Journal of Orthopaedic Research

Cover image for Vol. 34 Issue 12

Edited By: Linda J. Sandell

Impact Factor: 2.807

ISI Journal Citation Reports © Ranking: 2015: 9/74 (Orthopedics)

Online ISSN: 1554-527X

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  • Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon

    Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon

    Schematic showing a fascicle; highlighting the imaging planes in which confocal images are taken of the fascicular and inter-fascicular matrix. The images on the right show representative images of nuclei and cilia in the inter-fascicular and fascicular matrix.

  • Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix

    Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix

    Representative bioluminescent images of rats inoculated with HeLa (a) and Ace-1 (b) 21 days post-inoculation. Metastatic growth was observed in various regions of the rat anatomy with the region of interest being the spinal column area (indicated by oval overlay). The dotted square overlay indicates the approximate location of T8–T13 vertebrae.

  • Establishment and characterization of a novel osteosarcoma cell line: CHOS

    Establishment and characterization of a novel osteosarcoma cell line: CHOS

    Immunohistochemical stained sections of xenograft tumors and pulmonary metastatic lesions demonstrating co-expression of vimentin, COL II, ACAN, and S-100A4.

  • Alcohol-related deficient fracture healing is associated with activation of FoxO transcription factors in mice

    Alcohol‐related deficient fracture healing is associated with activation of FoxO transcription factors in mice

    The effects of alcohol and antioxidant (NAC) treatment on callus components at day 9 post-fracture. (A) Representative H&E images of fracture calluses from each treatment group (Saline, Alcohol, Saline + NAC, and Alcohol + NAC) 9 days after fracture at 20× and 100× magnification. Lines indicate transverse fracture site; boxes indicate site of magnification; arrowheads indicate sites of hypertrophic chondrocytes. (B–D) Quantifications of (B) the total area of the cartilaginous component of the callus, (C) the total area of hypertrophic chondrocytes within the callus, and (D) the percentage of the total area of the cartilaginous component of the callus that was composed of hypertrophic chondrocytes are shown comparing all four treatment groups. Different letters denote a statistical difference between groups compared by one-way ANOVA.

  • BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing

    BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing

    Comparison of mBMPR1A-mFC treatment initiated on post-operative day 1 (D1Onset) versus Control: In all bar graphs, the height of a column represents the group mean, and the error bar represents ±1 standard deviation. Lowercase letters above the column denote differences between post-operative days, as identified by Tukey post hoc tests carried out after the ANOVA revealed p < 0.05 for post-operative day: “a” denotes a difference compared to day 21; “b” denotes a difference compared to day 14; and “c” denotes a difference compared to day 7. (A) Cartilage volume fraction (the ratio of cartilage volume to total callus volume) was smaller at day 21 compared to days 7 and 14 for both D1Onset and Control calluses combined (a: p < 0.001). Cartilage volume fraction was also smaller at day 21 compared to day 14 for the D1Onset calluses specifically (*p = 0.016 for Tukey pairwise post hoc test comparing these two groups, on account of the significant interaction effect (p = 0.04)). There was only a weak trend toward a decrease between days 14 and 21 for the Control calluses specifically (p = 0.098 for Tukey pairwise post hoc test comparing these two groups). (B) Renderings of representative calluses (cortex included) at days 14 and 21, imaged using contrast-enhanced micro-computed tomography, with mineralized tissue rendered in blue and cartilage in red. (C) Mineralized callus volume, normalized by callus length, increased over time (a–c: p < 0.001) and was larger in D1Onset calluses compared to Control for all timepoints combined (p = 0.002 for treatment as the main effect). (D) Mineralized callus volume fraction also increased over time (a–c: p < 0.001) and showed a strong trend toward higher values in D1Onset versus Control calluses at day 14 (#p = 0.051 for pairwise Tukey post hoc test comparing these two groups). (E) As seen in longitudinal cut-away views of μCT renderings of representative calluses at day 21 (cortex included, mineralized tissue is shown in grey, and the plane of the virtual cut is shaded red for ease of visualization), the D1Onset group retains a more radiolucent fracture line, denoted by the black arrow.

  • New perspectives on ACL injury: On the role of repetitive sub-maximal knee loading in causing ACL fatigue failure

    New perspectives on ACL injury: On the role of repetitive sub‐maximal knee loading in causing ACL fatigue failure

    Schematic diagram of the in silico knee model. Reproduced from Bedi et al.

  • Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon
  • Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix
  • Establishment and characterization of a novel osteosarcoma cell line: CHOS
  • Alcohol‐related deficient fracture healing is associated with activation of FoxO transcription factors in mice
  • BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing
  • New perspectives on ACL injury: On the role of repetitive sub‐maximal knee loading in causing ACL fatigue failure

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