Molecular Nutrition & Food Research

Cover image for Vol. 61 Issue 2

Edited By: Hans-Ulrich Humpf

Impact Factor: 4.551

ISI Journal Citation Reports © Ranking: 2015: 5/125 (Food Science & Technology)

Online ISSN: 1613-4133

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  1. Targeted metabolomics reveals differences in the extended postprandial plasma metabolome of healthy subjects after intake of whole-grain rye porridges versus refined wheat bread

    Lin Shi, Carl Brunius, Magnus Lindelöf, Souad Abou Shameh, Huaxing Wu, Isabella Lee, Rikard Landberg and Ali A. Moazzami

    Version of Record online: 27 FEB 2017 | DOI: 10.1002/mnfr.201600924

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    Twenty-one healthy subjects consumed six test breakfasts in a randomized cross-over study. We used targeted NMR-profiling and GC-MS to investigated postprandial difference in 38 plasma metabolites. Essential amino acids in plasma before lunch reflected protein composition. Wheat bread leads to higher plasma concentrations of ketone bodies than rye porridges, shortly before lunch. The increase in acetate and butyrate after lunch was due to colonic fermentation of dietary fiber. However, difference was unrelated to inulin, GLP-1, appetite and second meal glucose responses.

  2. Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes

    Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli and Sylvie Bortoli

    Version of Record online: 27 FEB 2017 | DOI: 10.1002/mnfr.201600920

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    Adipocyte PDK4, by inhibiting PDH activity, is a key actor of fatty acid release via glyceroneogenesis. Here, we describe PDK4 as a new transcriptional target of RAs through two responsive elements (RAREa and RAREb). This regulation might participate to the reduced fatty acid release from the adipocyte and could play an important role in the development of metabolic diseases.

  3. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans

    Torsten Bohn, Charles Desmarchelier, Lars O. Dragsted, Charlotte S. Nielsen, Wilhelm Stahl, Ralph Rühl, Jaap Keijer and Patrick Borel

    Version of Record online: 27 FEB 2017 | DOI: 10.1002/mnfr.201600685

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    An overview of factors likely to contribute to interindividual variation of carotenoid bioavailability and thus tissue concentrations is presented.

  4. In vivo metabolomic interpretation of the anti-obesity effects of hyacinth bean (Dolichos lablab L.) administration in high-fat diet mice

    Dong Ho Suh, Hye Won Lee, Eun Sung Jung, Digar Singh, Seung-Hyung Kim and Choong Hwan Lee

    Version of Record online: 27 FEB 2017 | DOI: 10.1002/mnfr.201600895

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    This study investigates the anti-obesity effects between hyacinth bean (Dolichos lablab) and milk thistle administration in HFD-fed mice. Hyacinth bean or milk thistle administration shows similar anti-obesity effects in both clinical and metabolic data, but with some differences in metabolomics results. From this study, it is suggested that hyacinth bean could be a potential herbal medicine to treat obesity-related disorders with smaller doses than milk thistle.

  5. Prospective study of the dietary inflammatory index and risk of breast cancer in postmenopausal women

    Nitin Shivappa, Cindy K. Blair, Anna E. Prizment, David R. Jacobs and James R. Hébert

    Version of Record online: 27 FEB 2017 | DOI: 10.1002/mnfr.201600592

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    A pro-inflammatory diet as evidenced by higher dietary inflammatory index (DII) scores is associated with increased risk of breast cancer in the Iowa Women's Health Study. Hence, a diet rich in anti-inflammatory components and poor in pro-inflammatory components may play an important role in preventing breast cancer incidence.