American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Cover image for Vol. 171 Issue 5

Edited By: Ming T. Tsuang and Stephen V. Faraone

Impact Factor: 3.391

ISI Journal Citation Reports © Ranking: 2015: 41/140 (Psychiatry); 53/165 (Genetics & Heredity)

Online ISSN: 1552-485X

Associated Title(s): American Journal of Medical Genetics Part A, American Journal of Medical Genetics Part C: Seminars in Medical Genetics

Virtual Issue: Genetics of Schizophrenia


Schizophrenia is a psychotic disorder which typically onsets in adolescences or early adulthood. Genome-wide association studies (GWAS) have shown that some of its high heritability can be attributed to common SNP variants. This virtual issue presents replication and follow-up of prior GWAS findings along with a GWAS of age at onset of the disorder. It also highlights several studies about the functional consequences of genetic variants implicated in schizophrenia along with two studies of mRNA expression, one of which raises the possibility of biomarker development for the disorder. Please contact authors directly for reprints or for additional information described within the articles appearing in this issue. These virtual issue articles are freely available online.

Clinical and parental age characteristics of rare copy number variant burden in patients with schizophrenia.
Andrew K. Martin, Gail Robinson, David Reutens and Bryan Mowry. 2015. AJMG PART B: 168B:374-382.

The impact of genome wide supported microRNA-137 (MIR137) risk variants on frontal and striatal white matter integrity, neurocognitive functioning, and negative symptoms in schizophrenia.
Carissa Nadia Kuswanto, Min Yi Sum, Anqi Qiu, Yih-Yian Sitoh, Jianjun Liu and Kang Sim. 2015. AJMG PART B: 168B:317-326.

ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls.
Qinling Wei, Meng Li, Zhuang Kang, Leijun Li, Feici Diao, Ruibin Zhang, Junjing Wang, Liangrong Zheng, Xue Wen, Jinbei Zhang, Jingping Zhao and Ruiwang Huang. 2015. AJMG PART B: 168B:265-273.

Case history and genome-wide scans for copy number variants in a family with patient having 15q11.1–q11.2 duplication and 22q11.2 deletion, and schizophrenia.
Sakae Takahashi, Takahiro Suzuki, Sakura Nakamura-Tomizuka, Koichi Osaki, Yuta Sotome, Tomoaki Sagawa and Makoto Uchiyama. 2015. AJMG PART B: 168B:229-235.

DRD2 Ser311Cys polymorphism and risk of schizophrenia.
Yuichiro Watanabe, Masako Shibuya and Toshiyuki Someya. 2015. AJMG PART B: 168B:224-228.

Response to DRD2 Ser311Cys polymorphism and risk of schizophrenia.
Jun Yao and Bao-jie Wang. 2015. AJMG PART B: 168B:223.

A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia.
Xin-yang Sun, Jin Zhang, Wei Niu, Wei Guo, Hong-tao Song, Heng-yu Li, Hui-min Fan, Lin Zhao, Ai-fang Zhong, Yun-hua Dai, Zhong-min Guo, Li-yi Zhang, Jim Lu and Qiao-li Zhang. 2015. AJMG PART B: 168B:170-178.

Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: A preliminary report.
Mei-Hua Hall, Chia-Yen Chen, Bruce M. Cohen, Kevin M. Spencer, Deborah L. Levy, Dost Öngür and Jordan W. Smoller. 2015. AJMG PART B: 168B:151-161.

Genetic association of ACSM1 variation with schizophrenia and major depressive disorder in the Han Chinese population.
Wenjin Li, Weidong Ji, Zhiqiang Li, Kuanjun He, Qingzhong Wang, Jianhua Chen, Yu Qiang, Guoyin Feng, Xingwang Li, Jiawei Shen, Zujia Wen, Jue Ji and Yongyong Shi. 2015. AJMG PART B: 168B:144-149.

The relationship between schizophrenia and rheumatoid arthritis revisited: Genetic and epidemiological analyses.
Jack Euesden, Gerome Breen, Anne Farmer, Peter McGuffin and Cathryn M Lewis. 2015. AJMG PART B: 168B:81-88.

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Jonathan L. Hess, Thomas P. Quinn, Schahram Akbarian and Stephen J. Glatt. 2015. AJMG PART B: 168B:14-35.

Association between DRD2 (rs1799732 and rs1801028) and ANKK1 (rs1800497) polymorphisms and schizophrenia: A meta-analysis.
Jun Yao, Yu-qing Pan, Mei Ding, Hao Pang and Bao-jie Wang. 2015. AJMG PART B: 168B:1-13.

Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness.
Harpreet Kaur, Ajay Jajodia, Sandeep Grover, Ruchi Baghel, Sanjeev Jain and Ritushree Kukreti. 2014. AJMG PART B: 165B:635-646.

A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model.
Danielle S. Rudd, Michael Axelsen, Eric A. Epping, Nancy C. Andreasen and Thomas H. Wassink. 2014. AJMG PART B: 165B:619-626.

Mitochondrial DNA (mtDNA) variants in the European haplogroups HV, JT, and U do not have a major role in schizophrenia.
Helena Torrell, Antonio Salas, Nerea Abasolo, Constanza Morén, Glòria Garrabou, Joaquín Valero, Yolanda Alonso, Elisabet Vilella, Javier Costas and Lourdes Martorell. 2014. AJMG PART B: 165B:607-617.

Identification of ANKK1 rs1800497 variant in schizophrenia: New data and meta-analysis.
Chen Zhang, Jiangtao Zhang, Juan Fan, Wenhong Cheng, Yasong Du, Shunying Yu and Yiru Fang. 2014. AJMG PART B: 165B:564-571.

The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals.
Emma J. Rose, Derek W. Morris, Ciara Fahey, Dara Cannon, Colm McDonald, Cathy Scanlon, Sinead Kelly, Michael Gill, Aiden Corvin and Gary Donohoe. 2014. AJMG PART B: 165B:467-471.

Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
Jinjing Tan, Shan Chen, Li Su, Jianxiong Long, Juanjuan Xie, Tingting Shen, Juan Jiang and Lian Gu. 2014. AJMG PART B: 165B:438-455.

Replication and cross-phenotype study based upon schizophrenia GWASs data in the Japanese population: Support for association of MHC region with psychosis.
Takeo Saito, Kenji Kondo, Yoshimi Iwayama, Ayu Shimasaki, Branko Aleksic, Kazuo Yamada, Tomoko Toyota, Eiji Hattori, Kosei Esaki, Hiroshi Ujike, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Norio Ozaki, Masashi Ikeda and Nakao Iwata. 2014. AJMG PART B: 165B:421-427.

How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis.
Jonathan L. Hess and Stephen J. Glatt. 2014. AJMG PART B: 165B:28-40.

HLA associations in schizophrenia: Are we re-discovering the wheel?
Chowdari V. Kodavali, Annie M. Watson, Konasale M. Prasad, Cemil Celik, Hader Mansour, Robert H. Yolken and Vishwajit L. Nimgaonkar. 2014. AJMG PART B: 165B:19-27.

What can we learn about schizophrenia from studying the human model, drug-induced psychosis?
Robin M. Murray, Alessandra Paparelli, Paul D. Morrison, Arianna Marconi and Marta Di Forti. 2013. AJMG PART B: 162B:661-670.

A review of neuroimaging studies of young relatives of individuals with schizophrenia: A developmental perspective from schizotaxia to schizophrenia.
H.W. Thermenos, M.S. Keshavan, R.J. Juelich, E. Molokotos, S. Whitfield-Gabrieli, B.K. Brent, N. Makris and L.J. Seidman. 2013. AJMG PART B: 162B:604-635.

The evolutionary paradox and the missing heritability of schizophrenia.
Jenny van Dongen and Dorret I. Boomsma. 2013. AJMG PART B: 162B:122-136.

ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis.
Aihua Yuan, Zhenghui Yi, Qiang Wang, Jinhua Sun, Zhiqiang Li, Yasong Du, Chen Zhang, Tao Yu, Juan Fan, Huafang Li and Shunying Yu. 2012. AJMG PART B: 159B:997-1005.

A re-review of the association between the NOTCH4 locus and schizophrenia.
Christina Shayevitz, Ori S. Cohen, Stephen V. Faraone and Stephen J. Glatt. 2012. AJMG PART B: 159B:477-483.

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