zutter, Sonia; Nordin, Annelie; Norrback, Karl-Fredrik; Goossens, Dirk; De Rijk, Peter; Green, Elaine K.; Grozeva, Detelina; Mendlewicz, Julien; Craddock, Nick; Sabbe, Bernard G.; Adolfsson, Rolf; Souery, Daniel; Del-Favero, Jurgen. 2012. AJMG PART B 159B:465-475.