Journal of Biomedical Materials Research Part A

Cover image for Vol. 103 Issue 5

Edited By: James M. Anderson

Impact Factor: 2.841

ISI Journal Citation Reports © Ranking: 2013: 12/32 (Materials Science Biomaterials); 18/77 (Engineering Biomedical)

Online ISSN: 1552-4965

Associated Title(s): Journal of Biomedical Materials Research Part B: Applied Biomaterials

Featured

  • Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential

    Disruption of cell‐cell contact‐mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential

    LIVE/DEAD confocal microscopy of C3H10T1/2s encapsulated in PEG hydrogels (A-i) and traditional pellet cultures (B-i) both exhibit > 90% cell viability [live cells; calcein AM (green), dead cells; ethidium homodimer (red)]. Cell-cell contacts are reduced in PEG hydrogel encapsulations (A-ii) as compared with pellet cultures (B-ii). Representative images of frozen cell-laden hydrogels (A-iii) and pellets (B-iii) were immunohistochemically stained for N-cadherin (brown) to further illustrate decreased cell-cell contact in hydrogel encapsulated MSCs. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces

    Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces

    Parallel plate flow chamber and experimental set up. (A) The circular metallic piece and rectangle were secured around the flow chamber with screws. (B) The flow path was formed from a silicon gasket. Thin aluminum shim stock can be seen along the length of either side of the silicone gasket to ensure a precise chamber height. (C) The blood analogue was perfused through the chamber and across the sample for 5 min. Images were acquired, in real time, 4 mm from the inlet by a CCD camera. The transparent blood analogue and long working distance objective allowed for real time visualization of adherent fluorescent platelets through the flow path onto the opaque test surface. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: An ovine femoral condyle defect study

    The scale‐up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: An ovine femoral condyle defect study

    Timeline depicting the stages of the study. A: Aspiration of iliac crest, B: SSCs grown to confluence in vitro, C: scaffold seeded with each sheep SSCs in sterile containers. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Whole-organ tissue engineering: Decellularization and recellularization of three-dimensional matrix liver scaffolds

    Whole‐organ tissue engineering: Decellularization and recellularization of three‐dimensional matrix liver scaffolds

    Decellularization steps: (A) Normal cannulated Liver for decellularization process and (B) Second step of liver decellularization with triton and SDS. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Structural integrity, immunogenicity and biomechanical evaluation of rabbit decelluarized tracheal matrix

    Structural integrity, immunogenicity and biomechanical evaluation of rabbit decelluarized tracheal matrix

    Macroscopic observations of CAM treated with tracheal bioengineered matrices (A). On day 2 (B) and day 3 (C) of incubation, the implants were surrounded by allantoic vessels that developed radially towards the implant in a spoke-wheel pattern. On day 4 (D), acellular tracheal matrices were completely enveloped by CAM vessels. The scale bar is 1 mm. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration

    BMP‐2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration

    Attachment and spreading of BMSC on bare BCP (a), BCP-NP (b), and BCP-Dop-NP (c) scaffolds after 2 days of incubation. (d) Cell proliferation of BMSC on the scaffolds after 3 and 7 days of incubation. (e) ALP activity of BMSC on the scaffolds after 7 and 14 days of incubation. * Indicates the significant difference (p < 0.05). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Design and biocompatibility of endovascular aneurysm filling devices

    Design and biocompatibility of endovascular aneurysm filling devices

    A: Diagram of normal arterial structure. B: Dimensions to determine dome-to-neck ratio and aspect ratio of aneurysms for treatment. C: Example of locations for dimensions to determine dome to neck ratio and aspect ratio of aneurysms for treatment. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

  • Disruption of cell‐cell contact‐mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential
  • Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces
  • The scale‐up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: An ovine femoral condyle defect study
  • Whole‐organ tissue engineering: Decellularization and recellularization of three‐dimensional matrix liver scaffolds
  • Structural integrity, immunogenicity and biomechanical evaluation of rabbit decelluarized tracheal matrix
  • BMP‐2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration
  • Design and biocompatibility of endovascular aneurysm filling devices

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