Journal of Orthopaedic Research

Cover image for Vol. 34 Issue 11

Edited By: Linda J. Sandell

Impact Factor: 2.807

ISI Journal Citation Reports © Ranking: 2015: 9/74 (Orthopedics)

Online ISSN: 1554-527X

Featured

  • Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine

    Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine

    Deformed mesh models and stress based map value for the intact spine and once the lytic defect was introduced under a compressive load of 750 N. Significant increase in both principal and shear strength is evident at the cancellous bone at the defect site and at both the posterior and anterior cortices.

  • Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second-harmonic microscopy, and histological findings

    Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second‐harmonic microscopy, and histological findings

    T1ρ maps of proteoglycan content of the epiphyseal growth cartilage in both ridges of the trochlea. (A and B) T1ρ sagittal map of the medial and lateral ridges of the femoral trochlea. Color scale corresponds to T1ρ relaxation times. Longer T1ρ relaxation times reflect lower proteoglycan content. The growth cartilage of the proximal and middle ROIs, in both trochlear ridges, has distinct areas with high T1ρ relaxation times. The highest T1ρ relaxation times are located at the osteochondritis dissecans predilection region (yellow dotted line) in the lateral ridge of the trochlea. (C and D) Transverse T1ρ maps of the proximal ROIs with corresponding site-matched safranin O fast green stained sections. At the ROI Lproximal, lower proteoglycan content (increased T1ρ relaxation times and low safranin O staining uptake) is visible within a central area (asterisk) and also in a thin layer close to the metaphyseal ossification front (arrow). (E and F) Transverse T1ρ maps of the middle ROIs with corresponding site-matched safranin O fast green stained sections. Increased T1ρ relaxation times are still observed within the ROI Lmiddle (asterisk). (G and H) Transverse T1ρ maps of the distal ROIs with corresponding site-matched safranin o fast green stained sections. There is overall lower T1ρ relaxation times and homogeneous stain uptake in the matrix, except for small focal sites in the Mdistal (arrow head). Scale bar = 1 cm.

  • Regulation of BMP2-induced intracellular calcium increases in osteoblasts

    Regulation of BMP2‐induced intracellular calcium increases in osteoblasts

    BMP2 induces cytosol and ER calcium alternation in MC3T3-E1 cells. Representative images of the emission ratio of Cyto-Ca2+ FRET biosensor or ER-Ca2+ FRET biosensor upon BMP2 stimulation (A), and the average time course of (B) the Cyto-Ca2+ FRET biosensor showing the cytoplasmic Ca2+ concentration with (n = 12) or without (n = 6) calcium-free media pre-treatment, or with 2-APB (n = 5) pre-treatment. And the average time course of (C) the ER-calcium FRET biosensors showing ER Ca2+ concentration with (n = 5) or without 2-APB (n = 12) pre-treatment under BMP2 stimulation. Scale bars: 10 µm (A). The differences were significant between Cyto-Ca2+ and Ca2+ free, Cyto-Ca2+ and Cyto-Ca2+ + 2-APB after 200 s (B) or between ER-Ca2+ and ER-Ca2+ + 2-APB after 240 s (C) (p < 0.05).

  • Variations in medial-lateral hamstring force and force ratio influence tibiofemoral kinematics

    Variations in medial‐lateral hamstring force and force ratio influence tibiofemoral kinematics

    The average femoral lowest point kinematics superimposed on the tibia for the quadriceps and hamstrings (QH), high biceps femoris load I (LAT1), high biceps femoris load II (LAT2), quadriceps only (QO), high semimembranosus load I (MED1), high semimembranosus load II (MED2) loading configurations.

  • The effect of low-intensity pulsed ultrasound on bone-tendon junction healing: Initiating after inflammation stage

    The effect of low‐intensity pulsed ultrasound on bone‐tendon junction healing: Initiating after inflammation stage

    The safranin O staining showed the cartilage-like tissue formation (arrow) at bone-tendon junction. Proteoglycan was stained red by safranin O in the regenerated zone of cartilage-like tissue. With healing over time, more cartilage-like tissue was found at bone-tendon junction in both groups. Scanned bar = 1,000 µm.

  • Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic (7 images)

    Effect of low‐dose X‐ray irradiation and Ti particles on the osseointegration of prosthetic (7 images)

    Fixation device for the push-out test. The fixation device allowed for internal–external, flexion–extension, and varus–valgus rotations.

  • Contribution of mechanical unloading to trabecular bone loss following non-invasive knee injury in mice

    Contribution of mechanical unloading to trabecular bone loss following non‐invasive knee injury in mice

    Gait of injured and sham mice was analyzed during treadmill running using the Treadscan system (left). Average percent of stride spent in stance phase was decreased in injured limbs compared to sham, while percent of stride spent in swing phase was increased (right). Mean data for swing, propel, and brake phases are presented.

  • Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine
  • Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second‐harmonic microscopy, and histological findings
  • Regulation of BMP2‐induced intracellular calcium increases in osteoblasts
  • Variations in medial‐lateral hamstring force and force ratio influence tibiofemoral kinematics
  • The effect of low‐intensity pulsed ultrasound on bone‐tendon junction healing: Initiating after inflammation stage
  • Effect of low‐dose X‐ray irradiation and Ti particles on the osseointegration of prosthetic (7 images)
  • Contribution of mechanical unloading to trabecular bone loss following non‐invasive knee injury in mice

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The Association of Bone and Joint Surgeons® and the Orthopaedic Research Society jointly sponsor the CORR® ORS Richard A. Brand Award for Outstanding Orthopaedic Research.

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