Journal of Biomedical Materials Research Part A

Cover image for Vol. 104 Issue 9

Edited By: James M. Anderson

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2015: 13/76 (Engineering Biomedical); 14/33 (Materials Science Biomaterials)

Online ISSN: 1552-4965

Associated Title(s): Journal of Biomedical Materials Research Part B: Applied Biomaterials

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  • Biological performance of functionalized biomedical polymers for potential applications as intraocular lens

    Biological performance of functionalized biomedical polymers for potential applications as intraocular lens

    Transparence degree of IOLs in the rabbits at different time: (A) Sblank, (B) Splasma, (C) Splas-rH.

  • Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury

    Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury

    Cell processes adhere to FN via integrin β1. By immunoelectron microscopy, silver-enhanced nanogold labeled FN shows as dark thread-like line of varying thickness and length (arrows in A,B). Cell membrane (arrowheads in A and the inset of A for enlargement) adheres directly onto FN (arrows in the inset of A) and the cell processes (asterisks in the inset of A and in B) elongate along the FN line (arrows in B). When cocultured with SCs in a transwell system for 7 days, MSCs (green, arrows for cell processes and arrowhead for cell body) differentiate into neuron-like cells bearing NF positive long processes (red, arrows), which adhere to FN (blue, arrows and arrowhead) coating the surface of gelatin material (C1–C5). Their processes grow longer when they are being cultured for additional 7 days (D1–D5). Most of these processes extend along FN line (D2) and (D4) with integrin β1 (purple, arrows, and arrowhead in (D3–D5) and the insert in (D5) for enlarged view). But when cultured in medium added with FN blocking antibody (FNab), MSCs differentiate into NF positive neuron-like cells with shorter processes (arrows), whether for 7 (E1-E5) or 14 days (F1-F5). Note that these cells lack integrin β1 in their short processes (arrows in E3,F3). Scale bar: 1 μm in (A); 200 nm in the inset of (A) and in (B); and 20 μm in (C)–(F).

  • Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells

    Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells

    Confocal image of cells after 2 days in a 0/100 w/w PEUR/PCL fiber/collagen hydrogel composite. Cells in contact with the fiber layer appear to elongate parallel to the direction of the fibers. Fibers are green, cell nuclei blue, and actin cytoskeleton red.

  • Regulating the osteogenic function of rhBMP 2 by different titanium surface properties

    Regulating the osteogenic function of rhBMP 2 by different titanium surface properties

    The hoechest 3342 and rhodamine B staining of MSCs cultured with different surface modified titanium for 1, 4, 7, and 14 day. The bar is 50 μm. Cytoskeleton is stained red and the cell nucleus are stained blue. Cell expanded larger on BAA especially at the 7th day. Cell clusters emerged earlier on PT, AO, BPT, and BAO surface and cells are ranged in one direction as indicated in green arrow.

  • The use of SHP-2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat

    The use of SHP‐2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat

    Fluorescence images of transfected cells.

  • Preparation, characterization, and evaluation of genipin crosslinked chitosan/gelatin three-dimensional scaffolds for liver tissue engineering applications

    Preparation, characterization, and evaluation of genipin crosslinked chitosan/gelatin three‐dimensional scaffolds for liver tissue engineering applications

    Live/dead assay of HepG2 cells cultured in different scaffolds and H&E staining of HepG2 cells cultured in different scaffolds. (A, F. 0.8% genipin crosslinked scaffold; B, G. 1% genipin crosslinked scaffold; C, H. 2% genipin crosslinked scaffold; D, I. glutaraldehyde crosslinked scaffold; E, J. EDC crosslinked scaffold. HepG2 cells were cultured for 8 days in each scaffold) (The arrows directed cells.).

  • Biological performance of functionalized biomedical polymers for potential applications as intraocular lens
  • Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury
  • Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells
  • Regulating the osteogenic function of rhBMP 2 by different titanium surface properties
  • The use of SHP‐2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat
  • Preparation, characterization, and evaluation of genipin crosslinked chitosan/gelatin three‐dimensional scaffolds for liver tissue engineering applications

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