Molecular Nutrition & Food Research

Cover image for Vol. 61 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Hans-Ulrich Humpf

Impact Factor: 4.551

ISI Journal Citation Reports © Ranking: 2015: 5/125 (Food Science & Technology)

Online ISSN: 1613-4133


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  1. Research Articles

    1. Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men

      Kristen M. Roberts, Elizabeth M. Grainger, Jennifer M. Thomas-Ahner, Alice Hinton, Junnan Gu, Kenneth M. Riedl, Yael Vodovotz, Ronney Abaza, Steven J. Schwartz and Steven K. Clinton

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/mnfr.201600224

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      In men assigned either a control, low ellagitannin or low polyphenol, the Polyphenol Explorer® database was used to estimate dietary intake of polyphenols and ellagitannins. Based upon the dietary education, men achieved low-ellagitannin or low-polyphenol diets as evidence by the estimated intake and urinary and plasma ellagitannin metabolite detection.

  2. Reviews

    1. Dietary fibers and associated phytochemicals in cereals

      Knud Erik Bach Knudsen, Natalja P. Nørskov, Anne Katrine Bolvig, Mette Skou Hedemann and Helle Nygaard Lærke

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/mnfr.201600518

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      The underlying physiological mechanisms behind the protective health effects of whole-grain cereals are unclear, but are most likely assigned to a concerted action of dietary fiber and a wide variety of phenolic phytochemicals. Only a small fraction of the phenolics is absorbed in the small but the availability can be increased by bioprocessing.

  3. Research Articles

    1. Consumption of the total Western diet differentially affects the response to green tea in rodent models of chronic disease compared to the AIN93G diet

      Robert E. Ward, Abby D. Benninghoff, Brett J. Healy, Minghao Li, Bharath Vagu and Korry J. Hintze

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/mnfr.201600720

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      Mice were fed either a standard basal diet (AIN93G) or a diet that emulates American diets (Total Western Diet, TWD) with or without green tea extract (GTE). Mice consuming the TWD had a different chronic disease response to GTE compared to mice fed the standard AIN93G diet. Our data suggest basal diet is an important consideration for pre-clinical rodent models.

    2. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells

      Gavin S. Johnson, Jia Li, Laura M. Beaver, W. Mohaiza Dashwood, Deqiang Sun, Praveen Rajendran, David E. Williams, Emily Ho and Roderick H. Dashwood

      Version of Record online: 3 JAN 2017 | DOI: 10.1002/mnfr.201600769

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      NmrA-like redox sensor 2 (NMRAL2P) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream coregulator of Nrf2-dependent gene activation in response to sulforaphane treatment.

    3. Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) α1 in mice fed high-fat diet

      Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson and Min Du

      Version of Record online: 3 JAN 2017 | DOI: 10.1002/mnfr.201600746

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      In vivo, dietary 0.1% Resv promoted brown adipogenesis markers, increased oxygen consumption, and activated AMPKα activity in iBAT. In vitro, 10 μM Resv elicited the same effects on differentiated iBAT SVCs. However, the promotional effects of Resv were abolished by AMPK inhibition or AMPKα1 KO. These data showed that Resv enhanced brown adipocyte formation and function by activating AMPKα1.

    4. Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB

      Zhigang Liu, Yuwei Chen, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren and Xuebo Liu

      Version of Record online: 30 DEC 2016 | DOI: 10.1002/mnfr.201600734

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      Dietary supplementation of sesamol, a phenolic lignan nutraceutical component from sesame, suppresses systemic inflammation-induced memory impairment through inhibiting β-amyloid accumulation and acetylcholine system unbalance. The underlying molecular mechanism might be sesamol binding with nuclear translocation and DNA binding site of NFκB, an essential inflammatory transcriptional master regulator protein, and consequently blocking inflammatory cytokines release and β-amyloid production.

  4. Reviews

    1. Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

      Ching-Shu Lai, Jia-Ching Wu, Chi-Tang Ho and Min-Hsiung Pan

      Version of Record online: 30 DEC 2016 | DOI: 10.1002/mnfr.201600721

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      Mitochondrial dysfunction includes a decrease in mitochondrial biogenesis, remodeling, mitochondrial DNA content leads to impair adipogenesis, lipid metabolism, and insulin sensitivity in white adipocytes. Increasing mitochondrial reactive oxygen species causes oxidation of lipids, proteins, and mitochondrial DNA that amplifies mitochondrial defects in adipocytes. All of these biochemical changes from mitochondrial dysfunction consequently promote obesity and type 2 diabetes but could be improved by dietary natural compounds.

  5. Research Articles

    1. Human peripheral blood mononuclear cell in vitro system to test the efficacy of food bioactive compounds: Effects of polyunsaturated fatty acids and their relation with BMI

      Margalida Cifre, Rubén Díaz-Rúa, Rubén Varela-Calviño, Bàrbara Reynés, Jordi Pericás-Beltrán, Andreu Palou and Paula Oliver

      Version of Record online: 30 DEC 2016 | DOI: 10.1002/mnfr.201600353

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      The usefulness of in vitro incubation of human PBMC with n–3 LCPUFA is explored, in two groups of subjects differing in their BMI. It is found that this system reflects the effects of n–3 LCPUFA on lipid metabolism/inflammation. However, the response is BMI dependent as is impaired in overweight/obese subjects. This in vitro system could be useful to screen the effects of food bioactive compounds and to design dietary strategies aimed to obese population.

    2. You have full text access to this OnlineOpen article
      Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages

      Limei Wang, Veronika Palme, Susanne Rotter, Nicole Schilcher, Malsor Cukaj, Dongdong Wang, Angela Ladurner, Elke H. Heiss, Herbert Stangl, Verena M. Dirsch and Atanas G. Atanasov

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/mnfr.201500960

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      Piperine, the main ingredient of black pepper, is identified as enhancer of macrophage cholesterol efflux. The latter is of relevance for atherosclerosis, the most prevalent cause of death worldwide. It is shown piperine increases the amount of the transporter ABCA1, due to indirect inhibition of calpain activity. This work suggests that piperine has potential, and could be further studied, as possible agent for therapy or prevention of atherosclerosis.

    3. Simultaneous delivery of antibiotics neomycin and ampicillin in drinking water inhibits fermentation of resistant starch in rats

      Diana G. Carvajal-Aldaz, Justin L. Guice, Ryan C. Page, Anne M. Raggio, Roy J. Martin, Claudia Husseneder, Holiday A. Durham, James Geaghan, Marlene Janes, Ted Gauthier, Diana Coulon and Michael J. Keenan

      Version of Record online: 22 DEC 2016 | DOI: 10.1002/mnfr.201600609

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      Two studies are conducted using antibiotics to reduce the microbiota to determine if use of antibiotics was an effective method to knockout fermentation of dietary resistant starch (RS). Concurrent antibiotics treatment with feeding of RS results in a reduction in some markers of fermentation, but side effects of antibiotics give some concern.

    4. Short-term biomarkers of apple consumption

      Theresa Saenger, Florian Hübner and Hans-Ulrich Humpf

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mnfr.201600629

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      The presented study shows that it is possible to detect and distinguish between a low, medium, and high apple consumption just by quantifying short-term biomarkers in spot urine samples.

    5. Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats

      Adriano Lama, Claudio Pirozzi, Maria Pia Mollica, Giovanna Trinchese, Francesca Di Guida, Gina Cavaliere, Antonio Calignano, Giuseppina Mattace Raso, Roberto Berni Canani and Rosaria Meli

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mnfr.201600418

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      Nonalcoholic fatty liver disease is characterized by insulin resistance, hepatic inflammation and mitochondrial oxidative stress. Polyphenol-rich virgin olive oil (HPCOO) is able to reduce pro-inflammatory mediators (TNF-α, IL-1, COX-2, and leptin) and to increase anti-inflammatory ones (IL-10 and adiponectin). Moreover, HPCOO restores glucose homeostasis and increases fatty acid oxidation, activating AMPK/AKT pathway and PPAR-α transcription, and improves mitochondrial oxidative stress, inhibiting aconitase activity and reactive oxygen species and H2O2 production.

    6. Relationship between HMF intake and SMF formation in vivo: An animal and human study

      Silvia Pastoriza de la Cueva, Juana Álvarez, Ákos Végvári, Javier Montilla-Gómez, Olga Cruz-López, Cristina Delgado-Andrade and José A. Rufián-Henares

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mnfr.201600773

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      5-Hydroxymethylfurfural (HMF) is a compound produced during the heat processing of common foods such as chocolate, coffee, hamburgers, and so on. 5-Sulfooxymethylfurfural (SMF) is a metabolite of HMF with toxic and mutagenic characteristics. The presence of HMF and SMF in plasma, liver, and kidneys, as well as DNA adducts in leukocytes after HMF absorption is demonstrated. A high dietary intake of HMF in children is also shown, which is readily metabolized to SMF, giving rise to DNA adducts in those children with the highest intake of HMF.

    7. Endoplasmic reticulum stress contributes to ferritin molecules-mediated macrophage migration via P-selectin glycoprotein ligand-1

      Chi-Mei Wang, Yue-Hwa Chen, Yu-Chieh Lee and Jung-Su Chang

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mnfr.201600458

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      This study aims to investigate effects of serum ferritin on macrophage activation and migration. Human study shows that serum ferritin is an independent predictor of soluble PSGL-1. An in vitro study indicates that serum ferritin induced macrophage activation and migration is related to intracellular iron levels and iron-mediated endoplasmic reticulum stress associated mechanisms are required for ferritin-mediated macrophage migration via the PSGL-1-dependent pathway.

    8. Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro

      Katharina Vejdovszky, Verena Schmidt, Benedikt Warth and Doris Marko

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/mnfr.201600526

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      Binary mixtures of the phytoestrogen genistein with the mycoestrogen zearalenone mainly show potentiating effects on estrogenicity in an in vitro test system. Depending on the concentration range, combinations of genistein and the mycotoxin alternariol either potentiate or decrease estrogenic effects. In both mixtures combinatory effects found to depend on the applied concentration ranges and ratios.

  6. Food & Function

    1. Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion

      Masaki Kato, Sho Nishikawa, Akiho Ikehata, Kojiro Dochi, Tsubasa Tani, Tsukasa Takahashi, Atsushi Imaizumi and Takanori Tsuda

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/mnfr.201600471

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      GLP-1 stimulates glucose-dependent insulin secretion, and is an important factor in the treatment and prevention of type 2 diabetes. It is demonstrated that oral administration of curcumin significantly increases the plasma concentrations of GLP-1 and insulin, resulting in the amelioration of impaired glucose tolerance in rats, and also curcumin-induced GLP-1 secretion is mediated via GPR 40/120 pathway.

  7. Research Articles

    1. Modulation of iron transport, metabolism and reactive oxygen status by quercetin–iron complexes in vitro

      Richard D. Horniblow, Daisy Henesy, Tariq H. Iqbal and Chris Tselepis

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/mnfr.201600692

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      Excess free-iron is detrimental to health due to its ability to catalyse the formation of cytotoxic reactive oxygen species. Specifically it is implicated in inflammatory conditions, cancer growth and fuelling bacterial infections. Polyphenolic compounds within our diets demonstrate iron-binding ability. Quercetin has been identified to have both intracellular and extracellular iron chelating potential. Chelation of iron by quercetin renders iron inert, demonstrating the potential of quercetin as a therapeutic iron chelator.

    2. Offspring predisposition to obesity due to maternal-diet-induced obesity in rats is preventable by dietary normalization before mating

      Heriberto Castro, Catalina Amadora Pomar, Andreu Palou, Catalina Picó and Juana Sánchez

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/mnfr.201600513

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      Dietary normalization in rats made obese by cafeteria diet feeding for 1 month before gestation, even without a complete reversal in excess weight and adiposity, prevents the harmful effects on offspring associated with maternal obesity.

    3. An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat “Western-type” diet in mice

      Enrique Jurado-Ruiz, Lourdes M. Varela, Amparo Luque, Genoveva Berná, Gladys Cahuana, Enrique Martinez-Force, Rocío Gallego-Durán, Bernat Soria, Baukje de Roos, Manuel Romero Gómez and Franz Martín

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/mnfr.201600549

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      Dietary fat may be an important modifiable factor involved in nonalcoholic fatty liver disease. The protective effect of extra virgin olive oil (EVOO) in high-fat diets on the inflammatory response and liver damage is evaluated in a nonalcoholic fatty liver disease mouse model. EVOO diets improve plasma lipid profile, plasma and fat inflammation; ameliorate liver damage; increase MUFAs liver levels; and modify liver protein expression. Dietary EVOO could repair high-fat diet induced hepatic damage via an anti-inflammatory effect and changes in the liver lipid composition and signaling pathways.

    4. Anti-inflammatory potential of black carrot (Daucus carota L.) polyphenols in a co-culture model of intestinal Caco-2 and endothelial EA.hy926 cells

      Senem Kamiloglu, Charlotte Grootaert, Esra Capanoglu, Ceren Ozkan, Guy Smagghe, Katleen Raes and John Van Camp

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/mnfr.201600455

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      The ability of polyphenol-rich black carrot and its by-products, i.e., peel and pomace, to modulate the inflammatory response in tumor necrosis factor-α (TNF-α)-treated endothelial cells after gastrointestinal digestion and in a co-culture of intestinal Caco-2 and endothelial EA.hy926 cell model is determined. It is shown that the polyphenol-rich black carrot absorption products may function through an inhibitory regulation of the inflammatory cascade in endothelial cells.


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