Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages
Limei Wang, Veronika Palme, Susanne Rotter, Nicole Schilcher, Malsor Cukaj, Dongdong Wang, Angela Ladurner, Elke H. Heiss, Herbert Stangl, Verena M. Dirsch and Atanas G. Atanasov
Version of Record online: 23 DEC 2016 | DOI: 10.1002/mnfr.201500960
Piperine, the main ingredient of black pepper, is identified as enhancer of macrophage cholesterol efflux. The latter is of relevance for atherosclerosis, the most prevalent cause of death worldwide. It is shown piperine increases the amount of the transporter ABCA1, due to indirect inhibition of calpain activity. This work suggests that piperine has potential, and could be further studied, as possible agent for therapy or prevention of atherosclerosis.