Molecular Nutrition & Food Research

Cover image for Vol. 62 Issue 4

Editor-in-Chief: Christine Mayer, Deputy Editor: Kerstin Brachhold, Chairman-Executive Editorial Board: Hans-Ulrich Humpf

Impact Factor: 4.323

ISI Journal Citation Reports © Ranking: 2016: 9/130 (Food Science & Technology)

Online ISSN: 1613-4133

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Recently Published Articles

  1. An extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation

    Yongmei Yu, Tamra Mendoza, David Ribnicky, Alexander Poulev, Robert C. Noland, Randall L. Mynatt, Ilya Raskin, William T. Cefalu and Z. Elizabeth Floyd

    Accepted manuscript online: 23 FEB 2018 08:50PM EST | DOI: 10.1002/mnfr.201700856

  2. Cholesterol Absorption and Synthesis in Vegetarians and Omnivores

    Dieter Lütjohann, Sven Meyer, Klaus von Bergmann and Frans Stellaard

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/mnfr.201700689

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    A lower dietary cholesterol intake in vegetarian subjects does not lead to proportionally lowered plasma cholesterol concentrations. A 90% lower cholesterol intake in vegans leads to a significant 13% lower plasma LDL cholesterol and a similar plasma total cholesterol concentration when compared to omnivores. In lacto-ovo and lacto vegetarians both concentrations are not different from those in omnivores.

  3. Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways

    Sicong Tian, Baolong Li, Peng Lei, Xiuli Yang, Xiaohong Zhang, Yongping Bao and Yujuan Shan

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/mnfr.201700737

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    Sulforaphane (SFN) inhibits lipid synthesis by blocking the endoplasmic reticulum-stress (ERS). On the one hand, SFN suppresses IRE1 and its downstream transcript (sXBP1), which inactivates acetyl CoA carboxylase 1(ACC1) and stearoyl-CoA desaturase 1 (SCD1). On the other hand, SFN inhibits the expression of SREBP1 through downregulating PERK or stimulating insulin signal, which leads to the inhibition of fatty acid synthase (FAS).

  4. Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

    Lauren Housley, Armando Alcazar Magana, Anna Hsu, Laura M. Beaver, Carmen P. Wong, Jan F. Stevens, Jaewoo Choi, Yuan Jiang, Deborah Bella, David E. Williams, Claudia S. Maier, Jackilen Shannon, Roderick H. Dashwood and Emily Ho

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/mnfr.201700665

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    The effects of cruciferous vegetable consumption (raw broccoli sprouts) on human plasma metabolite profiles are examined using untargeted metabolomics. Plasma metabolite profiles are different before and after sprout consumption. This screen reveals changes in metabolites associated with fatty acid, steroid, and nucleotide metabolism, as well as cellular antioxidant defenses.

  5. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression

    Ming-Yao Gu, Yoon Sun Chun, Dong Zhao, Shi Yong Ryu and Hyun Ok Yang

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/mnfr.201700633

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    Glycyrrhiza uralensis extract (GUE) and its bio-activated compound semilicoisoflavone B (SB) are shown to inhibit Aβ secretion. This effect contributes to the downregulation of the BACE1 protein and mRNA. In a subsequent mechanism study, it is found that GUE and SB regulates BACE1 transcription factors by inducing the expression PPARγ and inhibiting the phosphorylation of STAT3. The results suggest that GUE and SB may function as PPARγ agonists, which inhibit BACE1 expression and ultimately reduce the secretion of Aβ.