Contrast Media & Molecular Imaging

Cover image for Vol. 11 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Co Editor-in-Chief: Silvio Aime & Robert N. Muller

Impact Factor: 3.286

ISI Journal Citation Reports © Ranking: 2015: 22/124 (Radiology Nuclear Medicine & Medical Imaging)

Online ISSN: 1555-4317

Associated Title(s): NMR in Biomedicine


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  1. Short communications

    1. A theoretical analysis of chemical exchange saturation transfer echo planar imaging (CEST-EPI) steady state solution and the CEST sensitivity efficiency-based optimization approach

      Weiping Jiang, Iris Yuwen Zhou, Lingyi Wen, Xin Zhou and Phillip Zhe Sun

      Version of Record online: 16 JUN 2016 | DOI: 10.1002/cmmi.1699

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      A steady state non-thermal equilibrium CEST MRI solution was derived to take into account key experimental parameters including TR, FA and B1. The solution expedites CEST imaging sensitivity efficiency calculation, enabling simultaneous prediction of multiple optimal parameters based on the chemical shift and exchange rate. The sensitivity efficiency-based exhaustive optimization approach could simplify and effectively guide CEST MRI experiment.

  2. Full papers

    1. The effect of superparamagnetic iron oxide nanoparticles surface engineering on relaxivity of magnetoliposome

      Sepideh Khaleghi, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Mahrooz Malek and Hamid Reza Madaah Hosseini

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/cmmi.1697

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      The purpose of this work is evaluating the effect of ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) coatings on encapsulation efficiency in liposomes and cytotoxicity. Moreover, the effects of surface engineering on the relaxivity of magnetoliposome nanoparticles were assessed for the intelligent MRI. The high ratio r2/r1 as well as high r2 in targeted MLs are the best combination of a negative contrast agent. Therefore the targeted magnetoliposomes are a good and stable candidate as contrast agents in biomedical research.

    2. Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging

      Sushanta Kumar Mishra, B. S. Hemanth Kumar, Subash Khushu, Rajendra P. Tripathi and Gurudutta Gangenahalli

      Version of Record online: 27 MAY 2016 | DOI: 10.1002/cmmi.1698

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      We have successfully synthesized ultrasmall superparamagnetic iron oxide nanoparticles modified with reduced dextran. The D-Fe3O4 nanoparticles have high r2 relaxivity (90.50 ± 0.80 s−1 mM−1) and T2 relaxation time and good stability. Negative contrast enhancement of early stages of solid tumor was detected by MRI after administration of low doses of magnetic nanoparticles intravenously. MR signal intensity of the specific organs and whole body imaging can be clearly distinguished in pre- and post-injected animals.

  3. Short communications

    1. In vivo quantification of ultrasound targeted microbubbles to enhance cancer assessment

      Claudia Sciallero, Emanuele Daglio and Andrea Trucco

      Version of Record online: 8 MAY 2016 | DOI: 10.1002/cmmi.1694

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      Contrast-enhanced ultrasound with targeted microbubble contrast agents is an emerging technique for imaging biological processes at the molecular level. The accumulation of targeted microbubbles at tissue sites overexpressing specific molecular markers increases the backscattered signal for noninvasive evaluations of diseases. The aim of this preliminary study was to combine molecular imaging with an in vivo contrast agent quantification to support the early diagnosis of the pathology and to enhance the assessment of neoplastic tissues.

  4. Full papers

    1. Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities

      Sam Massa, Niravkumar Vikani, Cecilia Betti, Steven Ballet, Saskia Vanderhaegen, Jan Steyaert, Benedicte Descamps, Christian Vanhove, Anton Bunschoten, Fijs W. B. van Leeuwen, Sophie Hernot, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans, Catarina Xavier and Nick Devoogdt

      Version of Record online: 5 MAY 2016 | DOI: 10.1002/cmmi.1696

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      Camelid single-domain antibody-fragments were labeled chemoenzymatically by Sortase A resulting in homogeneous imaging tracers. The conjugation of different imaging probes allowed tumor visualization in multiple imaging modalities, with high contrast as soon as 1 h post-injection.

  5. Personal communications

    1. Contrast agent comparison for three-dimensional micro-CT angiography: A cadaveric study

      Mitchell J. Kingston, Diana M. Perriman, Teresa Neeman, Paul N. Smith and Alexandra L. Webb

      Version of Record online: 13 APR 2016 | DOI: 10.1002/cmmi.1695

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      We compared two barium sulfate based and one lead oxide based contrast agents with regards to perfusion and accuracy of measurements from three-dimensional (3-D) reconstructions of micro-computed topography (CT) angiography scans. Barium sulfate combined with a low viscosity resin was more accurate for measurements from high resolution scans and was equivalent to lead oxide combined with milk powder in terms of extent of perfusion.

  6. Full papers

    1. HyperCEST detection of cucurbit[6]uril in whole blood using an ultrashort saturation Pre-pulse train

      Francis T. Hane, Peter S. Smylie, Tao Li, Julia Ruberto, Krista Dowhos, Iain Ball, Boguslaw Tomanek, Brenton DeBoef and Mitchell S. Albert

      Version of Record online: 13 APR 2016 | DOI: 10.1002/cmmi.1690

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      The xenon MR spectrum shows chemical shifts corresponding to it's binding to red blood cells, dissolved in blood plasma and exchanging with the cucurbit[6]uril (CB6) cage molecule. By applying an RF pulse at the CB6 chemical shift, a HyperCESt effect is produced allowing the detection of the CB6 molecule in blood (right panel).

    2. Developing imidazoles as CEST MRI pH sensors

      Xing Yang, Xiaolei Song, Sangeeta Ray Banerjee, Yuguo Li, Youngjoo Byun, Guanshu Liu, Zaver M. Bhujwalla, Martin G. Pomper and Michael T. McMahon

      Version of Record online: 13 APR 2016 | DOI: 10.1002/cmmi.1693

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      We have designed MRI pH sensors using Imidazole-4,5-diamides (I45DCs) with large chemical shifts using the principles of IntraMolecular-bond Shifted HYdrogens (IM-SHY). These were found to provide significant CEST contrast with a large chemical shift from water (7.8 ppm) strongly dependent on pH and reference signal. Furthermore, we demonstrate that these probes could be applied for in vivo detection of kidney pH after intravenous administration.

    3. How transfer rates generate Gd-BOPTA concentrations in rat liver compartments: implications for clinical liver imaging with hepatobiliary contrast agents

      Catherine M. Pastor

      Version of Record online: 5 APR 2016 | DOI: 10.1002/cmmi.1691

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      Gd-BOPTA true concentrations in hepatocytes depend on the simultaneous clearances from sinusoids to hepatocytes and from hepatocytes to bile canaliculi and back to sinusoids. The study better defines how signal intensities are generated when hepatobiliary contrast agents are injected.

    4. Evaluation of EuII-based positive contrast enhancement after intravenous, intraperitoneal, and subcutaneous injections

      Levi A. Ekanger, Lisa A. Polin, Yimin Shen, E. Mark Haacke and Matthew J. Allen

      Version of Record online: 30 MAR 2016 | DOI: 10.1002/cmmi.1692

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      EuII-based positive contrast enhancement is sensitive to the route of administration in vivo. Transient contrast enhancement is prolonged in tissues and fluids containing relatively low rates of diffusion and low oxygen partial pressures.

    5. Comparison of small animal CT contrast agents

      Julia G. Mannheim, Thomas Schlichthaerle, Laura Kuebler, Leticia Quintanilla-Martinez, Ursula Kohlhofer, Manfred Kneilling and Bernd J. Pichler

      Version of Record online: 18 MAR 2016 | DOI: 10.1002/cmmi.1689

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      The CT contrast agents ExiTron nano 12 000 and 6000 yielded a long-term contrast enhancement in the liver and spleen for up to 5 days. Some of the other CAs did not show any CE at all compared to the control group. Shown are representative CT images 120 h after injection of the respective contrast agent.

    6. Syntheses and preliminary evaluation of [18F]AlF-NOTA-G-TMTP1 for PET imaging of high aggressive hepatocellular carcinoma

      Yesen Li, Deliang Zhang, Ying Shi, Zhide Guo, Xinying Wu, Jian-Lin Ren, Xianzhong Zhang and Hua Wu

      Version of Record online: 1 MAR 2016 | DOI: 10.1002/cmmi.1688

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      A new 18F-labeled imaging agent [18F]AlF-NOTA-G-TMTP1 was synthesized and radiolabeled with 18F using NOTA-AlF chelation method. [18F]AlF-NOTA-G-TMTP1 can specifically target high metastatic or/and aggressive hepatocellular carcinoma with low background activity and, therefore, holds the potential to be used as an imaging agent for detecting tumor lesions within the liver area.

    7. In vivo comparison of tantalum, tungsten, and bismuth enteric contrast agents to complement intravenous iodine for double-contrast dual-energy CT of the bowel

      Samira Rathnayake, John Mongan, Andrew S. Torres, Robert Colborn, Dong-Wei Gao, Benjamin M. Yeh and Yanjun Fu

      Version of Record online: 18 FEB 2016 | DOI: 10.1002/cmmi.1687

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      Dual-energy CT (DECT) allows the signal of different materials to be separated based on their relative attenuation of X-rays at low versus high kVp. In 13 rabbits, we tested the ability of clinical rapid kVp switching DECT to separate a conventional iodinated intravenous contrast agent in the bowel wall from three different experimental enteric non-iodinated contrast agents in the bowel lumen, based on tantalum oxide, tungsten oxide, and bismuth subsalicylate respectively. Results suggest that double-contrast DECT provides better visualization of small bowel than conventional CT in vivo with tantalum- or tungsten-based enteric contrast, which encourages clinical enteric contrast agent development for DECT.


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