Journal of Biomedical Materials Research Part A

Cover image for Vol. 105 Issue 5

Edited By: James M. Anderson

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2015: 13/76 (Engineering Biomedical); 14/33 (Materials Science Biomaterials)

Online ISSN: 1552-4965

Associated Title(s): Journal of Biomedical Materials Research Part B: Applied Biomaterials

Featured

  • Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model

    Evaluation of novel biodegradable three‐armed‐ and hyper‐branched tissue adhesives in a meniscus explant model

    H&E and PR staining of meniscus explants incubated in a collagenase solution for 3 hours (bottom) and a control (top). The arrows indicate cells present close to the gap edge (slides stained with H&E) and decreased density of collagen fibers at the gap edge (slides stained with PR). View on the gap between inner cylinder and annulus of the explants.

  • Fabrication and characterization of cell sheets using methylcellulose and PNIPAAm thermoresponsive polymers: A comparison Study

    Fabrication and characterization of cell sheets using methylcellulose and PNIPAAm thermoresponsive polymers: A comparison Study

    Confocal images of hASCs in cell sheets one day after reattachment. Immunofluorescent staining shows cell nuclei (blue) and F-actin (green) in (A) Representative z-stack of MC cell sheet, (B) Representative image of PNIPAAm cell sheet.

  • Influence of random and oriented electrospun fibrous poly(lactic-co-glycolic acid) scaffolds on neural differentiation of mouse embryonic stem cells

    Influence of random and oriented electrospun fibrous poly(lactic‐co‐glycolic acid) scaffolds on neural differentiation of mouse embryonic stem cells

    SEM analysis of mESCs growth and differentiation on PLGA fiber scaffolds. (A) and (C) show differentiated mESCs on PLGA random fibers, (B) and (D) show differentiated mESCs on PLGA aligned fibers. Scale bar (A) 50 μm, (B) 100 μm, (C) 5 μm, (D) 10 μm.

  • Collagen/heparin sulfate scaffolds fabricated by a 3D bioprinter improved mechanical properties and neurological function after spinal cord injury in rats

    Collagen/heparin sulfate scaffolds fabricated by a 3D bioprinter improved mechanical properties and neurological function after spinal cord injury in rats

    Horizontal images of HE staining at 8 weeks post injury. Low magnification of spinal cord sections (left) and higher magnification of the white boxed sections (right). Scale bar, 50 µm.

  • Caspase mediated beclin-1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle

    Caspase mediated beclin‐1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle

    Mn3O4 (A) NPs induce higher level of apoptosis than Mn3O4 NPs. (a) After treatment of HeLa cells with PBS, Mn3O4 (100 μg mL−1) and Mn3O4 (A) (100 μg mL−1) NPs for 24 h, endogenous PARP, caspase 3, cleave caspase, Bcl-2, and PI3K-C3 levels were detected by protein gel blotting with PARP, procaspase, Bcl-2, and PI3K-C3 antibodies relative to GAPDH. (b) ANXA5-FITC PtdIns assay of HeLa cells treated with PBS, Mn3O4 or Mn3O4 (A) (100 μg mL−1) NPs and Dox (0.75 μg mL−1) for 24 h, showing relative percentage of live (Q4 quadrant), early apoptotic (Q3 quadrant), and late apoptotic and necrotic (Q2 and Q1 quadrant) cells.

  • Effects of aging upon the host response to implants

    Effects of aging upon the host response to implants

    (a) Fluorescence microscopy images of F4/80 CD68, F4/80 CD11b, and CD68 CD11b co-immunolabeled tissue cross-sections at a single mesh fiber at 7 days (additional days can be seen in Supporting Information, Figures 1–3). DAPI was used to stain cell nuclei. Scale bars represent 50 µm. Cell counts of (b) F4/80+, CD68+, and CD11b+ cells and (c) F4/80+ CD68+, F4/80+ CD11b+, and CD68+ CD11b+ cells surrounding single mesh fibers at 3, 7, and 14 days. Bars represent the mean ± SEM. Statistical significance as (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, and (****) p < 0.0001. All other differences are nonsignificant. N = 7.

  • Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model

    Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model

    Histological analysis of spleen, liver, kidney, lung, and lymph nodes collected at week-12, from animals of the experimental group PVA-CNTs. Magnification: 100×; scale bar = 10 µm. HE: hematoxylin-eosin; VK: Van-Kossa; MF: Masson Fontana staining.

  • Evaluation of novel biodegradable three‐armed‐ and hyper‐branched tissue adhesives in a meniscus explant model
  • Fabrication and characterization of cell sheets using methylcellulose and PNIPAAm thermoresponsive polymers: A comparison Study
  • Influence of random and oriented electrospun fibrous poly(lactic‐co‐glycolic acid) scaffolds on neural differentiation of mouse embryonic stem cells
  • Collagen/heparin sulfate scaffolds fabricated by a 3D bioprinter improved mechanical properties and neurological function after spinal cord injury in rats
  • Caspase mediated beclin‐1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle
  • Effects of aging upon the host response to implants
  • Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model

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