Journal of Biomedical Materials Research Part A

Cover image for Vol. 105 Issue 4

Edited By: James M. Anderson

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2015: 13/76 (Engineering Biomedical); 14/33 (Materials Science Biomaterials)

Online ISSN: 1552-4965

Associated Title(s): Journal of Biomedical Materials Research Part B: Applied Biomaterials

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  • Multilayer cellular stacks of gelatin-hydroxyapatite fiber scaffolds for bone tissue engineering

    Multilayer cellular stacks of gelatin‐hydroxyapatite fiber scaffolds for bone tissue engineering

    Histomorphology of cross-sections of the four-layer stack 3D bone graft models of 25 wt % HA-gelatin scaffolds {(a), (c), (e)}and pure gelatin scaffolds {(b), (d), (f)} after 4 days {(a), (b)}, 11 days {(c), (d)}, and 18 days {(e), (f)} of static cell culture. The red arrows point to the location of the hFOB cell layers.

  • Effect of matrix metalloproteinase-mediated matrix degradation on glioblastoma cell behavior in 3D PEG-based hydrogels

    Effect of matrix metalloproteinase‐mediated matrix degradation on glioblastoma cell behavior in 3D PEG‐based hydrogels

    Tumor cells displayed extensive F-actin-rich protrusions in 50 and 100% MMP-degradable gels, which were largely absent in 0% MMP-degradable gels. Confocal Z-stack maximal projection of tumor cell F-actin staining in 3D hydrogels of varying percentages of MMP-degradable crosslinks on day 14. A: Scale bar = 200 μm. B: Scale bar = 50 μm. Blue = nuclei. Red = F-actin.

  • Experimental and computational examination of anastellin (FnIII1c)–polymer interactions

    Experimental and computational examination of anastellin (FnIII1c)–polymer interactions

    Residue center-of-mass positions for protein starting in (top to bottom) Arg-down, Arg-up, C-down, and N-down conformations.

  • Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-κB signaling pathway

    Lung inflammation caused by long‐term exposure to titanium dioxide in mice involving in NF‐κB signaling pathway

    Histopathological observation of lung tissues of mice after intragastric administration of TiO2 NPs for three consecutive months (N = 15). Pictures a, b, c, and d are tissues of mice exposed to TiO2 NPs doses of 0, 2.5, 5, and 10 mg/kg BW, respectively. Red short arrows indicate hyperemia, black short arrows indicate fibrotic thickening, and the circles encompass areas with inflammatory cell infiltration which may suggest TiO2 NPs deposition. (a) Control group (400×) has normal lung architecture; (b) 2.5 mg/kg BW TiO2 NPs group (400×); (c) 5 mg/kg BW TiO2 NPs group (400×); and (d) 10 mg/kg BW TiO2 NPs group (400×). The sections were stained with HE and examined by light microscopy.

  • The effect of particle size on the genotoxicity of gold nanoparticles

    The effect of particle size on the genotoxicity of gold nanoparticles

    Intracellular ROS production in HepG2 cells treated with PBS control or 5 nm AuNPs (12.5 µg mL−1) was detected by confocal fluorescence microscopy. Intracellular ROS was measured using 10 μM DCF-DA probe. Magnification, ×10.

  • Differential magnesium implant corrosion coat formation and contribution to bone bonding

    Differential magnesium implant corrosion coat formation and contribution to bone bonding

    Decreased calcium and phosphate content below the magnesium corrosion surface exposed after mechanical shear force application. Magnesium pins with a diameter of 0.4 mm (0 h) were incubated in standard DMEM cell culture medium in the presence of 10% fetal calf serum albumin (FCS) for the time period indicated. After corrosion the samples were blotted dry on a article towel, air dried and subjected to reflection electron microscopic analysis (SEM and EDX). The elemental distribution on the exposed surface as indicated is indicated by the color intensity of the picture, the chemical symbols of the respective elements are given on top of the Figure. Three magnesium pins were inserted into the medullary cavity of an explanted murine tibia bone and after corrosion they were pulled out for analysis (7d p), one typical sample is shown. Three magnesium pins were corroded and then the corrosion layer was partially removed to expose the regions of the corrosion layer below the surface (7d s, white arrows).

  • Multilayer cellular stacks of gelatin‐hydroxyapatite fiber scaffolds for bone tissue engineering
  • Effect of matrix metalloproteinase‐mediated matrix degradation on glioblastoma cell behavior in 3D PEG‐based hydrogels
  • Experimental and computational examination of anastellin (FnIII1c)–polymer interactions
  • Lung inflammation caused by long‐term exposure to titanium dioxide in mice involving in NF‐κB signaling pathway
  • The effect of particle size on the genotoxicity of gold nanoparticles
  • Differential magnesium implant corrosion coat formation and contribution to bone bonding

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