Journal of Biomedical Materials Research Part A

Cover image for Vol. 104 Issue 10

Edited By: James M. Anderson

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2015: 13/76 (Engineering Biomedical); 14/33 (Materials Science Biomaterials)

Online ISSN: 1552-4965

Associated Title(s): Journal of Biomedical Materials Research Part B: Applied Biomaterials

Featured

  • The effect of fluid shear stress on the in vitro degradation of poly(lactide-co-glycolide) acid membranes

    The effect of fluid shear stress on the in vitro degradation of poly(lactide‐co‐glycolide) acid membranes

    Contour plot of wall shear stress distribution in the membrane's effective region.

  • Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion

    Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP‐9 secretion

    Representative fluorescence images of topographical effects on multinucleated cell (MC) formation in RAW264.7 macrophages cultured on G1 (left) and G2 (right) on Day 5. Cells were stained for vinculin (green), F-actin (red) and counter-stained with DAPI to demonstrate cell nuclei. Arrow indicates nuclei in multinucleated cells.

  • Acellular hydroxyapatite-collagen scaffolds support angiogenesis and osteogenic gene expression in an ectopic murine model: Effects of hydroxyapatite volume fraction

    Acellular hydroxyapatite‐collagen scaffolds support angiogenesis and osteogenic gene expression in an ectopic murine model: Effects of hydroxyapatite volume fraction

    Representative Masson's trichrome stained histological sections from explants after 6- and 12-weeks implantation for collagen scaffolds containing 0, 20, and 40 vol % HA. After 6-weeks implantation, uniform cellular infiltration was evident throughout the entire pore volume, and the original scaffold architecture (gray arrows) was still apparent, regardless of the HA content. Collagen scaffolds exhibited relatively low cell density and no angiogenesis at either time point. In contrast, collagen scaffolds containing HA exhibited increased cell density with increased HA content. Scaffolds with 40 vol % HA also exhibited angiogenesis (black arrows), but scaffolds with 20 vol % HA did not. After 12-weeks implantation, all or most of the original scaffold architecture (gray arrows) remained apparent in scaffolds containing 0 or 20 vol % HA, respectively. In contrast, scaffolds with 40 vol % HA exhibited extensive remodeling such that none of the original scaffold architecture remained.

  • Construction of a patterned hydrogel—fibrous mat bilayer structure to mimic choroid and Bruch's membrane layers of retina

    Construction of a patterned hydrogel—fibrous mat bilayer structure to mimic choroid and Bruch's membrane layers of retina

    Confocal micrographs of unseeded ESF and RPE seeded ESF surfaces. (A) Cell free, and (B–D) RPE seeded ESF surfaces on days 1, 3, and 7, respectively. Alexa Fluor® 532-Phalloidin (green) and DRAQ5 (blue) were used for actin and nucleus staining, respectively. SF fibers are blue due to the autofluorescence behind the cells. Cell seeding density: 3 × 104, DMEM-high glucose medium. Scale bar: 25 μm. Magnification (200×).

  • In vivo cartilage regeneration induced by a double-network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model

    In vivo cartilage regeneration induced by a double‐network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model

    Histological evaluation by Safranin-O staining at 12 weeks (2× original magnification). Black scale bar = 1 mm.

  • The effect of SDF-1α on low dose BMP-2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model

    The effect of SDF‐1α on low dose BMP‐2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model

    Representative according to Masson–Goldner stained histological sections of the defect areas at week 6. A (control group) resulted in the lowest bone formation and no defect bridging. Slightly more bone formation, but also no defect bridging was found in the low dose BMP-2 group (B). The low dose BMP-2 with SDF-1α group (C) and the high dose BMP-2 group (D) resulted in bridging of the defects. Thereby low dose BMP-2 with SDF-1α group seemed to have more directed end to end callus with less bone volume but a higher ratio of woven bone compared to the high dose BMP-2 group.

  • A novel method to in vitro evaluate biocompatibility of nanoscaled scaffolds

    A novel method to in vitro evaluate biocompatibility of nanoscaled scaffolds

    Histological appearance of the removed tissues from mouse subcutaneous dorsum with the injected material solutions at 2 weeks after the surgery. In the PLA and nHAC groups, large amounts of neutrophilic granulocytes, mononuclear cells, and lymphocytes were found, suggesting that the two kinds of implants caused serious foreign-body feedbacks. In the nHACP group, the amount of the inflammatory cells was significantly less than that in the nHAC and PLA groups. In the nHACP/CF group, no obvious foreign-body feedback could be seen.

  • The effect of fluid shear stress on the in vitro degradation of poly(lactide‐co‐glycolide) acid membranes
  • Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP‐9 secretion
  • Acellular hydroxyapatite‐collagen scaffolds support angiogenesis and osteogenic gene expression in an ectopic murine model: Effects of hydroxyapatite volume fraction
  • Construction of a patterned hydrogel—fibrous mat bilayer structure to mimic choroid and Bruch's membrane layers of retina
  • In vivo cartilage regeneration induced by a double‐network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model
  • The effect of SDF‐1α on low dose BMP‐2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model
  • A novel method to in vitro evaluate biocompatibility of nanoscaled scaffolds

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